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Chuan He

Deyuan Fu, Chunlan He, Jinli Wei, Zhengquan Zhang, Yulin Luo, Haosheng Tan, Chuanli Ren
BACKGROUND/AIMS: Glycolysis, a multi-step enzymatic reaction, is considered to be the root of cancer development and progression. The aim of this study is to figure out which glycolysis enzyme participates in the progression of breast cancer and its possible mechanisms. MATERIALS: We firstly screened out PGK1 by performing an RT-PCR array of glycolysis-related genes in three paired breast cancer samples, and further investigated PGK1 using TCGA and our own database...
2018: Cellular Physiology and Biochemistry
Honghui Ma, Xiaoyun Wang, Jiabin Cai, Qing Dai, S Kundhavai Natchiar, Ruitu Lv, Kai Chen, Zhike Lu, Hao Chen, Yujiang Geno Shi, Fei Lan, Jia Fan, Bruno P Klaholz, Tao Pan, Yang Shi, Chuan He
N6 -Methyladenosine (m6 A) RNA modification is present in messenger RNAs (mRNA), ribosomal RNAs (rRNA), and spliceosomal RNAs (snRNA) in humans. Although mRNA m6 A modifications have been extensively studied and shown to play critical roles in many cellular processes, the identity of m6 A methyltransferases for rRNAs and the function of rRNA m6 A modifications are unknown. Here we report a new m6 A methyltransferase, ZCCHC4, which primarily methylates human 28S rRNA and also interacts with a subset of mRNAs...
January 2019: Nature Chemical Biology
Ning Chen, Wei Su, Shu-Hui Cui, Jian Guo, Jia-Chuan Duan, Hong-Xia Li, Li He
Several animal models of migraine have been established, and those based on trigeminovascular system activation are widely accepted. However, most of these models have been established on lower animals, such as rodents, and involve only a single administration of a noxious stimulus. In this study, an inflammatory soup (10 μL), consisting of prostaglandin E2 (0.2 mM), serotonin (2 mM), bradykinin (2 mM) and histamine (2 mM), was injected into the dura mater of conscious rhesus monkeys through an indwelling catheter...
January 2019: Neural Regeneration Research
Yu-Chuan Wang, Bo Huang, Kang Li, Peng-Kang He, Er-Dong Chen, Yu-Long Xia, Jie Jiang, Qin-Hui Sheng, Jing Zhou, Yan-Sheng Ding
Objectives: To identify optimal predefined criteria (OPC) for filters of the VisiTag™ module in the CARTO 3 system during pulmonary vein isolation (PVI). Methods: Thirty patients with atrial fibrillation (AF) who experienced PVI first were enrolled. PVI was accomplished by using a Thermocool SmartTouch catheter. Ablation lesions were tagged automatically as soon as predefined criteria of the VisiTag™ module were met. OPC should be that ablation with the setting resulting in the conduction gap (CG) as few as possible, while contiguous encircling ablation line (CEAL) without the tag gap (TG) on the 3D anatomic model as much as possible...
2018: Cardiology Research and Practice
Chengchuan Ma, Rong Niu, Tianxiao Huang, Li-Wa Shao, Yong Peng, Wanqiu Ding, Ye Wang, Guifang Jia, Chuan He, Chuan-Yun Li, Aibin He, Ying Liu
N6-methyldeoxyadenine (6mA), a major type of DNA methylation in bacteria, represents a part of restriction-modification systems to discriminate host genome from invader DNA1 . With the recent advent of more sensitive detection techniques, 6mA has also been detected in some eukaryotes2-8 . However, the physiological function of this epigenetic mark in eukaryotes remains elusive. Heritable changes in DNA 5mC methylation have been associated with transgenerational inheritance of responses to a high-fat diet9 , thus raising the exciting possibility that 6mA may also be transmitted across generations and serve as a carrier of inheritable information...
December 3, 2018: Nature Cell Biology
Ye Zhang, Haiyue Jiang, Qinghua Yang, Leren He, Xiaobo Yu, Xueshuang Huang, Rongwei Wu, Meirong Yang, Chuan Li, Bo Pan
BACKGROUND: Microtia is a congenital anomaly of the external ear that can appear in isolation or in association with other congenital anomalies. In this study, the authors identify the prevalence and phenotypes of associated congenital malformations in patients with microtia in a Chinese specialty clinic population. METHODS: Data were collected from 672 patients seen between December of 2014 and February of 2016 in the Department of Auricular Reconstruction at the Plastic Surgery Hospital of Peking Union Medical College...
December 2018: Plastic and Reconstructive Surgery
Hai-Min Ding, Xue Wang, Wei-Chuan Mo, Ling-Ling Qin, Steven Wong, Jing-Peng Fu, Yan Tan, Ying Liu, Rong-Qiao He, Qian Hua
Hypomagnetic fields (HMF), that is, the elimination of the geomagnetic field (GMF), are a risk factor to the health of astronauts in outer space. It has been established that continuous HMF exposure affects cytoskeleton assembly, cell proliferation, embryonic development, and even learning and memory. In addition, although there were some previous studies that focused on the effects of long-term HMF-exposure, so far very limited investigations have been conducted to examine the short-term HMF effect in animals...
November 26, 2018: Bioelectromagnetics
Yuan Zhang, Xia He, Xuan Xiong, Junlan Chuan, Lei Zhong, Guo Chen, Dongke Yu
Published studies indicate the MTHFR C677T and A1298C polymorphisms are associated with abnormal homocysteine levels, which may cause various pregnancy complications and birth defects. However, the results obtained from different studies have been inconsistent. Therefore, this meta-analysis explores the association between MTHFR polymorphisms and birth defects and adverse pregnancy outcomes. The Pubmed, ScienceDirect, Embase, China Biology Medicine literature databases and ClinicalTrials were searched. Analyses of public bias, meta-regression, subgroups, and sensitivity were used to ensure the robustness of our results...
November 25, 2018: Prenatal Diagnosis
Bo Zhu, Yu Han, Chuan Wang, Xiaofeng Huang, Shiyong Xia, Yingbo Niu, Zixuan Yin, Lingyan He
Oxygenated volatile organic compounds (OVOCs) are key intermediates in the atmospheric photooxidation process. To further study the primary and secondary sources of OVOCs, their ambient levels were monitored using a proton-transfer reaction mass spectrometer (PTR-MS) at an urban site in the Pearl River Delta of China. Continuous monitoring campaigns were conducted in the spring, summer, fall, and winter of 2016. Among the six types of OVOC species, the mean concentrations of methanol were the highest in each season (up to 13-20ppbv), followed by those of acetone, acetaldehyde and acetic acid (approximately 2-4ppbv), while those of formic acid and methyl ethyl ketone (MEK) were the lowest (approximately 1-2ppbv)...
January 2019: Journal of Environmental Sciences (China)
Phillip J Hsu, Qili Fei, Qing Dai, Hailing Shi, Dan Dominissini, Lijia Ma, Chuan He
The post-transcriptional modification 2'-O-Methyl (2'OMe) could be present on the ribose of all four ribonucleosides, and is highly prevalent in a wide variety of RNA species, including the 5' RNA cap of viruses and higher eukaryotes, as well as internally in transfer RNA and ribosomal RNA. Recent studies have suggested that 2'OMe is also located internally in low-abundance RNA species such as viral RNA and mRNA. To profile 2'OMe on different RNA species, we have developed Nm-seq, which could identify 2'OMe sites at single base resolution...
November 22, 2018: Methods: a Companion to Methods in Enzymology
Wei Zhao, Hui Tang, Xiaodong Yang, Xiaoquan Luo, Xiaoya Wang, Chuan Shao, Jiaquan He
BACKGROUND: Inconsistent results of the association between fish consumption and stroke risk have been indicated in previous epidemiological studies. Therefore, we performed a meta-analysis of prospective cohort studies to estimate the impact of fish consumption on stroke risk. METHODS: The PubMed and EMBASE databases were searched through a computer search. Prospective cohort studies satisfying predetermined inclusion criterion were included. Random-effect model was adopted in this meta-analysis...
November 20, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Nianshuang Li, Yan Feng, Yi Hu, Cong He, Chuan Xie, Yaobin Ouyang, Stephen C Artim, Deqiang Huang, Yin Zhu, Zhijun Luo, Zhongming Ge, Nonghua Lu
BACKGROUND: Helicobacter pylori (H. pylori) delivers oncoprotein CagA into gastric epithelial cells via the T4SS and drives activation of multiple oncogenic signalling pathways. YAP, a core effector of the Hippo tumour suppressor pathway, is frequently overexpressed in human cancers, suggesting its potential tumor-promoting role. Although CagA is a casual factor in H. pylori induced gastric carcinogenesis, the link between CagA and YAP pathway has not been identified. In this work, we investigated the regulation of oncogenic YAP pathway by H...
November 22, 2018: Journal of Experimental & Clinical Cancer Research: CR
Marita de Waard, Yanqi Li, Yanna Zhu, Adejumoke I Ayede, Janet Berrington, Frank H Bloomfield, Olubunmi O Busari, Barbara E Cormack, Nicholas D Embleton, Johannes B van Goudoever, Gorm Greisen, Zhongqian He, Yan Huang, Xiaodong Li, Hung-Chih Lin, Jiaping Mei, Paula P Meier, Chuan Nie, Aloka L Patel, Christian Ritz, Per T Sangild, Thomas Skeath, Karen Simmer, Olukemi O Tongo, Signe S Uhlenfeldt, Sufen Ye, Xuqiang Ye, Chunyi Zhang, Ping Zhou
BACKGROUND: Transition to enteral feeding is difficult for very low-birth-weight (VLBW; ≤1500 g) infants, and optimal nutrition is important for clinical outcomes. METHOD: Data on feeding practices and short-term clinical outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2947). Specifically, 5 NICUs in Guangdong province in China (GD), mainly using formula feeding and slow feeding advancement (n = 1366), were compared with the remaining NICUs (non-GD, n = 1581, Oceania, Europe, United States, Taiwan, Africa) using mainly human milk with faster advancement rates...
November 22, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Chao Zhou, Sachin Barthwal, Wendong Zhang, Chuan He, Biao Tang, Lin Zhou, Jin Wang, Ming-Sheng Zhan
We present a method to characterize and optimize a tapered-amplifier laser system (TALS) by its spectral quality through a long multi-pass rubidium absorption cell. A thermal vapor cell is used to measure the non-resonant spectrum of TALS, including the broadband amplified spontaneous emission (ASE), which is its main spectral noise. This method gives a simple quantified measurement to optimize various working parameters of a TA, including current and temperature online. It can as well be used to compare various TA chips based on their usage time during our precision measurement experiments...
September 10, 2018: Applied Optics
Xiaolong Qi, Weimin An, Fuquan Liu, Ruizhao Qi, Lei Wang, Yanna Liu, Chuan Liu, Yi Xiang, Jialiang Hui, Zhao Liu, Xingshun Qi, Changchun Liu, Baogang Peng, Huiguo Ding, Yongping Yang, Xiaoshun He, Jinlin Hou, Jie Tian, Zhiwei Li
Purpose To develop and validate a computational model for estimating hepatic venous pressure gradient (HVPG) based on CT angiographic images, termed virtual HVPG, to enable the noninvasive diagnosis of portal hypertension in patients with cirrhosis. Materials and Methods In this prospective multicenter diagnostic trial ( identifier: NCT02842697), 102 consecutive eligible participants (mean age, 47 years [range, 21-75 years]; 68 men with a mean age of 44 years [range, 21-73 years] and 34 women with a mean age of 52 years [range, 24-75 years]) were recruited from three high-volume liver centers between August 2016 and April 2017...
November 20, 2018: Radiology
Kai-Chuan Yang, Qing-Zhu Li, Yu Liu, Qing-Qing He, Yue Liu, Hai-Jun Leng, Ai-Qiong Jia, Shanmugavel Ramachandran, Jun-Long Li
A series of iminoindoline-derived alkenes was found to be a new class of excellent aza-diene electrophiles in NHC-catalyzed asymmetric [4 + 2] cyclizations. This transformation is mainly characterized by excellent compatibility, which allows aza-diene substrates to incorporate various substituents and functionalities, including (hetero)aryl, (linear or branched)alkyl, alkenyl, alkynyl, and ester groups. Forty examples of the desired tetrahydro-α-carbolinones were facilely synthesized using this method, with up to 99% yield and >99% ee...
November 20, 2018: Organic Letters
Guan-Zheng Luo, Ziyang Hao, Liangzhi Luo, Mingren Shen, Daniela Sparvoli, Yuqing Zheng, Zijie Zhang, Xiaocheng Weng, Kai Chen, Qiang Cui, Aaron P Turkewitz, Chuan He
BACKGROUND: N6 -methyldeoxyadenosine (6mA or m6 dA) was shown more than 40 years ago in simple eukaryotes. Recent studies revealed the presence of 6mA in more prevalent eukaryotes, even in vertebrates. However, functional characterizations have been limited. RESULTS: We use Tetrahymena thermophila as a model organism to examine the effects of 6mA on nucleosome positioning. Independent methods reveal the enrichment of 6mA near and after transcription start sites with a periodic pattern and anti-correlation relationship with the positions of nucleosomes...
November 19, 2018: Genome Biology
Chao-Geng Lyu, Sheng Wang, Xia-Hong He, Lin He, Wan-Zhen Yang, Chuan-Zhi Kang, Jing-Yi Jiang, Lan-Ping Guo
Nowadays, the cultivation of traditional Chinese medicinal materials is faced with the problems of pesticides illegal uses and pesticides residues. In the early period of eco-agriculture of Chinese materia medica, the uses of pesticides in special time is still inevitable. However, the registration of pesticides for Chinese medicinal materials now is far from enough to meet demand. So it is necessary to publish policies to expand the pesticides registration for Chinese medicinal materials. We collected and analyzed the data of pesticide registration for Chinese medicinal materials, the results showed that till March 2018, there were 10 kinds of Chinese medicinal materials, 91 pesticide products and 46 kinds of pesticide ingredients registered...
October 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Chuan-Chang Li, Xue-Ting Qiu, Quan Sun, Ji-Peng Zhou, Hui-Jun Yang, Wan-Zhou Wu, Ling-Fang He, Can-E Tang, Guo-Gang Zhang, Yong-Ping Bai
Angiogenesis is critical for re-establishing the blood supply to the surviving myocardium after myocardial infarction (MI) in patients with acute coronary syndrome (ACS). MicroRNAs are recognised as important epigenetic regulators of endothelial function. The aim of this study was to determine the roles of microRNAs in angiogenesis. Eighteen circulating microRNAs including miR-185-5p were differently expressed in plasma from patients with ACS by high-throughput RNA sequencing. The expressional levels of miR-185-5p were dramatically reduced in hearts isolated from mice following MI and cultured human umbilical vein endothelial cells (HUVECs) under hypoxia, as determined by fluorescence in situ hybridisation and quantitative RT-PCR...
November 18, 2018: Journal of Cellular and Molecular Medicine
Wan-Xiang Niu, Chen-Xu Zhou, Chuan-Dong Cheng, De-Jun Bao, Yong-Fei Dong, Dong-Xue Li, Yang Yang, Hu He, Chao-Shi Niu
Gliomas are the most common malignant primary brain tumors with poor prognosis. We attempted to explore the role of CYP17A1 in glioma progression. We demonstrated that the expression of CYP17A1 was significantly higher in the glioma tissues than the normal brain tissues, especially in malignant glioma. Moreover, the expression of CYP17A1 gene was positively correlative with glioma pathological grades. In vitro, CYP17A1 gene silence inhibited the proliferation and invasion of glioma cells and promoted the apoptosis in glioma cells...
November 12, 2018: Neuroscience Letters
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