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https://www.readbyqxmd.com/read/29028535/baicalin-and-its-metabolites-suppresses-gluconeogenesis-through-activation-of-ampk-or-akt-in-insulin-resistant-hepg-2-cells
#1
Tao Wang, Hongmei Jiang, Shijie Cao, Qian Chen, Mingyuan Cui, Zhijie Wang, Dandan Li, Jing Zhou, Tao Wang, Feng Qiu, Ning Kang
Scutellaria baicalensis Georgi (S. baicalensis), as a traditional Chinese herbal medicine, is an important component of several famous Chinese medicinal formulas for treating patients with diabetes mellitus. Baicalin (BG), a main bioactive component of S. baicalensis, has been reported to have antidiabetic effects. However, pharmacokinetic studies have indicated that BG has poor oral bioavailability. Therefore, it is hard to explain the pharmacological effects of BG in vivo. Interestingly, several reports show that BG is extensively metabolized in rats and humans...
September 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29028366/synthesis-modeling-and-biological-evaluation-of-hybrids-from-pyrazolo-1-5c-pyrimidine-as-antileishmanial-agents
#2
Kamal Fahmy Mohamed Atta, Tamer Mohamed Ibrahim, Omaima Osman Mahmoud Farahat, Tareq Qasem Al-Shargabi, Mohamed Gaber Marei, Adnan Ahmed Bekhit, El Sayed Helmy El Ashry
AIM: A new series of pyrazolo[1,5-c]pyrimidines were synthesized by different hybridization strategies. METHODOLOGY: All structures were confirmed by IR, (1)H, (13)C, (1)H-(13)C heteronuclear multiple-quantum correlation (HMQC) spectra and microanalysis. They were evaluated for their in vitro antileishmanial activity against miltefosine and amphotericin B deoxycholate as reference drugs. RESULTS: The most active compounds 2a and 9a demonstrated superior potencies to miltefosine by ten- and six-fold, respectively, for the promastigote form, and by 5...
October 13, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29028179/reconstructing-one-articulated-networks-with-distance-matrices
#3
Kuang-Yu Chang, Yun Cui, Siu-Ming Yiu, Wing-Kai Hon
Given a distance matrix M that represents evolutionary distances between any two species, an edge-weighted phylogenetic network N is said to satisfy M if between any pair of species, there exists a path in N with a length equal to the corresponding entry in M. In this article, we consider a special class of networks called a one-articulated network, which is a proper superset of galled trees. We show that if the distance matrix M is derived from an ultrametric one-articulated network N (i.e., for any species X and Y, the entry [Formula: see text] is equal to the shortest distance between X and Y in N), we can re-construct a network that satisfies M in [Formula: see text] time, where n denotes the number of species; further, the reconstructed network is guaranteed to be the simplest, in a sense that the number of hybrid nodes is minimized...
October 13, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29028176/a-biclique-approach-to-reference-anchored-gene-blocks-and-its-applications-to-genomic-islands
#4
Arnon Benshahar, Vered Chalifa-Caspi, Danny Hermelin, Michal Ziv-Ukelson
We formalize a new problem variant in gene-block discovery, denoted Reference-Anchored Gene Blocks (RAGB), given a query sequence Q of length n, representing the gene array of a DNA element, a window size bound d on the length of a substring of interest in Q, and a set of target gene sequences [Formula: see text]. Our objective is to identify gene blocks in [Formula: see text] that are centered in a subset q of co-localized genes from Q, and contain genomes from [Formula: see text] in which the corresponding orthologs of the genes from q are also co-localized...
October 13, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29028125/ledipasvir-and-tenofovir-drug-interaction-in-hiv-hcv-co-infected-patients-impact-on-tenofovir-ctrough-and-renal-safety
#5
Caroline Solas, Sylvie Bregigeon, Olivia Faucher-Zaegel, Sylvie Quaranta, Véronique Obry-Roguet, Catherine Tamalet, Bruno Lacarelle, Isabelle Poizot-Martin
We evaluate the impact of ledipasvir on both tenofovir plasma trough concentration (Ctrough ) and estimated glomerular renal function (eGFR) in HIV-HCV co-infected patients receiving a tenofovir(TDF)-based antiretroviral regimen and treated with ledipasvir/sofosbuvir. Twenty-six patients [81% male, median age: 51years; HCV genotype 1(75%)/4(15%)] were included. Tenofovir Ctrough (interquartile:IQR) increased from 78ng/mL (53-110) at baseline to 141ng/mL (72-176) at M1 (p=0.003). No significant difference on eGFR using both Cockroft-Gault and MDRD formula, respectively [median(IQR)] was observed between baseline [101...
October 13, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29028106/correlation-between-presence-of-primary-iris-and-cilliary-body-cysts-and-intraocular-pressure
#6
K-C Xue, D-D Hu, L Zhao, N Li, H-Y Shen
OBJECTIVE: The objective of this study was to examine the correlation between the presence of primary iris-ciliary cysts and the intraocular pressure. PATIENTS AND METHODS: Sixty patients with short-sightedness undergoing routine examination for laser vision correction in our hospital in 2003 were enrolled. Patients with known high intraocular pressure and risk of glaucoma were excluded from the study. A total of 119 eyes were examined by the Ultrasound Biomicroscope (UBM), and the presence of the primary iris-ciliary cysts was confirmed...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027706/regional-citrate-anticoagulation-with-calcium-replacement-in-pediatric-apheresis
#7
Katie Sigler, Ji Lee, Poyyapakkam Srivaths
PURPOSE: The objective of this retrospective analysis was to present our single-center experience with intravenous (IV) calcium replacement and regional citrate anticoagulation in pediatric apheresis therapy with the aim of developing a standard operating procedure to minimize symptomatic hypocalcemia. METHODS: We analyzed apheresis procedures in patients <18 years of age over a 2-year time period (Jan 2012 to Dec 2014). Procedures in tandem with other extracorporeal therapies, including continuous renal replacement therapy, extracorporeal liver support, and extracorporeal membrane oxygenation, were excluded...
October 13, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29027684/chemical-interaction-between-lilium-brownii-and-rhizoma-anemarrhenae-the-herbal-constituents-of-baihe-zhimu-decoction-by-liquid-chromatography-coupled-to-hybrid-triple-quadrupole-linear-ion-trap-mass-spectrometer
#8
Bo Yang, Zhirui Liu, Qian Wang, Peiyuan Xia
During the course of decoction, the components of herbal formula interact with each other, such that chemical extraction characteristics are altered. The crude drugs, Lilium brownii (Baihe) and Rhizoma Anemarrhenae (Zhimu), are the herbal constituents of Baihe Zhimu decoction, a traditional herbal formula. To investigate the chemical interaction between Baihe and Zhimu when decocting together, eight marker components in Baihe Zhimu decoction were simultaneously characterized and quantified in one run by a hybrid triple quadrupole linear ion trap mass spectrometer in the multiple reactions monitoring-information dependent acquisition-enhanced product ion (MRM-IDA-EPI) mode...
October 13, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29027676/toxicokinetics-of-strychnine-and-brucine-after-the-oral-administration-of-biqi-capsule-to-rats-by-rrlc-ms-ms
#9
Hao Zheng, Zhe Wang, Wenwei Liu, Hongtao Jin, Jinlan Zhang
Biqi capsule is a well-known traditional Chinese medicine (TCM) formula that has been widely applied for the clinical treatment of such diseases as rheumatoid arthritis, scapulohumeral periarthritis, and cervical spondylopathy. However, there is concern regarding the toxicity of Biqi capsule due to its active ingredients, strychnine and brucine. To investigate the toxicokinetics of strychnine and brucine after the oral administration of Biqi capsule to rats, a sensitive and simple rapid-resolution liquid chromatography/tandem mass spectrometry (RRLC-MS/MS) method was developed to determine the levels of strychnine and brucine in rat plasma...
October 13, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29027590/diagnostic-utility-of-combined-retinal-ganglion-cell-count-estimates-in-japanese-glaucoma-patients
#10
Mari Sakamoto, Sotaro Mori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura
PURPOSE: To assess the combined estimate of retinal ganglion cell (RGC) count developed by Medeiros et al. as a tool for diagnosis of glaucoma in Japanese patients. STUDY DESIGN: Cross-sectional study. METHODS: Thirty-one eyes of 19 healthy controls and 106 eyes of 70 glaucoma patients underwent standard automated perimetry (SAP) and three types of spectral domain optical coherence tomography (SD-OCT) imaging using the Cirrus, RTVue, and 3D-OCT instruments...
October 13, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29027501/anticancer-activity-of-new-imidazole-derivative-of-1r-2r-diaminocyclohexane-palladium-and-platinum-complexes-as-dna-fluorescent-probes
#11
Sara Hadian Rasanani, Mahboube Eslami Moghadam, Esmaeil Soleimani, Adeleh Divsalar, Davood Ajloo, Aliakbar Tarlani, Majid Amiri
The aim of this study was synthesis of two new water-soluble fluorescent palladium and platinumcomplexes with formulas of [Pt(DACH)(FIP)](NO3)2 and [Pd(DACH)(FIP)](NO3)2, respectively, where FIP is 2-(furan-2-yl)-1H-imidazo[4,5-f][1,10] phenanthroline and DACH is 1R,2R-diaminocyclohexane. Fluorescence spectroscopy, circular dichroism (CD), thermal denaturation measurement, ionic strength, and kinetic study displayed groove binding of Pt complex on DNA, while due to binding of Pd complex,B form of DNA convert to Z form...
October 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29026969/extended-serum-lipid-profile-predicting-long-term-survival-in-patients-treated-for-abdominal-aortic-aneurysms
#12
Niina Khan, Leo-Pekka Lyytikäinen, Jahangir Khan, Ilkka Seppälä, Antti Lehtomäki, Tommi Kuorilehto, Velipekka Suominen, Terho Lehtimäki, Niku Oksala
BACKGROUND: Individuals treated for abdominal aortic aneurysms (AAAs) are high-risk patients in whom better risk prediction could improve survival. Contemporary serum lipid parameters, such as apolipoproteins and lipoprotein subfractions, may improve or complement the prognostic value of traditional serum lipids. The aim of this study was to ascertain the extended serum lipid profiles, long-term prognosis and their association in AAA patients. METHODS: Altogether 498 patients treated for AAAs and with available serum lipid values were retrospectively analysed...
October 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29026733/safety-of-a-new-synbiotic-starter-formula
#13
Yvan Vandenplas, Antonis Analitis, Chara Tziouvara, Athina Kountzoglou, Anastasia Drakou, Manos Tsouvalas, Antigoni Mavroudi, Ioannis Xinias
PURPOSE: Breastfeeding is the best way to feed all infants, but not all infants can be (exclusively) breastfed. Cow's milk based infant formula is the second choice infant feeding. METHODS: The safety of a new synbiotic infant formula, supplemented with Bifidobacterium lactis and fructo-oligosaccharides, with lactose and a whey/casein 60/40 protein ratio was tested in 280 infants during 3 months. RESULTS: The median age of the infants at inclusion was 0...
September 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29026688/establishing-the-presence-or-absence-of-chronic-kidney-disease-uses-and-limitations-of-formulas-estimating-the-glomerular-filtration-rate
#14
REVIEW
Ahmed Alaini, Deepak Malhotra, Helbert Rondon-Berrios, Christos P Argyropoulos, Zeid J Khitan, Dominic S C Raj, Mark Rohrscheib, Joseph I Shapiro, Antonios H Tzamaloukas
The development of formulas estimating glomerular filtration rate (eGFR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease (CKD), which is based on eGFR values and albuminuria. This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course...
September 26, 2017: World Journal of Methodology
https://www.readbyqxmd.com/read/29026370/preliminary-molecular-characterization-of-a-proinflammatory-and-nociceptive-molecule-from-the-echinometra-lucunter-spines-extracts
#15
Juliana Mozer Sciani, Bianca Zychar, Luis Roberto Gonçalves, Renata Giorgi, Thiago Nogueira, Daniel Carvalho Pimenta
BACKGROUND: Sea urchins are animals commonly found on the Brazilian shoreline, being Echinometra lucunter the most abundant species. Accidents caused by E. lucunter have been reported as one of the most frequent in Brazil, and are characterized by intense pain and inflammation, consequence of spine puncture in the skin. In order to characterize such toxic effects, we isolated one molecule that caused inflammatory and nociceptive effects. METHODS: E. lucunter specimens were collected without gender distinction...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29026344/convex-congruences
#16
Ivan Chajda, Helmut Länger
For an algebra [Formula: see text] belonging to a quasivariety [Formula: see text], the quotient [Formula: see text] need not belong to [Formula: see text] for every [Formula: see text]. The natural question arises for which [Formula: see text]. We consider algebras [Formula: see text] of type (2, 0) where a partial order relation is determined by the operations [Formula: see text] and 1. Within these, we characterize congruences on [Formula: see text] for which [Formula: see text] belongs to the same quasivariety as [Formula: see text]...
2017: Soft Computing
https://www.readbyqxmd.com/read/29026298/therapeutic-effects-of-lornoxicam-loaded-nanomicellar-formula-in-experimental-models-of-rheumatoid-arthritis
#17
Hebatullah Samy Helmy, Ayman E El-Sahar, Rabab H Sayed, Rehab Nabil Shamma, Alaa Hamed Salama, Eman Maher Elbaz
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease treated by nonsteroidal anti-inflammatory drugs (NSAIDs) including lornoxicam (LX). Nanocarriers have been used to increase the efficacy and reduce the side effects of various drugs. The objective of the present study was to compare the therapeutic efficacy of systemic administration of lornoxicam-loaded nanomicellar formula (LX-NM) with that of free LX. MATERIALS AND METHODS: The LX-loaded mixed polymeric nanomicellar formula was prepared by direct equilibrium technique...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29026279/inertial-proximal-alternating-minimization-for-nonconvex-and-nonsmooth-problems
#18
Yaxuan Zhang, Songnian He
In this paper, we study the minimization problem of the type [Formula: see text], where f and g are both nonconvex nonsmooth functions, and R is a smooth function we can choose. We present a proximal alternating minimization algorithm with inertial effect. We obtain the convergence by constructing a key function H that guarantees a sufficient decrease property of the iterates. In fact, we prove that if H satisfies the Kurdyka-Lojasiewicz inequality, then every bounded sequence generated by the algorithm converges strongly to a critical point of L...
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/29026270/longitudinal-study-on-the-effectiveness-of-vitamin-d-supplements-in-exclusively-breast-fed-infants
#19
Shintaro Terashita, Taichi Nakamura, Noboru Igarashi
Vitamin D deficiency is a common health problem in infancy. Breast-fed infants are at a higher risk of rickets than formula-fed infants. We observed fluctuations in vitamin D levels in infancy (phase I, 2009-2010) and considered the benefits of vitamin D supplementation specifically in exclusively breast-fed infants in Japan (phase II, 2015). Infants born at our hospital were enrolled in this study. In phase I, we measured 25-hydroxyvitamin D [25(OH)D] levels at 1- to 6-mo intervals from birth. In phase II, we measured 25(OH)D levels before and after supplementation...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29026165/appropriate-surgical-modalities-for-stages-t2a-and-t2b-in-the-eighth-tnm-classification-of-lung-cancer
#20
Fenglong Bie, Xiao Qu, Xudong Yang, Zhaofei Pang, Yufan Yang, Shaorui Liu, Wei Dong, Jiajun Du
Patients with tumors of 3 to 5 cm were divided into stages T2a (3 to 4 cm) and T2b (4 to 5 cm) based on the 8(th) tumor-node-metastasis staging system for lung cancer. The objective of our study was to explore appropriate surgical modalities for the new stages, T2a and T2b. We selected 6,996 node-negative non-small-cell lung cancer patients with tumor sizes of 3 to 5 cm, diagnosed between 2009 and 2013, from the Surveillance, Epidemiology, and End Results (SEER) program. The Pearson [Formula: see text]...
October 12, 2017: Scientific Reports
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