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https://www.readbyqxmd.com/read/30296304/assessment-of-bleeding-in-patients-with-disseminated-intravascular-coagulation-after-receiving-surgery-and-recombinant-human-soluble-thrombomodulin-a-cohort-study-using-a-database
#1
Takuhiro Yamaguchi, Yukio Kitajima, Yasuhiro Miyauchi, Kazutoshi Izawa, Masakazu Tanaka, Masatada Hirata, Yasunari Sadatsuki, Yoshihiro Ogawa
We aimed to investigate the incidence of bleeding-related adverse events (AEs) among patients with disseminated intravascular coagulation (DIC) receiving recombinant thrombomodulin (rTM) and those receiving other DIC treatments, the incidence by type of surgery, and the incidence when either blood transfusion or a hemostatic procedure was administered to treat DIC. In this cohort study, data were obtained from a large medical database (22 centers in Japan). The primary endpoint was the incidence rate of bleeding-related AEs by type of surgery...
2018: PloS One
https://www.readbyqxmd.com/read/30288122/number-of-radiotherapy-treatment-machines-in-the-population-and-cancer-mortality-an-ecological-study
#2
Daniel Medenwald, Dirk Vordermark, Christian T Dietzel
Objectives: The aim of this study was to assess the association between the number of radiotherapy treatment machines (RTMs) in the population and incidence-adjusted cancer mortality. Methods: Data on cancer incidence and mortality were obtained from the GLOBOCAN project (only high-quality data, C3, or higher according to GLOBOCAN quality label), information on the number of RTMs from the Directory of Radiotherapy Centers database, and remaining data from the World Bank and World Health Organization database...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/30275773/circulating-activated-protein-c-levels-are-not-increased-in-septic-patients-treated-with-recombinant-human-soluble-thrombomodulin
#3
Takuro Arishima, Takashi Ito, Tomotsugu Yasuda, Nozomi Yashima, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Takahiro Futatsuki, Yutaro Madokoro, Shotaro Miyamoto, Tomohiro Eguchi, Hiroyuki Haraura, Ikuro Maruyama, Yasuyuki Kakihana
Background: Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress. rTM mainly exerts its anticoagulant effects through an activated protein C (APC)-dependent mechanism, but the circulating APC levels after rTM treatment have not been clarified. This prospective observational study investigated plasma APC levels after rTM treatment...
2018: Thrombosis Journal
https://www.readbyqxmd.com/read/30272154/dmrt1-repression-using-a-novel-approach-to-genetic-manipulation-induces-testicular-dysgenesis-in-human-fetal-gonads
#4
Joni Macdonald, Karen R Kilcoyne, Richard M Sharpe, Áine Kavanagh, Richard A Anderson, Pamela Brown, Lee B Smith, Anne Jørgensen, Rod T Mitchell
STUDY QUESTION: Does loss of DMRT1 in human fetal testis alter testicular development and result in testicular dysgenesis? SUMMARY ANSWER: DMRT1 repression in human fetal testis alters the expression of key testicular and ovarian determining genes, and leads to focal testicular dysgenesis. WHAT IS KNOWN ALREADY: Testicular dysgenesis syndrome (TDS) is associated with common testicular disorders in young men, but its etiology is unknown. DMRT1 has been shown to play a role in the regulation of sex differentiation in the vertebrate gonad...
September 29, 2018: Human Reproduction
https://www.readbyqxmd.com/read/30253234/dosimetric-benefits-of-mid-position-compared-with-internal-target-volume-strategy-for-esophageal-cancer-radiation-therapy
#5
Peng Jin, Mélanie Machiels, Koen F Crama, Jorrit Visser, Niek van Wieringen, Arjan Bel, Maarten C C M Hulshof, Tanja Alderliesten
PURPOSE: Both mid-position (MidP) and internal target volume (ITV) strategies can take the respiration-induced target motion (RTM) into account. This study aimed to compare these two strategies in terms of clinical target volume (CTV) coverage and dose to organs at risk (OARs) for esophageal cancer radiation therapy (RT). MATERIALS AND METHODS: Fifteen esophageal cancer patients were retrospectively included for neoadjuvant RT planning. Per patient, a 10-phase 4D-CT was acquired with CTV and OARs delineated on the 20% phase...
September 22, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30239765/influence-of-risk-organ-based-tube-current-modulation-on-ct-induced-dna-double-strand-breaks-in-a-biological-phantom-model
#6
Michael Brand, Wolfgang Wuest, Matthias May, Michael Uder, Matthias Sommer
Techniques for dose reduction in computed tomography (CT) are receiving increasing attention. Lowering the tube current in front of the patient, known as risk-organ-based tube current modulation (RTM), represents a new approach. Physical dose parameters can determine the exposure but are not able to assess the biological-X-ray interactions. The purpose of this study was to establish a biological phantom model to evaluate the effect of RTM on X-ray-induced DNA double-strand breaks (DSBs). In breast phantoms and in the location of the spine in an Alderson phantom, isolated human blood lymphocytes were irradiated using a 128-slice CT scanner...
September 20, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30222511/transoceanic-telementoring-of-tube-thoracostomy-insertion-a-randomized-controlled-trial-of-telementored-versus-unmentored-insertion-of-tube-thoracostomy-by-military-medical-technicians
#7
Andrew W Kirkpatrick, Jessica L McKee, Itamar Netzer, Paul B McBeth, Scott D'Amours, Volker Kock, Alex Dobron, Chad G Ball, Elon Glassberg
BACKGROUND: Tension pneumothorax is a frequent cause of potentially preventable death. Tube thoracostomy (TT) can obviate death but is invasive and fraught with complications even in experienced hands. We assessed the utility of a remote international virtual network (RIVN) of specialized mentors to remotely guide military medical technicians (medics) using wireless informatics. METHODS: Medics were randomized to insert TT in training mannequins (TraumaMan; Abacus ALS, Meadowbrook, Australia) supervised by RIVN or not...
September 14, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/30212369/a-patient-centered-remote-therapy-monitoring-program-focusing-on-increased-adherence-to-wound-therapy-a-large-cohort-study
#8
Leah Griffin, Laura M Leyva Casillas
OBJECTIVE: This retrospective study of 510 patients receiving negative pressure wound therapy (NPWT) in a home care setting examines the relationship between remote therapy monitoring (RTM) and patient adherence, as well as determines the impact of patient adherence on wound progression. MATERIALS AND METHODS: Adherence to treatment was continuously monitored via RTM, and patients with therapy usage < 16 hours in 1 day received an adherence call. Repeated failures to reach a noncompliant patient led to an escalation call to the caregiver to discuss treatment...
August 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/30172556/multi-mode-reverse-time-migration-damage-imaging-using-ultrasonic-guided-waves
#9
Jiaze He, Cara A C Leckey, Patrick E Leser, William P Leser
The sensitivity of Lamb wave modes to a particular defect or instance of damage is dependent on various factors (e.g., the local strain energy density due to that wave mode). As a result, different modes will be more useful than others for damage detection and quantification, dependent on damage type and location. For example, prior work in the field has shown that out-of-plane modes may have a higher sensitivity than in-plane modes to surface defects in plates. The excitability of a certain data acquisition system and the corresponding resolution for damage imaging also varies with frequency...
August 24, 2018: Ultrasonics
https://www.readbyqxmd.com/read/30167759/efficient-qtl-detection-of-flowering-date-in-a-soybean-ril-population-using-the-novel-restricted-two-stage-multi-locus-gwas-procedure
#10
Liyuan Pan, Jianbo He, Tuanjie Zhao, Guangnan Xing, Yufeng Wang, Deyue Yu, Shouyi Chen, Junyi Gai
Eighty-six R1 QTLs accounting for 89.92% phenotypic variance in a soybean RIL population were identified using RTM-GWAS with SNPLDB marker which performed superior over CIM and MLM-GWAS with BIN/SNPLDB marker. A population (NJRIKY) composed of 427 recombinant inbred lines (RILs) derived from Kefeng-1 × NN1138-2 (MGII × MGV, MG maturity group) was applied for detecting flowering date (R1) quantitative trait locus (QTL) system in soybean. From a low-depth re-sequencing (~ 0.75 ×), 576,874 SNPs were detected and organized into 4737 BINs (recombination breakpoint determinations) and 3683 SNP linkage disequilibrium blocks (SNPLDBs), respectively...
August 30, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/30153307/trichuris-muris-whey-acidic-protein-induces-type-2-protective-immunity-against-whipworm
#11
Neima Briggs, Junfei Wei, Leroy Versteeg, Bin Zhan, Brian Keegan, Ashish Damania, Jeroen Pollet, Kelly S Hayes, Coreen Beaumier, Christopher A Seid, Jamie Leong, Richard K Grencis, Maria Elena Bottazzi, K Jagannadha Sastry, Peter J Hotez
Human whipworm (Trichuris trichiura) infects approximately 1 in 15 people worldwide, representing the leading infectious cause of colitis and subsequent, inflammatory bowel disease (IBD). Current control measures focused on mass deworming have had limited success due to low drug efficacies. Vaccination would be an ideal, cost-effective strategy to induce protective immunity, leading to control of infection and transmission. Here we report the identification of whey acidic protein, a whipworm secretory protein, as a strong immunogen for inducing protective efficacy in a surrogate mouse T...
August 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/30141451/an-echocardiographic-study-of-the-right-ventricular-diastolic-function-in-systemic-hypertension-and-its-relation-with-the-left-ventricular-homologous-changes
#12
R Perveen, M H Hoque, K Ahmed, C M Ahmed, M A Jalil, T Parvin, D F Osmany, S Rashid, M B Rashid, S Nahar, S S Shakil
Diastolic dysfunction is a major predictor of mortality and morbidity in hypertensive patients. Not only LV, the RV is also expected to be affected in this overall procedure. To observe the Echocardiographic changes of diastolic function of the RV in systemic HTN and their relation with similar parameters of the LV was the objective. TDI was used in association with standard Doppler modality. In this cross-sectional study, 50 hypertensive subjects were studied who were devoid of any other conditions that may influence the diastolic function of the RV from 01 May 2012 to 31 October 2012 at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh...
July 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/30104480/delamination-study-in-edge-trimming-of-basalt-fiber-reinforced-plastics-bfrp
#13
Maria Dolores Navarro-Mas, Juan Antonio García-Manrique, Maria Desamparados Meseguer, Isabel Ordeig, Ana Isabel Sánchez
Although there are many machining studies of carbon and glass fiber reinforced plastics, delamination and tool wear of basalt fiber reinforced plastics (BFRP) in edge trimming has not yet studied. This paper presents an end milling study of BFRP fabricated by resin transfer molding (RTM), to evaluate delamination types at the top layer of the machined edge with different cutting conditions (cutting speed, feed rate and depth of cut) and fiber volume fraction (40% and 60%). This work quantifies delamination types, using a parameter Sd/L, that evaluates the delamination area (Sd) and the length (L), taking into account tool position in the yarn and movement of yarns during RTM process, which show the random nature of delamination...
August 13, 2018: Materials
https://www.readbyqxmd.com/read/30080707/improving-patient-flow-from-the-emergency-department-utilizing-a-standardized-electronic-nursing-handoff-process
#14
Lisa Potts, Catherine Ryan, Lauren Diegel-Vacek, Alisa Murchek
OBJECTIVE: The goal of this project was to decrease handoff delays from the emergency department (ED) as measured by ready to move (RTM)-to-occupied time. BACKGROUND: ED boarding compromises the quality, safety, and experience of patient care. Lack of standardized and transparent handoff communication contributes to boarding time. This process improvement initiative implemented a standardized electronic situation, background, assessment, and recommendation (eSBAR) format-based nursing handoff process from the ED to a medical unit...
September 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/30055918/consumer-acceptance-of-natural-sweeteners-in-protein-beverages
#15
M N Parker, K Lopetcharat, M A Drake
Protein beverage consumption by Americans has increased in recent years. Coupled with this increased consumption is an interest in natural sweeteners. The objective of this study was to evaluate the sensory properties of naturally sweetened ready-to-mix (RTM) whey protein beverages using 3 temporal methods and to formulate a natural noncaloric sweetener blend that could be added to RTM protein beverages to provide sweetness while still appealing in flavor to consumers. Iso-sweet concentrations of sweeteners (sucralose, sucrose, fructose, stevia, monk fruit) in RTM vanilla whey protein beverages (25 g of protein/360 mL of water) were established using magnitude estimation scaling and 2-alternative forced-choice testing...
July 25, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/30042446/rapid-tremor-migration-and-pore-pressure-waves-in-subduction-zones
#16
Víctor M Cruz-Atienza, Carlos Villafuerte, Harsha S Bhat
Rapid tremor migration (RTM) in subduction zones is a manifestation of complex fault-zone processes on the plate interface. Recent observations have revealed a large diversity of RTM patterns that are always associated with aseismic, shear strain at the interface. Small unstable asperities embedded in the stable shear zone are thus believed to originate tremor radiation during migration. Tectonic tremors have been recognized to occur where overpressured fluids exist. Spatial variations of fluid pressure may lead to non-linear diffusion processes with potentially large implications in tremor generation...
July 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/30012500/persistent-therapeutic-effect-of-a-novel-%C3%AE-5-gaba-a-receptor-antagonist-in-rodent-preclinical-models-of-vascular-cognitive-impairment
#17
István Gacsályi, Krisztina Móricz, Gábor Gigler, Katalin Megyeri, Patricia Machado, Ferenc A Antoni
This study examined the potential of the selective extra-synaptic α5-GABAA receptor inhibitor S44819 (Egis-13529) to improve cognitive performance in preclinical models of vascular cognitive impairment (VCI). Chronic hypoperfusion of the brain in mice was induced by permanent occlusion of the right common carotid artery (rUCO). rUCO induced impairments of cognitive function in the object recognition test (OR) and the rewarded T-maze (RTM). In both tests, a single oral treatment with S44819 (OR - 0.1-3 mg/kg, RTM - 1-3 mg/kg p...
September 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30003636/prophylactic-recombinant-thrombomodulin-treatment-prevents-hepatic-sinusoidal-obstruction-syndrome-in-high-risk-pediatric-patients-that-undergo-hematopoietic-stem-cell-transplants
#18
Shohei Yamamoto, Daisuke Toyama, Yumiko Sugishita, Ryota Kaneko, Naoko Okamoto, Masaya Koganesawa, Sachio Fujita, Kosuke Akiyama, Ryosuke Matsuno, Keiichi Isoyama
Hepatic SOS is a potentially life-threatening complication of conditioning for allogeneic HSCT. rTM is a new drug for treating DIC. We report our experience of the use of rTM as a prophylaxis against SOS in high-risk pediatric patients that underwent HSCT. We evaluated the cases of 19 pediatric hematology and oncology patients who underwent HSCT at our institution between 2007 and 2016. The patients who received HSCT after 2012 (n = 8) were treated with rTM as a prophylaxis against SOS together with UDCA and LMWH, whereas the others (n = 11) were only treated with UDCA and LMWH...
July 12, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29997724/lower-extremity-joint-kinematics-of-shod-barefoot-and-simulated-barefoot-treadmill-running
#19
Michele Leblanc, Heidi Ferkranus
Barefoot running is considered to decrease injury risk, but is not always practical, particularly while running on a fitness center treadmill. The purpose of this study was to compare the kinematics of shod, barefoot, and simulated barefoot running. Twelve subjects (age = 21.1 ± 1.2 years) who regularly run on a treadmill for fitness participated in the study. After a warm up, each runner ran on a Biodex RTM 400 treadmill set at 7.4 mph (approximately 3.3 m/s) in their own shoes, barefoot, and while running "like they were barefoot" in their own shoes...
2018: International Journal of Exercise Science
https://www.readbyqxmd.com/read/29980855/analysis-of-qtl-allele-system-conferring-drought-tolerance-at-seedling-stage-in-a-nested-association-mapping-population-of-soybean-glycine-max-l-merr-using-a-novel-gwas-procedure
#20
Mueen Alam Khan, Fei Tong, Wubin Wang, Jianbo He, Tuanjie Zhao, Junyi Gai
RTM-GWAS identified 111 DT QTLs, 262 alleles with high proportion of QEI and genetic variation accounting for 88.55-95.92% PV in NAM, from which QTL-allele matrices were established and candidate genes annotated. Drought tolerance (DT) is one of the major challenges for world soybean production. A nested association mapping (NAM) population with 403 lines comprising two recombinant inbred line (RIL) populations: M8206 × TongShan and ZhengYang × M8206 was tested for DT using polyethylene-glycol (PEG) treatment under spring and summer environments...
October 2018: Planta
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