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https://www.readbyqxmd.com/read/27296242/demographic-based-content-analysis-of-web-based-health-related-social-media
#1
Shouq A Sadah, Moloud Shahbazi, Matthew T Wiley, Vagelis Hristidis
BACKGROUND: An increasing number of patients from diverse demographic groups share and search for health-related information on Web-based social media. However, little is known about the content of the posted information with respect to the users' demographics. OBJECTIVE: The aims of this study were to analyze the content of Web-based health-related social media based on users' demographics to identify which health topics are discussed in which social media by which demographic groups and to help guide educational and research activities...
June 13, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/22070192/histamine-pharmacology-and-new-cns-drug-targets
#2
REVIEW
Ekaterini Tiligada, Konstantinos Kyriakidis, Paul L Chazot, M Beatrice Passani
During the last decade, the identification of a number of novel drug targets led to the development of promising new compounds which are currently under evaluation for their therapeutic prospective in CNS related disorders. Besides the established pleiotropic regulatory functions in the periphery, the interest in the potential homeostatic role of histamine in the brain was revived following the identification of H(3) and H(4) receptors some years ago. Complementing classical CNS pharmacology, the development of selective histamine receptor agonists, antagonists, and inverse agonists provides the lead for the potential exploitation of the histaminergic system in the treatment of brain pathologies...
December 2011: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/21509086/a-rare-presentation-of-attention-deficit-hyperactivity-disorder-a-recommendation-to-be-more-alert
#3
Marwan Al-Sharbati, Rashid Al-Zaidi, Rahma Al-Naamani, Amna Al-Futaisi, Rajeev Jain
We report the case of a 7 year-old Omani girl with tuberous sclerosis (TS), attention deficit hyperactivity disorder (ADHD) and bipolar disorder (BD), at Sultan Qaboos University Hospital (SQUH), Oman. For a year she had been suffering from hyperactivity, aggression, over talkativeness, insomnia, risk-taking behaviour, distractibility, poor attention and seizures. This clinical picture evolved slowly, but was progressive in nature. Before the consultation at her local health centre, she was given four drugs without being properly investigated; she continued to deteriorate...
April 2010: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/18781987/the-endocannabinoid-system-in-peripheral-lymphocytes-as-a-mirror-of-neuroinflammatory-diseases
#4
REVIEW
Diego Centonze, Luca Battistini, Mauro Maccarrone
During immuno-mediated attack of the brain, activation of endocannabinoids represents a protective mechanism, aimed at reducing both neurodegenerative and inflammatory damage through various and partially converging mechanisms that involve neuronal and immune cells. Here, we review the main alterations of the endocannabinoid system (ECS) within the central nervous system and in peripheral blood mononuclear cells, in order to discuss the intriguing observation that elements of the peripheral ECS mirror central dysfunctions of endocannabinoid signaling...
2008: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/18729534/approved-and-investigational-uses-of-modafinil-an-evidence-based-review
#5
REVIEW
Raminder Kumar
Modafinil is a wake-promoting agent that is pharmacologically different from other stimulants. It has been investigated in healthy volunteers, and in individuals with clinical disorders associated with excessive sleepiness, fatigue, impaired cognition and other symptoms. This review examines the use of modafinil in clinical practice based on the results of randomized, double-blind, placebo-controlled clinical trials available in the English language in the MEDLINE database. In sleep-deprived individuals, modafinil improves mood, fatigue, sleepiness and cognition to a similar extent as caffeine but has a longer duration of action...
2008: Drugs
https://www.readbyqxmd.com/read/17342190/x-linked-adrenoleukodystrophy
#6
REVIEW
Hugo W Moser, Asif Mahmood, Gerald V Raymond
X-linked adrenoleukodystrophy (X-ALD) is caused by a defect in the gene ABCD1, which maps to Xq28 and codes for a peroxisomal membrane protein that is a member of the ATP-binding cassette transporter superfamily. X-ALD is panethnic and affects approximately 1:20,000 males. Phenotypes include the rapidly progressive childhood, adolescent, and adult cerebral forms; adrenomyeloneuropathy, which presents as slowly progressive paraparesis in adults; and Addison disease without neurologic manifestations. These phenotypes are frequently misdiagnosed, respectively, as attention-deficit hyperactivity disorder (ADHD), multiple sclerosis, or idiopathic Addison disease...
March 2007: Nature Clinical Practice. Neurology
https://www.readbyqxmd.com/read/16380594/adrenoleukodystrophy-new-approaches-to-a-neurodegenerative-disease
#7
Hugo W Moser, Gerald V Raymond, Prachi Dubey
X-linked adrenoleukodystrophy (X-ALD), which was first described in 1923, was viewed until 1976 as a rare and inexorably fatal neurodegenerative disorder that affected boys. The genetic defect and biochemical abnormalities have now been defined. Ongoing research has resulted in new findings: (1) there is a wide range of phenotypic expression. At least half of patients with X-ALD are adults with somewhat milder manifestations, and women who are carriers may become symptomatic. X-ALD is often misdiagnosed as attention-deficit/hyperactivity disorder in boys and as multiple sclerosis in men and women, and is not an uncommon cause of Addison disease; (2) the incidence of X-ALD, estimated to be 1:17,000 in all ethnic groups, approximates that of phenylketonuria; (3) noninvasive and presymptomatic diagnosis and prenatal diagnosis are available; family screening and genetic counseling are key to disease prevention; and (4) new therapies, applied early, show promise...
December 28, 2005: JAMA: the Journal of the American Medical Association
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