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Stroke volume variability

Sunghee Joo, Yongwoo Lee, Chang-Ho Song
OBJECTIVES: The purpose of this study was to investigate the immediate effects of thoracic spinal manipulation (TSM) on pulmonary function in stroke patients. METHODS: Thirty-six volunteers with stroke (20 men, 16 women) were recruited and randomized to a TSM group (n = 18) and a sham group (n = 18). All participants underwent initial pulmonary function test and then rested supine for 10 minutes before the intervention. Pulmonary function test was repeated immediately after the intervention...
August 15, 2018: Journal of Manipulative and Physiological Therapeutics
Hans Bahlmann, Robert G Hahn, Lena Nilsson
BACKGROUND: The impact of Goal Directed Fluid Therapy (GDFT) based on the non-invasive Pleth Variability Index (PVI) on clinical outcome after abdominal surgery has only sparingly been explored. The purpose of this study was to compare the effect of intraoperative GDFT guided by PVI to a control group using esophageal Doppler on the incidence of complications and length of hospital stay after major abdominal surgery. We hypothesized that there would be no difference between the groups...
August 18, 2018: BMC Anesthesiology
Melissa Burroughs Peña, Katrina Swett, Neil Schneiderman, Daniel M Spevack, Sonia G Ponce, Gregory A Talavera, Mayank M Kansal, Martha L Daviglus, Jianwen Cai, Barry E Hurwitz, Maria M Llabre, Carlos J Rodriguez
Objective: We assessed the hypothesis that metabolic syndrome is associated with adverse changes in cardiac structure and function in participants of the Echocardiographic Study of Latinos (Echo-SOL). Methods: Non-diabetic Echo-SOL participants were included in this cross-sectional analysis. Metabolic syndrome was defined according to the American Heart Association/National Heart, Lung, and Blood Institute 2009 Joint Scientific Statement. Survey multivariable linear regression analyses using sampling weights were used adjusting for multiple potential confounding variables...
2018: BMJ Open Diabetes Research & Care
Christian Weisstanner, Georg Kägi, Werner Krammer, Chin B Eap, Roland Wiest, John H Missimer, Bruno J Weder
INTRODUCTION: Serving as a pilot study of poststroke pharmacotherapy, the present investigation was intended to establish the effect of a single dose of escitalopram on motor task performance in normal volunteers. METHODS: Ten healthy volunteers of median age 63 years including four females performed a well-studied tactile manipulation task in two fMRI sessions using a double-blind cross-over design. The sessions began approximately three hours after ingestion of 20 mg escitalopram or placebo presented in pseudorandom order...
June 2018: Brain and Behavior
Vasileios Stavrou, Konstantinos Tsarouhas, Eleni Karetsi, Panagiotis Michos, Zoe Daniil, Konstantinos I Gourgoulianis
BACKGROUND: The purpose of our study was to investigate early differences in the adolescent female finswimmers' echocardiography parameters, possibly associated with different swimming-style training and different training equipment (monofin (MF) versus bifin (BF)). METHOD: Forty-three female finswimmers participated in our study (age: 15.6 ± 2.1 years, body mass index: 20.4 ± 2.2 kg/m², body surface area: 1.56 ± 0.04 m², body fat: 11.2 ± 0.6%) and were divided into two groups, according to the swimming style practiced (MF vs BF)...
August 10, 2018: Sports
Fraser M Callaghan, Paul Bannon, Edward Barin, David Celemajer, Richmond Jeremy, Gemma Figtree, Stuart M Grieve
BACKGROUND: Abnormal flow dynamics play an early and causative role in pathologic changes of the ascending aorta. PURPOSE: To identify: 1) the changes in flow, shape, and size that occur in the ascending aorta with normal human ageing and 2) the influence of these factors on aortic flow dynamics. STUDY TYPE: Retrospective. SUBJECTS: In all, 247 subjects (age range 19-86 years, mean 49 ± 17.7, 169 males) free of aortic or aortic valve pathology were included in this study...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Setareh Salehi Omran, Srikanth Reddy Boddu, Aaron M Gusdon, Benjamin Kummer, Hediyeh Baradaran, Praneil Patel, Iván Díaz, Babak B Navi, Ajay Gupta, Hooman Kamel, Athos Patsalides
BACKGROUND AND PURPOSE: Risk factors for hemorrhagic transformation of ischemic stroke after mechanical thrombectomy (MT) are not well established. We conducted a study to determine if prominent angiographic cerebral vascularity following recanalization with thrombectomy (angiographic blush) is associated with hemorrhagic transformation. METHODS: Using the Cornell AcutE Stroke Academic Registry, we identified stroke patients who had thrombectomy and achieved recanalization of anterior circulation large-vessel occlusion between 2012 and 2015...
August 4, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Adrian Gheorghe, Ulla Griffiths, Adrianna Murphy, Helena Legido-Quigley, Peter Lamptey, Pablo Perel
BACKGROUND: The evidence on the economic burden of cardiovascular disease (CVD) in low- and middle- income countries (LMICs) remains scarce. We conducted a comprehensive systematic review to establish the magnitude and knowledge gaps in relation to the economic burden of CVD and hypertension on households, health systems and the society. METHODS: We included studies using primary or secondary data to produce original economic estimates of the impact of CVD. We searched sixteen electronic databases from 1990 onwards without language restrictions...
August 6, 2018: BMC Public Health
Chih-Hao Chen, Sung-Chun Tang, Ding-Yuan Lee, Jiann-Shing Shieh, Dar-Ming Lai, An-Yu Wu, Jiann-Shing Jeng
Acute stroke commonly affects cardiac autonomic responses resulting in reduced heart rate variability (HRV). Multiscale entropy (MSE) is a novel non-linear method to quantify the complexity of HRV. This study investigated the influence of intracerebral hemorrhage (ICH) locations and intraventricular hemorrhage (IVH) on the complexity of HRV. We recruited 93 supratentorial ICH patients (male 59%, mean age 61 years), and the locations of ICH included basal ganglia (n = 40), thalamus (n = 35), and lobar (n = 18) group...
July 31, 2018: Scientific Reports
Seok-Joon Jin, Hyunsuk Peter Suh, Joonho Lee, Jai-Hyun Hwang, Joon Pio Jp Hong, Young-Kug Kim
BACKGROUND: In free flap surgery, the maintenance of proper blood flow after anastomosis of flap pedicle vessels is important. Lipo-prostaglandin E1 (lipo-PGE1) has been empirically administered to prevent blood flow insufficiency in a free flap reconstruction. We tested our hypothesis that lipo-PGE1 administration increases the arterial inflow of free flap. We also evaluated lipo-PGE1-related haemodynamic changes and complications. METHODS: Thirty-seven patients who underwent free flap reconstruction were analysed...
July 30, 2018: Acta Anaesthesiologica Scandinavica
William C Sasser, Andrea N Sims, Jeremy M Loberger, Nancy M Tofil, Priya Prabhakaran
A thorough understanding of cardiorespiratory interactions is essential when caring for critically ill children. These interactions are linked to changes in intrathoracic pressure and their impact on cardiac preload and afterload. The predominant effect of positive pressure ventilation in children with normal cardiac function is to decrease preload to the right heart with an eventual decrease in left ventricular stroke volume. This can be anticipated and mitigated by judicious fluid resuscitation. The effect of positive pressure ventilation on right heart afterload is more complex and variable depending on lung volume...
July 23, 2018: Minerva Pediatrica
Julie W Rutten, Bastian J Van Eijsden, Marco Duering, Eric Jouvent, Christian Opherk, Leonardo Pantoni, Antonio Federico, Martin Dichgans, Hugh S Markus, Hugues Chabriat, Saskia A J Lesnik Oberstein
PURPOSE: CADASIL is a small-vessel disease caused by a cysteine-altering pathogenic variant in one of the 34 epidermal growth factor-like repeat (EGFr) domains of the NOTCH3 protein. We recently found that pathogenic variant in EGFr domains 7-34 have an unexpectedly high frequency in the general population (1:300). We hypothesized that EGFr 7-34 pathogenic variant more frequently cause a much milder phenotype, thereby explaining an important part of CADASIL disease variability. METHODS: Age at first stroke, survival and white matter hyperintensity volume were compared between 664 CADASIL patients with either a NOTCH3 EGFr 1-6 pathogenic variant or an EGFr 7-34 pathogenic variant...
July 22, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Eleonora Solari, Cristiana Marcozzi, Daniela Negrini, Andrea Moriondo
Lymph formation and propulsion rely on an extrinsic mechanism based on the forces that surrounding tissues exert upon the vessel wall and lumen and an intrinsic mechanism based on spontaneous, rhythmic contractions of the lymphatic muscle layer of collecting vessels. The two spontaneous pacemakers described in literature involve chloride-dependent depolarizations (STDs) and If -like currents, both giving rise to a variable contraction frequency (fc ) of lymphatic vessels functional units (lymphangions). Several stimuli have been shown to modulate fc , such as temperature, shear stress, and several tissue chemical modulators (prostaglandins, norepinephrine, acetylcholine, substance P, and others)...
2018: Frontiers in Physiology
Estevo Santamarina, Laura Abraira, Manuel Toledo, Montserrat González-Cuevas, Manuel Quintana, Olga Maisterra, María Sueiras, Lorena Guzman, Javier Salas-Puig, José Álvarez Sabín
PURPOSE: This study aimed to investigate the prognosis of patients with status epilepticus (SE) following stroke, focusing on the timing of SE after the event and other unexplored variables. METHODS: All consecutive patients experiencing post-stroke SE (PSSE) in our center were included (2011-2016). We analyzed SE- and stroke-related factors in relation to the patients' outcome. RESULTS: 95 patients with PSSE (54 ischemic and 41 hemorrhagic stroke) were analyzed; 40 were women (42...
July 9, 2018: Seizure: the Journal of the British Epilepsy Association
Do-Hyeong Kim, Seokyung Shin, Ji Young Kim, Seung Hyun Kim, Minju Jo, Yong Seon Choi
Background: This study investigated the ability of pulse pressure variation (PPV) and pleth variability index (PVI) to predict fluid responsiveness of patients undergoing spinal surgery in the prone position. Patients and methods: A total of 53 patients undergoing posterior lumbar spinal fusion in the prone position on a Jackson table were studied. PPV, PVI, and hemodynamic and respiratory variables were measured both before and after the administration of 6 mL/kg colloid in both the supine and prone positions...
2018: Therapeutics and Clinical Risk Management
Meghana Adoor, Sriranjini S Jaideep, M U Sujan, Boris W Kramer, T R Raju, Talakad N Sathyaprabha
Background The current exploratory study was aimed at estimating measures of blood pressure variability (BPV) and baroreflex sensitivity (BRS) in a healthy population in the Indian sub-continent. Methods One hundred and forty-two healthy subjects were recruited for the study. Blood pressure (BP) was recorded continuously for 15 min using the Finometer (Finapres Medical Systems, The Netherlands). For offline analysis, Nevrokard cardiovascular parameter analysis (CVPA) software (version 2.1.0) was used for BPV analysis...
July 26, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Bryon A Tompkins, Angela C Rieger, Victoria Florea, Monisha N Banerjee, Makoto Natsumeda, Evan D Nigh, Ana Marie Landin, Gianna M Rodriguez, Konstantinos E Hatzistergos, Ivonne Hernandez Schulman, Joshua M Hare
BACKGROUND: Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) differ in histopathology and prognosis. Although transendocardial delivery of mesenchymal stem cells is safe and provides cardiovascular benefits in both, a comparison of mesenchymal stem cell efficacy in ICM versus DCM has not been done. METHODS AND RESULTS: We conducted a subanalysis of 3 single-center, randomized, and blinded clinical trials: (1) TAC-HFT (Transendocardial Autologous Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells in Ischemic Heart Failure Trial); (2) POSEIDON (A Phase I/II, Randomized Pilot Study of the Comparative Safety and Efficacy of Transendocardial Injection of Autologous Mesenchymal Stem Cells Versus Allogeneic Mesenchymal Stem Cells in Patients With Chronic Ischemic Left Ventricular Dysfunction Secondary to Myocardial Infarction); and (3) POSEIDON-DCM (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis in Dilated Cardiomyopathy)...
July 12, 2018: Journal of the American Heart Association
Natalia Miriã Troiano, Vinicius Araújo Armelin, Victor Hugo da Silva Braga, Augusto Shinya Abe, Francisco Tadeu Rantin, Luiz Henrique Florindo
In terrestrial environments, upright spatial orientation can dramatically influence animals' hemodynamics. Generally, large and elongated species are particularly sensitive to such influence due to the greater extent of their vascular beds being verticalized, favoring the establishment of blood columns in their bodies along with caudal blood pooling, and thus jeopardizing blood circulation through a cascade effect of reductions in venous return, cardiac filling, stroke volume, cardiac output, and arterial blood pressure...
July 10, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
Kai Liu, Bo Song, Yuan Gao, Lu Zhao, Hui Fang, Yunchao Wang, Lulu Pei, Kaihao Han, Shen Li, Yusheng Li, Yuming Xu
BACKGROUND: Anemia is associated with unfavorable functional outcome in ischemic and hemorrhagic stroke. However, the relationship between anemia and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied. METHODS: Consecutive CVT patients were retrospectively identified from November 2011, through January 2017. Anemia was defined according to the World Health Organization criteria (non-pregnant female hemoglobin level < 120 g/L, pregnant female < 110 g/L and male < 130 g/L), which was further classified as mild, moderate, and severe anemia according to hemoglobin concentration, and as microcytic, normocytic, and macrocytic anemia according to mean corpuscular volume...
July 9, 2018: Neurocritical Care
Amy Wright, Donna Tippett, Sadhvi Saxena, Rajani Sebastian, Bonnie Breining, Andreia Faria, Argye E Hillis
OBJECTIVE: To test the hypothesis that severity of leukoaraiosis in the noninfarcted hemisphere at onset is associated with poorer language outcome after poststroke aphasia independently of volume of infarct, damage to 3 critical language areas (left inferior frontal gyrus, superior longitudinal fasciculus, and superior temporal gyrus), comorbid conditions, and time since stroke. METHODS: In this cross-sectional study, we evaluated naming outcome (>3 months after stroke) in 42 individuals who initially had aphasia after stroke...
July 6, 2018: Neurology
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