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Breast volume measurement

John W Garrett, Yinsheng Li, Ke Li, Guang-Hong Chen
PURPOSE: Digital breast tomosynthesis (DBT) has been shown to somewhat alleviate the breast tissue overlapping issues of two dimensional (2D) mammography.However, the improvement in current DBT systems over mammography is still limited.Statistical image reconstruction (SIR) methods have the potential to reduce through-plane artifacts in DBT, and thus may be used to further reduce anatomical clutter. The purpose of this work was to study the impact of SIR on anatomical clutter in the reconstructed DBT image volumes...
March 15, 2018: Medical Physics
Erdem Karadeniz, Mehmet Nuri Kocak, Ali Ahiskalioglu, Kemal Alp Nalci, Sevilay Ozmen, Mufide Nuran Akcay, Nazan Aydin, Mehmet Dumlu Aydin, Ahmet Hacimuftuoglu
PURPOSE OF THE STUDY: Hypofunctioning breasts are typically considered a dysfunction of higher brain centers that regulate hormonal feedback, and olfactory information has been proposed as a triggering factor for lactation in the maternal body. However, there are no substantive studies regarding whether olfaction disorders and/or loss of olfactory sense may result in breast gland atrophy by causing diminished olfactory stimulation. To fill this gap in the literature, we studied the histologic features of breast glands as a sample model in animals that had undergone an olfactory bulb lesion (OBL)...
March 14, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Jue Hou, Joshua Williams, Elliot Botvinick, Eric Potma, Bruce J Tromberg
Label-free non-linear optical microscopy (NLOM) based on two-photon excited fluorescence (TPEF) from cofactors Nicotinamide Adenine Dinucleotide (NADH) and Flavin Adenine Dinucleotide (FAD+) is widely used for high-resolution cellular redox imaging. In this work, we combined three, label-free NLOM imaging methods to quantitatively characterize breast cancer cells and their relative invasive potential: 1) TPEF optical redox ratio (ORR = FAD+/NADH + FAD+), 2) coherent Raman scattering (CRS) of cellular lipids, and 3) second harmonic generation (SHG) of extracellular matrix (ECM) collagen...
March 13, 2018: Cancer Research
Abdulraouf H Alghufaili, Luxshan Shanmugarajah, Lalith K Kumaraswamy
Our study aimed to correlate the overall 3-dimensional (3-D) shape of the breast to the compensation depth to produce a homogeneous dose distribution using the electronic tissue compensation (ECOMP) treatment technique. The study involved creating a number of semioval water phantoms with the diameter of the larger axis representing the breast separation and the shorter axis representing the distance from the chest wall to the apex of the breast. Multiple plans with 2 tangential fields were created for each phantom using different transmission penetration depths (TPDs) to determine the optimum TPD value based on the evaluation of dose uniformity and maximum hot spot...
March 7, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Anna Kasielska-Trojan, Tomasz Zieliński, Paweł Pisera, Bogusław Antoszewski
INTRODUCTION: There are many methods of analyzing the appearance of the breasts, but most of them are based on the patient's subjective assessment or on the opinion of a specialist panel. Anthropometric measurements enable objective breast evaluation. The aim of the study was to compare the objective and subjective evaluation of aesthetic results of breast symmetrization in patients with Poland syndrome. MATERIAL AND METHODS: The analysis of the results of the treatment was performed in 7 patients treated surgically due to unilateral breast underdevelopment in Poland syndrome...
February 28, 2018: Polski Przeglad Chirurgiczny
Margaret A Adgent, David M Umbach, Babette S Zemel, Andrea Kelly, Joan I Schall, Eileen G Ford, Kerry James, Kassa Darge, Julianne C Botelho, Hubert W Vesper, Donald Walt Chandler, Jon M Nakamoto, Walter J Rogan, Virginia A Stallings
Purpose: Chemicals with hormone-like activity, such as estrogenic isoflavones, may perturb human development. Infants exclusively fed soy-based formula are highly exposed to isoflavones, but their physiologic responses remain uncharacterized. Here, we compare estrogen-responsive postnatal development in infants exclusively fed soy formula, cow-milk formula and breast milk. Methods: We enrolled 410 infants born in Philadelphia area hospitals, 2010-2013; 283 infants were exclusively fed soy formula (n=102), cow-milk formula (n=111), or breast milk (n=70) throughout the study (birth to 28 [boys] or 36 [girls] weeks)...
March 1, 2018: Journal of Clinical Endocrinology and Metabolism
Aliya Alimujiang, Kellie R Imm, Catherine M Appleton, Graham A Colditz, Catherine S Berkey, Adetunji T Toriola
Although childhood adiposity is inversely associated with breast cancer risk, the association of childhood adiposity with mammographic density in premenopausal women has not been adequately studied. We analyzed data from 365 premenopausal women who came in for screening mammography at Washington University in St. Louis from 2015 to 2016. Body size at age 10 was self-reported using Somatotype pictogram. Body mass index (BMI) at age 10 was imputed using data from Growing Up Today Study. Volpara software was used to evaluate volumetric percent density (VPD), dense volume (DV) and non-dense volume (NDV)...
March 2, 2018: Cancer Prevention Research
Mami Iima, Masako Kataoka, Shotaro Kanao, Makiko Kawai, Natsuko Onishi, Sho Koyasu, Katsutoshi Murata, Akane Ohashi, Rena Sakaguchi, Kaori Togashi
We prospectively examined the variability of non-Gaussian diffusion magnetic resonance imaging (MRI) and intravoxel incoherent motion (IVIM) measurements with different numbers of b-values and excitations in normal breast tissue and breast lesions. Thirteen volunteers and fourteen patients with breast lesions (seven malignant, eight benign; one patient had bilateral lesions) were recruited in this prospective study (approved by the Internal Review Board). Diffusion-weighted MRI was performed with 16 b-values (0-2500 s/mm2 with one number of excitations [NEX]) and five b-values (0-2500 s/mm2, 3 NEX), using a 3T breast MRI...
2018: PloS One
A Ranger, A Dunlop, K Hutchinson, H Convery, M K Maclennan, H Chantler, N Twyman, C Rose, D McQuaid, R A Amos, C Griffin, N M deSouza, E Donovan, E Harris, C E Coles, A Kirby
AIMS: Radiotherapy target volumes in early breast cancer treatment increasingly include the internal mammary chain (IMC). In order to maximise survival benefits of IMC radiotherapy, doses to the heart and lung should be minimised. This dosimetry study compared the ability of three-dimensional conformal radiotherapy, arc therapy and proton beam therapy (PBT) techniques with and without breath-hold to achieve target volume constraints while minimising dose to organs at risk (OARs). MATERIALS AND METHODS: In 14 patients' datasets, seven IMC radiotherapy techniques were compared: wide tangent (WT) three-dimensional conformal radiotherapy, volumetric-modulated arc therapy (VMAT) and PBT, each in voluntary deep inspiratory breath-hold (vDIBH) and free breathing (FB), and tomotherapy in FB only...
February 23, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
Amin Kalaaji, Stine Dreyer, Jannika Brinkmann, Ivana Maric, Cathrine Nordahl, Kjell Olafsen
Background: Research regarding quality of life (QoL) among women who underwent breast aesthetic surgery is expanding. A comparative, anonymous study between two main breast aesthetic procedures is needed. Objective: The authors compared patient characteristics and aspects of QoL among women who underwent breast enlargement with implants (BI group) and those who underwent augmentation mastopexy (AM group). Methods: Patients at the Oslo Plastic Surgery Clinic were given a 47-question survey to measure QoL...
February 22, 2018: Aesthetic Surgery Journal
John R Eisenbrey, Rawan Shraim, Ji-Bin Liu, Jingzhi Li, Maria Stanczak, Brian Oeffinger, Dennis B Leeper, Scott W Keith, Lauren J Jablonowski, Flemming Forsberg, Patrick O'Kane, Margaret A Wheatley
PURPOSE: Much of the volume of solid tumors typically exists in a chronically hypoxic microenvironment that has been shown to result in both chemotherapy and radiation therapy resistance. The purpose of this study was to use localized microbubble delivery to overcome hypoxia prior to therapy. MATERIALS AND METHODS: In this study, surfactant-shelled oxygen microbubbles were fabricated and injected intravenously to locally elevate tumor oxygen levels when triggered by noninvasive ultrasound in mice with human breast cancer tumors...
January 31, 2018: International Journal of Radiation Oncology, Biology, Physics
F T Baumann, A Reike, V Reimer, M Schumann, M Hallek, D R Taaffe, R U Newton, D A Galvao
PURPOSE: The aim of this systematic review is to assess the effect of different types of exercise on breast cancer-related lymphedema (BCRL) in order to elucidate the role of exercise in this patient group. METHODS: A systematic data search was performed using PubMed (December 2016). The review is focused on the rehabilitative aspect of BCRL and undertaken according to the PRISMA statement with Levels of Evidence (LoE) assessed. RESULTS: 11 randomized controlled trials (9 with LoE 1a and 2 with LoE 1b) that included 458 women with breast cancer in aftercare were included...
February 22, 2018: Breast Cancer Research and Treatment
Nuri El-Azem, Mario Pulido-Moran, Cesar L Ramirez-Tortosa, Jose L Quiles, Francisca E Cara, Pedro Sanchez-Rovira, Sergio Granados-Principal, MCarmen Ramirez-Tortosa
PURPOSE: The main objective of this study was to test the therapeutic potential of hydroxytyrosol and its combination with paclitaxel in breast cancer on oxidative stress status. METHODS: Impact on proliferation rates of different chemotherapy administration patterns was assayed in MCF-7 and MDA-MB-231 breast cancer cell lines. Breast tumor-bearing rats were randomly assigned to Control, Hydroxytyrosol, Paclitaxel and Paclitaxel plus hydroxytyrosol groups, for 6 weeks...
February 21, 2018: European Journal of Nutrition
Rafael Daibert DE Souza Motta, Ana Claudia Weck Roxo, Fabio Xerfan Nahas, Fernando Serra-Guimarães
OBJECTIVES: to assess the degree of patient satisfaction after undergoing breast augmentation and compare three different, easy, inexpensive and universal methods of preoperative choice of breast implant volume. METHODS: a prospective study was carried out at University Hospital Pedro Ernesto of State University of Rio de Janeiro, in 94 women from Rio de Janeiro, aged 18 to 49 years, submitted to breast augmentation mammaplasty with breast implant due to hypomastia...
February 19, 2018: Revista do Colégio Brasileiro de Cirurgiões
M Fillon, S Si-Mohamed, P Coulon, A Vuillod, P Klahr, L Boussel
PURPOSE: To evaluate the radiation dose reduction, image quality and diagnostic confidence with thoraco-abdominopelvic computed tomography (TACT) using a new organ based dose modulation system (liver dose right index [Liver DRI]), compared to TACT using a standard automatic exposure control adjusting mA according to attenuation. METHODS: A total of 37 patients who had two TACT examinations on 2 different CT scanners, one using standard automatic exposure control (combination of a DoseRight automatic current selection and Z modulation) and one using Liver DRI were included...
February 13, 2018: Diagnostic and Interventional Imaging
Pamela Douglas, Donna Geddes
BACKGROUND: breastfeeding optimises health outcomes for both mothers and infants. Although most women want to breastfeed, they report commencing infant formula because of nipple pain, unsettled infant behaviour, and infant growth concerns. To date, existing approaches to fit and hold ('latch and positioning') have been demonstrated not to help breastfeeding outcomes, and women report widespread dissatisfaction with the quality of support and conflicting advice they receive. Breast and nipple pain, difficulty with latching and sucking, fussing at the breast, back-arching, marathon feeds, excessively frequent feeds, poor weight gain, breast refusal, and crying due to poor satiety often signal suboptimal positional instability and impaired milk transfer, but may be misdiagnosed as medical conditions...
March 2018: Midwifery
Eunice Jeffs, Emma Ream, Cath Taylor, Debra Bick
OBJECTIVE: To identify the effect of decongestive lymphedema treatment on excess arm volume or patient-centered outcomes in women presenting within either 12 months or a mean nine months of developing arm lymphedema following breast cancer treatment. INTRODUCTION: Lymphedema is a common consequence of breast cancer treatment requiring life-long treatment to reduce symptoms and prevent complications. Currently, evidence to inform the optimal decongestive lymphedema treatment package is lacking...
February 2018: JBI Database of Systematic Reviews and Implementation Reports
E Durmaz, A Asci, P Erkekoglu, A Balcı, I Bircan, B Koçer-Gumusel
There is a growing concern over the timing of pubertal breast development and its possible association with exposure to endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA). BPA is abundantly used to harden plastics. The aim of this study was to investigate the relation between premature thelarche (PT) and BPA by comparing the urinary BPA levels of PT girls with those of healthy subjects. Twenty-five newly diagnosed nonobese PT subjects (aged 4-8 years) who were admitted to the Pediatric Endocrinology Department at Akdeniz University were recruited...
January 1, 2018: Human & Experimental Toxicology
C Fedon, M Caballo, R Longo, A Trianni, I Sechopoulos
PURPOSE: To investigate the performance, such as energy dependence and sensitivity, of thermoluminescent dosimeters (TLD), metal oxide semiconductor field-effect transistor dosimeters (MOSFET), and GafChromic™ films, and to validate the estimates of local dose deposition of a Monte Carlo (MC) simulation for breast dosimetry applications. METHODS: Experimental measurements were performed using a monoenergetic beam at the ELETTRA synchrotron radiation light source (Trieste, Italy)...
February 6, 2018: Medical Physics
Tsuicheng D Chiu, David Parsons, Yue Zhang, Brian Hrycushko, Bo Zhao, Rajiv Chopra, Nathan Kim, Ann Spangler, Asal Rahimi, Robert D Timmerman, Steve B Jiang, Weiguo Lu, Xuejun Gu
Accurate dose delivery in Stereotactic partial breast irradiation (S-PBI) is challenging because of the target position uncertainty caused by breast deformation, the target volume changes caused by lumpectomy cavity shrinkage, and target delineation uncertainty on simulation computed tomography (CT) images caused by poor soft tissue contrast. We have developed a volumetric ultrasound tomography (UST) image guidance system for prone position S-PBI. The system is composed of a novel 3D printed rotation water tank, a patient-specific resin breast immobilization cup, and a 1D array ultrasound transducer...
February 6, 2018: Physics in Medicine and Biology
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