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CCN1 FGF

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https://www.readbyqxmd.com/read/21628462/kallikrein-related-peptidase-12-hydrolyzes-matricellular-proteins-of-the-ccn-family-and-modifies-interactions-of-ccn1-and-ccn5-with-growth-factors
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Audrey Guillon-Munos, Katerina Oikonomopoulou, Noémie Michel, Chistopher R Smith, Agnès Petit-Courty, Sylvie Canepa, Pascale Reverdiau, Nathalie Heuzé-Vourc'h, Eleftherios P Diamandis, Yves Courty
Kallikrein-related peptidases (KLKs) are an emerging group of secreted serine proteases involved in several physiological and pathological processes. We used a degradomic approach to identify potential substrates of KLK12. MDA-MB-231 cells were treated either with KLK12 or vehicle control, and the proteome of the overlying medium was analyzed by mass spectrometry. CCN1 (cyr61, ctgf, nov) was among the proteins released by the KLK12-treated cells, suggesting that KLK12 might be responsible for the shedding of this protein from the cell surface...
July 22, 2011: Journal of Biological Chemistry
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