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Multiple sclerosis and epilepsy

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https://www.readbyqxmd.com/read/30114263/glial-responses-during-epileptogenesis-in-mus-musculus-point-to-potential-therapeutic-targets
#1
Georgia Kalozoumi, Olga Kel-Margoulis, Elizabeth Vafiadaki, David Greenberg, Hélène Bernard, Hermona Soreq, Antoine Depaulis, Despina Sanoudou
The Mesio-Temporal Lobe Epilepsy syndrome is the most common form of intractable epilepsy. It is characterized by recurrence of focal seizures and is often associated with hippocampal sclerosis and drug resistance. We aimed to characterize the molecular changes occurring during the initial stages of epileptogenesis in search of new therapeutic targets for Mesio-Temporal Lobe Epilepsy. We used a mouse model obtained by intra-hippocampal microinjection of kainate and performed hippocampal whole genome expression analysis at 6h, 12h and 24h post-injection, followed by multilevel bioinformatics analysis...
2018: PloS One
https://www.readbyqxmd.com/read/30103955/epilepsy-treatment-patterns-among-patients-with-tuberous-sclerosis-complex
#2
Jinlin Song, Elyse Swallow, Qayyim Said, Miranda Peeples, Mark Meiselbach, James Signorovitch, Michael Kohrman, Bruce Korf, Darcy Krueger, Michael Wong, Steven Sparagana
INTRODUCTION: Tuberous sclerosis complex (TSC) is a rare congenital disorder often associated with epilepsy. However, real-world treatment patterns for epilepsy in patients with TSC are not yet well categorized. METHODS: This study included patients with TSC and epilepsy from fifteen clinics in the United States and one in Belgium who were enrolled in the TSC Natural History Database (2006-2014). Patient demographics and epilepsy treatment patterns, including the use of anti-epileptic drugs (AEDs), epilepsy surgeries, and dietary therapies were assessed...
August 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30097696/targeting-pericytes-for-therapeutic-approaches-to-neurological-disorders
#3
REVIEW
Jinping Cheng, Nils Korte, Ross Nortley, Huma Sethi, Yamei Tang, David Attwell
Many central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood-brain barrier. Pericytes, an under-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood-brain barrier, capillary blood flow and the movement of immune cells into the brain...
August 10, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/30090134/tip-of-the-iceberg-forme-fruste-tuberous-sclerosis-in-a-child
#4
Sarah G K Engel, Sonal Bhatia
Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder characterized by dermatologic manifestations and growth of multiple benign tumors often involving the brain, skin, kidneys, heart, lungs, and liver. It exhibits wide phenotypic variation, ranging from the most severe cases with intellectual disability and intractable epilepsy to the mildest, clinically silent forms of the disease. The incidence of TSC is reported to be 1/6000; however, this does not account for those with milder forms of the disease, of which forme fruste is the mildest...
April 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/30067753/data-mining-mr-image-features-of-select-structures-for-lateralization-of-mesial-temporal-lobe-epilepsy
#5
Fariborz Mahmoudi, Kost Elisevich, Hassan Bagher-Ebadian, Mohammad-Reza Nazem-Zadeh, Esmaeil Davoodi-Bojd, Jason M Schwalb, Manpreet Kaur, Hamid Soltanian-Zadeh
PURPOSE: This study systematically investigates the predictive power of volumetric imaging feature sets extracted from select neuroanatomical sites in lateralizing the epileptogenic focus in mesial temporal lobe epilepsy (mTLE) patients. METHODS: A cohort of 68 unilateral mTLE patients who had achieved an Engel class I outcome postsurgically was studied retrospectively. The volumes of multiple brain structures were extracted from preoperative magnetic resonance (MR) images in each...
2018: PloS One
https://www.readbyqxmd.com/read/30066799/yawning-in-neurology-a-review
#6
Hélio A G Teive, Renato P Munhoz, Carlos Henrique F Camargo, Olivier Walusinski
Yawning is a stereotyped physiological behavior that can represent a sign or symptom of several conditions, such as stroke, parakinesia brachialis oscitans, parkinsonism, Parkinson's disease and epilepsy. More rarely, it can occur in patients with intracranial hypertension, brain tumor, multiple sclerosis, migraine, Chiari malformation type I, and amyotrophic lateral sclerosis. Drug-induced yawning is an uncommon clinical condition and yawning in patients with autism or schizophrenia is very rare. The aim of this review is to describe in detail the occurrence of the phenomenon in such conditions, and its' phenomenology and pathophysiology...
July 2018: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/30050611/-tuberous-sclerosis-complex-the-role-of-patient-s-history-and-clinical-examination
#7
Jawad El-Azhari, Naoufal Hjira
Tuberous sclerosis complex (TSC) is a neurocutaneous multisystemic syndrome most commonly affecting the skin, the brain, the kidneys, the lungs and the eyes. The diagnosis is based on clinical characteristics; 90% of patients have skin lesions and seizures are the initial symptom in 80% of patients. Patients with STB often show a high incidence of neuropsychiatric symptoms, including mental retardation, autism and learning difficulties. Epilepsy and brain and renal tumors are treated with aggressive therapeutic and surgical approaches...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/30039154/risks-and-benefits-of-marijuana-use-a-national-survey-of-u-s-adults
#8
Salomeh Keyhani, Stacey Steigerwald, Julie Ishida, Marzieh Vali, Magdalena Cerdá, Deborah Hasin, Camille Dollinger, Sodahm R Yoo, Beth E Cohen
Background: Despite insufficient evidence regarding its risks and benefits, marijuana is increasingly available and aggressively marketed to the public. Objective: To understand the public's views on the risks and benefits of marijuana use. Design: Probability-based online survey. Setting: United States, 2017. Participants: 16 280 U.S. adults. Measurements: Proportion of U...
July 24, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30005812/short-term-safety-of-mtor-inhibitors-in-infants-and-very-young-children-with-tuberous-sclerosis-complex-tsc-multicentre-clinical-experience
#9
Darcy A Krueger, Jamie K Capal, Paolo Curatolo, Orrin Devinsky, Kevin Ess, Michal Tzadok, Mary K Koenig, Vinodh Narayanan, Federico Ramos, Sergiusz Jozwiak, Petrus de Vries, Anna C Jansen, Michael Wong, David Mowat, John Lawson, Stephanie Bruns, David Neal Franz
OBJECTIVE: To evaluate the safety of mTOR inhibitors (sirolimus or everolimus) in infants and very young children with tuberous sclerosis complex (TSC) under two years of age. METHODS: Study design was retrospective to capture medical record data from 52 international TSC Centres who initiated treatment with sirolimus or everolimus in TSC children before the age of two years. Data collection included demographic and clinical information including reason(s) for initiating treatment with mTOR inhibitors, treatment duration, dosing, and corresponding serum trough levels, response to treatment, and adverse events (AE)...
July 4, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/30004841/unlocking-human-brain-metabolism-by-genome-scale-and-multiomics-metabolic-models-relevance-for-neurology-research-health-and-disease
#10
Mustafa Sertbas, Kutlu O Ulgen
Neurology research and clinical practice are transforming toward postgenomics integrative biology. One such example is the study of human brain metabolism that is highly sophisticated due to reactions occurring in and between the astrocytes and neurons. Because of the inherent difficulty of performing experimental studies in human brain, metabolic network modeling has grown in importance to decipher the contribution of brain metabolite kinetics to human health and disease. Multiomics system science-driven metabolic models, using genome-scale and transcriptomics Big Data, offer the promise of new insights on metabolic networks in human brain...
July 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29978658/medicinal-cannabis-in-pregnancy-panacea-or-noxious-weed
#11
Mike O'Connor
The use of medicinal cannabis has been the subject of enabling legislation in Australia since 2016. At present the medical profession has not supported its use for anything but a few indications which include paediatric treatment-resistant epilepsy (especially Dravet's syndrome), pain syndromes associated with multiple sclerosis, Parkinson's disease and chemotherapy-induced nausea. However, in the United States where medicinal cannabis has been legalised in 29 States and Washington DC, nausea is an approved indication in many jurisdictions and this has been followed by widespread use for pregnancy-induced nausea and vomiting...
April 2018: Journal of Law and Medicine
https://www.readbyqxmd.com/read/29976222/assessing-patients-acceptance-of-their-medication-to-reveal-unmet-needs-results-from-a-large-multi-diseases-study-using-a-patient-online-community
#12
Jérémy Lambert, Michael Chekroun, Hélène Gilet, Catherine Acquadro, Benoit Arnould
BACKGROUND: Patients with chronic conditions are required to take long-term treatments for their disease itself or to prevent any potential health risks. Measuring patient acceptance of their medication should help to better understand and predict patients' behavior toward treatment. This study aimed to describe the level of patient acceptance toward various long-term treatments in real life using an online patient community. METHODS: This was an observational, cross-sectional study conducted through the French Carenity platform...
July 6, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29971194/conditions-associated-with-essential-tremor-in-veterans-a-potential-role-for-chronic-stress
#13
Adrian Handforth, Gail A Parker
Background: Increased depression, hearing loss, dementia, alcoholism, and mortality in essential tremor patients remain unexplained. We investigated whether conditions associated with tremor are linked to chronic stress. Methods: The FY2013 Veterans Affairs database was queried for 38 selected dual diagnosis combinations in 5,854,223 veterans aged 21-95 years. Results: Post-traumatic stress disorder, anxiety, and depression were the most common psychiatric diagnoses in tremor patients, with the odds ratio exceeding 2 in all 15-year cohorts...
2018: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29953714/auras-as-a-prognostic-factor-in-anterior-temporal-lobe-resections-for-mesial-temporal-sclerosis
#14
Rodrigo Antonio Rocha da Cruz Adry, Lucas Crociati Meguins, Carlos Umberto Pereira, Sebastião Carlos da Silva Júnior, Gerardo Maria de Araújo Filho, Lúcia Helena Neves Marques
INTRODUCTION: Anterior temporal lobectomy for mesial temporal sclerosis is a very effective measure to control seizures, and the probability of being seizure-free is approximately 70-90%. However, 30% of patients still experience seizures after surgery. An Aura is a subjective ictal phenomenon that may precede an observable seizure. Nevertheless, few are the studies associating the prognostic factor with aura, although, being the initial symptoms of epileptic seizures, many types of auras have significant localizing or lateralizing value...
June 28, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29951646/temporal-lobe-epilepsy-stroke-and-traumatic-brain-injury-mechanisms-of-hyperpolarized-depolarized-and-flow-through-ion-channels-utilized-as-tri-coordinate-biomarkers-of-electrophysiologic-dysfunction
#15
Gina Sizemore, Brandon Lucke-Wold, Charles Rosen, James W Simpkins, Sanjay Bhatia, Dandan Sun
The brain is an integrated network of multiple variables that when compromised create a diseased state. The neuropathology of temporal lobe epilepsy (TLE), stroke, and traumatic brain injury (TBI) demonstrate both similarity and complexity that reflects this integrated variability; TLE with its live human tissue resection provides opportunity for translational science to demonstrate scale equivalent experimentation between the macroscopic world of clinical disease and the microscopic world of basic science...
2018: OBM neurobiology
https://www.readbyqxmd.com/read/29948920/now-is-the-critical-time-for-engineered-neuroplasticity
#16
REVIEW
Chet T Moritz
Recent advances in neuroscience and devices are ushering in a new generation of medical treatments. Engineered biodevices are demonstrating the potential to create long-term changes in neural circuits, termed neuroplasticity. Thus, the approach of engineering neuroplasticity is rapidly expanding, building on recent demonstrations of improved quality of life for people with movement disorders, epilepsy, and spinal cord injury. In addition, discovering the fundamental mechanisms of engineered neuroplasticity by leveraging anatomically well-documented systems like the spinal cord is likely to provide powerful insights into solutions for other neurotraumas, such as stroke and traumatic brain injury, as well as neurodegenerative disorders, such as Alzheimer's, Parkinson disease, and multiple sclerosis...
June 11, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29941830/structure-activity-relationship-of-cannabis-derived-compounds-for-the-treatment-of-neuronal-activity-related-diseases
#17
REVIEW
Cristina Prandi, Marco Blangetti, Dvora Namdar, Hinanit Koltai
Cannabis sativa active compounds are extensively studied for their therapeutic effects, beyond the well-known psychotropic activity. C. Sativa is used to treat different medical indications, such as multiple sclerosis, spasticity, epilepsy, ulcerative colitis and pain. Simultaneously, basic research is discovering new constituents of cannabis-derived compounds and their receptors capable of neuroprotection and neuronal activity modulation. The function of the various phytochemicals in different therapeutic processes is not fully understood, but their significant role is starting to emerge and be appreciated...
June 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29934763/anti-epileptogenic-and-anti-convulsive-effects-of-fingolimod-in-experimental-temporal-lobe-epilepsy
#18
Julika Pitsch, Julia C Kuehn, Vadym Gnatkovsky, Johannes Alexander Müller, Karen M J van Loo, Marco de Curtis, Hartmut Vatter, Susanne Schoch, Christian E Elger, Albert J Becker
Temporal lobe epilepsy (TLE) represents a devastating neurological condition, in which approximately 4/5 of patients remain refractory for anti-convulsive drugs. Epilepsy surgery biopsies often reveal the damage pattern of "hippocampal sclerosis" (HS) characterized not only by neuronal loss but also pronounced astrogliosis and inflammatory changes. Since TLE shares distinct pathogenetic aspects with multiple sclerosis (MS), we have here scrutinized therapeutic effects in experimental TLE of the immunmodulator fingolimod, which is established in MS therapy...
June 22, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29931718/multiple-sclerosis-and-epilepsy-much-more-than-a-coincidence
#19
EDITORIAL
M Calabrese
No abstract text is available yet for this article.
June 22, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29929111/calcification-in-cerebral-parenchyma-affects-pharmacoresistant-epilepsy-in-tuberous-sclerosis
#20
Meng-Na Zhang, Li-Ping Zou, Yang-Yang Wang, Ling-Yu Pang, Shu-Fang Ma, Lu-Lu Huang, Yang Gao, Qian Lu, David Neal Franz
PURPOSE: Tuberous sclerosis (TSC) is an autosomal dominant inherited disease caused by mutations in the TSC1 or TSC2 gene and results in the over-activation of the mammalian target of the rapamycin (mTOR) signaling pathway. Rapamycin, an mTOR inhibitor, is clinically used to treat hamartomatous lesionsas in TSC and its effect on controlling epilepsy is also reported in many studies. This study aims to evaluate the risk factors of pharmacoresistant epilepsy in patients with TSC receiving long-term rapamycin treatment...
June 15, 2018: Seizure: the Journal of the British Epilepsy Association
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