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https://www.readbyqxmd.com/read/30334339/quantification-and-phenotypic-characterization-of-peripheral-blood-v%C3%AE-1-t-cells-in-chronic-lymphocytic-leukemia-and-monoclonal-b-cell-lymphocytosis
#1
Catarina Simões, Isabel Silva, Anabela Carvalho, Sandra Silva, Susana Santos, Gilberto Marques, André Ribeiro, Adriana Roque, José Carda, A B Sarmento-Ribeiro, Maria do Rosário Domingues, Letícia Ribeiro, Artur Paiva
BACKGROUND: Vδ1+ T cells, a subset of γδ T cells, are responsible for innate-like immune responses. Recently, an anti-tumor function mediated by MHC-unrestricted recognition of lipid and stress molecules, has also been described in these cells. This study aimed to quantify and phenotypically characterize circulating Vδ1+ T cells in B cell Chronic Lymphocytic Leukemia (CLL) and Monoclonal B cell lymphocytosis (MBL). METHODS: This study enrolled 58 individuals distributed in five groups: Binet B and C CLL (n = 9), Binet A CLL (n = 26), High count-MBL (n = 10), Low count-MBL (n = 5), and a control group (n = 8)...
October 17, 2018: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/30326727/deficiency-of-crth2-a-prostaglandin-d-2-receptor-aggravates-bleomycin-induced-pulmonary-inflammation-and-fibrosis
#2
Soichiro Ueda, Koichi Fukunaga, Takahisa Takihara, Yoshiki Shiraishi, Tsuyoshi Oguma, Tetsuya Shiomi, Yusuke Suzuki, Makoto Ishii, Koichi Sayama, Shizuko Kagawa, Hiroyuki Hirai, Kinya Nagata, Masataka Nakamura, Taku Miyasho, Tomoko Betsuyaku, Koichiro Asano
Chemoattractant receptor homologous with Th2 cells (CRTH2), a receptor for prostaglandin D2 is preferentially expressed on Th2 lymphocytes, group 2 innate lymphoid cells, eosinophils, and basophils, and elicits production of type2 cytokines including profibrotic IL-13. We supposed lack of CRTH2 might be protective role against fibrotic lung disease and examined bleomycin-induced lung inflammation and fibrosis model with CRTH2-deficient (CRTH2-/-) or wild-type BALB/c mice. Compared to the wild-type, CRTH2-/- mice treated with bleomycin exhibited significantly higher mortality, enhanced accumulation of inflammatory cells 14-21 days after bleomycin injection, reduced pulmonary compliance, and increased levels of collagen and total protein in the lungs...
October 16, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30325010/th17-responses-to-pneumococcus-in-blood-and-adenoidal-cells-in-children
#3
Elizabeth Oliver, Caroline Pope, Ed Clarke, Claire Langton Hewer, Abiodun D Ogunniyi, James C Paton, Tim Mitchell, Richard Malley, Adam Finn
Pneumococcal infections cause a large global health burden and the search for serotype-independent vaccines continues. Existing conjugate vaccines reduce nasopharyngeal colonisation by target serotypes. Such mucosal effects of novel antigens may likewise be important. CD4+ Th17 cell-dependent, antibody-independent reductions in colonisation and enhanced clearance have been described in mice. Here we describe the evaluation of Th17 cytokine responses to candidate pneumococcal protein vaccine antigens in human cell culture, using adenoidal and peripheral blood mononuclear cells...
October 16, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/30307485/blockade-of-nkg2d-nkg2d-ligand-interaction-attenuated-cardiac-remodeling-after-myocardial-infarction
#4
Kotaro Matsumoto, Masanori Obana, Arisa Kobayashi, Miho Kihara, Go Shioi, Shigeru Miyagawa, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yoshiki Sawa, Yasushi Fujio
Aims: Accumulating evidence demonstrates that cardiomyocyte death contributes to the onset and progression of heart failure (HF) after myocardial injury. Recent studies revealed that immune/inflammatory reactions play important roles in cardiovascular diseases. However, it remains unclear whether immunosurveillance system, which eliminates cytopathic cells, including infected or malignant cancer cells, is involved in cardiomyocyte death, though cardiomyocytes are exposed to pathological stresses during post-infarct remodeling...
October 11, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/30300386/ablation-of-nasal-associated-lymphoid-tissue-does-not-affect-focal-ischemic-brain-injury-in-mice
#5
David Brea, Carrie Poon, Michelle Murphy, Gabrielle Lubitz, Costantino Iadecola, Josef Anrather
Stroke is a devastating disease with a strong inflammatory component. It has been shown that part of this response is mediated by IL17+ γδT cells. γδT cells constitute a lymphocyte population with innate features that mainly populates epithelial surfaces including skin, intestine, and airways. We have shown that in the context of stroke, T cells migrate from the small intestine to the meninges but whether they can migrate from other epithelial surfaces is still unknown. Because of its proximity, one possible source of stroke-associated IL17+ γδT cells could be the Nasal-Associated Lymphoid Tissue (NALT) from which T cells could migrate along olfactory nerve sheaths through the cribriform plate into the brain and/or meninges...
2018: PloS One
https://www.readbyqxmd.com/read/30277172/murine-skin-resident-%C3%AE-%C3%AE-t-cells-impair-the-immune-response-to-hsv-in-skin
#6
Marian A Fernandez, Uet Yu, Angela L Ferguson, Dongwei Wang, Elise Francis, Ben Roediger, Wolfgang Weninger, Laurence C Cantrill, Anthony L Cunningham, Stephen I Alexander, Cheryl A Jones
HSV is an important cause of brain infection. Virus entry is often through breeches in the skin. γδT cells play an immunoprotective role in mice after corneal, genital or footpad (subcutaneous) HSV infection. Here we report that the presence of γδT cells in murine skin is associated with increased severity of herpetic disease, reduced protective cytokine responses and increased viral spread from the skin to the sensory ganglia in the zosteriform model. γδT cell-deficient (TCR δ -/-) mice displayed significantly decreased herpetic lesion severity after flank HSV infection compared to WT C57BL/6 controls at both primary and secondary skin infection sites...
October 1, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/30275537/nkr-p1b-expression-in-gut-associated-innate-lymphoid-cells-is-required-for-the-control-of-gastrointestinal-tract-infections
#7
Elias Abou-Samra, Zachary Hickey, Oscar A Aguilar, Michal Scur, Ahmad Bakur Mahmoud, Sergey Pyatibrat, Megan M Tu, Jeffrey Francispillai, Arthur Mortha, James R Carlyle, Mir Munir A Rahim, Andrew P Makrigiannis
Helper-type innate lymphoid cells (ILC) play an important role in intestinal homeostasis. Members of the NKR-P1 gene family are expressed in various innate immune cells, including natural killer (NK) cells, and their cognate Clr ligand family members are expressed in various specialized tissues, including the intestinal epithelium, where they may play an important role in mucosal-associated innate immune responses. In this study, we show that the inhibitory NKR-P1B receptor, but not the Ly49 receptor, is expressed in gut-resident NK cells, ILC, and a subset of γδT cells in a tissue-specific manner...
October 1, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/30194922/the-role-of-gamma-delta-t-lymphocytes-in-breast-cancer-a-review
#8
REVIEW
Elizabeth S Morrow, Antonia Roseweir, Joanne Edwards
Gammadelta T (γδT) lymphocytes have provoked interest in oncology, particularly as regards their potential use in immunotherapy, because of their unique ability to recognise antigens without a requirement for major histocompatibility complex antigen presentation, and to quickly activate an anti-tumour response. However, work in some cancers has suggested that they also have pro-tumourigenic activity. Their role in breast cancer is unclear. This review outlines the evidence to date in in vitro studies, in vivo mouse models and in human studies regarding the role of γδT lymphocytes in breast cancer...
August 18, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/30122755/-cytotoxic-effects-of-%C3%AE-%C3%AE-t-cells-on-bladder-cancer-cells-and-expression-of-mica-b-in-bladder-cancer
#9
J H Zhou, D Wang, H R Wang, X L Hou, W D Yu, K X Xu, H Hu
OBJECTIVE: To explore the role of γδT cells against bladder cancer and to detect the expression of stress proteins MICA/B recognized by γδT cells in bladder cancer. METHODS: γδT cells from peripheral blood drawn from 6 bladder cancer patients with pamidronate stimulating were expanded. Flow cytometry was used to detect the purity and expansion folds of γδT cells, and the expression of CD107a on γδT cells after PMA/ionomycin stimulated. The cytotoxicity assay was carried out to test the cytotoxicity of γδT cells against human bladder cancer cell lines...
August 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/30110057/effects-of-baicalin-on-inflammatory-reaction-oxidative-stress-and-pkdl-and-nf-kb-protein-expressions-in-rats-with-severe-acute-pancreatitis1
#10
Yunzhong Qian, Yi Chen, Linyang Wang, Jinfa Tou
PURPOSE: To investigate the effects of baicalin on inflammatory reaction, oxidative stress and protein kinase D1 (PKD1) and nuclear factor-kappa B (NF-κB) protein expressions in severe acute pancreatitis (SAP) rats. METHODS: Sixty rats were divided into sham operation, model, and low-, medium- and high-dose baicalin group. SAP model was established in later 4 groups. The later 3 groups were injected with 0.1, 0.2 and 0.4 ml/100 g 5% baicalin injection, respectively...
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30003413/subpopulation-structure-of-ifn%C3%AE-producing-t-lymphocytes-in-patients-with-pulmonary-tuberculosis
#11
T E Kononova, O I Urazova, V V Novitskii, I E Esimova, E G Churina
The study of subpopulation structure of IFNγ-producing T cells in patients with pulmonary tuberculosis revealed a decrease in the number of CD3+ IFNγ+ cells against the background of significantly increased IFNγ secretion in vitro irrespective of the clinical form of the disease and drug sensitivity of M. tuberculosis, most strongly expressed in case of the disseminated tuberculosis. In patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis, increased number of Th1/Th17 lymphocytes (CD4+ IFNγ+ IL-17A+ ) and, conversely, decreased number of blood γδT cells was detected...
July 12, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29997614/engineering-approaches-in-human-gamma-delta-t-cells-for-cancer-immunotherapy
#12
REVIEW
Jonathan Fisher, John Anderson
Sharing both innate and adaptive immune properties, γδT cells are attractive candidates for cellular engineering. As the cancer immunotherapy field becomes increasingly busy, orthogonal approaches are required to drive advancement. Engineering of alternative effector cell types such as γδT cells represents one such approach. γδT cells can be modified using many of the techniques used in αβT cell engineering, with the added advantage of innate-like tumor recognition and killing. Progress has been made in T-cell receptor transfer to and from γδT cells as well as in a number of chimeric antigen receptor-based strategies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29996205/-changes-and-clinical-significance-of-%C3%AE-%C3%AE-t-cells-in-peripheral-blood-of-patients-with-chronic-hepatitis-b-during-pegylated-interferon-%C3%AE-2a-treatment
#13
K Liu, Y X Shen, N Ling, Y Lei, P Hu, H Ren, M Chen
Objective: To observe the changes of γδT cells in the peripheral blood of patients with chronic hepatitis B (CHB) during pegylated interferon α-2a treatment, and to analyze the correlation between clinical indicators and curative effects. Methods: Peripheral blood of hepatitis B e antigen (HBeAg)-positive CHB patients were collected at different time points of Peg-IFNα-2a treatment, including 17 patients at 0 weeks, 20 patients at 12 weeks, 20 patients at 24 weeks, and 16 patients at 48 weeks. From these 11 patients, blood samples were frequently observed at 0, 12, 24, and 48 weeks of treatment...
May 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29995107/imbalance-of-%C3%AE-%C3%AE-t17-%C3%AE-%C3%AE-treg-cells-in-the-pathogenesis-of-allergic-asthma-induced-by-ovalbumin
#14
Xia Yang, Jing-Hong Zhang, Wang-Sheng Deng, Chao-Qian Li
We aimed to explore the imbalance between the T helper 17 γδT cells (γδT17) and the regulatory γδT cells (γδTreg) in asthmatic mice. Male Balb/c mice were randomly divided into the normal control group and the asthmatic model group. The asthmatic model group mice were intraperitoneally injected with the mixture of ovalbumin (OVA)/Al(OH)3 and then activated by exposure of the animals to OVA atomization. Airway hyperresponsiveness (AHR) was determined by a non-invasive lung function machine. Hematoxylin and eosin and Alcian blue-periodic acid Schiff staining were done for histopathological analysis...
July 10, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29977242/pivotal-role-of-il-22-binding-protein-in-the-epithelial-autoregulation-of-interleukin-22-signaling-in-the-control-of-skin-inflammation
#15
Tomohiro Fukaya, Takehito Fukui, Tomofumi Uto, Hideaki Takagi, Junta Nasu, Noriaki Miyanaga, Keiichi Arimura, Takeshi Nakamura, Haruhiko Koseki, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato
Disruption of skin homeostasis can lead to inflammatory cutaneous diseases resulting from the dysregulated interplay between epithelial keratinocytes and immune cells. Interleukin (IL)-22 signaling through membrane-bound IL-22 receptor 1 (IL-22R1) is crucial to maintain cutaneous epithelial integrity, and its malfunction mediates deleterious skin inflammation. While IL-22 binding protein (IL-22BP) binds IL-22 to suppress IL-22 signaling, how IL-22BP controls epithelial functionality to prevent skin inflammation remains unclear...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29938921/prevalence-and-characteristics-of-persistent-clonal-t-lgl-expansions-in-rheumatoid-arthritis-a-comprehensive-analysis-of-529-patients
#16
Eva C Schwaneck, Regina Renner, Lara Junker, Hermann Einsele, Ottar Gadeholt, Eva Geissinger, Stefan Kleinert, Michael Gernert, Hans-Peter Tony, Marc Schmalzing
OBJECTIVE: Up to one third of patients with T-cell large granular lymphocyte leukemia (T-LGL-leukemia) display symptoms of rheumatoid arthritis (RA). In Crohn's disease and in psoriasis treatment with TNFα-inhibitors is associated with hepatosplenic γδT-cell-lymphoma and with clonal expansion of γδT-cells, respectively. Here, we determine the prevalence of clonal T-LGL cells in patients with RA and define risk factors for this rare hematologic malignancy. METHODS: 529 RA-patients were recruited between November, 2013 and August, 2015...
June 25, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29899740/gmp-grade-manufacturing-of-t-cells-engineered-to-express-a-defined-%C3%AE-%C3%AE-tcr
#17
Trudy Straetemans, Guido J J Kierkels, Ruud Doorn, Koen Jansen, Sabine Heijhuurs, Joao M Dos Santos, Anna D D van Muyden, Henri Vie, Béatrice Clemenceau, Reinier Raymakers, Moniek de Witte, Zsolt Sebestyén, Jürgen Kuball
γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-mediated metabolic changes. However, a major limitation of the therapeutic application of γ9δ2T cells is their diversity and regulation through innate co-receptors. In order to overcome natural obstacles of γ9δ2T cells, we have developed the concept of T cells engineered to express a defined γδT cell receptor (TEGs). This next generation of chimeric antigen receptor engineered T (CAR-T) cells not only allows for targeting of hematological but also of solid tumors and, therefore, overcomes major limitations of many CAR-T and γδT cell strategies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29867959/thymic-program-directing-the-functional-development-of-%C3%AE-%C3%AE-t17-cells
#18
REVIEW
Youenn Jouan, Emmanuel C Patin, Maya Hassane, Mustapha Si-Tahar, Thomas Baranek, Christophe Paget
γδT cells comprise a unique T cell sublineage endowed with a wide functional repertoire, which allow them to play important-sometimes opposite-roles in many immune responses associated with infection, cancer, and inflammatory processes. This is largely dependent on the existence of pre-programmed discrete functional subsets that differentiate within the thymus at specific temporal windows of life. Since they represent a major early source of interleukin-17A in many models of immune responses, the γδT17 cell population has recently gained considerable interest...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29867952/fish-lymphocytes-an-evolutionary-equivalent-of-mammalian-innate-like-lymphocytes
#19
REVIEW
Giuseppe Scapigliati, Anna M Fausto, Simona Picchietti
Lymphocytes are the responsible of adaptive responses, as they are classically described, but evidence shows that subpopulations of mammalian lymphocytes may behave as innate-like cells, engaging non-self rapidly and without antigen presentation. The innate-like lymphocytes of mammals have been mainly identified as γδT cells and B1-B cells, exert their activities principally in mucosal tissues, may be involved in human pathologies and their functions and tissue(s) of origin are not fully understood. Due to similarities in the morphology and immunobiology of immune system between fish and mammals, and to the uniqueness of having free-living larval stages where the development can be precisely monitored and engineered, teleost fish are proposed as an experimental model to investigate human immunity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29797009/isolating-immune-cells-from-mouse-embryonic-skin
#20
Ambika S Kurbet, Srikala Raghavan
Skin is the primary barrier against the external environment and develops a robust immune network for its surveillance. The origin of the resident immune cells of the skin has become a focus of interest over past a decade. Fate mapping studies have revealed that the macrophages home into the skin as early as E12.5 and are derived from the yolk sac and fetal liver. The resident γδT cells are born in the thymus and home to the skin by E16.5. Recent work from our lab has shown that the embryonic macrophages can actively remodel the extracellular matrix in skin suggesting that the skin immune system can be activated long before exposure to foreign antigens...
May 24, 2018: Methods in Molecular Biology
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