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Meniscal morphology

Russell Chapin
In the postmeniscectomy or meniscal repair setting, there is overlap between expected postoperative change and findings of a re-torn meniscus, particularly increased T1-weighted or proton density signal contacting the articular surface. Protocol selection and accurate diagnosis requires knowledge of meniscal tear treatment, the expected postoperative appearance, and criteria for re-tear. Criteria for meniscal re-tear on MR imaging are high T2-weighted signal reaching the articular surface, abnormal meniscal morphology not explained by the surgery, or a displaced fragment...
November 2018: Radiologic Clinics of North America
Valentina Pedoia, Berk Norman, Sarah N Mehany, Matthew D Bucknor, Thomas M Link, Sharmila Majumdar
BACKGROUND: Semiquantitative assessment of MRI plays a central role in musculoskeletal research; however, in the clinical setting MRI reports often tend to be subjective and qualitative. Grading schemes utilized in research are not used because they are extraordinarily time-consuming and unfeasible in clinical practice. PURPOSE: To evaluate the ability of deep-learning models to detect and stage severity of meniscus and patellofemoral cartilage lesions in osteoarthritis and anterior cruciate ligament (ACL) subjects...
October 10, 2018: Journal of Magnetic Resonance Imaging: JMRI
Fredrik Svensson, David T Felson, Fan Zhang, Ali Guermazi, Frank W Roemer, Jingbo Niu, Piran Aliabadi, Tuhina Neogi, Martin Englund
OBJECTIVES: To determine meniscal extrusion and cartilage coverage on magnetic resonance (MR) images and factors associated with these parameters in knees of middle-aged and elderly persons free from radiographic tibiofemoral osteoarthritis (OA). METHODS: Seven hundred eighteen persons, free of radiographic tibiofemoral OA, aged 50-90 years from Framingham, MA, USA, were included. We measured meniscal extrusion on 1.5 T MRI of both knees to evaluate both medial and lateral meniscal body extrusion and cartilage coverage...
October 2, 2018: European Radiology
Yan Liang, Enaam Idrees, Alexander R A Szojka, Stephen H J Andrews, Melanie Kunze, Aillette Mulet-Sierra, Nadr M Jomha, Adetola B Adesida
The objective of this study was to investigate whether meniscus-derived decellularized matrix (DCM) has the capacity to induce differentiation of synovial fluid-derived mesenchymal stem cells (SF-MSCs) towards a meniscus fibrochondrocyte (MFC) phenotype. The potential roles of transforming growth factor beta-3 (TGF-β3 ) and insulin-like growth factor 1 (IGF-1) in the differentiation of SF-MSCs towards an MFC phenotype were also investigated. SF-MSCs were isolated via plastic adherence cell culture from the synovial fluid of five donors (5 male, average age 34 years)...
September 26, 2018: Acta Biomaterialia
Yoshiki Okazaki, Takayuki Furumatsu, Shinichi Miyazawa, Yuya Kodama, Yusuke Kamatsuki, Tomohito Hino, Shin Masuda, Toshifumi Ozaki
PURPOSE: The purpose of this study was to evaluate the shape and shift of the medial meniscus before and after meniscal repair concurrent with anterior cruciate ligament (ACL) reconstruction using magnetic resonance imaging (MRI) at 90° of knee flexion. METHODS: This study included 18 patients with ACL-deficient knees without meniscus tears (group A), 11 patients with medial meniscus tears alone (group M), and 15 patients with ACL-deficient knees complicated with medial meniscus tears (group AM)...
September 24, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Mary Monica Bernardo-Bueno, Consuelo B Gonzalez-Suarez, Andrea Kristina Malvar, Ronald Cua, Daniel Feliciano, Bee Giok Tan-Sales, Svetlana Maris O Aycardo, Millicent Tan-Ong, Robert Chan, Francisco De Los Reyes
OBJECTIVE: The aim of this cross-sectional correlational study was to determine the association of pain with morphologic and inflammatory sonographic findings in patients with knee osteoarthritis. METHODS: A total of 113 participants with knee osteoarthritis were assessed using visual analog scale pain score and sonography. Ultrasound evaluation included morphologic changes (ie, articular cartilage degeneration, medial and lateral meniscal protrusion, and presence of osteophytes on the joint margins) and inflammatory changes (ie suprapatellar effusion and/or synovitis, Baker cyst, superficial and deep infrapatellar effusion, pes anserine tendinopathy, and Hoffa panniculitis)...
September 21, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Pei Wang, Jonas Balko, Rui Lu, Ángela I López-Lorente, Lutz Dürselen, Boris Mizaikoff
Degeneration of human meniscal tissue induces impairment of normal knee functions, and is a highly relevant etiology of knee joint tears and osteoarthritis. Currently, the grading scale of meniscus degeneration is conventionally derived from evaluating meniscal morphology and histological staining. However, mid-infrared attenuated total reflectance (IR-ATR) spectroscopy is a particularly useful technique that may analyze the biomolecular composition at a sample surface, and provide information on the intra- and/or inter-molecular chemical bonds...
September 19, 2018: Analyst
Gokhan Bahcecioglu, Nesrin Hasirci, Bahar Bilgen, Vasif Hasirci
In this study, porcine fibrochondrocyte-seeded agarose, methacrylated gelatin (GelMA), methacrylated hyaluronic acid (MeHA) and GelMA-MeHA blend hydrogels, and 3D printed PCL scaffolds were tested under dynamic compression for potential meniscal regeneration in vitro. Cell-carrying hydrogels produced higher levels of extracellular matrix (ECM) components after a 35-day incubation than the 3D printed PCL. Cells on GelMA exhibited strong cell adhesion (evidenced with intense paxillin staining) and dendritic cell morphology, and produced an order of magnitude higher level of collagen (p < 0...
September 12, 2018: International Journal of Biological Macromolecules
Shi Shen, Mingxue Chen, Shuang Gao, Weimin Guo, Zhenyong Wang, Haojiang Li, Xu Li, Bin Zhang, Hai Xian, Xueliang Zhang, Shuyun Liu, Libo Hao, Naiqiang Zhuo, Quanyi Guo
Objective: To manufacture a polycaprolactone (PCL)/type Ⅰ collagen (COL Ⅰ) tissue engineered meniscus scaffold (hereinafter referred to as PCL/COL Ⅰ meniscus scaffold) by three-dimensional (3D) printing with low temperature deposition technique and to study its physicochemical properties. Methods: First, the 15% PCL/4% COLⅠ composite solution and 15% PCL simple solution were prepared. Then, 15% PCL/4% COL Ⅰmeniscus scaffold and 15% PCL meniscal scaffold were prepared by using 3D printing with low temperature deposition techniques...
September 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Norifumi Suga, Tomoyuki Nakasa, Masakazu Ishikawa, Atsuo Nakamae, Seiju Hayashi, Masahiro Yoshikawa, Yoshikazu Sumida, Yusuke Tsuyuguchi, Nobuo Adachi
BACKGROUND: Patients with discoid lateral meniscus (DLM) are prone to meniscal injuries related to its shape and abnormal mobility. The anatomical joint inclination of the proximal tibiofibular joint (PTFJ) can also affect joint movement in knee motion. However, an association between PTFJ morphology and DLM remains unclear. The purpose of this study was to investigate the morphology of the PTFJ on MRI and how this differs between patients with and without DLM. MATERIALS AND METHODS: Fifty-eight patients with DLM and 58 age-matched controls (normal meniscus) were included in this study...
August 11, 2018: Knee
Stine Hangaard, Henrik Gudbergsen, Cecilie L Daugaard, Henning Bliddal, Janus Damm Nybing, Miika T Nieminen, Victor Casula, Carl-Johan Tiderius, Mikael Boesen
BACKGROUND: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). PURPOSE: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA. STUDY TYPE: Cross-sectional...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Candace Flynn, Mark Hurtig, Emma Lamoure, Erin Cummins, Valeria Roati, Mark Lowerison, Sang Young Jeong, Wonil Oh, Alex Zur Linden
Objective The objective of this study was to describe in life methods by which osteoarthritis can be staged in order to time therapeutic interventions that are relevant to osteoarthritis (OA) clinical trials Methods Twenty-two sheep underwent arthroscopic meniscal destabilization to induce OA. Serial computed tomography (CT) imaging and arthroscopy were used to monitor osteoarthritis progression at 3-month intervals over 9 months. Eleven sheep received 1 intra-articular injection of hyaluronate 3 months after OA induction and another group of 11 received saline...
August 6, 2018: Cartilage
F Bick, Y Iffland, E Zimmermann, F Welsch, R Hoffmann, Thomas Stein
PURPOSE: Meniscal changes in the lateral knee compartment after medial-opening high tibial osteotomy (HTO) with valgic overcorrection have not been investigated clinically with magnetic resonance imaging (MRI). The hypothesis of this study was that HTO with valgic overcorrection affects the lateral compartment due to the change in the bearing axis and the shift in the pressure load from the medial to the lateral compartment. This should lead to an accelerated degeneration of the lateral compartment...
August 3, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Kade L Paterson, David J Hunter, Ben R Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P Yu, Bing Hui Wang, David Connell, James Linklater, Kim L Bennell
BACKGROUND: Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and structural deterioration over time. Platelet-rich plasma (PRP) is a therapeutic agent that aims to address underlying biological processes responsible for OA pathogenesis. As such, it has the potential to improve both symptoms and joint structure. The aim of this clinical trial is to determine whether a series of injections of PRP into the knee joint will lead to a significantly greater reduction in knee pain, and less loss of medial tibial cartilage volume over 12 months when compared to a series of placebo saline injections in people with knee OA...
July 28, 2018: BMC Musculoskeletal Disorders
Brian C Lau, Toure Vashon, Abhinav Janghala, Nirav K Pandya
BACKGROUND: Discoid lateral meniscus (DLM) is a morphologic variant in which concomitant articular cartilage defects lead to poor outcomes. The purpose of this study was to quantify the prognostic ability of history, physical examination, and magnetic resonance imaging (MRI) to identify arthroscopically confirmed articular cartilage injury in pediatric and adolescent DLM patients. METHODS: An analysis of 34 consecutive patients (mean, 12.5 y) who underwent surgical treatment for DLM...
October 2018: Journal of Pediatric Orthopedics
Ashley A Williams, Matthew R Titchenal, Bao H Do, Aditi Guha, Constance R Chu
Alteration of deep cartilage matrix has been observed following anterior cruciate ligament (ACL) injury, evidenced by elevated MRI UTE-T2* values measured in small, 2-D cartilage regions of interest. This Level I diagnostic study seeks to more thoroughly evaluate deep cartilage matrix changes to medial tibiofemoral UTE-T2* maps 2 years after ACL reconstruction and examine the relative utilities of 3-D compared to 2-D assessments of cartilage UTE-T2* maps. Thirty-eight ACL-reconstructed and 20 uninjured subjects underwent MRI UTE-T2* mapping...
July 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Takayuki Furumatsu, Ami Maehara, Yuki Okazaki, Toshifumi Ozaki
BACKGROUND: A complete discoid lateral meniscus (DLM) has a high risk of horizontal tear. However, cellular phenotypes and extracellular matrix organizations in complete DLMs are still unclear. The aim of this study was to investigate histological and cellular biological characteristics in both the intercondylar and central regions of complete DLM. MATERIALS AND METHODS: Meniscal samples were obtained from the intercondylar and central regions of complete DLM (n = 6)...
September 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
C Park, J M Ahn, H Kim, Y Kang, E Lee, J W Lee, H S Kang
AIM: To evaluate the prevalence, clinical relevance, and magnetic resonance imaging (MRI) features of extra-capsular ganglia at the gastrocnemius origin and to assess their association with internal derangement and osteoarthritis of the knee. MATERIALS AND METHODS: One hundred consecutive knee MRI examinations, obtained within a 6-month period from patients with no history of recent knee trauma, recent injections, inflammatory arthritis, infection, or tumours, were evaluated retrospectively for the presence of ganglia at the gastrocnemius origin...
September 2018: Clinical Radiology
G B Joseph, M C Nevitt, C E McCulloch, J Neumann, J A Lynch, U Heilmeier, N E Lane, T M Link
OBJECTIVE: The purpose of this study was to assess the associations between serum/urine biomarkers for osteoarthritis and magnetic resonance (MR) imaging measures of cartilage composition and joint structure (cartilage, meniscus, and bone marrow), using MR imaging data from the Osteoarthritis Initiative (OAI). DESIGN: 141 subjects with Kellgren Lawrence (KL) grades 0-3 in the right knee and with available serum/urine biomarker assays were selected from the OAI. Cartilage magnetic resonance imaging (MRI) T2 measurements were performed in the medial femur, lateral femur, medial tibia, lateral tibia, and patella compartments...
August 2018: Osteoarthritis and Cartilage
Mehdi Shekarforoush, Jillian E Beveridge, David A Hart, Cyril B Frank, Nigel G Shrive
The relations between kinematic abnormalities and post traumatic osteoarthritis have not yet been clearly elucidated. This study was conducted to determine the finite helical axes parameters and the tibiofemoral translation vector in the knee joints of two surgically induced injury sheep models: anterior cruciate ligament and medial collateral ligament transection (ACL/MCL Tx) (n = 5) and lateral meniscectomy (n = 5). We hypothesized that morphological damage in the experimental joints would be correlated to alterations in these kinematic variables...
June 25, 2018: Journal of Biomechanics
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