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Nicolaus Kröger

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https://www.readbyqxmd.com/read/30317227/return-to-work-in-patients-with-hematological-cancers-1-year-after-treatment-a-prospective-longitudinal-study
#1
Tim J Hartung, Leon P Sautier, Angela Scherwath, Kirsten Sturm, Nicolaus Kröger, Uwe Koch, Anja Mehnert
BACKGROUND: Although hematological cancer survivors have a high risk of disability, data on work-related issues are scarce for this population. METHODS: We investigated return to work (RTW) and work ability (Work Ability Index, WAI) in hematological cancer patients 6 months and 1 year after cancer treatment. We explored associations between baseline sociodemographic and medical characteristics and RTW as well as work ability at follow-up. RESULTS: The participation rate was 42% (baseline n = 91, after 12 months n = 40 (44%))...
October 13, 2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30243581/the-outcome-of-haplo-identical-transplantation-in-patients-with-relapsed-multiple-myeloma-an-ebmt-cibmtr-report
#2
Firoozeh Sahebi, Laurent Garderet, Abraham S Kanate, Diderik-Jan Eikema, Nina Simone Knelange, Omar F Dávila Alvelo, Yener Koc, Didier Blaise, Qaiser Bashir, José M Moraleda, Peter Dreger, James F Sanchez, Stefan Ciurea, Harry Schouten, Nirav N Shah, Mareike Verbeek, Wolf Rösler, Jose L Diez-Martin, Stefan Schoenland, Anita D'Souza, Nicolaus Kröger, Parameswaran Hari
Allogeneic hematopoietic cell transplantation (allo-HCT) using siblings and matched donors has the potential for long-term disease control in a subset of high-risk multiple myeloma (MM) patients. However, the data on using haploidentical donors in this disease are limited. We conducted a retrospective analysis to examine the outcomes of patients with MM who underwent haploidentical allo-HCT within EBMT/CIBMTR centers. A total of 96 patients underwent haploidentical transplantation between 2008 and 2016. With a median follow up of 24...
September 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30172776/hla-mismatched-donors-in-patients-with-myelodysplastic-syndrome-an-ebmt-registry-analysis
#3
Marie Robin, Raphaël Porcher, Annalisa Ruggeri, Didier Blaise, Christine Wolschke, Linda Koster, Emanuele Angelucci, Friedrich Stölzel, Victoria Potter, Ibrahim Yakoub-Agha, Yener Koc, Fabio Ciceri, Jürgen Finke, Hélène Labussière-Wallet, Maria Jesús Pascual Cascon, Mareike Verbeek, Alessandro Rambaldi, Jan J Cornelissen, Patrice Chevallier, Rohini Radia, Arnon Nagler, Nathalie Fegueux, Eliane Gluckman, Theo de Witte, Nicolaus Kröger
Recently, haploidentical transplantation (haplo) using post-transplant cyclophosphamide (PTCy) has been reported to give very encouraging results in patients with hematological malignancies. Patients who have no HLA-matched donor currently have the choice between a mismatched unrelated donor, an unrelated cord blood (CB) donor, and a haploidentical related donor. The aim of our study is to compare the outcome of patients with myelodysplastic syndrome (MDS) who have been transplanted from a haploidentical donor using PTCy, an HLA-mismatched unrelated donor (marrow or peripheral blood stem cells), or an unrelated mismatched CB donor...
August 30, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30135313/an-early-biomarker-algorithm-predicts-lethal-graft-versus-host-disease-and-survival
#4
Matthew J Hartwell, Umut Özbek, Ernst Holler, Anne S Renteria, Hannah Major-Monfried, Pavan Reddy, Mina Aziz, William J Hogan, Francis Ayuk, Yvonne A Efebera, Elizabeth O Hexner, Udomsak Bunworasate, Muna Qayed, Rainer Ordemann, Matthias Wölfl, Stephan Mielke, Attaphol Pawarode, Yi-Bin Chen, Steven Devine, Andrew C Harris, Madan Jagasia, Carrie L Kitko, Mark R Litzow, Nicolaus Kröger, Franco Locatelli, George Morales, Ryotaro Nakamura, Ran Reshef, Wolf Rösler, Daniela Weber, Kitsada Wudhikarn, Gregory A Yanik, John E Levine, James Lm Ferrara
No abstract text is available yet for this article.
August 23, 2018: JCI Insight
https://www.readbyqxmd.com/read/30116018/methods-and-role-of-minimal-residual-disease-after-stem-cell-transplantation
#5
Marco Ladetto, Sebastian Böttcher, Nicolaus Kröger, Michael A Pulsipher, Peter Bader
Relapse is the major cause of treatment failure after stem cell transplantation. Despite the fact that relapses occurred even if transplantation was performed in complete remission, it is obvious that minimal residual disease is present though not morphologically evident. Since adaptive immunotherapy by donor lymphocyte infusion or other novel cell therapies as well as less toxic drugs, which can be used after transplantation, the detection of minimal residual disease (MRD) has become a clinical important variable for outcome...
August 16, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/30082852/narrowing-the-gap-for-hematopoietic-stem-cell-transplantation-in-the-east-mediterranean-african-region-comparison-with-global-hsct-indications-and-trends
#6
Helen Baldomero, Mahmoud Aljurf, Syed Z A Zaidi, Shahrukh K Hashmi, Ardeshir Ghavamzadeh, Alaa Elhaddad, Rose-Marie Hamladji, Parvez Ahmed, Lamia Torjemane, Miguel Abboud, Abdelghani Tbakhi, Murtadha Al Khabori, Asma El Quessar, Nosa Bazuaye, Mohamed Amine Bekadja, Salman Adil, Omar Fahmy, Mani Ramzi, Ahmed Ibrahim, Amal Alseraihy, Nour Ben Abdejalil, Mahmoud Sarhan, Mohammed Al Huneini, Lahoucine Mahmal, Hassan ElSolh, Fazal Hussain, Amr Nassar, Hani Al-Hashmi, Amir Ali Hamidieh, Marcelo Pasquini, Yoshihisa Kodera, Nicolaus Kröger, Mohamed Mohty, Gregorio Jaimovich, Juliana Martinez Rolon, Kristjan Paulson, Hildegard Greinix, Daniel Weisdorf, Mary Horowitz, José Nunez, Alois Gratwohl, Jacob Passweg, Mickey Koh, Jeff Szer, Dietger Niederwieser, Nicolas Novitzky
Hematopoietic Stem Cell Transplantation (HSCT) activity was evaluated in the African (AFR)/EMRO region and compared to the global activity for the years 2006-2013. Data were obtained from 1570 teams in the 6 WHO continental regions. Of these, 29 (1.85%) of all teams were active in 12 of the 68 AFR/EMRO countries. They reported 2.331 (3.3%) of the worldwide 71.036 HSCT, and a transplant rate of 32.8 (TR; HSCT/10 million inhabitants; worldwide 128.5). This reflects still the lowest regional TR despite an increase of 90% since 2006...
August 6, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/30038353/methods-to-prevent-and-treat-relapse-after-hematopoietic-stem-cell-transplantation-with-tyrosine-kinase-inhibitors-immunomodulating-drugs-deacetylase-inhibitors-and-hypomethylating-agents
#7
REVIEW
Yi-Bin Chen, Philip L McCarthy, Theresa Hahn, Sarah A Holstein, Masumi Ueda, Nicolaus Kröger, Michael Bishop, Marcos de Lima
Relapse is a major cause of treatment failure after stem cell transplantation. Novel agents given as maintenance or preemptive post transplant were discussed at the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse after Stem Cell Transplantation in Hamburg/Germany in November 2016 under the auspices of EBMT and ASBMT. Maintenance therapy is started after SCT without detectable disease, while preemptive therapy is triggered by the detection of minimal residual disease (MRD). The maintenance approach treats all patients, and overtreats a significant amount...
July 23, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29966760/relative-impact-of-hla-matching-and-non-hla-donor-characteristics-on-outcomes-of-allogeneic-stem-cell-transplantation-for-acute-myeloid-leukemia-and-myelodysplastic-syndrome
#8
Francis Ayuk, Dietrich W Beelen, Martin Bornhäuser, Matthias Stelljes, Tatjana Zabelina, Jürgen Finke, Guido Kobbe, Daniel Wolff, Eva-Maria Wagner, Maximilian Christopeit, Christoph Schmid, Hellmut Ottinger, Christoph Groth, Christoph Faul, Hartmut Bertz, Elena Rachlis, Christine Wolschke, Johannes Schetelig, Peter A Horn, Joannis Mytilineos, Martina Guellstorf, Reinhard Kelsch, Katharina Fleischhauer, Nicolaus Kröger, Wolfgang Bethge
Increasing donor-recipient HLA disparity is associated with negative outcomes of allogeneic hematopoietic stem cell transplantation (HSCT), but its comparative relevance amid non-HLA donor characteristics is not well established. We addressed this question in 3215 HSCTs performed between 2005 and 2013 in Germany for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Donors were HLA-matched related (MRD; n = 872) or unrelated (10/10 MUD, n = 1553) or HLA-mismatched unrelated (<10/10 MMUD, n = 790)...
July 24, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29907810/asxl1-ezh2-mutations-promote-clonal-expansion-of-neoplastic-hsc-and-impair-erythropoiesis-in-pmf
#9
Ioanna Triviai, Silke Zeschke, Jan Rentel, Marios Spanakis, Theo Scherer, Razif Gabdoulline, Victoria Panagiota, Felicitas Thol, Michael Heuser, Carol Stocking, Nicolaus Kröger
Primary myelofibrosis (PMF) is a hematopoietic stem cell (HSC) disease, characterized by aberrant differentiation of all myeloid lineages and profound disruption of the bone marrow niche. PMF samples carry several mutations, but their cell origin and hierarchy in regulating the different waves of clonal and aberrant myeloproliferation from the prime HSC compartment is poorly understood. Genotyping of >2000 colonies from CD133+HSC and progenitors from PMF patients confirmed the complex genetic heterogeneity within the neoplastic population...
June 15, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29880610/competing-risk-outcomes-after-hematopoietic-stem-cell-transplantation-from-the-perspective-of-time-dependent-effects
#10
Daniel Fuerst, Sandra Frank, Carlheinz Mueller, Dietrich W Beelen, Johannes Schetelig, Dietger Niederwieser, Jürgen Finke, Donald Bunjes, Nicolaus Kröger, Christine Neuchel, Chrysanthi Tsamadou, Hubert Schrezenmeier, Jan Beyersmann, Joannis Mytilineos
The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects. We evaluated the effect of predictors on competing-risk outcomes after hematopoietic stem cell transplantation in a time-dependent manner. We analyzed 14951 outcomes of adult patients with hematologic malignancies who underwent a first allogeneic transplant. We extended the combined endpoints of disease-free and overall survival to competing-risk settings: disease-free survival was split into relapse and non-relapse mortality...
September 2018: Haematologica
https://www.readbyqxmd.com/read/29808926/outcome-of-patients-with-myelofibrosis-relapsing-after-allogeneic-stem-cell-transplant-a-retrospective-study-by-the-chronic-malignancies-working-party-of-ebmt
#11
Donal P McLornan, Richard Szydlo, Marie Robin, Anja van Biezen, Linda Koster, Henrik J P Blok, Maria T Van Lint, Jürgen Finke, Antonin Vitek, Kristina Carlson, Laimonas Griskevicius, Ernst Holler, Maija Itälä-Remes, Michel Schaap, Gerard Socié, Jacques-Olivier Bay, Yves Beguin, Benedetto Bruno, Jan J Cornelissen, Tobias Gedde-Dahl, Per Ljungman, Marie T Rubio, Ibrahim Yakoub-Agha, Evgeny Klyuchnikov, Eduardo Olavarria, Yves Chalandon, Nicolaus Kröger
Allogeneic Haematopoietic Stem Cell Transplant (allo-HSCT) remains the only curative approach for Myelofibrosis (MF). Scarce information exists in the literature on the outcome and, indeed, management of those MF patients who relapse following transplant. We hereby report on the management and outcome of 202 patients who relapsed post allo-HSCT for MF.
May 29, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29800615/peritransplantation-ruxolitinib-prevents-acute-graft-versus-host-disease-in-patients-with-myelofibrosis-undergoing-allogenic-stem-cell-transplantation
#12
Nicolaus Kröger, Sharifah Shahnaz Syed Abd Kadir, Tatjana Zabelina, Anita Badbaran, Maximilian Christopeit, Francis Ayuk, Christine Wolschke
JAK inhibition by ruxolitinib is approved for treating myelofibrosis and also has shown efficacy in treating steroid-resistant acute and chronic graft-versus-host disease (GVHD). In 12 patients with myelofibrosis (median age, 63 years; range, 43 to 71 years) who were treated with ruxolitinib and underwent allogeneic stem cell transplantation (ASCT), ruxolitinib was continued (2 × 5 mg daily) until stable engraftment. No graft failure was observed, and leukocyte engraftment was achieved after a median of 12 days (range, 11 to 18 days)...
May 22, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29795433/prevention-and-treatment-of-relapse-after-stem-cell-transplantation-in-lymphoid-malignancies
#13
Anna Sureda, Peter Dreger, Michael R Bishop, Nicolaus Kroger, David L Porter
Relapse is now the major cause of treatment failure after allogeneic HSCT (alloHSCT). Many novel strategies to address this critical issue are now being developed and tested. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg, Germany in November 2016, international experts presented and discussed recent developments in the field. Some approaches may be applicable to a wide range of patients after transplant, whereas some may be very disease-specific. We present a report from the session dedicated to issues related to prevention and treatment of relapse of lymphoid malignancies after alloHSCT...
May 24, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29795427/prevention-and-treatment-of-relapse-after-stem-cell-transplantation-with-immunotherapy
#14
REVIEW
Nicola Gökbuget, Jonathan Canaani, Arnon Nagler, Michael Bishop, Nicolaus Kröger, David Avigan
Relapse has become the leading cause of treatment failure after stem cell transplantation. Besides cellular therapies and novel agents, immunotherapeutic strategies have entered clinical practice in order to reduce or prevent relapse. Here, we summarize the presentations on checkpoint inhibitors, vaccination strategies, and novel antibody therapies, which were presented and discussed at the third International Workshop on Biology, Prevention, and Treatment of Relapse after Stem Cell Transplantation.
June 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29795426/prevention-and-treatment-of-relapse-after-stem-cell-transplantation-by-cellular-therapies
#15
Fred Falkenburg, Eliana Ruggiero, Chaira Bonini, David Porter, Jeff Miller, Floran Malard, Mohamad Mohty, Nicolaus Kröger, Hans Jochem Kolb
Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized...
May 24, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29791053/impact-of-ruxolitinib-pretreatment-on-outcomes-after-allogeneic-stem-cell-transplantation-in-patients-with-myelofibrosis
#16
Sharifah Shahnaz Syed Abd Kadir, Maximilian Christopeit, Gerald Wulf, Eva Wagner, Martin Bornhauser, Thomas Schroeder, Martina Crysandt, Karin Mayer, Julia Jonas, Matthias Stelljes, Anita Badbaran, Francis Ayuketang Ayuk, Ioanna Triviai, Dominik Wolf, Christine Wolschke, Nicolaus Kröger
INTRODUCTION: Ruxolitinib is the first approved drug for treatment of myelofibrosis, but its impact of outcome after allogeneic stem cell transplantation (ASCT) is unknown. PATIENTS AND METHODS: We reported on 159 myelofibrosis patients (pts) with a median age of 59 years (r: 28-74) who received reduced intensity ASCT between 2000 and 2015 in eight German centers from related (n = 23), matched (n = 86) or mismatched (n = 50) unrelated donors. Forty-six (29%) patients received ruxolitinib at any time point prior to ASCT...
September 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29777868/comparative-efficacy-and-safety-of-different-antiviral-agents-for-cytomegalovirus-prophylaxis-in-allogeneic-hematopoietic-cell-transplantation-a-systematic-review-and-meta-analysis
#17
Nico Gagelmann, Per Ljungman, Jan Styczynski, Nicolaus Kröger
Over the past 25 years, several randomized controlled trials have investigated the efficacy of different antiviral agents for cytomegalovirus (CMV) prophylaxis in allogeneic hematopoietic cell transplantation. We performed a systematic literature review, conventional meta-analysis, and network meta-analysis using a random-effects model and risk ratios (RRs) with corresponding 95% confidence intervals (CIs) as effect estimates. Fifteen randomized controlled trials were identified, including 7 different antiviral agents: acyclovir, ganciclovir, maribavir, brincidofovir, letermovir, valacyclovir, and vaccine...
May 16, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29728701/ibrutinib-for-bridging-to-allogeneic-hematopoietic-cell-transplantation-in-patients-with-chronic-lymphocytic-leukemia-or-mantle-cell-lymphoma-a-study-by-the-ebmt-chronic-malignancies-and-lymphoma-working-parties
#18
Peter Dreger, Mauricette Michallet, Paul Bosman, Sascha Dietrich, Mohamad Sobh, Ariane Boumendil, Arnon Nagler, Christof Scheid, Jan Cornelissen, Dietger Niederwieser, Lutz Müller, Elizabeth Vandenberghe, Ilaria Scortechini, Helene Schoemans, Niels S Andersen, Jürgen Finke, Domenico Russo, Per Ljungman, Jakob Passweg, Michel van Gelder, Nadira Durakovic, Helene Labussiere-Wallet, Tobias Berg, Gerald Wulf, Wolfgang Bethge, Donald Bunjes, Stefan Stilgenbauer, Maria Elisa Canepari, Michel Schaap, Christopher P Fox, Nicolaus Kröger, Silvia Montoto, Johannes Schetelig
The aim of this retrospective study was to investigate the safety and efficacy of allogeneic hematopoietic cell transplantation (alloHCT) in patients pre-treated with ibrutinib. Eligible were patients aged >18 years allotransplanted for chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL) after prior exposure to ibrutinib who were registered with the EBMT registry. Seventy patients (CLL 48, MCL 22) were included. At the time of alloHCT, 73% of the patients were ibrutinib responsive. All patients except one engrafted, and acute GVHD grade 2-4 (3-4) was observed in 49% (12%) of 68 evaluable patients...
May 4, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29720705/recommendations-from-the-european-society-for-blood-and-marrow-transplantation-ebmt-for-a-curriculum-in-hematopoietic-cell-transplantation
#19
Mohamad Mohty, Rafael F Duarte, Jurgen Kuball, Peter Bader, Grzegorz W Basak, Chiara Bonini, Enric Carreras, Christian Chabannon, Carlo Dufour, Andrew Gennery, Arjan Lankester, Francesco Lanza, Per Ljungman, Silvia Montoto, Arnon Nagler, John A Snowden, Jan Styczynski, Anna Sureda, Nicolaus Kröger
Hematopoietic cell transplantation (HCT) is increasingly used worldwide. This treatment approach is complex and requires specific knowledge and training. The European Society for Blood and Marrow Transplantation (EBMT) identified the need for a set of international recommendations for the clinical training of physicians to qualify them as being competent in performing HCT procedures as well as novel cellular immune therapies and taking care of such patients. The goal is to implement an EBMT HCT-focused global curriculum (EBMT-GC) that can serve as a tool for the development of the HCT sub-specialty worldwide...
May 2, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29684563/long-term-results-of-prophylactic-donor-lymphocyte-infusions-for-patients-with-multiple-myeloma-after-allogeneic-stem-cell-transplantation
#20
Maximilian Gröger, Nico Gagelmann, Christine Wolschke, Ute-Marie von Pein, Evgeny Klyuchnikov, Max Christopeit, Axel Zander, Francis Ayuk, Nicolaus Kröger
The major reason for treatment failure after allografting in multiple myeloma (MM) is relapse. Donor lymphocyte infusions (DLIs) are considered a valuable post-transplant strategy mainly for relapsed patients but using them to prevent relapse in MM has been reported rarely. In the present study, we examined the efficacy of prophylactic DLIs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in myeloma patients with a long-term follow-up of more than 5 years. A total of 61 patients with MM who did not relapse or develop disease progression after allo-HSCT were treated with prophylactic DLI in an escalating fashion (overall 132 DLI procedures) to deepen remission status and prevent relapse...
July 2018: Biology of Blood and Marrow Transplantation
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