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https://www.readbyqxmd.com/read/30542820/nmr-resonance-assignments-of-the-pathogenesis-related-peach-allergen-pru-p-1-0101
#1
Sebastian Führer, Simone Trimmel, Kathrin Breuker, Martin Tollinger
In Europe, Northern America, and China a large number of individuals are suffering from peach (Prunus persica) allergy caused by the protein Pru p 1. Immunologic reactions against this 17.5 kDa protein result from initial sensitization to the birch (Betula verrucosa) pollen allergen Bet v 1 and subsequent immunologic cross-reactivity of Bet v 1 specific antibodies. Allergic symptoms typically include severe itching, scratching of the throat, and rhino conjunctivitis. So far, experimental structural data for the peach allergen Pru p 1 are not available...
December 12, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/30510401/a-new-strategy-for-taste-masking-of-azithromycin-antibiotic-development-characterization-and-evaluation-of-azithromycin-titanium-nanohybrid-for-masking-of-bitter-taste-using-physisorption-and-panel-testing-studies
#2
Fazli Amin, Shahzeb Khan, Syed Muhammad Hassan Shah, Haroon Rahim, Zahid Hussain, Muhammad Sohail, Riaz Ullah, Mansour S Alsaid, Abdelaaty A Shahat
Background: The obnoxious bitter taste of orally taken antibiotics is one of the biggest problems in the treatment of children. The pediatric population cannot tolerate the bitter taste of drugs and vomit out which ultimately leads to suboptimal therapeutic value, grimace and mental stress so it is the challenging task for the formulation scientists to formulate a palatable formulation particularly to overcome address the issue. Purpose of study: The study aimed to mask and evaluate the unpleasant bitter taste of azithro-mycin (AZ) in the dry suspension dosage form by physisorption technique...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/30463793/predicting-local-drug-availability-of-locally-acting-lozenges-from-method-design-to-a-linear-level-a-ivivc
#3
Katharina Tietz, Sina Ingrid Gutknecht, Sandra Klein
Lozenges are commonly applied in the treatment of sore throat. They often contain drugs intended to exert their effect locally in the oral cavity and throat. In the recent past, an increasing interest in development of generic products for locally acting lozenges could be noted. However, it was not clear, if therapeutic equivalence of locally applied, locally acting lozenges can be predicted based on results from in vitro studies. The aim of the present study was to determine an in vitro model that enables the assessment of local availability and bioequivalence of locally acting lozenges...
December 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/30322822/vocal-dose-in-older-adults-with-presbyphonia-an-analytic-cross-sectional-study
#4
Aaron Ziegler, Edie R Hapner
PURPOSE: Older patients with age-related voice changes (presbyphonia) are considered vocal under-doers due to a reportedly low a amount and intensity of voice use (ie, low vocal dose). This low voice use may be consequential to negative effects of presbyphonia like throat discomfort, as well as anxiety and frustration from difficulty communicating. Causally speaking, vocal fold atrophy (presbylaryngis) may indicate inadequate intrinsic laryngeal muscle loading with low voice use, though research is lacking...
October 12, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/30266565/pharmacist-physician-and-patient-opinions-of-pharmacist-treated-minor-ailments-and-conditions
#5
Kimberly C McKeirnan, Linda Garrelts MacLean
OBJECTIVES: To determine physician, pharmacist, and patient perceptions of pharmacist-provided treatment services for minor ailments and conditions and to assess the potential for community pharmacists to improve access to care in medically underserved areas. DESIGN: Qualitative and quantitative semi-structured key informant interview. SETTING: Rural eastern Washington State from March to June 2016. PARTICIPANTS: Physicians, pharmacists, and pharmacy patients in rural eastern Washington State...
September 25, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/30222645/globus-current-concepts-and-dilemmas
#6
José Tawil, Ronnie Fass
Globus is an area of interest for many medical specialists including otorhinolaryngologists, gastroenterologist, allergists, and psychiatrists. It may be caused by an organic disease, but it is not uncommon that an underlying etiology remains unidentified even after a full workup has been performed. Patients who suffer from globus usually visit several physicians from different specialties without finding a solution for their symptoms. Identifying the underlying cause of globus is not always a simple task; therefore, structural or functional abnormalities of the thyroid, larynx, pharynx, and esophagus should be investigated...
November 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29948361/high-levels-of-staphylococcus-aureus-and-mrsa-carriage-in-healthy-population-of-algiers-revealed-by-additional-enrichment-and-multisite-screening
#7
Kenza Antri, Madjid Akkou, Coralie Bouchiat, Michèle Bes, Patricia Martins-Simoes, Olivier Dauwalder, Anne Tristan, Hélène Meugnier, Jean-Philippe Rasigade, Jerome Etienne, François Vandenesch, Frédéric Laurent, Nadjia Ramdani-Bouguessa
The purpose of the research is to characterize Staphylococcus aureus colonization in healthy population of Algiers, to assess the impact on diagnostic performance of systematic additional broth enrichment, and to ascertain the additional benefits of multiple site screening. In order to more accurately determine the prevalence of S. aureus colonization, the swab specimens from multiple screening sites were incubated in brain-heart broth before agar plating. From 2009 to 2011, 1176 samples were collected from 459 participants (201 adults and 258 children)...
August 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29849831/optimizing-the-delivery-of-inhaled-medication-for-respiratory-patients-the-role-of-valved-holding-chambers
#8
REVIEW
R Andrew McIvor, Hollie M Devlin, Alan Kaplan
Valved holding chambers (VHCs) have been used with pressurized metered-dose inhalers since the early 1980s. They have been shown to increase fine particle delivery to the lungs, decrease oropharyngeal deposition, and reduce side effects such as throat irritation, dysphonia, and oral candidiasis that are common with use of pressurized metered-dose inhalers (pMDIs) alone. VHCs act as aerosol reservoirs, allowing the user to actuate the pMDI device and then inhale the medication in a two-step process that helps users overcome challenges in coordinating pMDI actuation with inhalation...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29847387/readiness-for-discharge-after-foot-and-ankle-surgery-using-peripheral-nerve-blocks-a-randomized-controlled-trial-comparing-spinal-and-general-anesthesia-as-supplements-to-nerve-blocks
#9
Jacques T YaDeau, Kara G Fields, Richard L Kahn, Vincent R LaSala, Scott J Ellis, David S Levine, Leonardo Paroli, Thuyvan H Luu, Matthew M Roberts
BACKGROUND: Neuraxial anesthesia is often viewed as superior to general anesthesia but may delay discharge. Comparisons do not typically use multimodal analgesics and nerve blockade. Combining nerve blockade with general anesthesia may reduce pain, opioid consumption, and nausea. We hypothesized that general anesthesia (with nerve blocks) would lead to earlier readiness for discharge, compared to spinal anesthesia (with nerve blocks). METHODS: All patients underwent ambulatory foot and ankle surgery, with a predicted case duration of 1-3 hours...
September 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29725412/locally-advanced-laryngeal-cancer-total-laryngectomy-or-primary-non-surgical-treatment
#10
Aleš Čoček, Miloslav Ambruš, Alena Dohnalová, Martin Chovanec, Martina Kubecová, Kateřina Licková
Between January 1997 and December 2013, the Charles University 3rd Medical School and Royal Vinohrady Teaching Hospital Ear, Nose and Throat oncology team treated 185 patients with advanced laryngeal cancer, which, from a surgical perspective, required a total laryngectomy. Overall, ~70% of these patients (n=129) underwent conventional treatment (i.e., total laryngectomy with post-operative radiotherapy), and ~30% (n=56) were treated with larynx preservation protocols (including primary radiotherapy, neoadjuvant chemotherapy followed by radiotherapy or chemoradiotherapy, or primary chemoradiotherapy)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29720432/evaluation-of-the-illumigene-mycoplasma-direct-dna-amplification-assay
#11
Neena Kanwar, Morgan A Pence, Donna Mayne, Jeffrey Michael, Rangaraj Selvarangan
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia. The illumigene Mycoplasma Direct (iMD) DNA amplification assay is a qualitative in vitro test utilizing loop-mediated isothermal amplification (LAMP) technology for the direct detection of M. pneumoniae DNA in respiratory specimens. The iMD assay does not require the preextraction of nucleic acids from specimens, which is a prerequisite step for the previously approved illumigene Mycoplasma (iM) assay. The aim of this prospective multicenter study was to evaluate the performance characteristics of the newly developed iMD assay, compared with the iM assay...
July 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29704426/epidemiological-and-molecular-investigation-of-a-measles-outbreak-in-punjab-pakistan-2013-2015
#12
Syed Sohail Zahoor Zaidi, Abdul Hameed, Naeem Ali, Muhammad Suleman Rana, Massab Umair, Muhammad Masroor Alam, Uzma Bashir Aamir, Adnan Khurshid, Salmaan Sharif, Shahzad Shaukat, Mehar Angez, Ghulam Mujtaba, Yasir Arshad, Ribqa Akthar, Mian Muhammad Sufian, Nayab Mehmood
Despite the availability of an effective vaccine, the measles virus continues to cause significant morbidity and mortality in children worldwide. Molecular characterization of wild-type measles strains is an invaluable component of epidemiological studies or surveillance systems that provides important information pertinent to outbreak linkages and transmission pathways. Serum samples and throat swabs were collected from suspected measles cases from the Punjab province of Pakistan (2013-2015) and further tested for measles immunoglobulin M (IgM) through enzyme-linked immunosorbent assay and reverse-transcriptase polymerase chain reaction for molecular characterization...
April 28, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29593277/prevalence-and-serogroup-changes-of-neisseria-meningitidis-in-south-korea-2010-2016
#13
Hyukmin Lee, Younghee Seo, Kyung-Hyo Kim, Kyungwon Lee, Kang-Won Choe
Determination of the major serogroups is an important step for establishing a vaccine programme and management strategy targeting Neisseria meningitidis. From April 2010 to November 2016, a total of 25 N. meningitidis isolates were collected in South Korea, in collaboration with the Korean Society of Clinical Microbiology. Among isolates, 19 isolates were recovered from blood and/or cerebrospinal fluid (CSF) in 46 patients who suffered from invasive meningococcal disease (IMD), and six isolates were found in sputum or the throat...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29584610/a-quasi-experimental-study-to-explore-the-effect-of-barrier-cream-on-the-peristomal-skin-of-patients-with-a-tracheostomy
#14
Turkan Karaca, Fatoș Korkmaz
Peristomal skin problems represent one of the most common complications of a tracheostomy. A quasi-experimental study was conducted among patients ages 18 to 65 years hospitalized in a Turkish university hospital ear-nose-throat clinic between August 15, 2013, and December 15, 2013, to compare the effect of using or not using a barrier cream on the peristomal skin with regard to pH, moisture, temperature, color, odor, turgor, infections, and lesions after tracheostomy surgery. Patients were selected using a purposeful sampling method and included if they had not undergone another operation for a complication (eg, pneumothorax, tube misplacement, hemorrhage) within 24 hours following the tracheostomy operation...
March 2018: Ostomy/wound Management
https://www.readbyqxmd.com/read/29545956/agranulocytosis-associated-with-topiramate-a-case-report-and-review-of-published-cases
#15
Saroj Lohani, Niranjan Tachamo, Salik Nazir, Anthony Donato
A 41-year-old female presented to the hospital with sore throat and shortness of breath. She was hypoxic with an oxygen saturation of 87% in room air. Physical examination revealed swollen uvula with exudates. She had been started on topiramate for treatment of migraine few months ago. The dose of topiramate was increased to 100 mg twice daily 2 weeks ago. Complete blood count revealed an absolute neutrophil count (ANC) of 8 c/mm3 . She was intubated and started on broad-spectrum antibiotics. She was transferred to our hospital on the fifth day of hospitalization...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29534352/-clinicopathologic-characteristics-and-prognositic-indicators-of-tonsillar-mantle-cell-lymphoma
#16
W H Hou, P Wei, J L Xie, Y Y Zheng, Y L Zhang, X G Zhou
Objective: To investigate clinicopathological features and prognosis of tonsillar mantle cell lymphoma(TMCL). Methods: Clinical data of 25 patients with TMCL at Beijing Friendship Hospital, Capital Medical University from 2002 to 2016 were included. All the cases were reviewed microscopically. Various immunohistochemical stains were performed using the MaxVision two-step method. IgH/CCND1 gene fusion was detected by fluorescent in situ hybridization(FISH). Additionally, randomly selected 40 cases of non-tonsil MCL of the same period were compared...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29405836/expanded-transcanal-transpromontorial-approach-a-novel-surgical-technique-for-cerebellopontine-angle-vestibular-schwannoma-removal
#17
Daniele Marchioni, Marco Carner, Davide Soloperto, Luca Bianconi, Andrea Sacchetto, Luca Sacchetto, Barbara Masotto, Livio Presutti
Objective Vestibular schwannoma (VS) is a benign tumor of the lateral skull base. Different microscopic surgical techniques are described in literature: the retrosigmoid and translabyrinthine approaches are used to treat big tumors located in the cerebellopontine angle, and the middle cranial fossa approach is utilized for small tumors with good hearing preservation. The expanded transcanal transpromontorial (ExpTT) approach is a combined microscopic-endoscopic technique previously indicated for Koos stage I and II VS and now proposed for larger VS, up to 3 cm in diameter, with linear progression into the cerebellopontine angle and touching the brainstem...
April 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29306883/clinical-decisions-presented-to-patients-in-hospital-encounters-a-cross-sectional-study-using-a-novel-taxonomy
#18
RANDOMIZED CONTROLLED TRIAL
Eirik Hugaas Ofstad, Jan C Frich, Edvin Schei, Richard M Frankel, Jūratė Šaltytė Benth, Pål Gulbrandsen
OBJECTIVE: To identify and classify all clinical decisions that emerged in a sample of patient-physician encounters and compare different categories of decisions across clinical settings and personal characteristics. DESIGN: Cross-sectional descriptive evaluation of hospital encounters videotaped in 2007-2008 using a novel taxonomy to identify and classify clinically relevant decisions (both actions and judgements). PARTICIPANTS AND SETTING: 372 patients and 58 physicians from 17 clinical specialties in ward round (WR), emergency room (ER) and outpatient (OP) encounters in a Norwegian university hospital...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29237333/predictors-of-entering-a-hearing-aid-evaluation-period-a-prospective-study-in-older-hearing-help-seekers
#19
Marieke Pronk, Dorly J H Deeg, Niek J Versfeld, Martijn W Heymans, Graham Naylor, Sophia E Kramer
This study aimed to determine the predictors of entering a hearing aid evaluation period (HAEP) using a prospective design drawing on the health belief model and the transtheoretical model. In total, 377 older persons who presented with hearing problems to an Ear, Nose, and Throat specialist ( n = 110) or a hearing aid dispenser ( n = 267) filled in a baseline questionnaire. After 4 months, it was determined via a telephone interview whether or not participants had decided to enter a HAEP. Multivariable logistic regression analyses were applied to determine which baseline variables predicted HAEP status...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/29129527/identification-of-measles-virus-genotype-b3-associated-with-outbreaks-in-islamabad-pakistan-2013-2015
#20
Syed S Z Zaidi, Abdul Hameed, Muhammad Suleman Rana, Muhammad M Alam, Massab Umair, Uzma B Aamir, Maqbool Hussain, Salmaan Sharif, Shahzad Shaukat, Mehar Angez, Adnan Khurshid
BACKGROUND: Measles virus infection remains a significant cause of childhood mortality and morbidity despite continued global efforts and the availability of a safe and effective vaccine. Molecular analysis of indigenous measles viruses could provide critical information on outbreak linkages and transmission pathways that can aid the implementation of appropriate control programs in Pakistan. METHODS: Blood samples and throat swabs were collected from subjects suspected with measles in Islamabad, Pakistan from 2013 to 2015...
July 2018: Journal of Infection and Public Health
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