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https://www.readbyqxmd.com/read/30340815/a-high-sucrose-diet-does-not-enhance-spontaneous-metastasis-of-lewis-lung-carcinoma-in-mice
#1
Lin Yan, Sneha Sundaram
A high energy intake contributes to obesity, a risk factor for cancer. We previously reported that an excessive intake of dietary fat enhances malignant spread in mice. This study tested the hypothesis that consumption of a diet with an excessive amount of sucrose enhances metastasis. In a spontaneous metastasis model of Lewis lung carcinoma (LLC), male C57BL/6 mice were maintained on an AIN93G, a high-fat, or a high-sucrose diet for the duration of the study. Pulmonary metastases from a primary tumor, established by a subcutaneous injection of LLC cells, were quantified...
October 2018: Nutrition Research
https://www.readbyqxmd.com/read/30340503/aerobic-and-resistance-exercise-improves-physical-fitness-bone-health-and-quality-of-life-in-overweight-and-obese-breast-cancer-survivors-a-randomized-controlled-trial
#2
Christina M Dieli-Conwright, Kerry S Courneya, Wendy Demark-Wahnefried, Nathalie Sami, Kyuwan Lee, Frank C Sweeney, Christina Stewart, Thomas A Buchanan, Darcy Spicer, Debu Tripathy, Leslie Bernstein, Joanne E Mortimer
BACKGROUND: Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors...
October 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/30339517/2017-aua-renal-mass-and-localized-renal-cancer-guidelines-imaging-implications
#3
Ryan D Ward, Hajime Tanaka, Steven C Campbell, Erick M Remer
Renal cell carcinoma (RCC) is a common cancer that is increasing in incidence because of the increased prevalence of risk factors, including tobacco use, hypertension, and obesity, and the improved detection of these tumors due to increased use of imaging. Localized renal cancer now accounts for more than 60%-70% of new RCC cases. Renal masses suggestive of cancer include enhancing solid renal lesions and Bosniak III and IV complex cystic lesions. Most of these tumors are detected incidentally, and many are slow growing with little propensity to metastasize...
October 19, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/30338797/biomolecular-basis-related-to-inflammation-in-the-pathogenesis-of-endometrial-cancer
#4
C Borghi, U Indraccolo, G Scutiero, P Iannone, R Martinello, P Greco, F Greco, L Nappi
OBJECTIVE: Endometrial cancer (EC) is a complex gynecological neoplasm with several clinical, histopathological and genetic features. Different hormonal, metabolic and biochemical axes are involved in pathogenesis. Obesity is a well-known risk factor for this disease and the role of local and systemic effects of adipose tissue, especially in the promotion of subclinical chronic inflammation, is an important issue. Indeed, inflammation is related to the pathogenesis of different tumors, including EC...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30337696/adherence-to-mediterranean-diet-and-prostate-cancer-risk-in-sicily-population-based-case-control-study
#5
Giorgio Ivan Russo, Tatiana Solinas, Daniele Urzì, Salvatore Privitera, Daniele Campisi, Andrea Cocci, Marco Carini, Massimo Madonia, Sebastiano Cimino, Giuseppe Morgia
Prostate cancer (PCa) is the second most frequently diagnosed cancer and the sixth leading cause of death from cancer worldwide. Countries following a Mediterranean-type dietary pattern, has been reported to have lower PCa incidence and mortality compared with other European regions. A population-based case-control study has been conducted from January 2015 to December 2016 in a single institution of the municipality of Catania, southern Italy. A total of 118 PCa and 238 population-based controls were collected...
October 18, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/30337343/a-group-randomized-trial-to-reduce-obesity-among-appalachian-church-members-the-walk-by-faith-study
#6
EDITORIAL
Electra D Paskett, Ryan D Baltic, Gregory S Young, Mira L Katz, Samuel M Lesko, Kelly H Webber, Karen A Roberto, Eugene J Lengerich, Nancy E Schoenberg, Stephenie K Kennedy, Scherezade Mama, Courtney C Midkiff, Mark B Dignan
Background: Appalachia is a rural, socioeconomically disadvantaged region with high rates of cancer and obesity. Using community-based participatory research principles, the Appalachia Community Cancer Network tested an initiative to reduce weight among overweight and obese participants by partnering with churches, an important community-based institution in Appalachia. Methods: A group randomized trial was conducted with counties or groups of counties in five Appalachian states. These groups were randomly assigned to receive either monthly diet and exercise education sessions ("Walk by Faith"; WbF) or an educational program focused on cancer screening and education ("Ribbons of Faith"; RoF) to examine effects on weight change...
October 18, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/30336729/analysis-of-carboplatin-dosing-in-patients-with-a-glomerular-filtration-rate-greater-than-125-ml-min-to-cap-or-not-to-cap-a-retrospective-analysis-and-review
#7
Amy Morrow, Campbell Garland, Fei Yang, Mike De Luna, Jon D Herrington
The use of the Calvert formula to calculate carboplatin doses allows clinicians to achieve the appropriate carboplatin area under the concentration (AUC) curve. Thrombocytopenia is the dose limiting toxicity of carboplatin and optimizing AUC minimizes the risk of thrombocytopenia. Carboplatin clearance directly correlates with glomerular filtration rate (GFR) and, therefore, an accurate estimation of the renal function is needed. The Calvert formula was designed using the GFR measured by 51 Cr-EDTA; however, many clinicians substitute estimated creatinine clearance (CrCl) as calculated by the Cockcroft-Gault (C-G) equation...
October 18, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/30336659/genetic-risk-score-combined-lifestyle-factors-and-risk-of-colorectal-cancer
#8
Young Ae Cho, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Purpose: Both genetic and lifestyle factors contribute to the risk of colorectal cancer, but each individual factor has a limited effect. Therefore, we investigated the association between colorectal cancer and the combined effects of genetic factors or/and lifestyle risk factors. Materials and Methods: In a case-control study of 632 colorectal cancer patients and 1,295 healthy controls, we quantified the genetic risk score for colorectal cancer using 13 polymorphisms...
October 18, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30336621/eight-week-consumption-of-high-sucrose-diet-has-a-pro-oxidant-effect-and-alters-the-function-of-the-salivary-glands-of-rats
#9
Mateusz Maciejczyk, Jan Matczuk, Małgorzata Żendzian-Piotrowska, Wiesława Niklińska, Katarzyna Fejfer, Izabela Szarmach, Jerzy Robert Ładny, Izabela Zieniewska, Anna Zalewska
A high-sucrose diet (HSD) is widely known for its cariogenic effects and promotion of obesity, insulin resistance, type 2 diabetes, and cancer. However, the impact of the HSD diet on the salivary gland function as well as the level of salivary oxidative stress is still unknown and requires evaluation. Our study is the first to determine both redox balance and oxidative injury in the parotid and submandibular glands of rats fed the HSD diet compared to the control group. We have demonstrated that uric acid concentration and the activity of superoxide dismutase and peroxidase varied significantly in both the submandibular and parotid glands of HSD rats vs...
October 17, 2018: Nutrients
https://www.readbyqxmd.com/read/30336163/dietary-fibers-and-their-fermented-short-chain-fatty-acids-in-prevention-of-human-diseases
#10
REVIEW
Kedar N Prasad, Stephen C Bondy
Many studies show that daily consumption of high-fiber diet is associated with a reduced risk of developing kidney stones, inflammatory disease, colon cancer and other malignancies, obesity, type II diabetes, and cardiovascular disease. Dietary fibers are non-digestible polysaccharides that are composed of complex carbohydrates. Based on their relative solubility in water, dietary fibers can be divided into insoluble and soluble forms. An important property of insoluble fibers is their ability to bind with carcinogens, mutagens, and other toxic chemicals that are formed during digestion of food and eliminate them through the feces...
October 15, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/30335885/molecular-and-disease-association-of-gestational-diabetes-mellitus-affected-mother-and-placental-datasets-reveal-a-strong-link-between-insulin-growth-factor-igf-genes-in-amino-acid-transport-pathway-a-network-biology-approach
#11
Madhusmita Rout, Sajitha Lulu S
Discerning the relationship between molecules involved in diseases based on their underlying biological mechanisms is one of the greatest challenges in therapeutic development today. Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, which adversely affects both mothers and offspring during and after pregnancy. We have constructed two datasets of (GDM associated genes from affected mother and placenta to systematically analyze and evaluate their interactions like gene-gene, gene-protein, gene-microRNA (miRNA), gene-transcription factors, and gene-associated diseases to enhance our current knowledge, which may lead to further advancements in disease diagnosis, prognosis, and treatment...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30334153/opioid-free-colorectal-surgery-a-method-to-improve-patient-financial-outcomes-in-surgery
#12
Deborah S Keller, Jianying Zhang, Manish Chand
BACKGROUND: Opioids are a mainstay for postsurgical pain management, but have associated complications and costs, and contribute to the opioid epidemic. While efforts to reduce opioid use exist, little study has been done on opioid utilization and its impact across surgical approaches. Our goal was to evaluate the impact of opioid utilization on quality measures and costs after open and laparoscopic colorectal surgery. METHODS: The Premier database was reviewed for inpatient colorectal procedures from January 01, 2014, to September 30, 2015...
October 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30329173/therapeutic-potential-of-melatonin-related-to-its-role-as-an-autophagy-regulator-a-review
#13
REVIEW
Jose A Boga, Beatriz Caballero, Yaiza Potes, Zulema Perez-Martinez, Russel J Reiter, Ignacio Vega-Naredo, Ana Coto-Montes
There are several pathologies, syndromes and physiological processes in which autophagy is involved. This process of self-digestion that cells trigger as a survival mechanism is complex and tightly regulated, according to the homeostatic conditions of the organ. However, in all cases, its relationship with oxidative stress alterations is evident, following a pathway that suggests endoplasmic reticulum stress and/or mitochondrial changes. There is accumulating evidence of the beneficial role that melatonin has in the regulation and restoration of damaged autophagic processes...
October 17, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/30328795/interleukin-1-signaling-mediates-obesity-promoted-elevations-in-inflammatory-cytokines-wnt-activation-and-epithelial-proliferation-in-the-mouse-colon
#14
Anna C Pfalzer, Jimmy W Crott, Gar Yee Koh, Donald E Smith, Paloma E Garcia, Joel B Mason
Obesity is a prominent risk factor for colorectal cancer (CRC). One mechanism by which obesity promotes the development of CRC is by generating a chronic, low-grade state of colonic inflammation. Interleukin-1β (IL-1β), a proinflammatory cytokine often elevated in obesity, is known to activate several procarcinogenic signaling pathways that are implicated in colonic carcinogenesis. We therefore sought to define the role of IL-1β in mediating some of the early biochemical and molecular events leading up to obesity-promoted CRC...
October 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/30327963/rising-inpatient-encounters-and-economic-burden-for-patients-with-nonalcoholic-fatty-liver-disease-in-the-usa
#15
Mindie H Nguyen, Alexander L Nguyen, Haesuk Park, Pauline Nguyen, Edward Sheen, Yoona A Kim
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the fastest-growing chronic liver disease. However, little is known about NAFLD inpatient resource utilization and clinical outcomes. AIMS: The aim of this study was to quantify inpatient NAFLD encounters using patient-level data over time. METHODS: This was a retrospective analysis of de-identified data for NAFLD patients from the California Patient Discharge Database from 2006 to 2013...
October 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30327876/mononuclear-phagocyte-system-function-and-nanoparticle-pharmacology-in-obese-and-normal-weight-ovarian-and-endometrial-cancer-patients
#16
Brittney R Starling, Parag Kumar, Andrew T Lucas, David Barrow, Laura Farnan, Laura Hendrix, Hugh Giovinazzo, Gina Song, Paola Gehrig, Jeannette T Bensen, William C Zamboni
PURPOSE: Obesity may alter mononuclear phagocyte system (MPS) function and the pharmacology and efficacy of nanoparticles therapies, such as PEGylated liposomal doxorubicin (PLD). We aimed to evaluate the relationships between hormone and chemokine mediators of MPS function and the pharmacokinetic (PK) exposure of PLD in obese and normal weight patients with ovarian and endometrial cancer. METHODS: Hormone and chemokine mediators in obese and normal weight ovarian and endometrial cancer patients were measured...
October 16, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/30327727/obesity-is-associated-with-early-onset-of-gastrointestinal-cancers-in-california
#17
Yen-Yi Juo, Melinda A Maggard Gibbons, Erik Dutson, Anne Y Lin, Jane Yanagawa, O Joe Hines, Guido Eibl, Yijun Chen
Background: Although it is well known that obesity is a risk factor for gastrointestinal (GI) cancer, it is not well established if obesity can cause earlier GI cancer onset. Methods: A cross-sectional study examining the linked 2004-2008 California Cancer Registry Patient Discharge Database was performed to evaluate the association between obesity and onset age among four gastrointestinal cancers, including esophageal, gastric, pancreatic, and colorectal cancers...
2018: Journal of Obesity
https://www.readbyqxmd.com/read/30327562/waist-circumference-and-risk-of-23-site-specific-cancers-a-population-based-cohort-study-of-korean-adults
#18
Kyu Rae Lee, Mi Hae Seo, Kyung Do Han, Jinhyung Jung, In Cheol Hwang
BACKGROUND: Large waist circumference (WC) is a risk factor for several site-specific cancers, but a large-scale systematic investigation across all common cancers adjusted for potential confounders has not been conducted. This study aimed to evaluate the possible links between WC and common cancers. METHODS: We prospectively examined the association between WC and the risk of cancers in a 7-year cohort study of nearly 22.9 million Korean adults. Using the claims database merged with the national health check-up data, we fitted proportional hazard models to investigate associations between WC and 23 of the most common cancers, with adjustment for potential confounders, including body mass index (BMI)...
October 17, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30327367/genome-wide-meta-analysis-of-gene-environmental-interaction-for-insulin-resistance-phenotypes-and-breast-cancer-risk-in-postmenopausal-women
#19
Su Yon Jung, Nick Mancuso, Herbert Yu, Jeanette Papp, Eric M Sobel, Zuo-Feng Zhang
Insulin-resistance (IR)-related genetic variants are possibly associated with breast cancer, and the gene-phenotype-cancer association could be modified by lifestyle factors including obesity, physical inactivity, and high-fat diet. Using data from postmenopausal women, a population highly susceptible to obesity, IR, and increased risk of breast cancer, we implemented a genome-wide association study (GWAS) in 2 steps: 1) GWAS meta-analysis of gene-environmental (i.e., behavioral) interaction (G*E) for IR phenotypes (hyperglycemia, hyperinsulinemia, and homeostatic model assessment-insulin resistance); and 2) after the G*E GWAS meta-analysis, the identified single-nucleotide polymorphisms (SNPs) were tested for their associations with breast cancer risk in overall or subgroup population, where the SNPs were identified at genome-wide significance...
October 16, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30326670/new-mammalian-target-of-rapamycin-mtor-modulators-derived-from-natural-product-databases-and-marine-extracts-by-using-molecular-docking-techniques
#20
Verónica Ruiz-Torres, Maria Losada-Echeberría, Maria Herranz-López, Enrique Barrajón-Catalán, Vicente Galiano, Vicente Micol, José Antonio Encinar
Mammalian target of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that functions as a master regulator of cellular growth and metabolism, in response to nutrient and hormonal stimuli. mTOR functions in two distinct complexes-mTORC1 is sensitive to rapamycin, while, mTORC2 is insensitive to this drug. Deregulation of mTOR's enzymatic activity has roles in cancer, obesity, and aging. Rapamycin and its chemical derivatives are the only drugs that inhibit the hyperactivity of mTOR, but numerous side effects have been described due to its therapeutic use...
October 15, 2018: Marine Drugs
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