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spinal tuberculosis

Justin Arockiaraj, Magdalenal Robert, Winsley Rose, Rohit Amritanand, Kenny Samuel David, Venkatesh Krishnan
Study Design: Retrospective case series. Purpose: The aim of the study is to report the clinical characteristics, early diagnosis, management, and outcome of children with multidrug-resistant (MDR) tubercular spondylodiscitis and to assess the early detection of rifampicin resistance using the Xpert MTB/ RIF assay. Overview of Literature: MDR tuberculosis is on the rise, especially in developing countries. The incidence rate of MDR has been reported as 8...
October 18, 2018: Asian Spine Journal
Myung-Sang Moon, Sang-Jae Kim, Min-Su Kim, Dong-Suk Kim
Study Design: A case study. Purpose: To assess the chronological changes of the disease-related kyphosis after chemotherapy alone, secondly to clarify the role of growth cartilage in the healed lesion on kyphosis change, and to define the accurate prediction time in assessing residual kyphosis. Overview of Literature: None of the previous papers up to now dealt with the residual kyphosis, stability and remodeling processes of the affected segments...
October 16, 2018: Asian Spine Journal
Xinhua Yin, Liang Yan, Ming Yang, Shichang Liu, Baorong He, Zhongkai Liu, Dingjun Hao
The study aims to evaluate the clinical efficacy of bilateral costotransverse debridement, transpedicular fixation, fusion, and local continuous chemotherapy in 20 patients of contiguous multisegmental thoracic spinal tuberculosis (CMTSTB). We analyzed 20 patients with contiguous thoracic spinal tuberculosis (TB) who underwent surgery via bilateral costotransverse debridement, fusion, posterior instrumentation, and postural drainage with local continuous chemotherapy. The clinical outcomes were evaluated in terms of kyphotic angle, bone fusion, neurologic status, erythrocyte sedimentation rate (ESR), and intraoperative and postoperative complications...
October 2018: Medicine (Baltimore)
Suzaan Marais, Izanne Roos, Ayesha Mitha, Vinod Patel, Ahmed I Bhigjee
OBJECTIVES: To describe the clinical presentation, spinal magnetic resonance imaging (MRI) findings and outcome of HIV-infected patients with tuberculosis (TB)-associated syringomyelia and to compare these findings between all HIV-infected and -uninfected cases published in the literature. METHODS: A retrospective observational study conducted over a 12.5-year period at a public-sector referral hospital in South Africa. HIV-infected adults with neurological TB in whom MRI confirmed a syrinx were included...
September 28, 2018: Journal of the Neurological Sciences
T N Mann, H S Schaaf, R N Dunn, S Dix-Peek, K du Preez, R P Lamberts, J du Toit, J H Davis
The aim of this retrospective review was to assess the overall burden and trend in spinal tuberculosis (TB) at tertiary hospitals in the Western Cape Province of South Africa. All spinal TB cases seen at the province's three tertiary hospitals between 2012 and 2015 were identified and clinical records of each case assessed. Cases were subsequently classified as bacteriologically confirmed or clinically diagnosed and reported with accompanying clinical and demographic information. Odds ratios (OR) for severe spinal disease and corrective surgery in child vs...
September 28, 2018: Epidemiology and Infection
Yong Zhu, Peng Wu, Wei Luo, Zenghui Zhao, Yunsheng Ou
This study aimed to compare the efficacy and safety of single-stage posterior instrumentation and unilateral transpedicular debridement with traditional posterior operation for the treatment of thoracolumbar tuberculosis. 53 patients underwent posterior unilateral transpedicular debridement and pedicle screw fixation (group A), and traditional posterior operation was performed in 44 patients (group B). We compared the outcomes including the correction of kyphosis (Cobb angle), bone fusion, visual analog scale (VAS), Frankel classification, and Short-Form 12-Item Health Survey (SF-12) between two groups...
September 24, 2018: World Neurosurgery
Jingtong Lyu, Wenjie Wu, Peng Cheng, Xun Liu, Fei Luo, Zehua Zhang, Kanglai Tang, Jianzhong Xu
Objective: A Tag Array chip was used to detect plasmids of different template concentration, and then analyzed for sensitivity and specificity. Drug resistance genes from tuberculosis clinical specimens were detected, giving comparative phenotypic resistance results to explore the feasibility and value of clinical applications. Methods: Twenty-four strains of Mycobacterium Tuberculosis (MTB) having sequence differences in extracted plasmids of mutant strains. The plasmid was diluted into different concentrations, and then was performed to analyze the sensitivity and specificity of the chip system...
2018: Frontiers in Microbiology
Ravindra Kumar Garg, Manan Mayur Mehta, Riddhi Jaiswal, Hardeep Singh Malhotra, Imran Rizvi, Shweta Pandey
No abstract text is available yet for this article.
September 25, 2018: Neurology
Edinson Dante Meregildo Rodriguez
Central nervous system (CNS) tuberculosis includes three clinical entities: tuberculous meningitis, intracranial tuberculoma, and spinal tuberculous arachnoiditis. All three categories are encountered frequently in regions of the world where the incidence of TB is high. Meningeal tuberculosis is a medical emergency: it is the most severe, lethal and disabling form of tuberculosis. Early diagnosis and treatment can be lifesaving. Even, in developed countries the diagnosis of tuberculous meningitis is difficult, frequently delayed or missed, and is often not microbiologically confirmed...
September 1, 2018: Le Infezioni in Medicina
Daniela Franco-Herrera, Daniela González-Ocampo, Valentina Restrepo-Montoya, Juan Esteban Gómez-Guevara, Nathalia Alvear-Villacorte, Alfonso J Rodríguez-Morales
Central nervous system (CNS) tuberculosis includes three clinical entities: tuberculous meningitis, intracranial tuberculoma, and spinal tuberculous arachnoiditis. All three categories are encountered frequently in regions of the world where the incidence of TB is high. Meningeal tuberculosis is a medical emergency: it is the most severe, lethal and disabling form of tuberculosis. Early diagnosis and treatment can be lifesaving. Even, in developed countries the diagnosis of tuberculous meningitis is difficult, frequently delayed or missed, and is often not microbiologically confirmed...
September 1, 2018: Le Infezioni in Medicina
Zhongyang Li, Fei Lei, Peng Xiu, Xi Yang, Lei Wang, Ganjun Feng, Limin Liu, Yueming Song, Chunguang Zhou
BACKGROUND: Spinal tuberculosis accounts for more than 50% of bone tuberculosis cases. This study compared clinical, radiological and functional outcomes between anterior and posterior approaches for treatment of middle or lower thoracic spinal tuberculosis in elderly patients. METHODS: We retrospectively examined middle or lower thoracic spinal tuberculosis (T5-T12) in patients over 65 years. All procedures included debridement, decompression, autologous bone graft and fixation...
September 20, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Martin Alexander Schaller, Felix Wicke, Christian Foerch, Stefan Weidauer
PURPOSE: As a result of multilateral migration and globalization in times of humanitarian crises, western countries face a possible increase in the incidence of central nervous system tuberculosis (CNS TB). The diagnosis of CNS TB is challenging and often delayed due to the manifold and often non-specific presentation of the disease. The aim of this review is to analyze and summarize imaging features and correlated clinical findings of CNS TB. METHODS: The different manifestations of CNS TB are explained and illustrated by characteristic neuroradiological as well as neuropathological findings...
September 17, 2018: Clinical Neuroradiology
Pengfei Qiao, Pengfei Zhao, Yang Gao, Yuzhen Bai, Guangming Niu
Objective: In the present study, spinal metastatic tumors, brucellar spondylitis and spinal tuberculosis were quantitatively analyzed using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess the value of DCE-MRI in the differential diagnosis of these diseases. Methods: Patients with brucellar spondylitis, spinal tuberculosis or a spinal metastatic tumor (30 cases of each) received conventional MRI and DCE-MRI examination. The volume transfer constant (Ktrans ), rate constant (Kep ), extravascular extracellular volume fraction (Ve ) and plasma volume fraction (Vp ) of the diseased vertebral bodies were measured on the perfusion parameter map, and the differences in these parameters between the patients were compared...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Alexander Yu Mushkin, Denis G Naumov, Valery A Evseev
PURPOSE: To evaluate the influence of anterior fusion option on the short- and long-time outcomes on multilevel spinal reconstructions in young children. METHODS: Forty-five patients aged under 4 years old (2 years 2 months ± 11 months in average) underwent spinal reconstruction due to tuberculosis spondylitis (35), pyogenic spondylitis (9) and spinal tumors (1) complicated by angular kyphosis exceeded 20° (49.2° ± 14.3° in average). All lesions involved two or more spinal motion segments...
September 7, 2018: European Spine Journal
Ravindra Kumar Garg, Neeraj Kumar, Shweta Pandey, Imran Rizvi, Ravi Uniyal, Hardeep Singh Malhotra
No abstract text is available yet for this article.
October 2018: Journal of Emergency Medicine
Yongchun Zhou, Weiwei Li, Jun Liu, Liqun Gong, Jing Luo
BACKGROUND: To compare the clinical efficacy of single posterior debridement, bone grafting and instrumentation with that of single-stage anterior debridement, bone grafting and posterior instrumentation for treatment of adult patients with thoracic and thoracolumbar spinal tuberculosis (TB). METHODS: We performed a retrospective analysis of 64 adult patients with thoracic and thoracolumbar spinal TB who underwent surgery between January 2011 and December 2014. Of the 64 patients, 34 patients were treated using a single posterior-only approach (posterior debridement, bone grafting and instrumentation; Group A)...
September 3, 2018: BMC Surgery
U N F Ukunda, M M Lukhele
Aims: The surgical treatment of tuberculosis (TB) of the spine consists of debridement and reconstruction of the anterior column. Loss of correction is the most significant challenge. Our aim was to report the outcome of single-stage posterior surgery using bone allografts in the management of this condition. Patients and Methods: The study involved 24 patients with thoracolumbar TB who underwent single-stage posterior spinal surgery with a cortical bone allograft for anterior column reconstruction and posterior instrumentation between 2008 and 2015...
September 2018: Bone & Joint Journal
Maria Elena Cucuzza, Flavia La Mendola, Angela D'Ambra, Pierluigi Smilari, Filippo Greco, Agata Fiumara, Andrea D Praticò
Extrapulmonary manifestations of tuberculosis (TB) are particularly frequent during childhood, and usually involve the lymph nodes and the skull. They are related to predisposing immunosuppression conditions. A patient affected by diabetes mellitus type 1 (DMT1) and congenital lamellar ichthyosis type 3 came at our attention with a 4-year history of recurrent parotitis and severe back pain and inferior limb hypomobility, which had lasted for 6 months. A diagnosis of chronic TB parotitis combined with Pott disease was performed after a suggestive spinal magnetic resonance imaging, and positive culture and polymerase-chain reaction examination...
July 2018: Journal of Global Infectious Diseases
Paerhati Rexiti, Tuerhongjiang Abudurexiti, Nueraihemaiti Abuduwali, Qiang Deng, Hailong Guo
OBJECTIVE: To evaluate the application and therapeutic effects of debridement from a single posterior approach for bone grafting and internal fixation treatment of lumbosacral tuberculosis. METHODS: From January 2010 to December 2016, 96 patients with lumbosacral tuberculosis were treated by single posterior debridement and internal fixation with bone graft. Among these patients, there were 9 cases involving the L3-L4 segment, 57 involving L4-L5, and 30 involving L5-S1...
August 23, 2018: World Neurosurgery
Xin Hua Yin, Shi Chang Liu, Ming Yang, Bao Rong He, Zhong Kai Liu, Ding Jun Hao
This retrospective cohort study aimed to evaluate the clinical outcomes of posterior surgical treatment of ankylosing spondylitis (AS) with spinal tuberculosis (STB). This was a retrospective study including 12 patients treated between January 2004 and April 2014 for AS with STB at our department. All patients underwent 1-stage posterior internal fixation, debridement, and bone fusion. The patients were evaluated based on the American Spinal Injury Association (ASIA), kyphotic Cobb angle, and the visual analog score (VAS)...
August 2018: Medicine (Baltimore)
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