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Chuan He

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https://www.readbyqxmd.com/read/30341428/publisher-correction-post-transcriptional-gene-regulation-by-mrna-modifications
#1
Boxuan Simen Zhao, Ian A Roundtree, Chuan He
In Figure 5, translation initiation is promoted not by the indicated protein, but by YTHDF1 (see below).
October 19, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30339909/differences-in-the-electrophysiological-monitoring-results-of-spinal-cord-arteriovenous-and-intramedullary-spinal-cord-cavernous-malformations
#2
Xiaoyu Li, Zhang Hongqi, Feng Ling, Chuan He, Jian Ren
No abstract text is available yet for this article.
October 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30336408/pm2-5-induces-liver-fibrosis-via-triggering-ros-mediated-mitophagy
#3
Yi-Ning Qiu, Guo-Hui Wang, Fen Zhou, Jin-Jin Hao, Li Tian, Long-Fei Guan, Xiao-Kun Geng, Yu-Chuan Ding, He-Wen Wu, Ke-Zhong Zhang
BACKGROUND: The increasing epidemic of fine particulate matter (PM2.5) is a serious threat to human health. It induces the occurrence of liver fibrosis, but its molecular mechanism is not yet clear. The molecular mechanisms of PM2.5 inducing liver fibrosis were investigated in this study. METHODS: The cell viability of LX-2 cells and primary hepatic stellate cells (HSCs) was detected using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
October 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30325306/ogt-binds-a-conserved-c-terminal-domain-of-tet1-to-regulate-tet1-activity-and-function-in-development
#4
Joel Hrit, Leeanne Goodrich, Cheng Li, Bang-An Wang, Ji Nie, Xiaolong Cui, Elizabeth Allene Martin, Eric Simental, Jenna Fernandez, Monica Y Liu, Joseph R Nery, Rosa Castanon, Rahul M Kohli, Natalia Tretyakova, Chuan He, Joseph R Ecker, Mary Goll, Barbara Panning
TET enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine and higher oxidized derivatives. TETs stably associate with and are post-translationally modified by the nutrient-sensing enzyme OGT, suggesting a connection between metabolism and the epigenome. Here, we show for the first time that modification by OGT enhances TET1 activity in vitro. We identify a TET1 domain that is necessary and sufficient for binding to OGT and report a point mutation that disrupts the TET1-OGT interaction. We show that this interaction is necessary for TET1 to rescue hematopoetic stem cell production in tet mutant zebrafish embryos, suggesting that OGT promotes TET1's function during development...
October 16, 2018: ELife
https://www.readbyqxmd.com/read/30324715/copper-catalyzed-trifunctionalization-of-alkynes-rapid-assembly-of-oxindoles-bearing-geminal-diboron
#5
Tao He, Bin Li, Li-Chuan Liu, Jing Wang, Wenpeng Ma, Guang-Yu Li, Qing-Wei Zhang, Wei He
We report a copper catalyzed trifunctionalization of alkynes that provides rapid entry to oxindoles bearing a geminal bis(boronates) side chain, highlighted by the simultaneous formation of one C-C bond and two C-B bonds. This new reaction features simple reaction conditions (ligand free catalysis), a general substrate scope, as well as excellent chemoselectivity. Mechanistic study revealed a reaction sequence in the order of borylation/intramolecular cross coupling/hydroboration, which has been rarely documented...
October 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30297871/a-dynamic-n-6-methyladenosine-methylome-regulates-intrinsic-and-acquired-resistance-to-tyrosine-kinase-inhibitors
#6
Fei Yan, Aref Al-Kali, Zijie Zhang, Jun Liu, Jiuxia Pang, Na Zhao, Chuan He, Mark R Litzow, Shujun Liu
N6 -methyladenosine (m6 A) on mRNAs is critical for various biological processes, yet whether m6 A regulates drug resistance remains unknown. Here we show that developing resistant phenotypes during tyrosine kinase inhibitor (TKI) therapy depends on m6 A reduction resulting from FTO overexpression in leukemia cells. This deregulated FTO-m6 A axis pre-exists in naïve cell populations that are genetically homogeneous and is inducible/reversible in response to TKI treatment. Cells with mRNA m6 A hypomethylation and FTO upregulation demonstrate more TKI tolerance and higher growth rates in mice...
October 8, 2018: Cell Research
https://www.readbyqxmd.com/read/30278133/bisulfite-free-nanoscale-analysis-of-5-hydroxymethylcytosine-at-single-base-resolution
#7
Hu Zeng, Bo He, Bo Xia, Dongsheng Bai, Xingyu Lu, Jiabin Cai, Lei Chen, Ankun Zhou, Chenxu Zhu, Haowei Meng, Yun Gao, Hongshan Guo, Chuan He, Qing Dai, Chengqi Yi
High-resolution detection of genome-wide 5-hydroxymethylcytosine (5hmC) sites of small-scale samples remains challenging. Here, we present hmC-CATCH, a bisulfite-free, base-resolution method for the genome-wide detection of 5hmC. hmC-CATCH is based on selective 5hmC oxidation, chemical labeling and subsequent C-to-T transition during PCR. Requiring only nanoscale input genomic DNA samples, hmC-CATCH enabled us to detect genome-wide hydroxymethylome of human embryonic stem cells in a cost-effective manner. Further application of hmC-CATCH to cell-free DNA (cfDNA) of healthy donors and cancer patients revealed base-resolution hydroxymethylome in the human cfDNA for the first time...
October 17, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30278067/is-topical-or-intravenous-tranexamic-acid-preferred-in-total-hip-arthroplasty-a-randomized-controlled-noninferiority-clinical-trial
#8
Kai-di Zhou, Hong-Yi Wang, Yi Wang, Zhi-Hong Liu, Chuan He, Jian-Min Feng
PURPOSE: The present study aimed to confirm the efficacy and safety of topical and intravenous tranexamic acid (TXA) compared with that of topical placebo and to assess the noninferiority between the two application methods of TXA in patients undergoing unilateral primary total hip arthroplasty. METHODS: Our randomized controlled trial investigated 170 patients with 1:1:1 allocation to two doses of 10-mg/kg intravenous TXA, 3-g topical TXA, and topical placebo of 60-ml physiological saline groups...
2018: PloS One
https://www.readbyqxmd.com/read/30275345/hsp70-interacts-with-mapk-activated-protein-kinase-2-to-regulate-p38mapk-stability-and-myoblast-differentiation-during-skeletal-muscle-regeneration
#9
Wei Fan, Xiu Kui Gao, Xi Sheng Rao, Yin Pu Shi, Xiao Ceng Liu, Fei Ya Wang, Yu Fen Liu, Xiao Xia Cong, Min Yi He, Shui Bo Xu, Wei Liang Shen, Yue Shen, Shi Gui Yan, Yan Luo, Boon Chuan Low, Hongwei Ouyang, Zhang Bao, Li Ling Zheng, Yi Ting Zhou
The regenerative process of injured muscle is dependent on the fusion and differentiation of myoblast cells derived from muscle stem cells. Hsp70 is important for maintaining skeletal muscle homeostasis and regeneration but the precise cellular mechanism remains elusive. Here we found that Hsp70 was upregulated during myoblast differentiation. Depletion or inhibition of Hsp70/Hsc70 impaired myoblast differentiation. Importantly, overexpression of p38MAPKα, but not AKT1, rescued the impairment of myogenic differentiation in Hsp70- or Hsc70-depleted myoblasts...
October 1, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30272970/fabrication-of-zein-pectin-hybrid-particles-stabilized-pickering-high-internal-phase-emulsions-hipes-with-robust-and-ordered-interface-architecture
#10
Fu-Zhen Zhou, Xiao-Nan Huang, Zi-Ling Wu, Shou-Wei Yin, Jian Hua Zhu, Chuan-He Tang, Xiaoquan Yang
Diets containing partially hydrogenated oils (PHOs) expose human body to trans fatty acids thus endangering cardiovascular health. Pickering HIPE is a promising alternative of PHOs. This work attempted to construct stable Pickering-HIPEs by engineering interface architecture through manipulating the interfacial, self-assembly, and packing behavior of zein particles using the interaction between protein and pectin. Partially wettable zein/pectin hybrid particles (ZPHPs) with three-phase contact angles ranging from 84° to 87° were developed successfully...
October 1, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/30272823/estrogen-inhibits-osteoclasts-formation-and-bone-resorption-via-microrna-27a-targeting-ppar%C3%AE-and-apc
#11
Lei Guo, Kaizhe Chen, Jun Yuan, Ping Huang, Xing Xu, Changwei Li, Niandong Qian, Jin Qi, Zhiliang Shao, Lianfu Deng, Chuan He, Jiping Xu
Inhibition of osteoclasts formation and bone resorption by estrogen is very important in the etiology of postmenopausal osteoporosis. The mechanisms of this process are still not fully understood. Recent studies implicated an important role of microRNAs in estrogen-mediated responses in various cellular processes, including cell differentiation and proliferation. Thus, we hypothesized that these regulatory molecules might be implicated in the process of estrogen-decreased osteoclasts formation and bone resorption...
September 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30266141/retraction-notice-to-evaluation-of-the-efficacy-of-a-recombinant-entamoeba-histolytica-cysteine-proteinase-ehcp112-antigen-in-minipig-yexpr-131-2-2012-258-260
#12
Guang-Zhi He, Shu-Xuan Deng, Chuan-Wei An
No abstract text is available yet for this article.
October 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/30266140/retraction-notice-to-cloning-expression-and-evaluation-of-the-efficacy-of-a-recombinant-entamoeba-histolytica-cysteine-proteinase-ehcp4-antigen-in-minipig-yexpr-130-4-2012-412-415
#13
Guang-Zhi He, Yong Feng, Shu-Xuan Deng, Chuan-Wei An
No abstract text is available yet for this article.
October 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/30265195/high-wall-shear-stress-beyond-a-certain-range-in-the-parent-artery-could-predict-the-risk-of-anterior-communicating-artery-aneurysm-rupture-at-follow-up
#14
Xin Zhang, Tamrakar Karuna, Zhi-Qiang Yao, Chuan-Zhi Duan, Xue-Min Wang, Shun-Ting Jiang, Xi-Feng Li, Jia-He Yin, Xu-Ying He, Shen-Quan Guo, Yun-Chang Chen, Wen-Chao Liu, Ran Li, Hai-Yan Fan
OBJECTIVE: Among clinical and morphological criteria, hemodynamics is the main predictor of aneurysm growth and rupture. This study aimed to identify which hemodynamic parameter in the parent artery could independently predict the rupture of anterior communicating artery (ACoA) aneurysms by using multivariate logistic regression and two-piecewise linear regression models. An additional objective was to look for a more simplified and convenient alternative to the widely used computational fluid dynamics (CFD) techniques to detect wall shear stress (WSS) as a screening tool for predicting the risk of aneurysm rupture during the follow-up of patients who did not undergo embolization or surgery...
September 28, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30262725/enhanced-sensitivity-of-a-love-wave-based-methane-gas-sensor-incorporating-a-cryptophane-a-thin-film
#15
Wen Wang, Shuyao Fan, Yong Liang, Shitang He, Yong Pan, Caihong Zhang, Chuan Dong
A Love wave-based sensing chip incorporating a supramolecular cryptophane A (CrypA) thin film was proposed for methane gas sensing in this work. The waveguide effect in the structure of SiO₂/36° YX LiTaO₃ will confine the acoustic wave energy in SiO₂ thin-film, which contributes well to improvement of the mass loading sensitivity. The CrypA synthesized from vanillyl alcohol by a double trimerisation method was dropped onto the wave propagation path of the sensing device, and the adsorption to methane gas molecules by supramolecular interactions in CrypA modulates the acoustic wave propagation, and the corresponding frequency shifts were connected as the sensing signal...
September 27, 2018: Sensors
https://www.readbyqxmd.com/read/30262497/rna-modifications-modulate-gene-expression-during-development
#16
REVIEW
Michaela Frye, Bryan T Harada, Mikaela Behm, Chuan He
RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA (mRNA) modifications regulate various aspects of mRNA metabolism. For example, N 6 -methyladenosine (m6 A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition...
September 28, 2018: Science
https://www.readbyqxmd.com/read/30258947/characterization-of-the-essential-role-of-bone-morphogenetic-protein-9-bmp9-in-osteogenic-differentiation-of-mesenchymal-stem-cells-mscs-through-rna-interference
#17
Shujuan Yan, Ruyi Zhang, Ke Wu, Jing Cui, Shifeng Huang, Xiaojuan Ji, Liping An, Chengfu Yuan, Cheng Gong, Linghuan Zhang, Wei Liu, Yixiao Feng, Bo Zhang, Zhengyu Dai, Yi Shen, Xi Wang, Wenping Luo, Bo Liu, Rex C Haydon, Michael J Lee, Russell R Reid, Jennifer Moriatis Wolf, Qiong Shi, Hue H Luu, Tong-Chuan He, Yaguang Weng
Mesenchymal stem cells (MSCs) are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic, chondrogenic and adipogenic lineages. We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood. Here, we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs...
June 2018: Genes & Diseases
https://www.readbyqxmd.com/read/30258943/establishment-and-functional-characterization-of-the-reversibly-immortalized-mouse-glomerular-podocytes-impods
#18
Xinyi Yu, Liqun Chen, Ke Wu, Shujuan Yan, Ruyi Zhang, Chen Zhao, Zongyue Zeng, Yi Shu, Shifeng Huang, Jiayan Lei, Xiaojuan Ji, Chengfu Yuan, Linghuan Zhang, Yixiao Feng, Wei Liu, Bo Huang, Bo Zhang, Wenping Luo, Xi Wang, Bo Liu, Rex C Haydon, Hue H Luu, Tong-Chuan He, Hua Gan
Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney. Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases, which requires a thorough understanding of podocyte cell biology. As mature podocytes lose proliferative capacity, a conditionally SV40 mutant tsA58-immortalized mouse podocyte line (designated as tsPC) was established from the Immortomouse over 20 years ago...
June 2018: Genes & Diseases
https://www.readbyqxmd.com/read/30258937/breast-cancer-development-and-progression-risk-factors-cancer-stem-cells-signaling-pathways-genomics-and-molecular-pathogenesis
#19
REVIEW
Yixiao Feng, Mia Spezia, Shifeng Huang, Chengfu Yuan, Zongyue Zeng, Linghuan Zhang, Xiaojuan Ji, Wei Liu, Bo Huang, Wenping Luo, Bo Liu, Yan Lei, Scott Du, Akhila Vuppalapati, Hue H Luu, Rex C Haydon, Tong-Chuan He, Guosheng Ren
As the most commonly occurring cancer in women worldwide, breast cancer poses a formidable public health challenge on a global scale. Breast cancer consists of a group of biologically and molecularly heterogeneous diseases originated from the breast. While the risk factors associated with this cancer varies with respect to other cancers, genetic predisposition, most notably mutations in BRCA1 or BRCA2 gene, is an important causative factor for this malignancy. Breast cancers can begin in different areas of the breast, such as the ducts, the lobules, or the tissue in between...
June 2018: Genes & Diseases
https://www.readbyqxmd.com/read/30257302/lower-ionized-calcium-predicts-hematoma-expansion-and-poor-outcome-in-patients-with-hypertensive-intracerebral-hemorrhage
#20
Yi-Bin Zhang, Shu-Fa Zheng, Pei-Sen Yao, Guo-Rong Chen, Guang-Hai Li, Song-Chuan Li, Yi-Fang Zheng, Jian-Qun Wang, De-Zhi Kang, Huang-Cheng Shang-Guan
BACKGROUND AND OBJECTIVE: We tested the hypothesis that ionized calcium levels at admission are associated with early hematoma expansion and functional outcome in patients with hypertensive intracerebral hemorrhage (HICH). METHODS: Patients presenting with HICH were enrolled in the observational cohort study that prospectively collected age, sex, blood pressure, history of diabetes and smoking, time from symptom onset to initial computed tomography (CT), admission ionized calcium (iCa) and total calcium (tCa), coagulation function, Glasgow Coma Scale (GCS), and postoperative modified Rankin Scale score...
October 2018: World Neurosurgery
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