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https://www.readbyqxmd.com/read/28814019/stiffness-control-of-a-nylon-twisted-coiled-actuator-for-use-in-mechatronic-rehabilitation-devices
#1
Brandon P R Edmonds, Ana Luisa Trejos
Mechatronic rehabilitation devices, especially wearables, have been researched extensively and proven to be promising additions to physical therapy, but most designs utilize traditional actuators providing unnatural, robot-like movements. Therefore, many researchers have focused on the development of actuators that mimic biological properties to provide patients with improved results, safety, and comfort. Recently, a twisted-coiled actuator (TCA) made from nylon thread has been found to possess many of these important properties when heated, such as variable stiffness, flexibility, and high power density...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28814015/postoperative-healing-patterns-in-elbow-using-electromyography-towards-the-development-of-a-wearable-mechatronic-elbow-brace
#2
Raneem Haddara, Yue Zhou, Shrikant Chinchalkar, Ana Luisa Trejos
Musculoskeletal (MSK) conditions are the most common cause of severe long-term pain and physical disability. Current postoperative treatment for patients requires them to follow a long-term physiotherapy program customized for each specific case; however, this process can be complex, time-consuming and without the right therapy it may end up being ineffective. A possible solution involves the development of wearable mechatronic elbow braces that use electromyography (EMG) to identify patient intent. However, EMG characteristics change based on the health of the individual and therefore require further investigation...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813577/spatial-correspondence-between-intraretinal-fluid-subretinal-fluid-and-pigment-epithelial-detachment-in-neovascular-age-related-macular-degeneration
#3
Sophie Klimscha, Sebastian M Waldstein, Thomas Schlegl, Hrvoje Bogunovic, Amir Sadeghipour, Ana-Maria Philip, Dominika Podkowinski, Eleonore Pablik, Li Zhang, Michael D Abramoff, Milan Sonka, Bianca S Gerendas, Ursula Schmidt-Erfurth
Purpose: To identify the spatial distribution of exudative features of choroidal neovascularization in neovascular age-related macular degeneration (nAMD) based on the localization of intraretinal cystoid fluid (IRC), subretinal fluid (SRF), and pigment-epithelial detachment (PED). Methods: This retrospective cross-sectional study included spectral-domain optical coherence tomography volume scans (6 × 6 mm) of 1341 patients with treatment-naïve nAMD. IRC, SRF, and PED were detected on a per-voxel basis using fully automated segmentation algorithms...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28813518/changes-in-the-incidence-of-pneumonia-bacterial-meningitis-and-infant-mortality-5-years-following-introduction-of-the-13-valent-pneumococcal-conjugate-vaccine-in-a-3-0-schedule
#4
Sylvia Becker-Dreps, Bryan Blette, Rafaela Briceño, Jorge Alemán, Michael G Hudgens, Gilberto Moreno, Ana Ordoñez, Julio Rocha, David J Weber, Erick Amaya
BACKGROUND: Streptococcus pneumoniae causes about 826,000 deaths of children in the world each year and many health facility visits. To reduce the burden of pneumococcal disease, many nations have added pneumococcal conjugate vaccines to their national immunization schedules. Nicaragua was the first country eligible for GAVI Alliance funding to introduce the 13-valent pneumococcal conjugate vaccine (PCV13) in 2010, provided to infants at 2, 4, and 6 months of age. The goal of this study was to evaluate the population impact of the first five years of the program...
2017: PloS One
https://www.readbyqxmd.com/read/28813500/telomere-biology-and-telomerase-mutations-in-cirrhotic-patients-with-hepatocellular-carcinoma
#5
Flávia S Donaires, Natália F Scatena, Raquel M Alves-Paiva, Joshua D Podlevsky, Dhenugen Logeswaran, Barbara A Santana, Andreza C Teixeira, Julian J-L Chen, Rodrigo T Calado, Ana L C Martinelli
Telomeres are repetitive DNA sequences at linear chromosome termini, protecting chromosomes against end-to-end fusion and damage, providing chromosomal stability. Telomeres shorten with mitotic cellular division, but are maintained in cells with high proliferative capacity by telomerase. Loss-of-function mutations in telomere-maintenance genes are genetic risk factors for cirrhosis development in humans and murine models. Telomerase deficiency provokes accelerated telomere shortening and dysfunction, facilitating genomic instability and oncogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28813377/women-s-work
#6
Ana L Revenga, Ana Maria Munoz Boudet
No abstract text is available yet for this article.
August 15, 2017: Scientific American
https://www.readbyqxmd.com/read/28813151/the-medicinal-and-biological-chemistry-mbc-library-an-efficient-source-on-new-hits
#7
Víctor Sebastián Pérez, Carlos Roca, Mahendra Awale, Jean-Louis Reymond, Ana Martínez, Carmen Gil, Nuria E Campillo
Identification of new hits is one of the biggest challenges in drug discovery. Creating a library of well-characterized drug-like compounds is a key step in this process. Our group has developed an in-house chemical library called Medicinal and Biological Chemistry (MBC) library. This collection has been successfully used to start several medicinal chemistry programs and developed in an accumulation of more than thirty years of experience in drug design and discovery of new drugs for unmet diseases. It contains over 1,000 compounds, mainly heterocyclic scaffolds...
August 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28813107/climatic-characteristics-of-the-2010-2016-drought-in-the-semiarid-northeast-brazil-region
#8
José A Marengo, Lincoln M Alves, Regina C S Alvala, Ana Paula Cunha, Sheila Brito, Osvaldo L L Moraes
This study discusses the climatological aspects of the most severe drought ever recorded in the semiarid region Northeast Brazil. Droughts are recurrent in the region and while El Nino has driven some of these events others are more dependent on the tropical North Atlantic sea surface temperature fields. The drought affecting this region during the last 5 years shows an intensity and impact not seen in several decades in the regional economy and society. The analysis of this event using drought indicators as well as meteorological fields shows that since the middle 1990s to 2016, 16 out of 25 years experienced rainfall below normal...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28813102/terpene-esters-from-natural-products-synthesis-and-evaluation-of-cytotoxic-activity
#9
Mauricio M Victor, Jorge M David, Maria C K Sakukuma, Letícia V Costa-Lotufo, Andrea F Moura, Ana J Araújo
Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28813098/modeling-and-mapping-basal-area-of-pinus-taeda-l-plantation-using-airborne-lidar-data
#10
Carlos A Silva, Carine Klauberg, Andrew T Hudak, Lee A Vierling, Scott J Fennema, Ana Paula D Corte
Basal area (BA) is a good predictor of timber stand volume and forest growth. This study developed predictive models using field and airborne LiDAR (Light Detection and Ranging) data for estimation of basal area in Pinus taeda plantation in south Brazil. In the field, BA was collected from conventional forest inventory plots. Multiple linear regression models for predicting BA from LiDAR-derived metrics were developed and evaluated for predictive power and parsimony. The best model to predict BA from a family of six models was selected based on corrected Akaike Information Criterion (AICc) and assessed by the adjusted coefficient of determination (adj...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28813095/evaluation-of-cell-proliferation-and-endometrial-thickness-of-bitches-in-different-periods-of-diestrus
#11
Vanessa S A Gossler, Francislaine A G Santos, Aline R DE Azevedo, Priscila C Gonçalves, Hugo A Rigolo, Cleonice Trevisan, Ana Paula B Masseno, Ana Paula M M Cardoso, Paula C Papa, Caliê Castilho, Ines C Giometti
This study aimed to determine the histological features of the endometrium of bitches, as well as the cell proliferation at specific moments of diestrus, 10, 20, 30, 40, 50 and 60 days post ovulation, correlating the endometrial thickness with the uterine cell proliferation and the metabolic state (weight, blood glucose and plasma cholesterol) of the animals. Therefore, the right and left uterine horns of 26 clinically healthy bitches submitted to ovariohysterectomy were histologically analyzed 10, 20, 30, 40, 50 and 60 days post ovulation...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28813078/quality-of-life-in-parkinson-s-disease-patients-progression-markers-of-mild-to-moderate-stages
#12
Raissa Carla Moreira, Marise Bueno Zonta, Ana Paula Serra de Araújo, Vera Lúcia Israel, Hélio A G Teive
Objective: To investigate which factors are associated with the quality of life decline in Parkinson's disease patients from mild to moderate stages. Methods: The Unified Parkinson's Disease Rating Scale and Parkinson's Disease Questionnaire-39 were used to evaluate clinical/functional data and the quality of life. Results: The markers of clinical/functional worsening were drooling (p < 0.004), need for assistance with hygiene (p = 0.02), greater freezing frequency (p = 0...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28813071/content-validation-clarity-relevance-reliability-and-internal-consistency-of-enunciative-signs-of-language-acquisition
#13
Anelise Henrich Crestani, Anaelena Bragança de Moraes, Ana Paula Ramos de Souza
Purpose: To analyze the results of the validation of building enunciative signs of language acquisition for children aged 3 to 12 months. Methods: The signs were built based on mechanisms of language acquisition in an enunciative perspective and on clinical experience with language disorders. The signs were submitted to judgment of clarity and relevance by a sample of six experts, doctors in linguistic in with knowledge of psycholinguistics and language clinic. In the validation of reliability, two judges/evaluators helped to implement the instruments in videos of 20% of the total sample of mother-infant dyads using the inter-evaluator method...
August 10, 2017: CoDAS
https://www.readbyqxmd.com/read/28813069/atualiza%C3%A3-%C3%A3-o-da-diretriz-brasileira-de-dislipidemias-e-preven%C3%A3-%C3%A3-o-da-aterosclerose-%C3%A2-2017
#14
André Arpad Faludi, Maria Cristina de Oliveira Izar, José Francisco Kerr Saraiva, Ana Paula Marte Chacra, Henrique Tria Bianco, Abrahão Afiune, Adriana Bertolami, Alexandre C Pereira, Ana Maria Lottenberg, Andrei C Sposito, Antonio Carlos Palandri Chagas, Antonio Casella, Antônio Felipe Simão, Aristóteles Comte de Alencar, Bruno Caramelli, Carlos Costa Magalhães, Carlos Eduardo Negrão, Carlos Eduardo Dos Santos Ferreira, Carlos Scherr, Claudine Maria Alves Feio, Cristiane Kovacs, Daniel Branco de Araújo, Daniel Magnoni, Daniela Calderaro, Danielle Menosi Gualandro, Edgard Pessoa de Mello, Elizabeth Regina Giunco Alexandre, Emília Inoue Sato, Emilio Hideyuki Moriguchi, Fabiana Hanna Rached, Fábio César Dos Santos, Fernando Henpin Yue Cesena, Francisco Antonio Helfenstein Fonseca, Henrique Andrade Rodrigues da Fonseca, Hermes Toros Xavier, Isabela Cardoso Pimentel Mota, Isabela de Carlos Back Giuliano, Jaqueline Scholz Issa, Jayme Diament, João Bosco Pesquero, José Ernesto Dos Santos, José Rocha Faria, José Xavier de Melo, Juliana Tieko Kato, Kerginaldo Paulo Torres, Marcelo Chiara Bertolami, Marcelo Heitor Vieira Assad, Márcio Hiroshi Miname, Marileia Scartezini, Neusa Assumpta Forti, Otávio Rizzi Coelho, Raul Cavalcante Maranhão, Raul Dias Dos Santos, Renato Jorge Alves, Roberta Lara Cassani, Roberto Tadeu Barcellos Betti, Tales de Carvalho, Tânia Leme da Rocha Martinez, Viviane Zorzanelli Rocha Giraldez, Wilson Salgado
No abstract text is available yet for this article.
July 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28812924/susceptibility-testing-and-reporting-of-new-antibiotics-with-a-focus-on-tedizolid-an-international-working-group-report
#15
Mark H Wilcox, Natalia Dmitrieva, Ana Cristina Gales, Irina Petukhova, Suleiman Al-Obeid, Flavia Rossi, Joseph M Blondeau
Inappropriate use and overuse of antibiotics are among the most important factors in resistance development, and effective antibiotic stewardship measures are needed to optimize outcomes. Selection of appropriate antimicrobials relies on accurate and timely antimicrobial susceptibility testing. However, the availability of clinical breakpoints and in vitro susceptibility testing often lags behind regulatory approval by several years for new antimicrobials. A Working Group of clinical/medical microbiologists from Brazil, Canada, Mexico, Saudi Arabia, Russia and the UK recently examined issues surrounding antimicrobial susceptibility testing for novel antibiotics...
August 16, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28812768/chemical-nutritive-composition-and-a-wide-range-of-bioactive-properties-of-honey-mushroom-armillaria-mellea-vahl-fr-kummer
#16
Marina Kostić, Marija Smiljković, Jovana Petrović, Jasmina Glamočlija, Lillian Barros, Isabel C F R Ferreira, Ana Ćirić, Marina Soković
A. mellea fruiting bodies collected from nature were chemically characterized and shown to be rich in carbohydrates (81.25 g per 100 g dw), ash, fat and proteins (8.84 g per 100 g dw, 1.97 g per 100 g dw and 1.81 g per 100 g dw, respectively). Mannitol was the main free sugar while malic acid was the most abundant organic acid. δ-Tocopherol was the dominant form of tocopherols with 42.41 μg per 100 g dw. Polyunsaturated fatty acids were predominant, followed by saturated and monounsaturated fatty acids. A methanolic extract prepared from these samples was tested for antioxidant, quorum sensing and antimicrobial assays, as well as for its cytotoxicity effects...
August 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28812637/spatial-conservation-prioritization-of-biodiversity-spanning-the-evolutionary-continuum
#17
Silvia B Carvalho, Guillermo Velo-Antón, Pedro Tarroso, Ana Paula Portela, Mafalda Barata, Salvador Carranza, Craig Moritz, Hugh P Possingham
Accounting for evolutionary relationships between and within species is important for biodiversity conservation planning, but is rarely considered in practice. Here we introduce a novel framework to identify priority conservation areas accounting for phylogenetic and intraspecific diversity, integrating concepts from phylogeny, phylogeography, spatial statistics and spatial conservation prioritization. The framework allows planners to incorporate and combine different levels of evolutionary diversity and can be applied to any taxonomic group and to any region in the world...
April 28, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812243/a-two-stage-predictive-model-to-simultaneous-control-of-trihalomethanes-in-water-treatment-plants-and-distribution-systems-adaptability-to-treatment-processes
#18
Antonio Domínguez-Tello, Ana Arias-Borrego, Tamara García-Barrera, José Luis Gómez-Ariza
The trihalomethanes (TTHMs) and others disinfection by-products (DBPs) are formed in drinking water by the reaction of chlorine with organic precursors contained in the source water, in two consecutive and linked stages, that starts at the treatment plant and continues in second stage along the distribution system (DS) by reaction of residual chlorine with organic precursors not removed. Following this approach, this study aimed at developing a two-stage empirical model for predicting the formation of TTHMs in the water treatment plant and subsequently their evolution along the water distribution system (WDS)...
August 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28812231/the-neuroprotective-effect-of-conditioned-medium-from-human-adipose-derived-mesenchymal-stem-cells-is-impaired-by-n-acetyl-cysteine-supplementation
#19
Teodoro Palomares, María Cordero, Cristina Bruzos-Cidon, María Torrecilla, Luisa Ugedo, Ana Alonso-Varona
Oxidative stress is a common feature in neurodegenerative diseases associated with neuroinflammation, and therefore, has been proposed as a key target for novel therapies for these diseases. Recently, adipose-derived stem cell (ASC)-based cell therapy has emerged as a novel strategy for neuroprotection. In this study, we evaluate the therapeutic role of ASC-conditioned medium (ASC-CM) against H2O2-induced neurotoxicity in a new in vitro model of ec23/brain-derived neurotrophic factor (BDNF)-differentiated human SH-SY5Y neuron-like cells (SH-SY5Yd)...
August 15, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28812192/safety-of-vaccination-against-brucellosis-with-the-rough-strain-in-pregnant-cattle
#20
Adriana Agostini Barbosa, Ana Cristina Silva Figueiredo, Miller Pereira Palhao, Joao Henrique Moreira Viana, Carlos Antonio Carvalho Fernandes
Brucellosis is an infectious and contagious disease that profoundly impacts public health. However, in many countries, disease prevention is restricted to the vaccination of calves, and there is no prophylactic strategy for pregnant heifers and cows. The aim of this study was to evaluate the safety of the rough strain vaccine against brucellosis in pregnant cattle. Crossbred cows (N = 96) at three gestational periods (early, mid, or late pregnancy) were randomly allocated into the vaccine treatment group or to the control group...
August 15, 2017: Tropical Animal Health and Production
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