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Chuan He

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https://www.readbyqxmd.com/read/30120361/allosteric-mechanisms-underlie-gpcr-signaling-to-sh3-domain-proteins-through-arrestin
#1
Fan Yang, Peng Xiao, Chang-Xiu Qu, Qi Liu, Liu-Yang Wang, Zhi-Xin Liu, Qing-Tao He, Chuan Liu, Jian-Ye Xu, Rui-Rui Li, Meng-Jing Li, Qing Li, Xu-Zhen Guo, Zhao-Ya Yang, Dong-Fang He, Fan Yi, Ke Ruan, Yue-Mao Shen, Xiao Yu, Jin-Peng Sun, Jiangyun Wang
Signals from 800 G-protein-coupled receptors (GPCRs) to many SH3 domain-containing proteins (SH3-CPs) regulate important physiological functions. These GPCRs may share a common pathway by signaling to SH3-CPs via agonist-dependent arrestin recruitment rather than through direct interactions. In the present study, 19 F-NMR and cellular studies revealed that downstream of GPCR activation engagement of the receptor-phospho-tail with arrestin allosterically regulates the specific conformational states and functional outcomes of remote β-arrestin 1 proline regions (PRs)...
August 17, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/30118306/experimental-cyclic-interconversion-between-coherence-and-quantum-correlations
#2
Kang-Da Wu, Zhibo Hou, Yuan-Yuan Zhao, Guo-Yong Xiang, Chuan-Feng Li, Guang-Can Guo, Jiajun Ma, Qiong-Yi He, Jayne Thompson, Mile Gu
Quantum resource theories seek to quantify sources of nonclassicality that bestow quantum technologies their operational advantage. Chief among these are studies of quantum correlations and quantum coherence. The former isolates nonclassicality in the correlations between systems, and the latter captures nonclassicality of quantum superpositions within a single physical system. Here, we present a scheme that cyclically interconverts between these resources without loss. The first stage converts coherence present in an input system into correlations with an ancilla...
August 3, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30110429/optimized-modelling-and-application-of-exhaust-gas-recirculation-performance-evaluation-of-turbocharged-diesel-engine
#3
Chuan-Lei Yang, Xiang-Huan Zu, He-Chun Wang, Yin-Yan Wang
Aimed at the problem of exhaust gas recirculation (EGR) performance evaluation and optimal EGR rate determination of turbocharged diesel engines, an optimized decision-making method, based on grey theory and entropy weight, was proposed. The internal combustion pressure, fuel consumption rate, NOX , CO and smoke were selected as the decision-making targets and the initial decision-making model was established based on the traditional grey decision-making theory. According to the characteristics and optimization requirements of EGR, the optimal compromise between combustion and emission performance is proposed to transform into decision-making target weighting problem, then an optimized subjective weighting method based on expert scoring and grey relational analysis is proposed...
June 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/30106124/cold-exposure-promotes-obesity-and-impairs-glucose-homeostasis-in-mice-subjected-to-a-high%C3%A2-fat-diet
#4
Ping Zhu, Zhi-Hui Zhang, Xu-Feng Huang, Yan-Chuan Shi, Neeta Khandekar, He-Qin Yang, Shi-Yu Liang, Zhi-Yuan Song, Shu Lin
Cold exposure is considered to be a form of stress and has various adverse effects on the body. The present study aimed to investigate the effects of chronic daily cold exposure on food intake, body weight, serum glucose levels and the central energy balance regulatory pathway in mice fed with a high‑fat diet (HFD). C57BL/6 mice were divided into two groups, which were fed with a standard chow or with a HFD. Half of the mice in each group were exposed to ice‑cold water for 1 h/day for 7 weeks, while the controls were exposed to room temperature...
August 10, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30104384/human-exonization-through-differential-nucleosome-occupancy
#5
Yumei Li, Chen Li, Shuxian Li, Qi Peng, Ni A An, Aibin He, Chuan-Yun Li
Nucleosomal modifications have been implicated in fundamental epigenetic regulation, but the roles of nucleosome occupancy in shaping changes through evolution remain to be addressed. Here we present high-resolution nucleosome occupancy profiles for multiple tissues derived from human, macaque, tree shrew, mouse, and pig. Genome-wide comparison reveals conserved nucleosome occupancy profiles across both different species and tissue types. Notably, we found significantly higher levels of nucleosome occupancy in exons than in introns, a pattern correlated with the different exon-intron GC content...
August 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30094975/-effect-of-electroacupuncture-at-shenmen-ht-7-tongli-ht-5-of-heart-meridian-on-neuronal-activities-in-paraventricular-nucleus-of-hypothalamus-in-myocardial-ischemia-rats
#6
Rong-Lin Cai, Shuai Cui, Zi-Jian Wu, Lu He, Qing Yu, Jie Wang, Chuan-Yu Peng, Ling Hu, Yi-Ping Zhou
OBJECTIVE: To observe the effect of electroacupuncture (EA) stimulation of "Shenmen" (HT 7) - "Tongli" (HT 5) segment of the Heart Meridian on neuronal electrical activities of hypothalamic paraventricular nucleus (PVN) in rats with myocardial ischemia (MI), so as to investigate its possible mechanism underlying improvement of MI. METHODS: Thirty-two SD rats were randomly divided into sham control, model, HT 7-HT 5 and "Taiyuan" (LU 9)- "Lieque" (LU 7) groups ( n =8 in each group)...
July 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/30092578/lncrna-tug1-mediated-mir-142-3p-downregulation-contributes-to-metastasis-and-the-epithelial-to-mesenchymal-transition-of-hepatocellular-carcinoma-by-targeting-zeb1
#7
Chuan He, Zhigang Liu, Li Jin, Fang Zhang, Xinhao Peng, Yaqin Xiao, Xi Wang, Qian Lyu, XiaoJun Cai
BACKGROUND/AIMS: MicroRNA-142-3p (miR-142-3p) is dysregulated in many malignancies and may function as a tumor suppressor or oncogene in tumorigenesis and tumor development. However, few studies have investigated the clinical significance and biological function of miR-142-3p in hepatocellular carcinoma (HCC). METHODS: The expression levels of taurine upregulated gene 1 (TUG1), miR-142-3p, and zinc finger E-box-binding homeobox 1 (ZEB1) were evaluated in HCC tissues and cell lines by quantitative real-time PCR...
August 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30085335/reversibly-immortalized-hepatic-progenitor-cell-line-containing-double-suicide-genes
#8
Shu-Yu Fang, Chao-Qun Hu, Meng-Nan Liu, Li Tao, Yi Wang, Meng-Jia Gong, Yun He, Tong-Chuan He, Yang Bi
A large number of functional hepatocytes is required for bioartificial liver therapy. Simian virus 40 T‑antigen (SV40T) has been previously reported to improve the immortalized proliferation of primary hepatocytes to generate a sufficient number of cells; however, these long‑term immortalized hepatocytes may induce further malignant transformation in vivo. In the present study, the SV40T immortalization gene and two suicide genes, herpes simplex virus thymidine kinase (HSV‑tk) and cytosine deaminase (CD), were transducted into primary hepatocytes to construct a novel type of Cre/LoxP‑mediated reversible immortalized hepatocyte line...
October 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30081250/influenza-virus-like-particles-composed-of-conserved-influenza-proteins-and-gpi-anchored-ccl28-gm-csf-fusion-proteins-enhance-protective-immunity-against-homologous-and-heterologous-viruses
#9
Jing Liu, Zhiguang Ren, Hongmei Wang, Yongkun Zhao, Peter R Wilker, Zhijun Yu, Weiyang Sun, Tiecheng Wang, Na Feng, Yuanguo Li, Hualei Wang, Xianliang Ji, Nan Li, Songtao Yang, Hongbin He, Chuan Qin, Yuwei Gao, Xianzhu Xia
Influenza viruses cause significant morbidity and mortality and pose a substantial threat to public health. Vaccination represents the principle means of preventing influenza virus infection. Current vaccine approaches are hindered by the need to routinely reformulate vaccine compositions in an effort to account for the progressive antigenic changes that occur as influenza viruses circulate in the human population. In this study, we evaluated chimeric virus-like particle (cVLP) vaccines containing conserved elements of influenza proteins (HL5M2e (HA stem gene with 5M2e gene inserted) and NP), with or without glycosylphosphatidylinositol-anchored CCL28 (GPI-CCL28) and/or GM-CSF (GPI-GM-CSF) fusion proteins as molecular adjuvants...
August 3, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30077404/bioaccessibility-and-exposure-assessment-of-trace-metals-from-urban-airborne-particulate-matter-pm-10-and-pm-2-5-in-simulated-digestive-fluid
#10
Peng Gao, Huiyuan Guo, Zhaohan Zhang, Cuiyun Ou, Jian Hang, Qi Fan, Chuan He, Bing Wu, Yujie Feng, Baoshan Xing
We describe a batch-extraction with simulated digestive fluid (salivary fluid, gastric fluid and intestinal fluid) to estimate the bioaccessibility of inhaled trace metals (TMs) in particulate matter less than 10 and 2.5 μm in aerodynamic diameter (PM10 and PM2.5 ). Concentrations of the assayed TMs (As, Cd, Cr, Ni, Mn, Cu, Zn, Sb, Hg and Pb) were determined in PM10 and PM2.5 samples by inductively coupled plasma-mass spectrometry. The TMs with the largest soluble fractions for airborne PM collected from winter and summer in saliva were Mn and Sb, respectively; in seasons this became Co in gastric fluid and Cu in intestinal fluid...
July 26, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/30076626/reversibly-immortalized-human-umbilical-cord-derived-mesenchymal-stem-cells-uc-mscs-are-responsive-to-bmp9-induced-osteogenic-and-adipogenic-differentiation
#11
Yi Shu, Chao Yang, Xiaojuan Ji, Linghuan Zhang, Yang Bi, Ke Yang, Mengjia Gong, Xing Liu, Qi Guo, Yuxi Su, Xiangyang Qu, Guoxin Nan, Chen Zhao, Zongyue Zeng, Xinyi Yu, Ruyi Zhang, Shujuan Yan, Jiayan Lei, Ke Wu, Ying Wu, Liping An, Shifeng Huang, Cheng Gong, Chengfu Yuan, Wei Liu, Bo Huang, Yixiao Feng, Bo Zhang, Zhengyu Dai, Yi Shen, Wenping Luo, Xi Wang, Rex C Haydon, Hue H Luu, Russell R Reid, Jennifer Moriatis Wolf, Michael J Lee, Tong-Chuan He, Yasha Li
Human mesenchymal stem cells (MSCs) are a heterogeneous subset of nonhematopoietic multipotent stromal stem cells and can differentiate into mesodermal lineage, such as adipocytes, osteocytes, and chondrocytes, as well as ectodermal and endodermal lineages. Human umbilical cord (UC) is one of the most promising sources of MSCs. However, the molecular and cellular characteristics of UC-derived MSCs (UC-MSCs) require extensive investigations, which are hampered by the limited lifespan and the diminished potency over passages...
August 4, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30065499/type-i-choledochal-cyst-complicated-with-acute-hemorrhagic-pancreatitis-a-case-report
#12
Ping-Hua Tsai, Yueh-Chin Yen, Yi-Hong Chou, Chien-Hua Lin, Yu-Lin Bai, Shu-Chuan Kao, Yu-Meu Lin, Yu-Ling Wang, Ya-Chun Chou, Peter Tien-Ying Lee, Chui-Mei Tiu
Choledochal cysts rarely present with acute pancreatitis. We report a patient with type I choledochal cyst(s) who had concomitant acute frank hemorrhagic pancreatitis. A 14-year-old male noted with a history of recurrent abdominal pain, fever and jaundice. Ultrasonography (US) of abdomen at the Emergency Department depicted distended gall bladder with wall thickening. Apparently dilated intrahepatic ducts (IHDs) and fusiform dilatation of the common bile duct (CBD), and mild dilatation of the pancreatic duct were also noted, suggesting a type I choledochal cyst( )...
October 2017: Journal of Medical Ultrasound
https://www.readbyqxmd.com/read/30065315/suppression-of-m-6-a-reader-ythdf2-promotes-hematopoietic-stem-cell-expansion
#13
Zhenrui Li, Pengxu Qian, Wanqing Shao, Hailing Shi, Xi C He, Madelaine Gogol, Zulin Yu, Yongfu Wang, Meijie Qi, Yunfei Zhu, John M Perry, Kai Zhang, Fang Tao, Kun Zhou, Deqing Hu, Yingli Han, Chongbei Zhao, Richard Alexander, Hanzhang Xu, Shiyuan Chen, Allison Peak, Kathyrn Hall, Michael Peterson, Anoja Perera, Jeffrey S Haug, Tari Parmely, Hua Li, Bin Shen, Julia Zeitlinger, Chuan He, Linheng Li
Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood (hUCB) holds great promise for treating a broad spectrum of hematological disorders including cancer. However, the limited number of HSCs in a single hUCB unit restricts its widespread use. Although extensive efforts have led to multiple methods for ex vivo expansion of human HSCs by targeting single molecules or pathways, it remains unknown whether it is possible to simultaneously manipulate the large number of targets essential for stem cell self-renewal...
July 31, 2018: Cell Research
https://www.readbyqxmd.com/read/30056831/mettl14-is-essential-for-epitranscriptomic-regulation-of-striatal-function-and-learning
#14
Jessica L Koranda, Lou Dore, Hailing Shi, Meera J Patel, Lee O Vaasjo, Meghana N Rao, Kai Chen, Zhike Lu, Yangtian Yi, Wanhao Chi, Chuan He, Xiaoxi Zhuang
N6 -methyladenosine (m6 A) regulates mRNA metabolism and translation, serving as an important source of post-transcriptional regulation. To date, the functional consequences of m6 A deficiency within the adult brain have not been determined. To achieve m6 A deficiency, we deleted Mettl14, an essential component of the m6 A methyltransferase complex, in two related yet discrete mouse neuronal populations: striatonigral and striatopallidal. Mettl14 deletion reduced striatal m6 A levels without altering cell numbers or morphology...
July 25, 2018: Neuron
https://www.readbyqxmd.com/read/30044922/ovalbumin-as-an-outstanding-pickering-nanostabilizer-for-high-internal-phase-emulsions
#15
Yan-Teng Xu, Chuan-He Tang, Tong-Xun Liu, Ruihai Liu
There is still a debate about the effectiveness of native globular proteins to perform as Pickering-like stabilizers for oil-in-water high internal phase emulsions (HIPEs). In the work, we report one native globular protein (ovalbumin) with strong structural integrity and high refolding ability, exhibits an outstanding Pickering stabilization for HIPEs. Ultrastable gel-like HIPEs can be formed through a facile one-pot homogenization even at a concentration as low as 0.2 wt %. The HIPEs formed in the protein-poor regime are a kind of self-supporting and remoldable hydrogel consisting of bridging droplets...
August 9, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/30044787/quantifying-the-effects-of-climate-and-anthropogenic-change-on-regional-species-loss-in-china
#16
Jinxing He, Chuan Yan, Marcel Holyoak, Xinru Wan, Guoyu Ren, Yangfang Hou, Yan Xie, Zhibin Zhang
Human-induced environmental and climate change are widely blamed for causing rapid global biodiversity loss, but direct estimation of the proportion of biodiversity lost at local or regional scales are still infrequent. This prevents us from quantifying the main and interactive effects of anthropogenic environmental and climate change on species loss. Here, we demonstrate that the estimated proportion of species loss of 252 key protected vertebrate species at a county level of China during the past half century was 27...
2018: PloS One
https://www.readbyqxmd.com/read/30036397/a-quantitative-assessment-method-for-the-space-design-of-products-based-on-ergonomics-and-virtual-simulation
#17
Ziyue Guo, Dong Zhou, Pengyan Liu, Zhiyi He, Chuan Lv
Work spaces for assembly or maintenance operations are considered in the design stage of products. Maintenance space is a key factor in determining how well a product can be maintained. If the work space is sufficiently considered in the design stage, it will benefit both the user and the maintainer. From a maintenance perspective, this paper proposes a quantitative method to evaluate the maintenance space by virtual simulation and consideration of ergonomics. In this method, maintenance operations are concisely classified into three types...
2018: PloS One
https://www.readbyqxmd.com/read/30030497/a-blockade-of-pi3k%C3%AE-signaling-effectively-mitigates-angiotensin-ii-induced-renal-injury-and-fibrosis-in-a-mouse-model
#18
Xinyi Yu, Yunfeng Xia, Liyi Zeng, Xi Zhang, Liqun Chen, Shujuan Yan, Ruyi Zhang, Chen Zhao, Zongyue Zeng, Yi Shu, Shifeng Huang, Jiayan Lei, Chengfu Yuan, Linghuan Zhang, Yixiao Feng, Wei Liu, Bo Huang, Bo Zhang, Wenping Luo, Xi Wang, Hongmei Zhang, Rex C Haydon, Hue H Luu, Tong-Chuan He, Hua Gan
Chronic kidney disease (CKD) poses a formidable challenge for public healthcare worldwide as vast majority of patients with CKD are also at risk of accelerated cardiovascular disease and death. Renal fibrosis is the common manifestation of CKD that usually leads to end-stage renal disease although the molecular events leading to chronic renal fibrosis and eventually chronic renal failure remain to be fully understood. Nonetheless, emerging evidence suggests that an aberrant activation of PI3Kγ signaling may play an important role in regulating profibrotic phenotypes...
July 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30028726/propofol-based-total-intravenous-anesthesia-is-associated-with-better-survival-than-desflurane-anesthesia-in-colon-cancer-surgery
#19
Zhi-Fu Wu, Meei-Shyuan Lee, Chih-Shung Wong, Chueng-He Lu, Yuan-Shiou Huang, Kuen-Tze Lin, Yu-Sheng Lou, Chin Lin, Yue-Cune Chang, Hou-Chuan Lai
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Previous research has shown different effects of anesthetics on cancer cell growth. Here, the authors investigated the association between type of anesthetic and patient survival after elective colon cancer surgery. METHODS: A retrospective cohort study included patients who received elective colon cancer surgery between January 2005 and December 2014. Patients were grouped according to anesthesia received: propofol or desflurane...
July 20, 2018: Anesthesiology
https://www.readbyqxmd.com/read/30027930/pretreatment-serum-albumin-globulin-ratio-as-a-prognostic-biomarker-in-metastatic-prostate-cancer-patients-treated-with-maximal-androgen-blockade
#20
Ning Wang, Jian-Ye Liu, Xiong Li, Min-Hua Deng, Zhi Long, Jin Tang, Kun Yao, Yi-Chuan Zhang, Le-Ye He
The pretreatment serum albumin/globulin ratio (AGR) has been used as a prognostic biomarker for various cancer types. However, the prognostic value of the AGR for prostate cancer, especially for metastatic prostate cancer (mPCa) after maximal androgen blockade (MAB), remains unclear. The aim of this study was to evaluate the prognostic value of the pretreatment serum AGR for mPCa treated with MAB. This retrospective study included 214 mPCa patients receiving MAB from October 2007 to March 2017. The correlation of the AGR with survival was estimated using Kaplan-Meier analysis and Cox proportional hazards models...
July 17, 2018: Asian Journal of Andrology
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