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spinal tuberculosis

Jia-Long Nong, Zhen-Xue Long, Chun-Xian Lu
OBJECTIVE: To compare clinical efficacy of complete and incomplete radical debridement for spinal tuberculosis by Meta-analysis. METHODS: The literatures of RCT or non-RCT with complete and incomplete radical debridement for spinal tuberculosis from Medline, EMBASE, Cochrane Library, Web of Science, CBM, CNKI and Wanfang were searched from the time of creating database to July, 2017. Two independent reviewers identified eligible studies, extracted data and evaluated risk of bias of included studies...
July 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Fengping Gan, Jianzhong Jiang, Zhaolin Xie, Shengbin Huang, Ying Li, Guoping Chen, Haitao Tan
BACKGROUND: To investigate the clinical efficacy of minimally invasive direct lateral approach debridement, interbody bone grafting, and interbody fusion in the treatment of the thoracic and lumbar spinal tuberculosis. METHODS: From January 2013 to January 2016, 35 cases with thoracic and lumbar spinal tuberculosis received direct lateral approach debridement, interbody bone grafting, and interbody fusion. Of the 35 cases, 16 patients were male and 19 were female and the median age was 55...
August 7, 2018: BMC Musculoskeletal Disorders
Noni Novisari Soeroso, Andika Pradana, Netty Lubis, Luhur Soeroso
A 12-year-old boy presented with progressive disability to walk for four months, which was so severe that he could no longer perform daily activities. No respiratory symptom was found. On physical examination, there was a soft tissue mass in the thoracic vertebrae. Physiological reflexes of both limbs were diminished. Tuberculin skin test was positive with a 12 mm induration. Magnetic resonance imaging (MRI) of the spine showed a kyphotic cervico-thoracal region with predominantly anterior paravertebral mass that was enhanced with contrast, compressing the spinal cord at level Th-3 and Th-4, suggestive of tuberculous spondylitis...
August 2018: Respirology Case Reports
Asmita Gupte, Anupama Matcha, Michael Lauzardo
BCG has been used as intravesical immunotherapy for the treatment of bladder carcinoma. However, this treatment is not harmless and may lead to complications, with a reported incidence of systemic BCG infection ranging from 3% to 7%. We report a case of culture-proven Mycobacterium bovis (BCG) vertebral osteomyelitis in a 72-year-old patient with bladder carcinoma who was treated with intravesical mitomycin C but did not receive BCG. Cultures from biopsy recovered isolate resembling Mycobacterium tuberculosis biochemically, but resistant to pyrazinamide (PZA)...
July 30, 2018: BMJ Case Reports
Mohammed Azfar Siddiqui, Sara Sartaj, Syed Wajahat A Rizvi, Mohammad Jesan Khan, Iraj Alam Khan
STUDY DESIGN: Retrospective review. PURPOSE: The purpose of the present study was to evaluate the role of whole-spine screening using short tau inversion recovery (STIR) or fat-suppressed T2W fast spin echo (FSE) sequences in patients with spinal tuberculosis (TB). OVERVIEW OF LITERATURE: The identification of noncontiguous multiple-level spinal tuberculosis (NMLST), symptomatic or not, is important because of its management implications. Most centers do not perform routine whole-spine magnetic resonance imaging (MRI), and the reported incidence of NMLST varies from 1...
August 2018: Asian Spine Journal
Rahel Bornemann, Philip Rössler, Cornelius Jacobs, Thomas Martin Randau, Yorck Rommelspacher, Dieter Christian Wirtz, Robert Pflugmacher
Spondylodiscitis is an infection of the intervertebral disc with subsequent infection of the adjacent vertebral bodies. The main causes are 3 pathogen groups: bacteria, particularly tuberculosis pathogens, fungi and parasites. In pyogenic spondylodiscitis, infections with Staphylococcus aureus are the most common, with an incidence of up to 80%. Mortality is around 2 - 3%. Infections with tuberculosis are often associated with psoas and paravertebral abscesses. Neurological deficits are registered in up to 50% of patients...
July 27, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
Roghie Golsha, Fatemeh Mehravar, Akram Alinezhad Esboie, Sara Rafiee, Soheil Rafiee
Background: The incidence of tuberculosis (TB) has increased in recent years in both developed and developing countries. Skeletal tuberculosis occurs in approximately 1% of patients with tuberculosis. The present study aimed to evaluate the epidemiology of skeletal tuberculosis in Golestan province in northeastern Iran during 2005-2014. Methods: In the present retrospective study, the epidemiology of skeletal tuberculosis was studied in 229 skeletal tuberculosis patients who were diagnosed during 2005-2014...
July 2018: Iranian Journal of Medical Sciences
Abhay M Nene, Sanganagouda Patil, Ambadas P Kathare, Premik Nagad, Amita Nene, Farhad Kapadia
STUDY DESIGN: A single centre pilot study, open labeled, prospective randomized clinical trial OBJECTIVE.: To compare six versus twelve months of anti TB therapy in patients with biopsy proven spinal TB. SUMMARY OF THE BACKGROUND DATA: There is no clear consensus or evidence based guidelines for the duration of treatment of spinal tuberculosis. We studied if 6 and 12 months of anti tubercular therapy (ATT) had equivalent outcomes at 24 months from completion of therapy...
July 24, 2018: Spine
Arsene Mekinian, Lucas Maisonobe, Latifatou Boukari, Cléa Melenotte, Benjamin Terrier, Xavier Ayrignac, Nicolas Schleinitz, Damien Sène, Mohamed Hamidou, Amadou Konaté, Philippe Guilpain, Noémie Abisror, Etienne Ghrenassia, Florence Lachenal, Ramiro Cevallos, Richard Roos-Weil, Le Thi Huong Du, Francois Lhote, Claire Larroche, Jean-Francois Bergmann, Sébastien Humbert, Jean Baptiste Fraison, Jean Charles Piette, Loïc Guillevin, Robin Dhote, Zahir Amoura, Julien Haroche, Olivier Fain
The aim of this study was to determine the characteristics, treatment, and outcome according to each etiology of pachymeningitis.We conducted a retrospective multicenter French nationwide study between 2000 and 2016 to describe the characteristics, outcome, and treatment of pachymeningitis.We included 60 patients (median age 55.5 years; interquartile range [IQR] 30-80, female/male ratio 0.43). Neurologic signs were present in 59 patients (98%) and consisted of headache in 43 (72%), cranial nerve palsy in 33 (55%), confusion in 10 (17%), seizures in 7 (12%), and focal neurologic signs in 9 (15%)...
July 2018: Medicine (Baltimore)
Sandip Chatterjee, Aditya Banta
INTRODUCTION: Pediatric spinal tuberculosis is characterized by rapid bone destruction and carries the risk of rapid onset neurological deficits and severe deformity of the spine. Behavior of spinal deformity over time is affected by growth of spine. Owing to this dynamic behavior of pediatric spinal tuberculosis both in active phase and in healed phase, it presents with challenges which are quite different from adults with caries spine. A clinician must have high index of suspicion for accurate and early diagnosis of spinal tuberculosis in the pediatric population and should also have a thorough knowledge of differences in natural history between adult and pediatric spinal tuberculosis...
July 13, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Xin Hua Yin, Bao Rong He, Zhong Kai Liu, Ding Jun Hao
Literature on the treatment of cervical spinal tuberculosis (CSTB) is uncommon, the surgical approaches to cervical spinal tuberculosis were controversial. The aim of the study was to evaluate the clinical outcomes of 3 surgical techniques in CSTB patients, and to determine the most appropriate approach for CSTB patients. Between April 2006 and June 2012, we performed a retrospective review of clinical and radiographic data that were collected from 850 consecutive spinal tubercular patients, including 87 patients who were diagnosed and treated for CSTB in our hospital...
July 2018: Medicine (Baltimore)
Yaerim Kim, Sang Pyo Kim, Seungyeup Han
A paradoxical reaction during anti-tuberculosis (anti-TB) therapy is commonly reported in patients with human immunodeficiency virus (HIV). However, a similar reaction to anti-TB therapy can also occur in patients without HIV, especially in patients who have undergone solid organ transplantation. A 65-year-old woman who underwent kidney transplantation six months prior presented to our emergency room with progressive paraparesis. She had been diagnosed with drug-susceptible miliary TB and had undergone two weeks of treatment with anti-TB medication...
May 2018: Saudi Journal of Kidney Diseases and Transplantation
Yuji Takakura, Masahiko Fujimori, Koichi Okugawa, Hiroyuki Egi, Hideki Ohdan, Shinya Kaneko, Hirofumi Nakatsuka
INTRODUCTION: Spinal tuberculosis (TB) is the most common manifestation of extra-pulmonary TB. TB of the lumbosacral junction is rare and occurs in only 1 to 2% of all cases of spinal TB. Moreover, isolated sacrococcygeal TB is extremely rare. Herein, we report a rare case of sacrococcygeal TB, which was difficult to distinguish from complex anal fistula. CASE PRESENTATION: A 93-year-old man presented with sacral pain and peri-anal discharge. He had pulmonary TB at 25 years of age...
June 28, 2018: International Journal of Surgery Case Reports
Wenjing Wang, Baozhi Yang, Yong Cui, Ying Zhan
Spinal tuberculosis (ST) is the tuberculosis caused by Mycobacterium tuberculosis ( Mtb ) infections in spinal curds. Isoliquiritigenin 4,2',4'-trihydroxychalcone, ISL) is an anti-inflammatory flavonoid derived from licorice ( Glycyrrhiza uralensis ), a Chinese traditional medicine. In this study, we evaluated the potential of ISL in treating ST in New Zealand white rabbit models. In the model, rabbits (n=40) were infected with Mtb strain H37Rv or not in their 6th lumbar vertebral bodies. Since the day of infection, rabbits were treated with 20 mg/kg and 100 mg/kg of ISL respectively...
July 2018: Korean Journal of Physiology & Pharmacology
Karen M Galloway, Romy Parker
BACKGROUND: Expert clinicians and researchers in the field of spinal tuberculosis (STB) advocate for early identification and diagnosis as a key to reducing disability, severity of disease, expensive surgery and death, especially in tuberculosis (TB) endemic countries like South Africa. South Africa has the highest incidence per capita of tuberculosis in the world, and a conservative estimate of the incidence of STB in South Africa is 8-16:100 000. People living with STB may initially present to primary health care (PHC) centres, where the opportunity exists for early identification...
June 18, 2018: African Journal of Primary Health Care & Family Medicine
Guirong Wang, Weijie Dong, Tinglong Lan, Jun Fan, Kai Tang, Yuan Li, Guangxuan Yan, Guanglu Jiang, Yifeng Ma, Yuanyuan Shang, Shibing Qin, Hairong Huang
Early diagnosis of spinal tuberculosis (TB) is hampered by the flaws of conventional tests. The aim of this study was to assess the value of new and existing molecular tests in a prospective, head-to-head cohort study. Specimens were consecutively collected from spinal TB suspects in four hospitals in Beijing, China. Smear, culture, histopathology, Xpert MTB/RIF (Xpert), and MeltPro TB assays were performed in parallel using the same specimen from each patient. Drug-susceptibility testing (DST) was conducted on the isolates recovered...
June 20, 2018: Emerging Microbes & Infections
Philipp Schwenkenbecher, Alexandra Neyazi, Frank Donnerstag, Felix C Ringshausen, Roland Jacobs, Matthias Stoll, Philip Kirschner, Florian Peter Länger, Emil Valizada, Stefan Gingele, Florian Wegner, Kurt-Wolfram Sühs, Martin Stangel, Thomas Skripuletz
Chronic granulomatous disease (CGD) is a rare genetic immunodeficiency, which is characterized by recurrent severe bacterial and fungal infections caused by a defect in phagocytic cells due to loss of superoxide production. The disease usually manifests within the first years of life. Early diagnosis allows therapeutic intervention to improve the limited life expectancy. Nevertheless, only half of the patients exceed the age of 25. Here, we present the case of a 41-year old female patient who presented with an extensive spinal cord infection and atypical pneumonia mimicking tuberculosis...
2018: Frontiers in Immunology
Vasfiye Burcu Dogan, Batuhan Kara, Hakan Hatem Selcuk, Ayten Ceyhan Dirican, Ayhan Koksal
Anterior spinal artery syndrome (ASAS) is a rare syndrome which occurs due to thrombosis of anterior spinal artery (ASA) which supplies anterior two thirds of the spinal cord. A 27-year-old female patient was admitted to emergency clinic with sudden onset neck pain, sensory loss and weakness in proximal upper extremities which occurred at rest. Thrombophilia assessment tests were negative. Echocardiography was normal. Serum viral markers were negative. In cerebrospinal fluid (CSF) examination, cell count and biochemistry was normal, oligoclonal band was negative, viral markers for herpes simplex virus (HSV) type-1 and type-2, Brucella, Borrellia, Treponema pallidum, Tuberculosis were negative...
March 30, 2018: Ideggyógyászati Szemle
Zongqiang Yang, Jinwen He, Jiandang Shi, Ningkui Niu, Huiqiang Ding, Zili Wang
To determine the clinical efficacy of posterior intervertebral surgery for single-segment thoracolumbar spinal tuberculosis.
 Methods: Clinical data were retrospectively analyzed in 62 patients with thoracolumbar spinal tuberculosis who underwent posterior intervertebral surgery (A group) or posterior and anterior combined intervertebral surgery (B group) from January 2010 to January 2015 in Department of Spinal Surgery, General Hospital, Ningxia Medical University. The operative time, blood loss, length of hospital stay, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, neurological function, VAS score, vertebral Cobb angle, bone healing, and postoperative complications were compared between the 2 groups...
May 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Sonia Bianchini, Andrea Esposito, Nicola Principi, Susanna Esposito
Background: Spondylodiscitis (SD), the concurrent infection of a vertebral disc and the adjacent vertebral bodies, is a very severe disease that can lead to death or cause spinal deformities, segmental instabilities, and chronic pain, which significantly reduces the quality of life for affected patients. Early diagnosis and treatment are essential in order to reduce the risk of negative outcomes. The two cases of SD that are described in this paper might be useful for informing paediatric approaches to children with SD...
June 7, 2018: International Journal of Environmental Research and Public Health
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