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https://www.readbyqxmd.com/read/29948361/high-levels-of-staphylococcus-aureus-and-mrsa-carriage-in-healthy-population-of-algiers-revealed-by-additional-enrichment-and-multisite-screening
#1
Kenza Antri, Madjid Akkou, Coralie Bouchiat, Michèle Bes, Patricia Martins-Simoes, Olivier Dauwalder, Anne Tristan, Hélène Meugnier, Jean-Philippe Rasigade, Jerome Etienne, François Vandenesch, Frédéric Laurent, Nadjia Ramdani-Bouguessa
The purpose of the research is to characterize Staphylococcus aureus colonization in healthy population of Algiers, to assess the impact on diagnostic performance of systematic additional broth enrichment, and to ascertain the additional benefits of multiple site screening. In order to more accurately determine the prevalence of S. aureus colonization, the swab specimens from multiple screening sites were incubated in brain-heart broth before agar plating. From 2009 to 2011, 1176 samples were collected from 459 participants (201 adults and 258 children)...
August 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29849831/optimizing-the-delivery-of-inhaled-medication-for-respiratory-patients-the-role-of-valved-holding-chambers
#2
REVIEW
R Andrew McIvor, Hollie M Devlin, Alan Kaplan
Valved holding chambers (VHCs) have been used with pressurized metered-dose inhalers since the early 1980s. They have been shown to increase fine particle delivery to the lungs, decrease oropharyngeal deposition, and reduce side effects such as throat irritation, dysphonia, and oral candidiasis that are common with use of pressurized metered-dose inhalers (pMDIs) alone. VHCs act as aerosol reservoirs, allowing the user to actuate the pMDI device and then inhale the medication in a two-step process that helps users overcome challenges in coordinating pMDI actuation with inhalation...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29847387/readiness-for-discharge-after-foot-and-ankle-surgery-using-peripheral-nerve-blocks-a-randomized-controlled-trial-comparing-spinal-and-general-anesthesia-as-supplements-to-nerve-blocks
#3
Jacques T YaDeau, Kara G Fields, Richard L Kahn, Vincent R LaSala, Scott J Ellis, David S Levine, Leonardo Paroli, Thuyvan H Luu, Matthew M Roberts
BACKGROUND: Neuraxial anesthesia is often viewed as superior to general anesthesia but may delay discharge. Comparisons do not typically use multimodal analgesics and nerve blockade. Combining nerve blockade with general anesthesia may reduce pain, opioid consumption, and nausea. We hypothesized that general anesthesia (with nerve blocks) would lead to earlier readiness for discharge, compared to spinal anesthesia (with nerve blocks). METHODS: All patients underwent ambulatory foot and ankle surgery, with a predicted case duration of 1-3 hours...
May 25, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29725412/locally-advanced-laryngeal-cancer-total-laryngectomy-or-primary-non-surgical-treatment
#4
Aleš Čoček, Miloslav Ambruš, Alena Dohnalová, Martin Chovanec, Martina Kubecová, Kateřina Licková
Between January 1997 and December 2013, the Charles University 3rd Medical School and Royal Vinohrady Teaching Hospital Ear, Nose and Throat oncology team treated 185 patients with advanced laryngeal cancer, which, from a surgical perspective, required a total laryngectomy. Overall, ~70% of these patients (n=129) underwent conventional treatment (i.e., total laryngectomy with post-operative radiotherapy), and ~30% (n=56) were treated with larynx preservation protocols (including primary radiotherapy, neoadjuvant chemotherapy followed by radiotherapy or chemoradiotherapy, or primary chemoradiotherapy)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29720432/evaluation-of-the-illumigene-mycoplasma-direct-dna-amplification-assay
#5
Neena Kanwar, Morgan A Pence, Donna Mayne, Jeffrey Michael, Rangaraj Selvarangan
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia. The illumigene Mycoplasma Direct (iMD) DNA amplification assay is a qualitative in vitro test utilizing loop-mediated isothermal amplification (LAMP) technology for the direct detection of M. pneumoniae DNA in respiratory specimens. The iMD assay does not require the preextraction of nucleic acids from specimens, which is a prerequisite step for the previously approved illumigene Mycoplasma (iM) assay. The aim of this prospective multicenter study was to evaluate the performance characteristics of the newly developed iMD assay, compared with the iM assay...
July 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29704426/epidemiological-and-molecular-investigation-of-a-measles-outbreak-in-punjab-pakistan-2013-2015
#6
Syed Sohail Zahoor Zaidi, Abdul Hameed, Naeem Ali, Muhammad Suleman Rana, Massab Umair, Muhammad Masroor Alam, Uzma Bashir Aamir, Adnan Khurshid, Salmaan Sharif, Shahzad Shaukat, Mehar Angez, Ghulam Mujtaba, Yasir Arshad, Ribqa Akthar, Mian Muhammad Sufian, Nayab Mehmood
Despite the availability of an effective vaccine, the measles virus continues to cause significant morbidity and mortality in children worldwide. Molecular characterization of wild-type measles strains is an invaluable component of epidemiological studies or surveillance systems that provides important information pertinent to outbreak linkages and transmission pathways. Serum samples and throat swabs were collected from suspected measles cases from the Punjab province of Pakistan (2013-2015) and further tested for measles immunoglobulin M (IgM) through enzyme-linked immunosorbent assay and reverse-transcriptase polymerase chain reaction for molecular characterization...
April 28, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29593277/prevalence-and-serogroup-changes-of-neisseria-meningitidis-in-south-korea-2010-2016
#7
Hyukmin Lee, Younghee Seo, Kyung-Hyo Kim, Kyungwon Lee, Kang-Won Choe
Determination of the major serogroups is an important step for establishing a vaccine programme and management strategy targeting Neisseria meningitidis. From April 2010 to November 2016, a total of 25 N. meningitidis isolates were collected in South Korea, in collaboration with the Korean Society of Clinical Microbiology. Among isolates, 19 isolates were recovered from blood and/or cerebrospinal fluid (CSF) in 46 patients who suffered from invasive meningococcal disease (IMD), and six isolates were found in sputum or the throat...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29584610/a-quasi-experimental-study-to-explore-the-effect-of-barrier-cream-on-the-peristomal-skin-of-patients-with-a-tracheostomy
#8
Turkan Karaca, Fatoș Korkmaz
Peristomal skin problems represent one of the most common complications of a tracheostomy. A quasi-experimental study was conducted among patients ages 18 to 65 years hospitalized in a Turkish university hospital ear-nose-throat clinic between August 15, 2013, and December 15, 2013, to compare the effect of using or not using a barrier cream on the peristomal skin with regard to pH, moisture, temperature, color, odor, turgor, infections, and lesions after tracheostomy surgery. Patients were selected using a purposeful sampling method and included if they had not undergone another operation for a complication (eg, pneumothorax, tube misplacement, hemorrhage) within 24 hours following the tracheostomy operation...
March 2018: Ostomy/wound Management
https://www.readbyqxmd.com/read/29545956/agranulocytosis-associated-with-topiramate-a-case-report-and-review-of-published-cases
#9
Saroj Lohani, Niranjan Tachamo, Salik Nazir, Anthony Donato
A 41-year-old female presented to the hospital with sore throat and shortness of breath. She was hypoxic with an oxygen saturation of 87% in room air. Physical examination revealed swollen uvula with exudates. She had been started on topiramate for treatment of migraine few months ago. The dose of topiramate was increased to 100 mg twice daily 2 weeks ago. Complete blood count revealed an absolute neutrophil count (ANC) of 8 c/mm3 . She was intubated and started on broad-spectrum antibiotics. She was transferred to our hospital on the fifth day of hospitalization...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29534352/-clinicopathologic-characteristics-and-prognositic-indicators-of-tonsillar-mantle-cell-lymphoma
#10
W H Hou, P Wei, J L Xie, Y Y Zheng, Y L Zhang, X G Zhou
Objective: To investigate clinicopathological features and prognosis of tonsillar mantle cell lymphoma(TMCL). Methods: Clinical data of 25 patients with TMCL at Beijing Friendship Hospital, Capital Medical University from 2002 to 2016 were included. All the cases were reviewed microscopically. Various immunohistochemical stains were performed using the MaxVision two-step method. IgH/CCND1 gene fusion was detected by fluorescent in situ hybridization(FISH). Additionally, randomly selected 40 cases of non-tonsil MCL of the same period were compared...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29405836/expanded-transcanal-transpromontorial-approach-a-novel-surgical-technique-for-cerebellopontine-angle-vestibular-schwannoma-removal
#11
Daniele Marchioni, Marco Carner, Davide Soloperto, Luca Bianconi, Andrea Sacchetto, Luca Sacchetto, Barbara Masotto, Livio Presutti
Objective Vestibular schwannoma (VS) is a benign tumor of the lateral skull base. Different microscopic surgical techniques are described in literature: the retrosigmoid and translabyrinthine approaches are used to treat big tumors located in the cerebellopontine angle, and the middle cranial fossa approach is utilized for small tumors with good hearing preservation. The expanded transcanal transpromontorial (ExpTT) approach is a combined microscopic-endoscopic technique previously indicated for Koos stage I and II VS and now proposed for larger VS, up to 3 cm in diameter, with linear progression into the cerebellopontine angle and touching the brainstem...
April 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29306883/clinical-decisions-presented-to-patients-in-hospital-encounters-a-cross-sectional-study-using-a-novel-taxonomy
#12
Eirik Hugaas Ofstad, Jan C Frich, Edvin Schei, Richard M Frankel, Jūratė Šaltytė Benth, Pål Gulbrandsen
OBJECTIVE: To identify and classify all clinical decisions that emerged in a sample of patient-physician encounters and compare different categories of decisions across clinical settings and personal characteristics. DESIGN: Cross-sectional descriptive evaluation of hospital encounters videotaped in 2007-2008 using a novel taxonomy to identify and classify clinically relevant decisions (both actions and judgements). PARTICIPANTS AND SETTING: 372 patients and 58 physicians from 17 clinical specialties in ward round (WR), emergency room (ER) and outpatient (OP) encounters in a Norwegian university hospital...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29237333/predictors-of-entering-a-hearing-aid-evaluation-period-a-prospective-study-in-older-hearing-help-seekers
#13
Marieke Pronk, Dorly J H Deeg, Niek J Versfeld, Martijn W Heymans, Graham Naylor, Sophia E Kramer
This study aimed to determine the predictors of entering a hearing aid evaluation period (HAEP) using a prospective design drawing on the health belief model and the transtheoretical model. In total, 377 older persons who presented with hearing problems to an Ear, Nose, and Throat specialist ( n = 110) or a hearing aid dispenser ( n = 267) filled in a baseline questionnaire. After 4 months, it was determined via a telephone interview whether or not participants had decided to enter a HAEP. Multivariable logistic regression analyses were applied to determine which baseline variables predicted HAEP status...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/29129527/identification-of-measles-virus-genotype-b3-associated-with-outbreaks-in-islamabad-pakistan-2013-2015
#14
Syed S Z Zaidi, Abdul Hameed, Muhammad Suleman Rana, Muhammad M Alam, Massab Umair, Uzma B Aamir, Maqbool Hussain, Salmaan Sharif, Shahzad Shaukat, Mehar Angez, Adnan Khurshid
BACKGROUND: Measles virus infection remains a significant cause of childhood mortality and morbidity despite continued global efforts and the availability of a safe and effective vaccine. Molecular analysis of indigenous measles viruses could provide critical information on outbreak linkages and transmission pathways that can aid the implementation of appropriate control programs in Pakistan. METHODS: Blood samples and throat swabs were collected from subjects suspected with measles in Islamabad, Pakistan from 2013 to 2015...
July 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29127075/evidence-of-high-transport-and-phosphorylation-capacity-for-both-glucose-and-fructose-in-the-ruby-throated-hummingbird-archilochus-colubris
#15
Alexander M Myrka, Kenneth C Welch
Hummingbirds are able to fuel hovering flight entirely with recently ingested glucose or fructose. Among vertebrates, several steps of sugar flux from circulation to skeletal muscle are potentially rate-limiting, including transport into muscle and subsequent phosphorylation. While capacities for glucose flux are substantial, capacities for fructose flux are comparatively low. The mechanisms underlying apparent high rates of glucose and fructose oxidation in hummingbird flight muscle remain unclear. We examined relative expression of facilitative sugar transporters (GLUTs) and enzymes of fructolysis in ruby-throated hummingbird (Archilochus colubris) tissues involved in energy homeostasis and flight, via qPCR and measured hexokinase activity in pectoralis in vitro...
October 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29031546/influenza-virus-but-not-mers-coronavirus-circulation-in-iran-2013-2016-comparison-between-pilgrims-and-general-population
#16
COMPARATIVE STUDY
Jila Yavarian, Nazanin Zahra Shafiei Jandaghi, Maryam Naseri, Peyman Hemmati, Mohhamadnasr Dadras, Mohammad Mehdi Gouya, Talat Mokhtari Azad
BACKGROUND: The pilgrimage to Mecca and Karbala bring many Muslims to a confined area. Respiratory tract infections are the most common diseases transmitted during mass gatherings in Hajj, Umrah and Karbala. The aim of this study was to determine and compare the prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) and influenza virus infections among Iranian general population and pilgrims with severe acute respiratory infections (SARI) returning from Mecca and Karbala during 2013-2016...
January 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28944126/oral-hygiene-practices-and-teeth-cleaning-techniques-among-medical-students
#17
Sajida Naseem, Syeda H Fatima, Haider Ghazanfar, Sana Haq, Najeeb A Khan, Moeez Mehmood, Ali Ghazanfar
Objectives Oral health is essential for general health and quality of life. It is a state of being free from mouth and facial pain, oral and throat cancer, oral infections and sores, periodontal disease, tooth decay, tooth loss, and other diseases and disorders that limit an individual's capacity to bite, chew, smile, and speak; it affects psychosocial well-being too. The objective of our study was to assess teeth cleaning techniques and oral hygiene practices among medical students. Methods The data of the study were collected in two stages...
July 18, 2017: Curēus
https://www.readbyqxmd.com/read/28853427/ear-nose-and-throat-ent-aspects-of-obstructive-sleep-apnea-syndrome-osas-diagnosis-and-therapy
#18
Desiderio Passali, Maria Carla Spinosi, Francesco Maria Passali
This article analyzes the role played by the ear, nose and throat (ENT) specialist in the diagnosis and treatment of the Obstructive Sleep Apnea Syndrome (OSAS). DIAGNOSIS: The instrumental methods of investigation of otolaryngology expertise are fiberoptic rhinolaryngoscopy and sleep endoscopy. To better define and treat OSAS it is essential to define location, extension and degree of obstruction. The major limitation of rhinolaryngoscopy is that it is conducted while the patient is awake...
August 28, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28832676/genome-wide-discovery-of-novel-m1t1-group-a-streptococcal-determinants-important-for-fitness-and-virulence-during-soft-tissue-infection
#19
Yoann Le Breton, Ashton T Belew, Jeffrey A Freiberg, Ganesh S Sundar, Emrul Islam, Joshua Lieberman, Mark E Shirtliff, Hervé Tettelin, Najib M El-Sayed, Kevin S McIver
The Group A Streptococcus remains a significant human pathogen causing a wide array of disease ranging from self-limiting to life-threatening invasive infections. Epithelium (skin or throat) colonization with progression to the subepithelial tissues is the common step in all GAS infections. Here, we used transposon-sequencing (Tn-seq) to define the GAS 5448 genetic requirements for in vivo fitness in subepithelial tissue. A near-saturation transposon library of the M1T1 GAS 5448 strain was injected subcutaneously into mice, producing suppurative inflammation at 24 h that progressed to prominent abscesses with tissue necrosis at 48 h...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28604361/synthetic-scaffolds-with-full-pore-interconnectivity-for-bone-regeneration-prepared-by-supercritical-foaming-using-advanced-biofunctional-plasticizers
#20
Aurelio Salerno, Sara Diéguez, Luis Diaz-Gomez, José L Gómez-Amoza, Beatriz Magariños, Angel Concheiro, Concepción Domingo, Carmen Alvarez-Lorenzo, Carlos A García-González
Supercritical foaming allows for the solvent-free processing of synthetic scaffolds for bone regeneration. However, the control on the pore interconnectivity and throat pore size with this technique still needs to be improved. The use of plasticizers may help overcome these limitations. Eugenol, a GRAS natural compound extracted from plants, is proposed in this work as an advanced plasticizer with bioactive properties. Eugenol-containing poly(ε-caprolactone) (PCL) scaffolds were obtained by supercritical foaming (20...
June 30, 2017: Biofabrication
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