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JOURNAL ARTICLE
Anne Mørup-Petersen, Michael Rindom Krogsgaard, Mogens Laursen, Frank Madsen, Kristian Breds Geoffroy Mongelard, Lone Rømer, Matilde Winther-Jensen, Anders Odgaard
PURPOSE: Revision rates following primary knee arthroplasty vary by country, region and hospital. The SPARK study was initiated to compare primary surgery across three Danish regions with consistently different revision rates. The present study investigated whether the variations were associated with differences in the primary patient selection. METHODS: A prospective observational cohort study included patients scheduled Sep 2016 Dec 2017 for primary knee arthroplasty (total, medial/lateral unicompartmental or patellofemoral) at three high-volume hospitals, representing regions with 2-year cumulative revision rates of 1, 2 and 5%, respectively...
April 21, 2023: Knee Surgery, Sports Traumatology, Arthroscopy
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JOURNAL ARTICLE
Jens Eg Nørgaard, Stig Andersen, Jesper Ryg, Andrew James Thomas Stevenson, Jane Andreasen, Anderson Souza Oliveira, Mathias Brix Danielsen, Martin Gronbech Jorgensen
IMPORTANCE: Falls are common and the leading cause of injuries among older adults, but falls may be attenuated by the promising and time-efficient intervention called perturbation-based balance training (PBT). OBJECTIVE: To evaluate the effects of a 4-session treadmill PBT intervention compared with regular treadmill walking on daily-life fall rates among community-dwelling older adults. DESIGN, SETTING, AND PARTICIPANTS: This 12-month, assessor-blinded randomized clinical trial was conducted from March 2021 through December 2022 in Aalborg University in Denmark...
April 3, 2023: JAMA Network Open
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COMPARATIVE STUDY
Mathilde Gottschau, Susanne Rosthøj, Annette Settnes, Gitte Lerche Aalborg, Jakob Hansen Viuff, Christian Munk, Allan Jensen, Susanne K Kjær, Lene Mellemkjær
BACKGROUND: More evidence is needed to substantiate current recommendations about removing ovaries during hysterectomy for benign conditions. OBJECTIVE: To compare long-term outcomes in women with and without bilateral salpingo-oophorectomy (BSO) during hysterectomy for benign conditions. DESIGN: Emulated target trial using data from a population-based cohort. SETTING: Women in Denmark aged 20 years or older during 1977 to 2017...
May 2023: Annals of Internal Medicine
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JOURNAL ARTICLE
Michael Adelsen Jakobsen, Mia Carøe Sørensen, Jette Brommann Kornum, Alina Zalounina Falborg, Malene Plejdrup Hansen
Objective: To characterise and explore the development in the number and content of urine samples sent from general practice in the North Denmark Region to the Department of Clinical Microbiology (DCM) at Aalborg University Hospital during a five-year period. Design: A register-based study. Setting: General practice. Subjects: Urine samples received at DCM, Aalborg University Hospital from general practice between 2017 and 2022. Main outcome measures: Number and content of urine samples. Results: A total of 255,271 urine samples from general practice were received at DCM, with 76...
April 13, 2023: Scandinavian Journal of Primary Health Care
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JOURNAL ARTICLE
Anne Mørup-Petersen, Michael Rindom Krogsgaard, Mogens Laursen, Frank Madsen, Matilde Winther-Jensen, Anders Odgaard
PURPOSE: It is well-known that revision rates after primary knee arthroplasty vary widely. However, it is uncertain whether hospital revision rates are reliable indicators of general surgical quality as defined by patients. The SPARK study compared primary knee arthroplasty surgery at three high-volume hospitals whose revision rates differed for unknown reasons. METHODS: This prospective observational study included primary knee arthroplasty patients (total, medial/lateral unicompartmental and patellofemoral) in two low-revision hospitals (Aarhus University Hospital and Aalborg University Hospital Farsø) and one high-revision hospital (Copenhagen University Hospital Herlev-Gentofte)...
April 12, 2023: Knee Surgery, Sports Traumatology, Arthroscopy
#26
JOURNAL ARTICLE
Line Cleman Hatting, Marie Østergaard Kristensen, Maja Hjelm Lundgaard, Anne Sørensen, Stine Linding Andersen
BACKGROUND: Thyroid disease in pregnant women is a matter of clinical awareness, and current clinical guidelines recommend a risk-based screening strategy. This study aimed to evaluate current clinical practice regarding screening for thyroid disease in pregnancy in Denmark. METHODS: A cross-sectional study was performed in the North Denmark Region with consecutive inclusion of 150 pregnant women from Aalborg University Hospital each year in 2020 and 2021. Medical records were reviewed according to the recommended risk-based screening criteria for thyroid disease in pregnancy...
March 31, 2023: Thyroid Research
#27
JOURNAL ARTICLE
Stine Linding Andersen, Jesper Karmisholt, Peter Vestergaard, Lise Husted, Stine Krogh Venø, Peter Astrup Christensen
Parathyroid hormone (PTH) is a routine biochemical analysis, and it varies whether a second- or third-generation assay is used. Information on the levels obtained with different assays and evidence to substantiate local assay-specific reference ranges are important to inform clinical practice. Prior to a shift from the second- to the third-generation PTH assay (Cobas 8000, Roche Diagnostics) in the Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark, a total of 59 EDTA-plasma samples were collected for method comparison (Passing-Bablok)...
January 10, 2023: Scandinavian Journal of Clinical and Laboratory Investigation
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JOURNAL ARTICLE
P Rossignol, K Duarte, E Bresso, Åsberg A, M D Devignes, N Eriksson, N Girerd, R Glerup, A G Jardine, H Holdaas, Z Lamiral, C Leroy, Z Massy, W März, B Krämer, P H Wu, R Schmieder, I Soveri, J H Christensen, M Svensson, F Zannad, B Fellström
AIMS: End-stage renal disease (ESRD) treated by chronic hemodialysis (HD) is associated with poor cardiovascular (CV) outcomes, with no available evidence-based therapeutics. A multiplexed proteomic approach may identify new pathophysiological pathways associated with CV outcomes, potentially actionable for precision medicine. METHODS AND RESULTS: The AURORA trial was an international, multicentre, randomized, double-blind trial involving 2776 patients undergoing maintenance HD...
November 2022: Eur Heart J Open
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JOURNAL ARTICLE
Tina Okdahl, Anne-Marie Wegeberg, Flemming Pociot, Birgitte Brock, Joachim Størling, Christina Brock
OBJECTIVES: To investigate low-grade inflammation in type 2 diabetes and explore associations to clinical aspects as well as microvascular and macrovascular complications. DESIGN: Cross-sectional analysis. SETTING: The outpatient diabetes clinic at the Department of Endocrinology at Aalborg University Hospital, Denmark. PARTICIPANTS: 100 participants with type 2 diabetes confirmed by a haemoglobin A1c (HbA1c)≥6...
December 14, 2022: BMJ Open
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JOURNAL ARTICLE
Charles Vesteghem, Weronika M Szejniuk, Rasmus F Brøndum, Ursula G Falkmer, Chloé-Agathe Azencott, Martin Bøgsted
PURPOSE: Administering systemic anticancer treatment (SACT) to patients near death can negatively affect their health-related quality of life. Late SACT administrations should be avoided in these cases. Machine learning techniques could be used to build decision support tools leveraging registry data for clinicians to limit late SACT administration. MATERIALS AND METHODS: Patients with advanced lung cancer who were treated at the Department of Oncology, Aalborg University Hospital and died between 2010 and 2019 were included (N = 2,368)...
November 2022: JCO Clinical Cancer Informatics
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REVIEW
François Hug, Simon Avrillon, Jaime Ibáñez, Dario Farina
Understanding how movement is controlled by the central nervous system remains a major challenge, with ongoing debate about basic features underlying this control. In current established views, the concepts of motor neuron recruitment order, common synaptic input to motor neurons, muscle synergies, are usually addressed separately and therefore seen as independent features of motor control. In this review, we analyze the body of literature in a broader perspective and we identify a unified approach to explain apparently divergent observations at different scales of motor control...
November 10, 2022: Journal of Physiology
#32
JOURNAL ARTICLE
Stine L Jacobsen, Gustavo Gattino, Ulla Holck, Julie Ørnholt Bøtker
BACKGROUND: General mental health and interpersonal skills of families are crucial to children's development and future. Research suggests a link between participation in music activities and individuals' own sense of mental health, as well as an effect in objective measures of health such as quality of life, social skills, and rehabilitation of various kinds. However, in Denmark there are not many services for families with school-aged children (7-12 years) that focus on prevention and strengthening family interaction hereby minimising the risk of children not thriving and developing optimally in terms of social and emotional skills and competences...
November 4, 2022: BMC Psychology
#33
JOURNAL ARTICLE
Rikhof Cindy J H, Gerdienke B Prange-Lasonder, Erik C Prinsen, Jaap H Buurke, Johan S Rietman
Stroke is one of the leading causes of disability in adults in the European Union. It often leads to motor impairments, such as a hemiparetic lower extremity. Research indicates that early task-specific and intensive training promotes neuroplasticity and leads to recovery and/or compensation. One way to provide intensive training early after a stroke is via robot-supported training. A rehabilitation robot was designed by Life Science Robotics (Aalborg, Denmark) that can provide continuous repetitive movements of the hip, knee, and/or ankle in e...
July 2022: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
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JOURNAL ARTICLE
Christian Sander Danstrup, Nina Munk Lyhne, Adrienn Kovacsne, Rune Fisker, Helle Damgaard Zacho
PURPOSE: We aimed to evaluate the frequency and malignancy rate of incidental salivary gland lesions (ISGLs) in patients undergoing 18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT). METHODS: Using a predefined algorithm, all descriptions of FDG-PET/CT scans performed in the North Denmark Region at the Department of Nuclear Medicine, Aalborg University Hospital from 1.12 2009 to 31.12 2019 were electronically searched for focal uptake in one or more salivary glands...
August 8, 2022: European Archives of Oto-rhino-laryngology
#35
JOURNAL ARTICLE
Anna S Andersen, Sidsel Linneberg Rathcke, Trine Tang Christensen, Anne Sørensen
OBJECTIVE: Gestational diabetes mellitus (GDM) is the most common metabolic complication of pregnancy. The incidence of GDM is increasing worldwide and 5-25% of pregnancies are diagnosed with GDM depending on screening strategies and diagnostic criteria. GDM may lead to obstetric complications and increases the risk of adult metabolic disease in the offspring. Timely identification of GDM allows for regulation of maternal glucose levels which may reduce the obstetric complications considerably...
September 2022: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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JOURNAL ARTICLE
Ane Pastor, Andrés Ospina-Alvarez, Janus Larsen, Flemming Thorbjørn Hansen, Dorte Krause-Jensen, Marie Maar
The North Sea and the Baltic Sea, including Danish coastal waters, have experienced a drastic decline in eelgrass Zostera marina coverage during the past century. Around 1900, eelgrass meadows covered about 6700 km2 of Danish coastal waters while the current potential distribution area is only about one third of this. In some areas, the potential distribution area is far from realized, and restoration efforts are needed to assist recovery. Such efforts are challenging, and resource-demanding and careful site selection is, therefore, important...
June 29, 2022: Marine Environmental Research
#37
JOURNAL ARTICLE
Barrett M Welch, Alexander P Keil, Jessie P Buckley, Antonia M Calafat, Kate E Christenbury, Stephanie M Engel, Katie M O'Brien, Emma M Rosen, Tamarra James-Todd, Ami R Zota, Kelly K Ferguson, Akram N Alshawabkeh, José F Cordero, John D Meeker, Emily S Barrett, Nicole R Bush, Ruby H N Nguyen, Sheela Sathyanarayana, Shanna H Swan, David E Cantonwine, Thomas F McElrath, Jenny Aalborg, Dana Dabelea, Anne P Starling, Russ Hauser, Carmen Messerlian, Yu Zhang, Asa Bradman, Brenda Eskenazi, Kim G Harley, Nina Holland, Michael S Bloom, Roger B Newman, Abby G Wenzel, Joseph M Braun, Bruce P Lanphear, Kimberly Yolton, Pam Factor-Litvak, Julie B Herbstman, Virginia A Rauh, Erma Z Drobnis, Amy E Sparks, J Bruce Redmon, Christina Wang, Alexandra M Binder, Karin B Michels, Donna D Baird, Anne Marie Z Jukic, Clarice R Weinberg, Allen J Wilcox, David Q Rich, Barry Weinberger, Vasantha Padmanabhan, Deborah J Watkins, Irva Hertz-Picciotto, Rebecca J Schmidt
Importance: Phthalate exposure is widespread among pregnant women and may be a risk factor for preterm birth. Objective: To investigate the prospective association between urinary biomarkers of phthalates in pregnancy and preterm birth among individuals living in the US. Design, Setting, and Participants: Individual-level data were pooled from 16 preconception and pregnancy studies conducted in the US. Pregnant individuals who delivered between 1983 and 2018 and provided 1 or more urine samples during pregnancy were included...
September 1, 2022: JAMA Pediatrics
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JOURNAL ARTICLE
Mikkel Kunwald, Helga Angela Gulisan, Carsten Reidies Bjarkam
INTRODUCTION: Spinal cord stimulation (SCS) may be used to treat complex regional pain syndrome (CRPS) when other treatments fail. This study aimed to describe the effects of SCS for CRPS with known nerve injury, i.e. CRPS type 2 (CRPS-2), on pain reduction and opioid use. METHODS: Data from the outpatient clinic were retrieved from the Neurizon Neuromodulation Database. The patient records of 16 patients treated with SCS at Aalborg University Hospital, Denmark, who met the Budapest (2003) criteria for CRPS-2 and completed six- and 12+-month follow-up were included...
June 15, 2022: Danish Medical Journal
#39
JOURNAL ARTICLE
Pierre Jouannais, Stefan Hindersin, Sarah Löhn, Massimo Pizzol
Microalgae are currently being investigated for their promising metabolites but assessing the environmental impact of producing these compounds remains a challenge. Microalgae cultivation performance results from the complex interaction of biological, technological, geographical, and physical factors, which bioengineers try to optimize during the upscaling process. The path from the discovery of a microalgal compound to its industrial production is therefore highly uncertain. Nonetheless, it is key to anticipate the potential environmental impacts associated with the future production of a microalgal target compound...
June 28, 2022: Environmental Science & Technology
#40
JOURNAL ARTICLE
C Nørgaard-Pedersen, L H Rom, R Steffensen, U S Kesmodel, O B Christiansen
STUDY QUESTION: Are low or high plasma mannose-binding lectin (p-MBL) levels associated with recurrent pregnancy loss (RPL) and the reproductive and perinatal outcomes before and after RPL? SUMMARY ANSWER: The prevalence of low p-MBL levels was significantly higher in RPL patients, while high levels were significantly less prevalent. No association was found between p-MBL level and reproductive and perinatal outcomes before and after RPL. WHAT IS KNOWN ALREADY: Mannose-binding lectin (MBL) is an important component in the innate immune system...
2022: Human Reproduction Open
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