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Human Milk Fortifiers Preterm Infants

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https://www.readbyqxmd.com/read/30486700/a-randomized-controlled-trial-comparing-the-effect-of-fortification-of-human-milk-with-an-infant-formula-powder-versus-unfortified-human-milk-on-the-growth-of-preterm-very-low-birth-weight-infants
#1
Vijay Gupta, Grace Rebekah, Yesudas Sudhakar, Sridhar Santhanam, Manish Kumar, Niranjan Thomas
OBJECTIVE: To optimize growth in very low birth weight (VLBW) infants, human milk fortification is standard of care in neonatal units of high income countries. However, commercial fortifiers may not be available or it may be too expensive in resource limited settings. As an alternative to using human milk fortifiers, we studied the effects of milk fortification with an infant formula on growth and biochemical parameters of very low birth weight (VLBW) infants Methods: We undertook a prospective, randomized controlled trial in the neonatal unit of a tertiary care hospital in south India...
November 28, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30407223/human-milk-protein-vs-formula-protein-and-their-use-in-preterm-infants
#2
Maria L Gianni, Paola Roggero, Fabio Mosca
PURPOSE OF REVIEW: We review the current available evidence on the metabolic fate of human milk proteins and their potential clinical implications for growth and body composition development vs. those of formula proteins in preterm infants. RECENT FINDINGS: The decreased content of human milk protein in preterm mothers throughout lactation might contribute to the reduced growth reported in exclusively human milk-fed infants compared with that of formula-fed infants...
November 6, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/30356677/the-effect-of-human-milk-on-modulating-the-quality-of-growth-in-preterm-infants
#3
Pasqua Piemontese, Nadia Liotto, Domenica Mallardi, Paola Roggero, Valeria Puricelli, Maria Lorella Giannì, Daniela Morniroli, Chiara Tabasso, Michela Perrone, Camilla Menis, Anna Orsi, Orsola Amato, Fabio Mosca
Introduction: Human milk is the optimal nutrition for preterm infants. When the mother's own milk is unavailable, donor human milk is recommended as an alternative for preterm infants. The association among early nutrition, body composition and the future risk of disease has recently attracted much interest. The aim of this study was to investigate the effect of human milk on the body composition of preterm infants. Materials and Methods: Very low birth weight infants (VLBW: birth weight <1,500 g) with a gestational age (GA) between 26 and 34 weeks were included...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/30320665/a-novel-donkey-milk-derived-human-milk-fortifier-in-feeding-preterm-infants-a-randomized-controlled-trial
#4
Enrico Bertino, Laura Cavallarin, Francesco Cresi, Paola Tonetto, Chiara Peila, Giulia Ansaldi, Melissa Raia, Alessia Varalda, Marzia Giribaldi, Amedeo Conti, Sara Antoniazzi, Guido E Moro, Elena Spada, Silvano Milani, Alessandra Coscia
OBJECTIVES: The purpose of the present randomized controlled clinical trial was to compare the use of donkey milk-derived fortifier with commercial bovine milk-derived fortifier in very preterm or very low-birthweight newborns, in terms of feeding tolerance. METHODS: This trial included 156 newborns born at <32 weeks of gestational age and/or with a birthweight ≤1500 g. Newborns were randomized 1:1 to receive enteral feeding with either a bovine milk-based fortifier (BF-arm), or a new, donkey milk-derived fortifier (DF-arm) for 21 days...
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30320413/tolerance-of-hydrolyzed-liquid-protein-fortified-human-milk-and-effect-on-growth-in-premature-infants
#5
Fauzia Shakeel, Melanie Newkirk, Taymeyah Altoubah, Denise Martinez, Ernest K Amankwah
BACKGROUND: We evaluated tolerance of hydrolyzed liquid protein (LP) supplement added to fortified human milk (HM) to optimize protein intake in preterm infants. METHODS: A prospective observational study of 31 subjects compared with 31 historic controls, receiving mothers own milk (MOM) and/or donor milk (DM) to assess LP tolerance, growth, and risk for morbidities was conducted. Milk was analyzed for nutrient content. Feeding intolerance, defined as cessation of feedings for ≥48 hours, abdominal distension and/or residuals, necrotizing enterocolitis (NEC), and metabolic acidosis were used to assess safety, while weight and head circumference (HC) were used to evaluate growth...
October 15, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/30287775/evaluation-of-a-concentrated-preterm-formula-as-a-liquid-human-milk-fortifier-in-preterm-babies-at-increased-risk-of-feed-intolerance
#6
Anish Pillai, Susan Albersheim, Julie Matheson, Vikki Lalari, Sylvia Wei, Sheila M Innis, Rajavel Elango
There are concerns around safety and tolerance of powder human milk fortifiers to optimize nutrition in preterm infants. The purpose of this study was to evaluate the tolerance and safety of a concentrated preterm formula (CPF) as a liquid human milk fortifier (HMF) for premature infants at increased risk of feeding intolerance. We prospectively enrolled preterm infants over an 18-month period, for whom a clinical decision had been made to add CPF to human milk due to concerns regarding tolerance of powder HMF...
October 4, 2018: Nutrients
https://www.readbyqxmd.com/read/30252854/human-milk-enriched-with-human-milk-lyophilisate-for-feeding-very-low-birth-weight-preterm-infants-a-preclinical-experimental-study-focusing-on-fatty-acid-profile
#7
Vanessa S Bomfim, Alceu A Jordão, Larissa G Alves, Francisco E Martinez, José Simon Camelo
BACKGROUND: Human milk, with essential nutrients and long chain polyunsaturated fatty acids (LC-PUFAs) such as the omega 3 and 6 fatty acids is important for development of the central nervous system and the retina in very low birth weight infants (<1,500 g). However, breast milk may not be sufficient to meet these needs. The possibility of supplementing breast milk with a lyophilisate of human milk was explored in this study. The objectives of this study were to determine the total lipid content and the lipid profile of the Human Milk on Baseline (HMB) and that of the Concentrates with the Human Milk + lyophilisate (with lyophilisate of milk in the immediate period (HMCI), at 3 months (HMC3m), and at 6 months (HMC6m) of storage)...
2018: PloS One
https://www.readbyqxmd.com/read/30237896/the-fortification-method-relying-on-assumed-human-milk-composition-overestimates-the-actual-energy-and-macronutrient-intakes-in-very-preterm-infants
#8
Israel Macedo, Luis Pereira-da-Silva, Manuela Cardoso
Background: To achieve recommended nutrient intakes in preterm infants, the target fortification method of human milk (HM) was proposed as an alternative to standard fortification method. We aimed to compare assumed energy and macronutrient intakes based on standard fortified HM with actual intakes relying on measured composition of human milk (HM), in a cohort of HM-fed very preterm infants. Methods: This study is a secondary retrospective analysis, in which assumed energy and macronutrient contents of daily pools of own mother's milk (OMM) from 33 mothers and donated HM (DHM) delivered to infants were compared with the measured values using a mid-infrared HM analyzer...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/30234121/best-practices-for-handling-and-administration-of-expressed-human-milk-and-donor-human-milk-for-hospitalized-preterm-infants
#9
REVIEW
Caroline Steele
The importance of human milk for the preterm infant is well established (1-3). However, the feeding of human milk to preterm infants is typically much more complicated than the mere act of breastfeeding (3, 4). The limited oral feeding skills of many preterm infants often results in human milk being administered via an enteral feeding tube (4). In addition, fortification is commonly required to promote optimal growth and development-particularly in the smallest of preterm infants (2, 4, 5). Consequently, a mother's own milk must be pumped, labeled, transported to the hospital, stored, tracked for appropriate expiration dates and times, thawed (if previously frozen), fortified, and administered to the infant with care taken at each step of the process to avoid microbial contamination, misadministration (the wrong milk for the wrong patient), fortification errors, and waste (1-5)...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/30195561/improved-outcomes-in-preterm-infants-fed-a-nonacidified-liquid-human-milk-fortifier-a-prospective-randomized-clinical-trial
#10
Richard J Schanler, Sharon L Groh-Wargo, Bridget Barrett-Reis, Robert D White, Kaashif A Ahmad, Jeffery Oliver, Geraldine Baggs, Larry Williams, David Adamkin
OBJECTIVE: To compare growth, feeding tolerance, and clinical and biochemical evaluations in human milk-fed preterm infants randomized to receive either an acidified or a nonacidified liquid human milk fortifier. STUDY DESIGN: This prospective, controlled, parallel, multicenter growth and tolerance study included 164 preterm infants (≤32 weeks of gestation, birth weight 700-1500 g) who were randomized to acidified or nonacidified liquid human milk fortifier from study day 1, the first day of fortification, through study day 29 or until hospital discharge...
November 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30194887/improved-lung-function-at-age-6-in-children-born-very-preterm-and-fed-extra-protein-post-discharge
#11
Line Hedegaard Toftlund, Lone Agertoft, Susanne Halken, Gitte Zachariassen
BACKGROUND: In very preterm-born children alveolar maturation is challenged and lung function is often compromised during childhood. So far, very few studies have focused on type of early nutrition and lung function in children born preterm. METHODS: This study is a six years follow-up of 281 very preterm-born infants (VPI) with a gestational age (GA) < 32+0 weeks. Infants breastfed at discharge from hospital were randomized to unfortified (UHM) or fortified (FHM) mother's (human) milk, whereas those not breastfed received a preterm formula (PF)...
September 8, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/30149743/late-onset-hyponatremia-in-preterm-newborns-is-the-sodium-content-of-human-milk-fortifier-insufficient
#12
İsmail Kursad Gokçe, Serife Suna Oguz
INTRODUCTION: In this study, we aimed to define the incidence and time to detection of late onset hyponatremia (LOH) as well as factors affecting its development in preterm newborns. We also aimed to determine the daily sodium requirement of these patients. METHODS: We studied a total of 145 very low birth weight infants with a full or nearly full enteral diet and followed them up until discharge. We recorded demographic and clinic characteristics. We measured serum sodium (SNa) levels at least once a week after the second week...
September 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30148655/effects-of-refrigerated-and-frozen-storage-on-holder-pasteurized-donor-human-milk-a-systematic-review
#13
Hannah R Schlotterer, Maryanne T Perrin
BACKGROUND: Pasteurized donor human milk (PDHM) is the recommended feeding alternative for preterm infants when mother's own milk is not available. Use of PDHM in United States neonatal hospitals is increasing, although guidelines for the refrigerated and frozen storage are limited. OBJECTIVE: We aimed to review the current evidence for the storage of Holder PDHM (HPDHM) under refrigerated and frozen storage conditions. METHODS: A systematic review of the literature was conducted for studies published between 1985 and May 2018...
September 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/30022761/-effects-of-different-feeding-patterns-on-the-growth-and-development-of-infants-with-very-extremely-low-birth-weight
#14
Qian-Qian Li, Qian Liu, Jun-Mei Yan, Xian Wang
OBJECTIVE: To investigate the growth and development of very low birth weight (VLBW)/extremely low birth weight (ELBW) preterm infants within the corrected age of 6 months and the effect of different feeding patterns on growth and development. METHODS: A total of 109 VLBW/ELBW preterm infants who were discharged from January 2016 to April 2017 and who had completed regular follow-up were enrolled, and their growth and development within the corrected age of 6 months were monitored...
July 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30011395/catch-up-growth-rapid-weight-growth-and-continuous-growth-from-birth-to-6-years-of-age-in-very-preterm-born-children
#15
Line Hedegaard Toftlund, Susanne Halken, Lone Agertoft, Gitte Zachariassen
BACKGROUND: Breastfeeding promotes healthy growth in very-preterm-born infants (VPI), but extra nutritional supply is needed to ensure catch-up growth and brain development. OBJECTIVES: To investigate how different types of post-discharge nutrition affect growth until 6 years of age in children born VPI. METHODS: This was a 6-year follow-up study of 281 VPI. Median gestational age (GA) was 30 + 0 weeks (range 24-32 weeks). When breastfed at discharge, they were randomized to unfortified human milk (UHM) or fortified human milk (FHM)...
2018: Neonatology
https://www.readbyqxmd.com/read/29992630/human-milk-fortification-with-bovine-colostrum-is-superior-to-formula-based-fortifiers-to-prevent-gut-dysfunction-necrotizing-enterocolitis-and-systemic-infection-in-preterm-pigs
#16
Jing Sun, Yanqi Li, Xiaoyu Pan, Duc Ninh Nguyen, Anders Brunse, Anders M Bojesen, Silvia Rudloff, Martin S Mortensen, Douglas G Burrin, Per T Sangild
BACKGROUND: Fortification of donor human milk (DHM) is required for optimal growth of very preterm infants, but there are concerns of more gut dysfunction and necrotizing enterocolitis (NEC) when using formula-based fortifiers (FFs), especially soon after birth. Intact bovine colostrum (BC) is rich in nutrients and bioactive factors, and protects against NEC in preterm pigs. We hypothesized that fortification of DHM with BC is superior to FFs to prevent gut dysfunction and infections when provided shortly after preterm birth...
July 10, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29971449/-the-value-of-human-milk-for-preterm-infants-overview-and-practical-aspects
#17
REVIEW
Corinna Gebauer, Daniel Klotz, Skadi Springer
Over the last decades the immense benefit of human milk on the nutrition of preterm infants has become increasingly evident. Research has confirmed that human milk has significant advantages for the preterm infant in terms of host defense, gastrointestinal development and maturation, neurological development, reduction of necrotizing enterocolitis, retinopathy of prematurity and chronic lung disease as well as mental and physical benefits for the mother. Computing these factors into a health-cost-benefit equation, positive economic consequences for a national public health system were demonstrated...
August 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29931679/protein-supplementation-of-human-milk-for-promoting-growth-in-preterm-infants
#18
REVIEW
Emma A Amissah, Julie Brown, Jane E Harding
BACKGROUND: Preterm infants require high protein intake to achieve adequate growth and development. Although breast milk feeding has many benefits for this population, the protein content is highly variable, and inadequate to support rapid infant growth. This is a 2018 update of a Cochrane Review first published in 1999. OBJECTIVES: To determine whether protein-supplemented human milk compared with unsupplemented human milk, fed to preterm infants, improves growth, body composition, cardio-metabolic, and neurodevelopmental outcomes, without significant adverse effects...
June 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29924388/fat-supplementation-of-human-milk-for-promoting-growth-in-preterm-infants
#19
REVIEW
Emma A Amissah, Julie Brown, Jane E Harding
BACKGROUND: As preterm infants do not experience the nutrient accretion and rapid growth phase of the third trimester of pregnancy, they are vulnerable to postnatal nutritional deficits, including of fat. Consequently, they require higher fat intakes compared to their full term counterparts to achieve adequate growth and development. Human milk fat provides the major energy needs of the preterm infant and also contributes to several metabolic and physiological functions. Although human milk has many benefits for this population, its fat content is highly variable and may be inadequate for their optimum growth and development...
June 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29843467/effects-on-fatty-acid-metabolism-of-a-new-powdered-human-milk-fortifier-containing-medium-chain-triacylglycerols-and-docosahexaenoic-acid-in-preterm-infants
#20
RANDOMIZED CONTROLLED TRIAL
Claude Billeaud, Carole Boué-Vaysse, Leslie Couëdelo, Philippe Steenhout, Jonathan Jaeger, Cristina Cruz-Hernandez, Laurent Ameye, Jacques Rigo, Jean-Charles Picaud, Elie Saliba, Nicholas P Hays, Frédéric Destaillats
Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21)...
May 29, 2018: Nutrients
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