keyword
https://read.qxmd.com/read/38417443/a-conserved-antigen-induces-respiratory-th17-mediated-broad-serotype-protection-against-pneumococcal-superinfection
#21
JOURNAL ARTICLE
Xue Liu, Laurye Van Maele, Laura Matarazzo, Daphnée Soulard, Vinicius Alves Duarte da Silva, Vincent de Bakker, Julien Dénéréaz, Florian P Bock, Michael Taschner, Jinzhao Ou, Stephan Gruber, Victor Nizet, Jean-Claude Sirard, Jan-Willem Veening
Several vaccines targeting bacterial pathogens show reduced efficacy upon concurrent viral infection, indicating that a new vaccinology approach is required. To identify antigens for the human pathogen Streptococcus pneumoniae that are effective following influenza infection, we performed CRISPRi-seq in a murine model of superinfection and identified the conserved lafB gene as crucial for virulence. We show that LafB is a membrane-associated, intracellular protein that catalyzes the formation of galactosyl-glucosyl-diacylglycerol, a glycolipid important for cell wall homeostasis...
February 21, 2024: Cell Host & Microbe
https://read.qxmd.com/read/38416289/invasive-disease-caused-simultaneously-by-two-different-serotypes-of-streptococcus-pneumoniae-a-microbiological-appreciation
#22
JOURNAL ARTICLE
Emilia Cercenado, Belén Ramos, Marta Pérez-Abeledo, Julio Sempere, Jose Yuste, Juan Carlos Sanz
We report a clinical case of a child with an invasive pneumococcal disease caused by two different pneumococcal serotypes that belonged to different sequence types. She was a 15-month-old girl with pneumonia and pleural effusion in which S. pneumoniae colonies with different morphologies grew, one from the blood culture (characteristic greyish appearance) and the other from the pleural fluid (mucoid appearance). The isolate from blood was serotype 22 F (ST698/CC698/GPSC61), while the isolate from the pleural fluid was serotype 3 (ST180/CC180/GPSC12)...
February 28, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38403878/antimicrobial-resistance-of-streptococcus-pneumoniae-clinical-serotypes-between-2017-and-2022-in-crete-greece
#23
JOURNAL ARTICLE
Sofia Maraki, Viktoria Eirini Mavromanolaki, Dimitra Stafylaki, Evangelia Iliaki-Giannakoudaki, Anna Kasimati, George Hamilos
BACKGROUND: Pneumococcal disease is still considered a global problem. With the introduction of pneumococcal conjugate vaccines (PCVs) serotype epidemiology changed, but antimicrobial resistance persists constituting a serious problem. The current study aimed to determine the serotype distribution and the antimicrobial susceptibility of recent Streptococcus pneumoniae isolates, following implementation of the 13-valent conjugate vaccine (PCV13). MATERIALS AND METHODS: From January 2017 to December 2022 we evaluated 116 nonduplicate S...
January 30, 2024: Infection & Chemotherapy
https://read.qxmd.com/read/38400197/impaired-igm-memory-b-cell-function-is-common-in-coeliac-disease-but-conjugate-pneumococcal-vaccination-induces-robust-protective-immunity
#24
JOURNAL ARTICLE
Olivia G Moscatelli, Amy K Russell, Lee M Henneken, Melinda Y Hardy, Nadia Mazarakis, Rachel Higgins, Jesse Ekin, Harry McLeod, Paul Simkin, Paul V Licciardi, Vanessa L Bryant, Jason A Tye-Din
Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function associated with reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection. Little is known about the immune implications of hyposplenism in CD or the optimal pneumococcal vaccination strategy. In this study, the immune effects of hyposplenism in CD, and the accuracy of screening approaches and protective responses induced by two different pneumococcal vaccines were examined. Active and treated CD cohorts, and healthy and surgically splenectomised controls underwent testing for the presence of Howell-Jolly bodies and pitted red cells, spleen ultrasound, and immune assessment of IgM memory B cell frequency and IgM memory B cell responses to T cell-dependent (TD) or T cell-independent (TI) stimulation...
February 19, 2024: Vaccines
https://read.qxmd.com/read/38400162/mortality-of-invasive-pneumococcal-disease-following-introduction-of-the-13-valent-pneumococcal-conjugate-vaccine-in-greenland
#25
JOURNAL ARTICLE
Kristiana Alexandrova Nikolova, Mikael Andersson, Hans-Christian Slotved, Anders Koch
Before the incorporation of the 13-valent pneumococcal conjugate vaccine (PCV13) into the childhood vaccination regimen in Greenland in 2010, Inuit populations experienced a substantial prevalence of invasive pneumococcal disease (IPD). The PCV13 introduction has been shown to markedly reduce the incidence of IPD. This current study estimated the impact of PCV13 introduction on IPD mortality in Greenland. This was a nationwide register-based study using all available data on IPD cases 1995-2020 in Greenland...
February 9, 2024: Vaccines
https://read.qxmd.com/read/38400107/robust-immune-response-and-protection-against-lethal-pneumococcal-challenge-with-a-recombinant-bcg-pspa-pdt-prime-boost-scheme-administered-to-neonatal-mice
#26
JOURNAL ARTICLE
Monalisa Martins Trentini, Dunia Rodriguez, Alex Issamu Kanno, Cibelly Goulart, Michelle Darrieux, Luciana Cezar de Cerqueira Leite
Pneumococcal diseases are an important public health problem, with high mortality rates in young children. Although conjugated pneumococcal vaccines offer high protection against invasive pneumococcal diseases, this is restricted to vaccine serotypes, leading to serotype replacement. Furthermore, the current vaccines do not protect neonates. Therefore, several protein-based pneumococcal vaccines have been studied over the last few decades. Our group established a recombinant BCG expressing rPspA-PdT as a prime/rPspA-PdT boost strategy, which protected adult mice against lethal intranasal pneumococcal challenge...
January 25, 2024: Vaccines
https://read.qxmd.com/read/38399805/serotype-distribution-and-antimicrobial-susceptibility-pattern-of-streptococcus-pneumoniae-in-covid-19-pandemic-era-in-brazil
#27
JOURNAL ARTICLE
Samanta C G Almeida, Ana Paula S de Lemos, Ana Luiza Bierrenbach, José Cássio de Moraes, Maria Cristina de Cunto Brandileone
Despite the introduction of the pneumococcal vaccine, Streptococcus pneumoniae remains a cause of invasive diseases in Brazil. This study provides the distribution of serotypes and antimicrobial susceptibility patterns for pneumococcal isolates before and during the years of the COVID-19 pandemic in two age groups, <5 and ≥50 years. This is a national laboratory-based surveillance study that uses data from the Brazilian national laboratory for invasive S. pneumoniae from the pre-COVID-19 (January 2016 to January 2020) and COVID-19 (February 2020 to May 2022) periods...
February 17, 2024: Microorganisms
https://read.qxmd.com/read/38395155/liposome-based-dry-powder-vaccine-immunization-targeting-the-lungs-induces-broad-protection-against-pneumococcus
#28
JOURNAL ARTICLE
T C Rodrigues, D B Figueiredo, V M Gonçalves, K Kaneko, I Y Saleem, E N Miyaji
Streptococcus pneumoniae is an important human pathogen. Currently used conjugate vaccines are effective against invasive disease, but protection is restricted to serotypes included in the formulation, leading to serotype replacement. Furthermore, protection against non-invasive disease is reported to be considerably lower. The development of a serotype-independent vaccine is thus important and Pneumococcal surface protein A (PspA) is a promising vaccine candidate. PspA shows some diversity and can be classified in 6 clades and 3 families, with families 1 and 2 being the most frequent in clinical isolates...
February 21, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38390521/impact-of-age-on-pneumococcal-colonization-of-the-nasopharynx-and-oral-cavity-an-ecological-perspective
#29
JOURNAL ARTICLE
Willem R Miellet, Rob Mariman, Janieke van Veldhuizen, Paul Badoux, Alienke J Wijmenga-Monsuur, David Litt, Thijs Bosch, Elizabeth Miller, Norman K Fry, Marianne A van Houten, Nynke Y Rots, Elisabeth A M Sanders, Krzysztof Trzciński
Pneumococcal carriage studies have suggested that pneumococcal colonization in adults is largely limited to the oral cavity and oropharynx. In this study, we used total abundance-based β-diversity (dissimilarity) and β-diversity components to characterize age-related differences in pneumococcal serotype composition of respiratory samples. quantitative PCR (qPCR) was applied to detect pneumococcal serotypes in nasopharyngeal samples collected from 946 toddlers and 602 adults, saliva samples collected from a subset of 653 toddlers, and saliva and oropharyngeal samples collected from a subset of 318 adults...
January 2024: ISME Commun
https://read.qxmd.com/read/38380016/changes-in-pneumococcal-serotypes-distribution-and-penicillin-resistance-in-healthy-children-five-years-after-generalization-of-pcv10
#30
JOURNAL ARTICLE
Karima Warda, Sara Amari, Majda Boureddane, Youssef Elkamouni, Lamiae Arsalane, Said Zouhair, Mohammed Bouskraoui
OBJECTIVE: Streptococcus pneumoniae ( S. pneumoniae ) nasopharyngeal carriage has significantly decreased after the generalization of pneumococcal vaccination worldwide. This study sought to investigate changes in S. pneumoniae carriage rates, serotype distribution and penicillin non-susceptibility following the generalization of 10-valent pneumococcal conjugate vaccine. METHODS: A prospective study was conducted in Marrakesh, Morocco, between 2017 and 2018, among healthy children attending vaccination centers...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38369970/persistence-of-antibody-to-23-valent-pneumococcal-polysaccharide-vaccine-a-5-year-prospective-follow-up-cohort-study
#31
JOURNAL ARTICLE
Xiang Guo, Juan Li, Jing Qiu, Rui Zhang, Jia Ren, Zhuoying Huang, Zhi Li, Xiufang Liang, Fang Lan, Juan Chen, Fang Huang, Xiaodong Sun
BACKGROUND: Pneumococcal vaccines are effective in preventing pneumococcal diseases in adults. The evaluation of the antibodies persistence to the 23-valent pneumococcal polysaccharide vaccine (PPV23) could provide evidence on PPV23 revaccination. RESEARCH DESIGN AND METHODS: Adults aged ≥ 60 years were selected and vaccinated with PPV23 in Shanghai, and followed up for 5 years with blood samples collection of a 1-year interval...
2024: Expert Review of Vaccines
https://read.qxmd.com/read/38362541/experimental-pneumococcal-carriage-in-people-living-with-hiv-in-malawi-the-first-controlled-human-infection-model-in-a-key-at-risk-population
#32
JOURNAL ARTICLE
Klara Doherty, Dingase Dula, Anthony Chirwa, Edna Nsomba, Vitumbiko S Nkhoma, Neema Toto, Tarsizio Chikaonda, Raphael Kamng'ona, Joseph Phiri, Jesús Reiné, John Ndaferankhande, Lumbani Makhaza, Peter Banda, Kondwani Jambo, Daniela M Ferreira, Stephen B Gordon
Background: As well as suffering a high burden of pneumococcal disease people living with HIV (PLHIV) may contribute to community transmission in sub-Saharan African (sSA) settings. Pneumococcal vaccination is not currently offered to PLHIV in sSA but may prevent disease and reduce transmission. More evidence of vaccine effectiveness against carriage in PLHIV is needed. An Experimental Human Pneumococcal Carriage model (EHPC) has been safely and acceptably used in healthy adults in Malawi to evaluate pneumococcal vaccines against carriage and to identify immune correlates of protection from carriage...
2024: Wellcome Open Research
https://read.qxmd.com/read/38362498/serotype-antibiotic-susceptibility-and-whole-genome-characterization-of-streptococcus-pneumoniae-in-all-age-groups-living-in-southwest-china-during-2018-2022
#33
JOURNAL ARTICLE
Chenglin Miao, Ziyi Yan, Chunmei Chen, Linghan Kuang, Keping Ao, Yingying Li, Jialu Li, Xiaocui Huang, Xinghua Zhu, Yijia Zhao, Yali Cui, Yongmei Jiang, Yi Xie
BACKGROUND: Streptococcus pneumoniae is a common pathogen that colonizes the human upper respiratory tract, causing high morbidity and mortality worldwide. This study aimed to investigate the prevalence status of S. pneumoniae isolated from patients of all ages in Southwest China, including serotype, antibiotic susceptibility and other molecular characteristics, to provide a basis for clinical antibiotic usage and vaccine development. METHODS: This study was conducted from January 2018 to March 2022 at West China Hospital, West China Second University Hospital, First People's Hospital of Longquanyi District (West China Longquan Hospital), Meishan Women and Children's Hospital (Alliance Hospital of West China Second University Hospital) and Chengdu Jinjiang Hospital for Women and Children Health...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38360645/higher-valency-pneumococcal-conjugate-vaccines-in-older-adults-taking-into-account-indirect-effects-from-childhood-vaccination-a-cost-effectiveness-study-for-the-netherlands
#34
JOURNAL ARTICLE
Pieter T de Boer, Cornelis H van Werkhoven, Albert Jan van Hoek, Mirjam J Knol, Elisabeth A M Sanders, Jacco Wallinga, Hester E de Melker, Anneke Steens
BACKGROUND: New 15- and 20-valent pneumococcal vaccines (PCV15, PCV20) are available for both children and adults, while PCV21 for adults is in development. However, their cost-effectiveness for older adults, taking into account indirect protection and serotype replacement from a switch to PCV15 and PCV20 in childhood vaccination, remains unexamined. METHODS: We used a static model for the Netherlands to assess the cost-effectiveness of different strategies with 23-valent pneumococcal polysaccharide vaccine (PPV23), PCV15, PCV20, and PCV21 for a 65-year-old cohort from a societal perspective, over a 15-year time horizon...
February 16, 2024: BMC Medicine
https://read.qxmd.com/read/38360475/safety-tolerability-and-immunogenicity-of-a-novel-24-valent-pneumococcal-vaccine-in-toddlers-a-phase-1-randomized-controlled-trial
#35
JOURNAL ARTICLE
Dorota Borys, Richard Rupp, Ronald Smulders, Gurunadh R Chichili, Laura L Kovanda, Vicki Santos, Frank Malinoski, George Siber, Richard Malley, Shite Sebastian
BACKGROUND: Pneumococcal conjugate vaccines (PCVs) significantly reduced pneumococcal disease burden. Nevertheless, alternative approaches for controlling more serotypes are needed. Here, the safety, tolerability, and immunogenicity of a 24-valent (1/2/3/4/5/6A/6B/7F/8/9N/9V/10A/11A/12F/14/15B/17F/18C/19A/19F/20B/22F/23F/33F) pneumococcal vaccine based on Multiple Antigen-Presenting System (MAPS) technology (Pn-MAPS24v) was assessed in toddlers. METHODS: In this phase 1, blinded, dose-escalation, active-controlled multicenter study conducted in the United States (September/2020-April/2022), 12-15-month-old toddlers primed with three doses of 13-valent PCV (PCV13) were randomized 3:2 to receive a single dose of one of three Pn-MAPS24v dose levels (1 μg/2 μg/5 μg per polysaccharide) or PCV13 intramuscularly...
February 14, 2024: Vaccine
https://read.qxmd.com/read/38359926/indirect-impact-of-childhood-13-valent-pneumococcal-conjugate-vaccine-pcv13-in-canadian-older-adults-a-canadian-immunization-research-network-cirn-retrospective-observational-study
#36
JOURNAL ARTICLE
Sharifa Nasreen, Jun Wang, Fawziah Marra, Jeffrey C Kwong, Allison McGeer, Manish Sadarangani, Sarah E Wilson, Shaza A Fadel
BACKGROUND: 13-valent pneumococcal conjugate vaccine (PCV13) has been part of publicly funded childhood immunisation programmes in Ontario and British Columbia (BC) since 2010. We assessed the indirect impact of infant PCV13 programmes on invasive pneumococcal disease (IPD) and all-cause pneumonia hospitalisation in older adults (aged ≥65 years) using a retrospective observational study. METHODS: We extracted monthly IPD and all-cause pneumonia cases from laboratory and health administrative databases between January 2005 and December 2018...
February 15, 2024: Thorax
https://read.qxmd.com/read/38350767/immunization-with-a-whole-cell-vaccine-reduces-pneumococcal-nasopharyngeal-density-and-shedding-and-middle-ear-infection-in-mice
#37
JOURNAL ARTICLE
Jayne Manning, Sam Manna, Eileen M Dunne, Viktoria Bongcaron, Casey L Pell, Natalie L Patterson, Sacha D Kuil, Poshmaal Dhar, David Goldblatt, E Kim Mulholland, Paul V Licciardi, Roy M Robins-Browne, Richard Malley, Odilia Wijburg, Catherine Satzke
Pneumococcal Conjugate Vaccines (PCVs) have substantially reduced the burden of disease caused by Streptococcus pneumoniae (the pneumococcus). However, protection is limited to vaccine serotypes, and when administered to children who are colonized with pneumococci at the time of vaccination, immune responses to the vaccine are blunted. Here, we investigate the potential of a killed whole cell pneumococcal vaccine (WCV) to reduce existing pneumococcal carriage and mucosal disease when given therapeutically to infant mice colonized with pneumococci...
February 12, 2024: Vaccine
https://read.qxmd.com/read/38336560/surveillance-of-pneumococcal-serotypes-in-adults-hospitalised-with-acute-lower-respiratory-tract-infection-in-bristol-uk
#38
JOURNAL ARTICLE
Catherine Hyams, Maria Lahuerta, Christian Theilacker, Jade King, David Adegbite, Serena McGuinness, Charli Grimes, James Campling, Jo Southern, Michael W Pride, Elizabeth Begier, Nick Maskell, Jennifer Oliver, Luis Jodar, Bradford D Gessner, Adam Finn
INTRODUCTION: Pneumococcus remains a major cause of adult lower respiratory tract infections (LRTI). Few data exist on the relative contribution of serotypes included in pneumococcal vaccines to community-acquired pneumonia (CAP) and non-pneumonic (NP) LRTI. We measured the burden of all and vaccine-serotype pneumococcal respiratory infection following SARS-CoV-2 emergence to inform evidence-based vaccination policy. METHODS: A prospective cohort study at two Bristol hospitals (UK) including all adults age ≥ 18-years hospitalised with acute lower respiratory tract disease (aLRTD) from Nov2021-Nov2022...
February 8, 2024: Vaccine
https://read.qxmd.com/read/38336559/the-potential-impact-of-pcv-13-pcv-15-and-pcv-20-vaccines-in-colombia
#39
JOURNAL ARTICLE
Cristian C Serrano-Mayorga, Elsa D Ibáñez-Prada, Juan M Restrepo-Martínez, Esteban Garcia-Gallo, Sara Duque, David Felipe Severiche-Bueno, Diego Fernando Severiche-Bueno, Sandra Gomez, Hernán Vargas, Luis Felipe Reyes
PURPOSE: To provide information about which pneumococcal vaccine could have greater coverage in Colombia. METHODS: This is a retrospective analysis of patients diagnosed with invasive pneumococcal disease (IPD) between 2015 and 2019 in Bogotá, Colombia. We compared the theoretical serotype coverage of the available anti-pneumococcal vaccines (i.e., PCV-10, PCV-10 SII, PCV-13, PCV-15, PCV-20, PCV-21, PCV24, PPSV-23) and the non-vaccine-covered serotypes stratified by age...
February 8, 2024: Vaccine
https://read.qxmd.com/read/38331222/pneumococcus-and-the-stress-gradient-hypothesis-a-trade-off-links-r-0-and-susceptibility-to-co-colonization-across-countries
#40
JOURNAL ARTICLE
Ermanda Dekaj, Erida Gjini
Modern molecular technologies have revolutionized our understanding of bacterial epidemiology, but reported data across studies and different geographic endemic settings remain under-integrated in common theoretical frameworks. Pneumococcus serotype co-colonization, caused by the polymorphic bacteria Streptococcus pneumoniae, has been increasingly investigated and reported in recent years. While the global genomic diversity and serotype distribution of S. pneumoniae have been well-characterized, there is limited information on how co-colonization patterns vary globally, critical for understanding the evolution and transmission dynamics of the bacteria...
February 6, 2024: Theoretical Population Biology
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