Mahmoud M Habibullah, Syam Mohan, Nabeel Kashan Syed, Hafiz A Makeen, Qazi Mohammad Sajid Jamal, Hani Alothaid, Farkad Bantun, Alaa Alhazmi, Ali Hakamy, Yahia A Kaabi, Ghalia Samlan, Mohtashim Lohani, Neelaveni Thangavel, Mohamed Ahmed Al-Kasim
Introduction: Numerous drugs with potent toxicity against cancer cells are available for treating malignancies, but therapeutic efficacies are limited due to their inefficient tumor targeting and deleterious effects on non-cancerous tissue. Therefore, two improvements are mandatory for improved chemotherapy 1) novel delivery techniques that can target cancer cells to deliver anticancer drugs and 2) methods to specifically enhance drug efficacy within tumors. The loading of inert drug carriers with anticancer agents and peptides which are able to bind (target) tumor-related proteins to enhance tumor drug accumulation and local cytotoxicity is a most promising approach...
2022: Drug Design, Development and Therapy