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Meniscal morphology

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https://www.readbyqxmd.com/read/30536862/cellular-and-chemical-gradients-to-engineer-the-meniscus-to-bone-insertion
#1
Leanne E Iannucci, Alexander J Boys, Mary Clare McCorry, Lara A Estroff, Lawrence J Bonassar
Tissue-engineered menisci hold promise as an alternative to allograft procedures but require a means of robust fixation to the native bone. The insertion of the meniscus into bone is critical for meniscal function and inclusion of a soft tissue-to-bone interface in a tissue engineered implant can aid in the fixation process. The native insertion is characterized by gradients in composition, tissue architecture, and cellular phenotype, which are all difficult to replicate. In this study, a soft tissue-to-bone interface is tissue engineered with a cellular gradient of fibrochondrocytes and mesenchymal stem cells and subjected to a biochemical gradient through a custom media diffusion bioreactor...
December 10, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30525899/static-lateral-tibial-plateau-subluxation-predicts-high-grade-rotatory-knee-laxity-in-anterior-cruciate-ligament-deficient-knees
#2
Jayson Lian, João V Novaretti, Andrew J Sheean, Neel K Patel, Sean Whaley, Adam Popchak, Volker Musahl
BACKGROUND: In anterior cruciate ligament-deficient (ACL-D) knees, injury pattern and bony morphologic features have been shown to influence both static anterior tibial subluxation relative to the femur and dynamic rotatory knee laxity. Therefore, the relationship between static anterior tibial subluxation and dynamic rotatory knee laxity was investigated. PURPOSE: To determine whether static tibial subluxation as measured on magnetic resonance imaging (MRI) is associated with the grade of rotatory knee laxity in ACL-D knees...
December 7, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/30482514/discoid-meniscus-in-children-and-adolescents-correlation-between-morphology-and-meniscal-tears
#3
J J Masquijo, F Bernocco, J Porta
BACKGROUND: Some authors have suggested that the diminished vascular blood supply, peripheral stability and thickness of the discoid meniscus (DM) would make it more prone to tears. The aims of this study are two-fold: 1) To analyse morphological characteristics by magnetic resonance (MRI), and 2) To correlate the size of the meniscus with the presence of meniscal tears. METHODS: The MRI of patients ≤18 years-old over a period of 5 years were reviewed, and patients with DM were identified...
November 24, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/30430220/the-detached-stump-of-the-torn-anterior-cruciate-ligament-adheres-to-the-femoral-notch-wall-and-then-to-the-posterior-cruciate-ligament-within-6-months-from-injury
#4
Barak Haviv, Mohamed Kittani, Lee Yaari, Ehud Rath, Snir Heller, Shai Shemesh, Mustafa Yassin
PURPOSE: To evaluate the progressive changes in the morphology of traumatic ruptures of the anterior cruciate ligament (ACL) over time. A secondary objective was evaluating their correlation with meniscal tears or chondral lesions. METHODS: The study included one hundred and one patients who underwent ACL reconstruction surgery of the knee after a definite date of injury. The torn ACL remnant morphological pattern was assessed and classified during arthroscopy. A correlation analysis was performed between the pathological features of the remnant and the time length from injury...
November 14, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/30398398/swine-meniscus-are-femoral-tibial-surfaces-properly-tuned-to-bear-the-forces-exerted-on-the-tissue
#5
Giuseppe Michele Peretti, Umberto Polito, Mauro Di Giancamillo, Maria Elena Andreis, Federica Boschetti, Alessia Di Giancamillo
Menisci are subjected to different pathologies that affected the knee proper functions and biology. Over the years, different techniques were tried to repair meniscus injury, and, when the reparation was not possible, to replace or regenerate it. These techniques still present a lack of controlled and independent clinical studies that not allow identifying their effective failure rate. This rate could be due to a still incomplete knowledge about meniscal biology, its composition and biomechanical properties...
November 6, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/30374574/meniscal-tear-morphology-independently-affects-pain-relief-following-arthroscopic-partial-meniscectomy-in-middle-aged-patients
#6
Masayuki Kamimura, Jutaro Umehara, Atsushi Takahashi, Yu Mori, Daisuke Chiba, Yoshiyuki Kuwahara, Eiji Itoi
PURPOSE: To analyze the influence of meniscal tear pattern on clinical outcomes following arthroscopic partial meniscectomy in middle-aged patients with medial meniscal tears. METHODS: A total of 123 patients (130 knees) aged ≥ 50 years who underwent arthroscopic partial meniscectomy for medial meniscal tears were evaluated. Inclusion criteria were none to moderate medial knee osteoarthritis [Kellgren-Lawrence (KL) grade ≤ 3] and a minimum of 2-year follow-up (median 4...
October 29, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/30322492/imaging-of-the-postoperative-meniscus
#7
REVIEW
Russell Chapin
In the postmeniscectomy or meniscal repair setting, there is overlap between expected postoperative change and findings of a re-torn meniscus, particularly increased T1-weighted or proton density signal contacting the articular surface. Protocol selection and accurate diagnosis requires knowledge of meniscal tear treatment, the expected postoperative appearance, and criteria for re-tear. Criteria for meniscal re-tear on MR imaging are high T2-weighted signal reaching the articular surface, abnormal meniscal morphology not explained by the surgery, or a displaced fragment...
November 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/30306701/3d-convolutional-neural-networks-for-detection-and-severity-staging-of-meniscus-and-pfj-cartilage-morphological-degenerative-changes-in-osteoarthritis-and-anterior-cruciate-ligament-subjects
#8
Valentina Pedoia, Berk Norman, Sarah N Mehany, Matthew D Bucknor, Thomas M Link, Sharmila Majumdar
BACKGROUND: Semiquantitative assessment of MRI plays a central role in musculoskeletal research; however, in the clinical setting MRI reports often tend to be subjective and qualitative. Grading schemes utilized in research are not used because they are extraordinarily time-consuming and unfeasible in clinical practice. PURPOSE: To evaluate the ability of deep-learning models to detect and stage severity of meniscus and patellofemoral cartilage lesions in osteoarthritis and anterior cruciate ligament (ACL) subjects...
October 10, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/30280250/meniscal-body-extrusion-and-cartilage-coverage-in-middle-aged-and-elderly-without-radiographic-knee-osteoarthritis
#9
Fredrik Svensson, David T Felson, Fan Zhang, Ali Guermazi, Frank W Roemer, Jingbo Niu, Piran Aliabadi, Tuhina Neogi, Martin Englund
OBJECTIVES: To determine meniscal extrusion and cartilage coverage on magnetic resonance (MR) images and factors associated with these parameters in knees of middle-aged and elderly persons free from radiographic tibiofemoral osteoarthritis (OA). METHODS: Seven hundred eighteen persons, free of radiographic tibiofemoral OA, aged 50-90 years from Framingham, MA, USA, were included. We measured meniscal extrusion on 1.5 T MRI of both knees to evaluate both medial and lateral meniscal body extrusion and cartilage coverage...
October 2, 2018: European Radiology
https://www.readbyqxmd.com/read/30267878/chondrogenic-differentiation-of-synovial-fluid-mesenchymal-stem-cells-on-human-meniscus-derived-decellularized-matrix-requires-exogenous-growth-factors
#10
Yan Liang, Enaam Idrees, Alexander R A Szojka, Stephen H J Andrews, Melanie Kunze, Aillette Mulet-Sierra, Nadr M Jomha, Adetola B Adesida
The objective of this study was to investigate whether meniscus-derived decellularized matrix (DCM) has the capacity to induce differentiation of synovial fluid-derived mesenchymal stem cells (SF-MSCs) towards a meniscus fibrochondrocyte (MFC) phenotype. The potential roles of transforming growth factor beta-3 (TGF-β3 ) and insulin-like growth factor 1 (IGF-1) in the differentiation of SF-MSCs towards an MFC phenotype were also investigated. SF-MSCs were isolated via plastic adherence cell culture from the synovial fluid of five donors (5 male, average age 34 years)...
September 26, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30251100/meniscal-repair-concurrent-with-anterior-cruciate-ligament-reconstruction-restores-posterior-shift-of-the-medial-meniscus-in-the-knee-flexed-position
#11
Yoshiki Okazaki, Takayuki Furumatsu, Shinichi Miyazawa, Yuya Kodama, Yusuke Kamatsuki, Tomohito Hino, Shin Masuda, Toshifumi Ozaki
PURPOSE: The purpose of this study was to evaluate the shape and shift of the medial meniscus before and after meniscal repair concurrent with anterior cruciate ligament (ACL) reconstruction using magnetic resonance imaging (MRI) at 90° of knee flexion. METHODS: This study included 18 patients with ACL-deficient knees without meniscus tears (group A), 11 patients with medial meniscus tears alone (group M), and 15 patients with ACL-deficient knees complicated with medial meniscus tears (group AM)...
September 24, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/30239017/stratifying-minimal-versus-severe-pain-in-knee-osteoarthritis-using-a-musculoskeletal-ultrasound-protocol
#12
Mary Monica Bernardo-Bueno, Consuelo B Gonzalez-Suarez, Andrea Kristina Malvar, Ronald Cua, Daniel Feliciano, Bee Giok Tan-Sales, Svetlana Maris O Aycardo, Millicent Tan-Ong, Robert Chan, Francisco De Los Reyes
OBJECTIVE: The aim of this cross-sectional correlational study was to determine the association of pain with morphologic and inflammatory sonographic findings in patients with knee osteoarthritis. METHODS: A total of 113 participants with knee osteoarthritis were assessed using visual analog scale pain score and sonography. Ultrasound evaluation included morphologic changes (ie, articular cartilage degeneration, medial and lateral meniscal protrusion, and presence of osteophytes on the joint margins) and inflammatory changes (ie suprapatellar effusion and/or synovitis, Baker cyst, superficial and deep infrapatellar effusion, pes anserine tendinopathy, and Hoffa panniculitis)...
September 21, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/30229247/analysis-of-human-menisci-degeneration-via-infrared-attenuated-total-reflection-spectroscopy
#13
Pei Wang, Jonas Balko, Rui Lu, Ángela I López-Lorente, Lutz Dürselen, Boris Mizaikoff
Degeneration of human meniscal tissue induces impairment of normal knee functions, and is a highly relevant etiology of knee joint tears and osteoarthritis. Currently, the grading scale of meniscus degeneration is conventionally derived from evaluating meniscal morphology and histological staining. However, mid-infrared attenuated total reflectance (IR-ATR) spectroscopy is a particularly useful technique that may analyze the biomolecular composition at a sample surface, and provide information on the intra- and/or inter-molecular chemical bonds...
September 19, 2018: Analyst
https://www.readbyqxmd.com/read/30218727/hydrogels-of-agarose-and-methacrylated-gelatin-and-hyaluronic-acid-are-more-supportive-for-in-vitro-meniscus-regeneration-than-three-dimensional-printed-polycaprolactone-scaffolds
#14
Gokhan Bahcecioglu, Nesrin Hasirci, Bahar Bilgen, Vasif Hasirci
In this study, porcine fibrochondrocyte-seeded agarose, methacrylated gelatin (GelMA), methacrylated hyaluronic acid (MeHA) and GelMA-MeHA blend hydrogels, and 3D printed PCL scaffolds were tested under dynamic compression for potential meniscal regeneration in vitro. Cell-carrying hydrogels produced higher levels of extracellular matrix (ECM) components after a 35-day incubation than the 3D printed PCL. Cells on GelMA exhibited strong cell adhesion (evidenced with intense paxillin staining) and dendritic cell morphology, and produced an order of magnitude higher level of collagen (p < 0...
September 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30129332/-study-on-the-preparation-of-polycaprolactone-type-%C3%A2-collagen-tissue-engineered-meniscus-scaffold-by-three-dimensional-printing-and-its-physiochemical-properties
#15
Shi Shen, Mingxue Chen, Shuang Gao, Weimin Guo, Zhenyong Wang, Haojiang Li, Xu Li, Bin Zhang, Hai Xian, Xueliang Zhang, Shuyun Liu, Libo Hao, Naiqiang Zhuo, Quanyi Guo
Objective: To manufacture a polycaprolactone (PCL)/type Ⅰ collagen (COL Ⅰ) tissue engineered meniscus scaffold (hereinafter referred to as PCL/COL Ⅰ meniscus scaffold) by three-dimensional (3D) printing with low temperature deposition technique and to study its physicochemical properties. Methods: First, the 15% PCL/4% COLⅠ composite solution and 15% PCL simple solution were prepared. Then, 15% PCL/4% COL Ⅰmeniscus scaffold and 15% PCL meniscal scaffold were prepared by using 3D printing with low temperature deposition techniques...
September 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/30108012/characteristic-morphology-of-the-proximal-tibiofibular-joint-in-patients-with-discoid-lateral-meniscus
#16
Norifumi Suga, Tomoyuki Nakasa, Masakazu Ishikawa, Atsuo Nakamae, Seiju Hayashi, Masahiro Yoshikawa, Yoshikazu Sumida, Yusuke Tsuyuguchi, Nobuo Adachi
BACKGROUND: Patients with discoid lateral meniscus (DLM) are prone to meniscal injuries related to its shape and abnormal mobility. The anatomical joint inclination of the proximal tibiofibular joint (PTFJ) can also affect joint movement in knee motion. However, an association between PTFJ morphology and DLM remains unclear. The purpose of this study was to investigate the morphology of the PTFJ on MRI and how this differs between patients with and without DLM. MATERIALS AND METHODS: Fifty-eight patients with DLM and 58 age-matched controls (normal meniscus) were included in this study...
August 11, 2018: Knee
https://www.readbyqxmd.com/read/30102447/delayed-gadolinium-enhanced-mri-of-menisci-and-cartilage-dgemrim-dgemric-in-obese-patients-with-knee-osteoarthritis-cross-sectional-study-of-85-obese-patients-with-intra-articular-administered-gadolinium-contrast
#17
Stine Hangaard, Henrik Gudbergsen, Cecilie L Daugaard, Henning Bliddal, Janus Damm Nybing, Miika T Nieminen, Victor Casula, Carl-Johan Tiderius, Mikael Boesen
BACKGROUND: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). PURPOSE: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA. STUDY TYPE: Cross-sectional...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/30079757/modeling-and-staging-of-osteoarthritis-progression-using-serial-ct-imaging-and-arthroscopy
#18
Candace Flynn, Mark Hurtig, Emma Lamoure, Erin Cummins, Valeria Roati, Mark Lowerison, Sang Young Jeong, Wonil Oh, Alex Zur Linden
Objective The objective of this study was to describe in life methods by which osteoarthritis can be staged in order to time therapeutic interventions that are relevant to osteoarthritis (OA) clinical trials Methods Twenty-two sheep underwent arthroscopic meniscal destabilization to induce OA. Serial computed tomography (CT) imaging and arthroscopy were used to monitor osteoarthritis progression at 3-month intervals over 9 months. Eleven sheep received 1 intra-articular injection of hyaluronate 3 months after OA induction and another group of 11 received saline...
August 6, 2018: Cartilage
https://www.readbyqxmd.com/read/30074063/the-medial-open-wegde-osteotomy-generates-progressive-intrameniscal-integrity-changes-in-the-lateral-knee-compartment-a-prospective-mr-assessment-after-valgic-osteotomy-in-the-varus-gonarthritic-knee
#19
F Bick, Y Iffland, E Zimmermann, F Welsch, R Hoffmann, Thomas Stein
PURPOSE: Meniscal changes in the lateral knee compartment after medial-opening high tibial osteotomy (HTO) with valgic overcorrection have not been investigated clinically with magnetic resonance imaging (MRI). The hypothesis of this study was that HTO with valgic overcorrection affects the lateral compartment due to the change in the bearing axis and the shift in the pressure load from the medial to the lateral compartment. This should lead to an accelerated degeneration of the lateral compartment...
August 3, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/30055602/efficacy-of-intra-articular-injections-of-platelet-rich-plasma-as-a-symptom-and-disease-modifying-treatment-for-knee-osteoarthritis-the-restore-trial-protocol
#20
Kade L Paterson, David J Hunter, Ben R Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P Yu, Bing Hui Wang, David Connell, James Linklater, Kim L Bennell
BACKGROUND: Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and structural deterioration over time. Platelet-rich plasma (PRP) is a therapeutic agent that aims to address underlying biological processes responsible for OA pathogenesis. As such, it has the potential to improve both symptoms and joint structure. The aim of this clinical trial is to determine whether a series of injections of PRP into the knee joint will lead to a significantly greater reduction in knee pain, and less loss of medial tibial cartilage volume over 12 months when compared to a series of placebo saline injections in people with knee OA...
July 28, 2018: BMC Musculoskeletal Disorders
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