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Wayne X J Wei, Kenneth N K Fong, Raymond C K Chung, Hobby K Y Cheung, Eddie S L Chow
This study examined the effects of "Remind-to-Move" (RTM) via vibration cueing using wearable devices to increase the use of the affected upper limb and integrate upper limb activities undertaken at home in patients with subacute stroke after inpatient discharge. In a multi-centered randomized controlled trial, 84 eligible patients from four general hospitals who had had a first stroke in the last six months were randomly allocated to either an experimental, sham, or control group, stratified by arm function levels...
November 20, 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
William G Breed, Hazirah Hassan, Macarena Gonzalez, Hanna J McLennan, Chris M Leigh, Lawrence R Heaney
The high diversity of native Philippine murid rodents includes an old endemic group, the chrotomyines, which are the sister group of the Australasian hydromyines. Herein we detail their interspecific diversity of relative testes mass (RTM) and sperm morphology. We find that in chrotomyines, as in the Australasian hydromyines, testes mass relative to body mass differs by an order of magnitude across the species and ranges from a large RTM in Soricomys and Chrotomys species to a small RTM in Apomys. Sperm morphology is associated with these findings, with individuals in species of Soricomys and Chrotomys producing relatively larger spermatozoa with a prominent apical hook and long tail, whereas, by contrast, the Apomys species have a sperm head that either has a very short or no apical hook and a shorter tail...
November 27, 2018: Reproduction, Fertility, and Development
Nozomi Morita, Kazunari Nakahara, Ryo Morita, Keigo Suetani, Yosuke Michikawa, Junya Sato, Kensuke Tsuji, Hiroki Ikeda, Kotaro Matsunaga, Tsunamasa Watanabe, Nobuyuki Matsumoto, Chiaki Okuse, Michihiro Suzuki, Fumio Itoh
Objective The efficacy and safety of concomitant use of antithrombin (AT) with recombinant soluble human thrombomodulin (rTM) for acute cholangitis-induced disseminated intravascular coagulation (AC-induced DIC) remains unclear. This study was conducted to investigate the efficacy of AT combined with rTM as anticoagulant therapy for AC-induced DIC. Methods One hundred patients with AC-induced DIC received anticoagulant therapy using rTM from April 2010 to December 2017. Of the 83 patients treated with rTM immediately after the diagnosis of DIC, excluding those who had not undergone biliary drainage or who had malignancies or a serum AT III level >70%, 56 patients were studied...
November 19, 2018: Internal Medicine
Miyuki Ookura, Naoko Hosono, Toshiki Tasaki, Kana Oiwa, Kei Fujita, Kazuhiro Ito, Shin Lee, Yasufumi Matsuda, Mihoko Morita, Katsunori Tai, Eiju Negoro, Shinji Kishi, Hiromichi Iwasaki, Takanori Ueda, Takahiro Yamauchi
Disseminated intravascular coagulation (DIC) is a life-threatening condition that frequently occurs in patients with hematologic malignancies. Currently, recombinant human soluble thrombomodulin (rTM) is a therapeutic DIC drug that is manufactured and sold in Japan only. We evaluated the efficacy of rTM compared to that of gabexate mesilate (GM), which was previously used routinely for treating DIC in Japan, in patients with acute myeloid leukemia (AML). This retrospective study enrolled 43 AML patients, including 17 with acute promyelocytic leukemia (APL), that was complicated with DIC...
November 2018: Medicine (Baltimore)
Satoshi Takada, Tomoharu Miyashita, Yasuhiko Yamamoto, Shunsuke Kanou, Seiichi Munesue, Yoshinao Ohbatake, Shinichi Nakanuma, Koichi Okamoto, Seisho Sakai, Jun Kinoshita, Isamu Makino, Keishi Nakamura, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
BACKGROUND: Hepatic sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease, is a form of drug-induced liver injury, the initial morphological changes associated with which occur in liver sinusoidal endothelial cells (LSECs). Recombinant human soluble thrombomodulin (rTM) is reported to have anti-inflammatory and cytoprotective effects. Therefore, we investigated the ability of rTM to protect endothelial cells and enhance their functions in a monocrotaline (MCT)-induced model of SOS...
November 2018: In Vivo
Takuhiro Yamaguchi, Yukio Kitajima, Yasuhiro Miyauchi, Kazutoshi Izawa, Masakazu Tanaka, Masatada Hirata, Yasunari Sadatsuki, Yoshihiro Ogawa
We aimed to investigate the incidence of bleeding-related adverse events (AEs) among patients with disseminated intravascular coagulation (DIC) receiving recombinant thrombomodulin (rTM) and those receiving other DIC treatments, the incidence by type of surgery, and the incidence when either blood transfusion or a hemostatic procedure was administered to treat DIC. In this cohort study, data were obtained from a large medical database (22 centers in Japan). The primary endpoint was the incidence rate of bleeding-related AEs by type of surgery...
2018: PloS One
Daniel Medenwald, Dirk Vordermark, Christian T Dietzel
Objectives: The aim of this study was to assess the association between the number of radiotherapy treatment machines (RTMs) in the population and incidence-adjusted cancer mortality. Methods: Data on cancer incidence and mortality were obtained from the GLOBOCAN project (only high-quality data, C3, or higher according to GLOBOCAN quality label), information on the number of RTMs from the Directory of Radiotherapy Centers database, and remaining data from the World Bank and World Health Organization database...
2018: Clinical Epidemiology
Takuro Arishima, Takashi Ito, Tomotsugu Yasuda, Nozomi Yashima, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Takahiro Futatsuki, Yutaro Madokoro, Shotaro Miyamoto, Tomohiro Eguchi, Hiroyuki Haraura, Ikuro Maruyama, Yasuyuki Kakihana
Background: Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress. rTM mainly exerts its anticoagulant effects through an activated protein C (APC)-dependent mechanism, but the circulating APC levels after rTM treatment have not been clarified. This prospective observational study investigated plasma APC levels after rTM treatment...
2018: Thrombosis Journal
Joni Macdonald, Karen R Kilcoyne, Richard M Sharpe, Áine Kavanagh, Richard A Anderson, Pamela Brown, Lee B Smith, Anne Jørgensen, Rod T Mitchell
STUDY QUESTION: Does loss of DMRT1 in human fetal testis alter testicular development and result in testicular dysgenesis? SUMMARY ANSWER: DMRT1 repression in human fetal testis alters the expression of key testicular and ovarian determining genes, and leads to focal testicular dysgenesis. WHAT IS KNOWN ALREADY: Testicular dysgenesis syndrome (TDS) is associated with common testicular disorders in young men, but its etiology is unknown. DMRT1 has been shown to play a role in the regulation of sex differentiation in the vertebrate gonad...
November 1, 2018: Human Reproduction
Peng Jin, Mélanie Machiels, Koen F Crama, Jorrit Visser, Niek van Wieringen, Arjan Bel, Maarten C C M Hulshof, Tanja Alderliesten
PURPOSE: Both mid-position (MidP) and internal target volume (ITV) strategies can take the respiration-induced target motion (RTM) into account. This study aimed to compare these two strategies in terms of clinical target volume (CTV) coverage and dose to organs at risk (OARs) for esophageal cancer radiation therapy (RT). MATERIALS AND METHODS: Fifteen esophageal cancer patients were retrospectively included for neoadjuvant RT planning. Per patient, a 10-phase 4D-CT was acquired with CTV and OARs delineated on the 20% phase...
September 22, 2018: International Journal of Radiation Oncology, Biology, Physics
Michael Brand, Wolfgang Wuest, Matthias May, Michael Uder, Matthias Sommer
Techniques for dose reduction in computed tomography (CT) are receiving increasing attention. Lowering the tube current in front of the patient, known as risk-organ-based tube current modulation (RTM), represents a new approach. Physical dose parameters can determine the exposure but are not able to assess the biological-X-ray interactions. The purpose of this study was to establish a biological phantom model to evaluate the effect of RTM on X-ray-induced DNA double-strand breaks (DSBs). In breast phantoms and in the location of the spine in an Alderson phantom, isolated human blood lymphocytes were irradiated using a 128-slice CT scanner...
November 1, 2018: Journal of Radiation Research
Andrew W Kirkpatrick, Jessica L McKee, Itamar Netzer, Paul B McBeth, Scott D'Amours, Volker Kock, Alex Dobron, Chad G Ball, Elon Glassberg
BACKGROUND: Tension pneumothorax is a frequent cause of potentially preventable death. Tube thoracostomy (TT) can obviate death but is invasive and fraught with complications even in experienced hands. We assessed the utility of a remote international virtual network (RIVN) of specialized mentors to remotely guide military medical technicians (medics) using wireless informatics. METHODS: Medics were randomized to insert TT in training mannequins (TraumaMan; Abacus ALS, Meadowbrook, Australia) supervised by RIVN or not...
September 14, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Leah Griffin, Laura M Leyva Casillas
OBJECTIVE: This retrospective study of 510 patients receiving negative pressure wound therapy (NPWT) in a home care setting examines the relationship between remote therapy monitoring (RTM) and patient adherence, as well as determines the impact of patient adherence on wound progression. MATERIALS AND METHODS: Adherence to treatment was continuously monitored via RTM, and patients with therapy usage < 16 hours in 1 day received an adherence call. Repeated failures to reach a noncompliant patient led to an escalation call to the caregiver to discuss treatment...
August 2018: Wounds: a Compendium of Clinical Research and Practice
Jiaze He, Cara A C Leckey, Patrick E Leser, William P Leser
The sensitivity of Lamb wave modes to a particular defect or instance of damage is dependent on various factors (e.g., the local strain energy density due to that wave mode). As a result, different modes will be more useful than others for damage detection and quantification, dependent on damage type and location. For example, prior work in the field has shown that out-of-plane modes may have a higher sensitivity than in-plane modes to surface defects in plates. The excitability of a certain data acquisition system and the corresponding resolution for damage imaging also varies with frequency...
August 24, 2018: Ultrasonics
Liyuan Pan, Jianbo He, Tuanjie Zhao, Guangnan Xing, Yufeng Wang, Deyue Yu, Shouyi Chen, Junyi Gai
Eighty-six R1 QTLs accounting for 89.92% phenotypic variance in a soybean RIL population were identified using RTM-GWAS with SNPLDB marker which performed superior over CIM and MLM-GWAS with BIN/SNPLDB marker. A population (NJRIKY) composed of 427 recombinant inbred lines (RILs) derived from Kefeng-1 × NN1138-2 (MGII × MGV, MG maturity group) was applied for detecting flowering date (R1) quantitative trait locus (QTL) system in soybean. From a low-depth re-sequencing (~ 0.75 ×), 576,874 SNPs were detected and organized into 4737 BINs (recombination breakpoint determinations) and 3683 SNP linkage disequilibrium blocks (SNPLDBs), respectively...
December 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Neima Briggs, Junfei Wei, Leroy Versteeg, Bin Zhan, Brian Keegan, Ashish Damania, Jeroen Pollet, Kelly S Hayes, Coreen Beaumier, Christopher A Seid, Jamie Leong, Richard K Grencis, Maria Elena Bottazzi, K Jagannadha Sastry, Peter J Hotez
Human whipworm (Trichuris trichiura) infects approximately 1 in 15 people worldwide, representing the leading infectious cause of colitis and subsequent, inflammatory bowel disease (IBD). Current control measures focused on mass deworming have had limited success due to low drug efficacies. Vaccination would be an ideal, cost-effective strategy to induce protective immunity, leading to control of infection and transmission. Here we report the identification of whey acidic protein, a whipworm secretory protein, as a strong immunogen for inducing protective efficacy in a surrogate mouse T...
August 2018: PLoS Pathogens
R Perveen, M H Hoque, K Ahmed, C M Ahmed, M A Jalil, T Parvin, D F Osmany, S Rashid, M B Rashid, S Nahar, S S Shakil
Diastolic dysfunction is a major predictor of mortality and morbidity in hypertensive patients. Not only LV, the RV is also expected to be affected in this overall procedure. To observe the Echocardiographic changes of diastolic function of the RV in systemic HTN and their relation with similar parameters of the LV was the objective. TDI was used in association with standard Doppler modality. In this cross-sectional study, 50 hypertensive subjects were studied who were devoid of any other conditions that may influence the diastolic function of the RV from 01 May 2012 to 31 October 2012 at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh...
July 2018: Mymensingh Medical Journal: MMJ
Maria Dolores Navarro-Mas, Juan Antonio García-Manrique, Maria Desamparados Meseguer, Isabel Ordeig, Ana Isabel Sánchez
Although there are many machining studies of carbon and glass fiber reinforced plastics, delamination and tool wear of basalt fiber reinforced plastics (BFRP) in edge trimming has not yet studied. This paper presents an end milling study of BFRP fabricated by resin transfer molding (RTM), to evaluate delamination types at the top layer of the machined edge with different cutting conditions (cutting speed, feed rate and depth of cut) and fiber volume fraction (40% and 60%). This work quantifies delamination types, using a parameter Sd/L, that evaluates the delamination area (Sd) and the length (L), taking into account tool position in the yarn and movement of yarns during RTM process, which show the random nature of delamination...
August 13, 2018: Materials
Lisa Potts, Catherine Ryan, Lauren Diegel-Vacek, Alisa Murchek
OBJECTIVE: The goal of this project was to decrease handoff delays from the emergency department (ED) as measured by ready to move (RTM)-to-occupied time. BACKGROUND: ED boarding compromises the quality, safety, and experience of patient care. Lack of standardized and transparent handoff communication contributes to boarding time. This process improvement initiative implemented a standardized electronic situation, background, assessment, and recommendation (eSBAR) format-based nursing handoff process from the ED to a medical unit...
September 2018: Journal of Nursing Administration
M N Parker, K Lopetcharat, M A Drake
Protein beverage consumption by Americans has increased in recent years. Coupled with this increased consumption is an interest in natural sweeteners. The objective of this study was to evaluate the sensory properties of naturally sweetened ready-to-mix (RTM) whey protein beverages using 3 temporal methods and to formulate a natural noncaloric sweetener blend that could be added to RTM protein beverages to provide sweetness while still appealing in flavor to consumers. Iso-sweet concentrations of sweeteners (sucralose, sucrose, fructose, stevia, monk fruit) in RTM vanilla whey protein beverages (25 g of protein/360 mL of water) were established using magnitude estimation scaling and 2-alternative forced-choice testing...
July 25, 2018: Journal of Dairy Science
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