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https://www.readbyqxmd.com/read/30109544/phase-ii-feasibility-study-of-preoperative-concurrent-chemoradiotherapy-with-cisplatin-plus-5-fluorouracil-and-elective-lymph-node-irradiation-for-clinical-stage-ii-iii-esophageal-squamous-cell-carcinoma
#1
Jun Hashimoto, Ken Kato, Yoshinori Ito, Takashi Kojima, Tetsuo Akimoto, Hiroyuki Daiko, Yasuo Hamamoto, Hisayuki Matsushita, Susumu Katano, Hiroki Hara, Yoichi Tanaka, Yoshihiro Saito, Kengo Nagashima, Hiroyasu Igaki
BACKGROUND: Preoperative chemoradiotherapy (CRT) is a standard treatment for stage II/III esophageal cancer. Preoperative chemotherapy is also considered a standard treatment for stage II/III esophageal squamous cell carcinoma (ESCC) in patients who undergo radical lymph node dissection. We conducted a feasibility study of preoperative CRT with cisplatin plus 5-fluorouracil (CF) and elective lymph node irradiation followed by esophagectomy with radical lymph node dissection in patients with stage II/III ESCC...
August 14, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30105451/compensatory-hypertrophy-of-the-liver-after-external-beam-radiotherapy-for-primary-liver-cancer
#2
Chai Hong Rim, Sangjoon Park, Joong Yeol Woo, Jinsil Seong
PURPOSE: We investigated whether external beam radiotherapy (EBRT) could induce compensatory liver hypertrophy in liver cancers and assessed related clinical factors. METHODS: A total of 82 consecutive patients receiving EBRT for hepatocellular carcinoma (n = 77) or cholangiocarcinoma (n = 5) from April 2012 to June 2014 were recruited and divided into two subgroups according to tumor location in the right or left lobe. The left lateral and right lobes were considered as unirradiated volumes accordingly...
August 13, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30100754/prognostic-value-of-subcutaneous-adipose-tissue-volume-in-hepatocellular-carcinoma-treated-with-transcatheter-intra-arterial-therapy
#3
Takamasa Kobayashi, Hirokazu Kawai, Oki Nakano, Satoshi Abe, Hiroteru Kamimura, Akira Sakamaki, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Satoshi Yamagiwa, Shuji Terai
Background: Prognosis of patients with hepatocellular carcinoma (HCC) who undergo transcatheter intra-arterial therapies, including transcatheter arterial chemoembolization and transcatheter arterial infusion chemotherapy, is affected by many clinical factors including liver function and tumor progression. However, the effect of body composition such as skeletal muscle and visceral and subcutaneous adipose tissues (VAT and SAT, respectively) on the prognosis of these patients remains unclear...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30097433/a-phase-i-iia-trial-using-cd19-targeted-third-generation-car-t-cells-for-lymphoma-and-leukemia
#4
Gunilla Enblad, Hannah Karlsson, Gustav Gammelgard, Jessica Wenthe, Tanja Lovgren, Rose-Marie Amini, Kristina I Wikstrom, Magnus Essand, Barbara Savoldo, Helene Hallbook, Martin Höglund, Gianpietro Dotti, Malcolm K Brenner, Hans Hagberg, Angelica Loskog
PURPOSE: CAR T cell therapy has been effective for patients with CD19+ B cell malignancies. Most studies have investigated second generation CARs with either CD28 or 4-1BB co-stimulatory domains in the CAR receptor. Here we describe the first clinical phase I/IIa trial using third generation CAR T cells targeting CD19 to evaluate safety and efficacy. EXPERIMENTAL DESIGN: Fifteen patients with B cell lymphoma or leukemia were treated with CAR T cells. The lymphoma patients received chemotherapy during CAR manufacture and eleven of fifteen were given low dose cyclophosphamide and fludarabine conditioning prior to CAR infusion...
August 10, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30094066/high-incidence-of-cetuximab-related-infusion-reactions-in-head-and-neck-patients
#5
Virginia Palomar Coloma, Pamela Bravo, Naima Lezghed, Lamia Mayache-Badis, Ruth Gabriela Herrera Gómez, Mariana Iacob, Laurence Nicouleau, Romain Desmaris, Yungan Tao, Cristian Leibu, Margarida Matias, Francois Lemare, Caroline Even, Maxime Annereau, Charles Ferté
Background: Cetuximab is crucial in the management of squamous cell carcinoma of the head and neck of patients. Grade 3-4 cetuximab-induced infusion reactions (CI-IRs) occur in 2% of patients with colorectal cancer. Despite the 2.7% CI-IR rate in the EXTREME trial, higher rates were reported in small series of patients with head and neck squamous cell carcinoma (HNSCC) (6%-18%). There is an urgent need to better appraise the natural history and the predictive factors for CI-IRs in patients with HNSCC exposed to cetuximab...
2018: ESMO Open
https://www.readbyqxmd.com/read/30091239/significance-of-hepatic-resection-and-adjuvant-hepatic-arterial-infusion-chemotherapy-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus-in-the-first-branch-of-portal-vein-and-the-main-portal-trunk-a-project-study-for-hepatic-surgery-of-the-japanese
#6
Etsuro Hatano, Shinji Uemoto, Hiroki Yamaue, Masakazu Yamamoto
BACKGROUND: The prognosis of hepatocellular carcinoma (HCC) with tumor thrombus in the major portal vein (PV) is extremely poor. The purpose of this study is to clarify the impact of hepatic resection for HCC with tumor thrombus in the major PV. PATIENTS: Four hundred patients undergoing macroscopic curative resection for HCC involving the first branch or trunk of the PV between 2001 and 2010 at the 22 institutions were enrolled. We examined the effect of adjuvant hepatic arterial infusion chemotherapy (HAIC) on prognosis and validated the prognostic index consisting of ascites, prothrombin activity, and maximal tumor diameter...
August 8, 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/30083834/downstaging-with-localized-concurrent-chemoradiotherapy-can-identify-optimal-surgical-candidates-in-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus
#7
Jae Uk Chong, Gi Hong Choi, Dai Hoon Han, Kyung Sik Kim, Jinsil Seong, Kwang-Hyub Han, Jin Sub Choi
BACKGROUND: Locally advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) has a poor oncological outcome. This study evaluated the oncological outcomes and prognostic factors of surgical resection after downstaging with localized concurrent chemoradiotherapy (CCRT) followed by hepatic arterial infusion chemotherapy (HAIC). METHODS: From 2005 to 2014, 354 patients with locally advanced HCC underwent CCRT followed by HAIC. Among these patients, 149 patients with PVTT were analyzed...
August 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30081865/postoperative-hepatic-arterial-chemotherapy-in-high-risk-patients-as-adjuvant-treatment-after-resection-of-colorectal-liver-metastases-a-randomized-phase-ii-iii-trial-pacha-01-nct02494973
#8
Diane Goéré, Jean-Pierre Pignon, Maximiliano Gelli, Dominique Elias, Léonor Benhaim, Frédéric Deschamps, Caroline Caramella, Valérie Boige, Michel Ducreux, Thierry de Baere, David Malka
BACKGROUND: After curative-intent surgery for colorectal liver metastases (CRLM), liver recurrence occurs in more than 60% of patients, despite the administration of perioperative or adjuvant chemotherapy. This risk is even higher after resection of more than three CRLM. As CRLM are mostly supplied by arterial blood flow, hepatic arterial infusion (HAI) of chemotherapeutic agents after resection of CRLM is an attractive approach. Oxaliplatin-based HAI chemotherapy, in association with systemic fluoropyrimidines, has been shown to be safe and highly active in patients with CRLM...
August 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30081811/-metilin-improves-%C3%B0-ardiac-function-in-rabbits-with-chronic-heart-failure
#9
I M Studneva, V L Lakomkin, O M Veselova, A V Prosvirnin, A A Abramov, E R Pavlovich, R O Lubimov, V V Gramovich, O N Vyborov, O I Pisarenko, V I Kapelko
AIM: To study effects of intravenous infusion of a cardioprotective drug metilin, developed at the "National Medical Research Center of Cardiology" on indices of cardiac function in rabbits in vivo after prolonged administration of doxorubicin. MATERIALS AND METHODS: Animals of the experimental group were intravenously injected with doxorubicin (2 mg / kg once a week) for 8 weeks, animals of the control group received the same volume of saline. Myocardial damage was characterized by an increase in concentration of malondialdehyde (MDA), troponin (TnI) and MB-fraction of creatine kinase (CK-MB) in venous blood and by disturbances in the left ventricle (LV) structure at morphological examination...
July 2018: Kardiologiia
https://www.readbyqxmd.com/read/30079342/achievable-complete-remission-of-advanced-non-small-cell-lung-cancer-case-report-and-review-of-the-literature
#10
Ning-Ning Yang, Fei Xiong, Qing He, Yong-Song Guan
Surgery is the first choice of treatment for patients with non-small-cell lung cancer (NSCLC), but few patients can be treated surgically because of either advanced disease or poor pulmonary function. Other therapies include radiotherapy and chemotherapy, as well as complementary and alternative therapies, usually with disappointing results. Bronchial artery infusion (BAI) is a manageable and effective method for treating advanced NSCLC. Outcome is good by BAI due to its repeatability and low toxicity. Icotinib hydrochloride is a newly developed and highly specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor and has been safely and efficiently used to treat advanced NSCLC...
July 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/30077713/circadian-variations-in-the-pharmacokinetics-of-the-oral-anticancer-agent-tegafur-uracil-uft-and-its-metabolites-in-rats
#11
Shinji Kobuchi, Yukako Ito, Daiki Takamatsu, Toshiyuki Sakaeda
Uracil-tegafur (UFT) is an oral anticancer drug containing uracil and 5‑fluorouracil prodrug tegafur and is widely used for adjuvant chemotherapy of colorectal cancer. Although clinical data show circadian variations in plasma 5‑fluorouracil concentrations during its long-term infusion, and feasibility studies of chronomodulated administration have been previously reported, the circadian pattern in plasma 5‑fluorouracil concentration after UFT administrations remains unclear. The aim of this study was to identify factors causing circadian variations in UFT pharmacokinetics and estimate circadian patterns of plasma 5‑fluorouracil concentration corresponding to UFT dosing time in rats...
August 2, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30076946/subcortical-brain-iron-deposition-and-cognitive-performance-in-older-women-with-or-without-breast-cancer-receiving-adjuvant-chemotherapy-a-pilot-mri-study
#12
Bihong T Chen, Kiarash Ghassaban, Taihao Jin, Sunita K Patel, Ningrong Ye, Can-Lan Sun, Heeyoung Kim, Russell C Rockne, E Mark Haacke, James C Root, Andrew J Saykin, Tim A Ahles, Andrei I Holodny, Neal Prakash, Joanne Mortimer, James Waisman, Yuan Yuan, George Somlo, Daneng Li, Richard Yang, Heidi Tan, Vani Katheria, Rachel Morrison, Arti Hurria
As the number of older adults in the U.S. increases, so too will the incidence of cancer and cancer-related cognitive impairment (CRCI). However, the exact underlying biological mechanism for CRCI is not yet well understood. We utilized susceptibility-weighted imaging with quantitative susceptibility mapping, a non-invasive MRI-based technique, to assess longitudinal iron deposition in subcortical gray matter structures and evaluate its association with cognitive performance in women age 60+ with breast cancer receiving adjuvant chemotherapy and age-matched women without breast cancer as controls...
August 1, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/30073931/protective-role-of-silymarin-in-early-doxorubicin-induced-cardiac-dysfunction-in-children-with-acute-lymphoblastic-leukemia
#13
Adel A Hagag, Walid A El Shehaby, Aml I El-Abasy, Maaly M Mabrouk
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer constituting about one third of pediatric malignancies. Doxorubicin is a well- established chemotherapeutic agent for treatment of childhood ALL, but its efficacy is often limited by its related cardiotoxicity. Cardioprotection against doxorubicin- induced cardiotoxicity can be of great value, especially for children. Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant, has potent antioxidant properties that can be helpful in preventing cardiotoxicity...
August 3, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/30060000/safety-tolerability-and-pharmacokinetics-of-shorter-duration-of-infusion-of-obinutuzumab-in-japanese-patients-with-b-cell-non-hodgkin-lymphoma-final-results-of-the-phase-ii-gats-study
#14
Ken Ohmachi, Kiyoshi Ando, Tomohiro Kinoshita, Kyoya Kumagai, Kiyohiko Hatake, Takayuki Ishikawa, Takanori Teshima, Koji Kato, Koji Izutsu, Eisuke Ueda, Kiyohiko Nakai, Hiroshi Kuriki, Kensei Tobinai
Background: Shorter duration of infusion of monoclonal antibody treatments may reduce treatment burden and improve healthcare resource utilization. Methods: This phase II study recruited Japanese patients with previously untreated CD20+ B-cell non-Hodgkin lymphoma. Patients received intravenous obinutuzumab 1000 mg by regular infusion on Days 1, 8 and 15 of Cycle 1, followed by 90-min shorter duration of infusion in up to seven subsequent cycles, provided they received ≥3 regular infusions without any grade ≥3 infusion-related reactions and had a lymphocyte count <5...
August 1, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30056598/epidermal-growth-factor-receptor-peptide-vaccination-induces-cross-reactive-immunity-to-human-egfr-her2-and-her3
#15
Hester A Doyle, Raymond A Koski, Nathalie Bonafé, Ross A Bruck, Stephanie M Tagliatela, Renelle J Gee, Mark J Mamula
Current treatments for tumors expressing epidermal growth factor receptor (EGFR) include anti-EGFR monoclonal antibodies, often used in conjunction with the standard chemotherapy, radiation therapy, or other EGFR inhibitors. While monoclonal antibody treatment is efficacious in many patients, drawbacks include its high cost of treatment and side effects associated with multiple drug infusions. As an alternative to monoclonal antibody treatments, we have focused on peptide-based vaccination to trigger natural anti-tumor antibodies...
July 28, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/30052729/phase-3-randomised-trial-of-avelumab-versus-physician-s-choice-of-chemotherapy-as-third-line-treatment-for-patients-with-advanced-gastric-or-gastro-oesophageal-junction-cancer-primary-analysis-of-javelin-gastric-300
#16
Y-J Bang, E Yañez Ruiz, E Van Cutsem, K-W Lee, L Wyrwicz, M Schenker, M Alsina, M-H Ryu, H-C Chung, L Evesque, S-E Al-Batran, S H Park, M Lichinitser, N Boku, M H Moehler, J Hong, H Xiong, R Hallwachs, I Conti, J Taieb
Background: There currently are no internationally recognised treatment guidelines for patients with advanced gastric cancer/gastro-oesophageal junction cancer (GC/GEJC) in whom two prior lines of therapy have failed. The randomised, phase 3 JAVELIN Gastric 300 trial compared avelumab vs physician's choice of chemotherapy as third-line therapy in patients with advanced GC/GEJC. Patients and methods: Patients with unresectable, recurrent, locally advanced, or metastatic GC/GEJC were recruited at 147 sites globally...
July 24, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/30045149/long-term-outcome-after-doxorubicin-and-ifosfamide-overdose-in-a-patient-with-osteosarcoma-and-bard1-mutation
#17
Malvi Savani, Keith M Skubitz
Current treatment of high-grade osteosarcoma consists of preoperative chemotherapy, typically using some combination of doxorubicin, cisplatin, ifosfamide, and/or high-dose methotrexate followed by surgical resection. In this report, we present a case of a 21-year-old woman with high-grade osteosarcoma of the chest wall who received 5 times the planned dose of doxorubin and 4 times the planned dose of ifosfamide. She survived this chemotherapy overdose after administration of dimethyl sulfoxide and phenobarbital...
July 24, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30044763/refractory-hypoglycemia-in-a-pediatric-patient-with-desmoplastic-small-round-cell-tumor
#18
Abdullah Almaghraby, Wendy J Brickman, Jeffery A Goldstein, Reema L Habiby
Background Tumor-induced hypoglycemia is a rare and serious complication that is usually a consequence of either excessive insulin secretion (insulinoma) or because of non-islet cell tumor hypoglycemia (NICTH). NICTH is a rare phenomenon seen most often in adult patients. It is associated with different tumor types. Here, we report the first case to the best of our knowledge in the literature of a pediatric patient with NICTH associated with desmoplastic small round cell tumor (DSRT). Case presentation This is a 15-year-old girl who presented with symptomatic hypoglycemia and abdominal mass...
August 28, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30041616/rapidly-declining-skeletal-muscle-mass-predicts-poor-prognosis-of-hepatocellular-carcinoma-treated-with-transcatheter-intra-arterial-therapies
#19
Takamasa Kobayashi, Hirokazu Kawai, Oki Nakano, Satoshi Abe, Hiroteru Kamimura, Akira Sakamaki, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Satoshi Yamagiwa, Shuji Terai
BACKGROUND: The impact of sarcopenia on the prognosis of patients with hepatocellular carcinoma (HCC) who receive transcatheter intra-arterial therapies, including transcatheter arterial chemoembolization and transcatheter arterial infusion chemotherapy, remains unclear. We investigated the prognostic value of skeletal muscle loss (SML) stratified by cutoffs for sarcopenia and rate of change in skeletal muscle mass over 6 months. METHODS: We retrospectively evaluated 102 patients with HCC treated with transcatheter intra-arterial therapies between 2005 and 2015...
July 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30038911/fatal-type-b-lactic-acidosis-associated-with-metastatic-colorectal-cancer-a-case-report-with-review-of-literature-pathogenesis-and-treatment
#20
Bharatsinh Gharia, Karan Seegobin, Hetavi Mahida, Marwan Shaikh, Trevanne Matthews Hew, Dat Pham
Type B lactic acidosis associated with malignancy is a life-threatening complication and mostly seen in hematological malignancies but can also be seen in solid tumors. We report a rare case of a 64-year-old female diagnosed with metastatic adenocarcinoma of the colon with liver metastasis associated with severe type B lactic acidosis. We discuss pathophysiology, previously reported cases, and their outcomes. The most widely used therapies are bicarbonate infusion, thiamine supplementation, chemotherapy, and supportive care but is associated with poor outcomes, and no standard treatment recommendations are available...
January 2018: Journal of Investigative Medicine High Impact Case Reports
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