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https://www.readbyqxmd.com/read/28735755/protective-effects-of-acute-exercise-prior-to-doxorubicin-on-cardiac-function-of-breast-cancer-patients-a-proof-of-concept-rct
#1
A A Kirkham, R E Shave, K A Bland, J M Bovard, N D Eves, K A Gelmon, D C McKenzie, S A Virani, E J Stöhr, D E R Warburton, K L Campbell
BACKGROUND: Preclinical studies have reported that a single treadmill session performed 24h prior to doxorubicin provides cardio-protection. We aimed to characterize the acute change in cardiac function following an initial doxorubicin treatment in humans and determine whether an exercise session performed 24h prior to treatment changes this response. METHODS: Breast cancer patients were randomized to either 30min of vigorous-intensity exercise 24h prior to the first doxorubicin treatment (n=13), or no vigorous exercise for 72h prior to treatment (control, n=11)...
July 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28734684/factors-influencing-list-prices-for-radiologists-services
#2
Andrew B Rosenkrantz, Wenyi Wang, Arvind Vijayasarathi, Richard Duszak
PURPOSE: To identify factors associated with list price variation for radiologists' services. METHODS: The 2014 Medicare Physician and Other Supplier Public Use File was used to identify submitted charges ("list prices") and payments for radiologists' services (ie, not hospital service charges). Charge-to-payment ratios were computed for individual radiologists as a measure of excess charges. Numerous radiologist-level factors identifiable using publicly available data sets were explored...
July 20, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28725257/study-protocol-an-investigation-of-mother-infant-signalling-during-breastfeeding-using-a-randomised-trial-to-test-the-effectiveness-of-breastfeeding-relaxation-therapy-on-maternal-psychological-state-breast-milk-production-and-infant-behaviour-and-growth
#3
N H M Shukri, J Wells, F Mukhtar, M H S Lee, M Fewtrell
BACKGROUND: The physiological and psychological signalling between mother and infant during lactation is one of the prominent mother-infant factors that may influence breastfeeding outcomes. The infant can 'signal' his needs through vocalisation, and the mother can respond by allowing or restricting nipple access, which might alter the breast milk composition or volume. This may lead to parent-offspring conflict during the lactation period. Challenging infant behaviour has also been associated with maternal psychological distress, which might affect breastfeeding performance...
2017: International Breastfeeding Journal
https://www.readbyqxmd.com/read/28724133/a-nationwide-analysis-of-cost-variation-for-autologous-free-flap-breast-reconstruction
#4
Jessica I Billig, Yiwen Lu, Adeyiza O Momoh, Kevin C Chung
Importance: Cost variation among hospitals has been demonstrated for surgical procedures. Uncovering these differences has helped guide measures taken to reduce health care spending. To date, the fiscal consequence of hospital variation for autologous free flap breast reconstruction is unknown. Objective: To investigate factors that influence cost variation for autologous free flap breast reconstruction. Design, Setting, and Participants: A secondary cross-sectional analysis was performed using the Healthcare Cost and Utilization Project National Inpatient Sample database from 2008 to 2010...
July 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28717826/operator-radiation-exposure-during-transradial-coronary-angiography-effect-of-single-vs-double-catheters
#5
A Tarighatnia, L Pourafkari, A Farajollahi, A H Mohammadalian, M Ghojazadeh, N D Nader
BACKGROUND: The right radial artery has gained popularity as the preferred access site for coronary angiography. To save time and limit the radiation exposure of operators and patients, newly designed catheters can be used to access both the right and left coronary arteries. The aim of this study was to compare operator radiation exposure between single-catheter (SCA) and two-catheter approaches (TCA). METHODS: In all, 256 patients undergoing diagnostic coronary angiography via the right radial artery in a high-volume medical center were randomized to either the SCA or TCA group...
July 17, 2017: Herz
https://www.readbyqxmd.com/read/28717404/physical-activity-does-not-alter-prolactin-levels-in-post-menopausal-women-results-from-a-dose-response-randomized-controlled-trial
#6
Darren R Brenner, Yibing Ruan, Andria R Morielli, Kerry S Courneya, Christine M Friedenreich
BACKGROUND: Increased circulating levels of prolactin have been associated with increased risk of both in situ and invasive breast cancer. We investigated whether or not physical activity had a dose-response effect in lowering plasma levels of prolactin in postmenopausal women. METHODS: Four hundred previously inactive but healthy postmenopausal women aged 50-74 years of age were randomized to 150 or 300 min per week of aerobic physical activity in a year-long intervention...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28716678/cancer-recurrence-monitoring-using-hyperpolarized-1-13-c-pyruvate-metabolic-imaging-in-murine-breast-cancer-model
#7
Peter J Shin, Zihan Zhu, Roman Camarda, Robert A Bok, Alicia Y Zhou, John Kurhanewicz, Andrei Goga, Daniel B Vigneron
The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progression, regression and recurrence in a switchable MYC-driven murine breast cancer model. Serial (1)H MRI and hyperpolarized [1-(13)C]pyruvate metabolic imaging were used to investigate the changes in tumor volume and glycolytic metabolism over time during the multistage tumorigenesis. We show that acute de-induction of MYC expression in established tumors results in rapid tumor regression and significantly reduced glycolytic metabolism as measured by pyruvate-to-lactate conversion...
July 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28715130/average-glandular-dose-coefficients-for-pendant-geometry-breast-ct-using-realistic-breast-phantoms
#8
Andrew M Hernandez, John M Boone
PURPOSE: To design volume-specific breast phantoms from breast CT (bCT) data sets and estimate the associated normalized mean glandular dose coefficients for breast CT using Monte Carlo methods. METHODS: A large cohort of bCT data sets (N=215) was used to evaluate breast volume into quintiles (plus the top 5%). The average radius profile was then determined for each of the six volume-specific groups and used to both fabricate physical phantoms and generate mathematical phantoms (V1-V6; "V" denotes classification by volume)...
July 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28707988/first-clinical-report-of-helical-tomotherapy-with-simultaneous-integrated-boost-for-synchronous-bilateral-breast-cancer
#9
Tabassum Wadasadawala, Shanu Jain, Siji Paul, Reena Phurailatpam, Kishore Joshi, Palak Popat, Sandip Tandon, Aruna Alahari, Rajiv Sarin
OBJECTIVE: Radiotherapy for synchronous bilateral breast cancer (SBBC) is technically very challenging. This study reports the clinical feasibility, dosimetry and safety of helical tomotherapy (HT) with simultaneous integrated boost (SIB) in patients treated with adjuvant radiotherapy for SBBC. MATERIAL AND METHODS: Twenty one women with SBBC treated with HT from January 2013 to June 2016 were retrospectively evaluated. Radiation lung toxicity was assessed using pulmonary function test (PFT) and high resolution computerized tomography scan (HRCT) scan at baseline and 1 year post RT in 18 patients...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28702890/adiposity-during-early-adulthood-changes-in-adiposity-during-adulthood-attained-adiposity-and-mammographic-density-among-premenopausal-women
#10
Aliya Alimujiang, Catherine Appleton, Graham A Colditz, Adetunji T Toriola
PURPOSE: We investigated the associations of adolescent adiposity, changes in adiposity during adulthood, and attained adiposity with volumetric mammographic density measures. METHODS: We recruited 383 premenopausal women who had a routine screening mammogram at the Breast Health Center, Washington University in St. Louis, MO from December 2015 to October 2016. Trained research personnel assessed current adiposity measures. Weight at ages 18 and 30 were self-reported...
July 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28690055/antitumor-effect-of-ferula-assa-foetida-oleo-gum-resin-against-breast-cancer-induced-by-4t1-cells-in-balb-c-mice
#11
Seyyed Majid Bagheri, Amir Abdian-Asl, Mahin Taheri Moghadam, Maryam Yadegari, Aghdas Mirjalili, Fatemeh Zare-Mohazabieh, Haniyeh Momeni
BACKGROUND: Ferula assa foetida commonly consumed as a healthy beverage has been demonstrated to have various biological activities, including antioxidation, anti-obesity and anti-cancer. OBJECTIVE: Our study aims to investigate the antitumor effect of asafoetida in vivo using mouse mammary carcinoma 4T1 cells. MATERIALS AND METHODS: In the study, female BALB/c mice were divided into two groups (n = 6), which were control (untreated) and other group of mice with breast cancer treated with 100 mg/kg of asafoetida, respectively, by oral gavage...
July 6, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28688644/a-mussel-inspired-double-crosslinked-tissue-adhesive-on-rat-mastectomy-model-seroma-prevention-and-in%C3%A2-vivo-biocompatibility
#12
Wenzhen Zhu, Jian Yang, Jabed Iqbal, Yvonne Peck, Changjiang Fan, Dong-An Wang
BACKGROUND: Seroma formation is a common postsurgical complication of breast cancer surgery. It delays wound healing and may lead to other more serious complications. Conventional methods of reducing seroma formation through suturing or placement of surgical drainage produce inconsistent clinical outcomes. Tissue adhesives are viable alternatives but most of them are unsuitable for internal use and for large-area applications because of weak tissue adhesion strength or biocompatibility issues...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28682683/setting-quality-improvement-priorities-for-women-receiving-systemic-therapy-for-early-stage-breast-cancer-by-using-population-level-administrative-data
#13
Katherine A Enright, Nathan Taback, Melanie Lynn Powis, Alejandro Gonzalez, Lingsong Yun, Rinku Sutradhar, Maureen E Trudeau, Christopher M Booth, Monika K Krzyzanowska
Purpose Routine evaluation of quality measures (QMs) can drive improvement in cancer systems by highlighting gaps in care. Targeting quality improvement at QMs that demonstrate substantial variation has the potential to make the largest impact at the population level. We developed an approach that uses both variation in performance and number of patients affected by the QM to set priorities for improving the quality of systemic therapy for women with early-stage breast cancer (EBC). Patients and Methods Patients with EBC diagnosed from 2006 to 2010 in Ontario, Canada, were identified in the Ontario Cancer Registry and linked deterministically to multiple health care databases...
July 6, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28679773/bevacizumab-induces-acute-hypoxia-and-cancer-progression-in-patients-with-refractory-breast-cancer-multimodal-functional-imaging-and-multiplex-cytokine-analysis
#14
Shigeto Ueda, Toshiaki Saeki, Akihiko Osaki, Tomohiko Yamane, Ichiei Kuji
Bevacizumab, an antibody against endothelial growth factor, is a key but controversial drug in the treatment of metastatic breast cancer. We, therefore, aimed to determine the intrinsic resistance to bevacizumab at the physiological and molecular levels in advanced breast cancer using positron emission tomography (PET), dynamic contrast-enhanced MRI, diffuse optical spectroscopic imaging (DOSI), and multiplex cytokine assays.<br />Experimental Design: In total, 28 patients diagnosed with stage III/IV advanced breast cancer receiving single-agent bevacizumab for 1 week followed by paclitaxel combined with bevacizumab underwent (18)F-fluorodeoxyglucose (FDG)-PET, (18)F-fluoromisonidazole (FMISO)-PET, and MRI at both baseline and two courses after treatment initiation...
July 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28678022/eigentumors-for-prediction-of-treatment-failure-in-patients-with-early-stage-breast-cancer-using-dynamic-contrast-enhanced-mri-a-feasibility-study
#15
Hui Shan M Chan, Bas H M van der Velden, Claudette E Loo, Kenneth G A Gilhuijs
We present a radiomics model to discriminate between patients at low risk and those at high risk of treatment failure at long-term follow-up based on eigentumors: principal components computed from volumes encompassing tumors in washin and washout images of pre-treatment dynamic contrast-enhanced (DCE-) MR images. Eigentumors were computed from the images of 563 patients from the MARGINS study. Subsequently, a least absolute shrinkage selection operator (LASSO) selected candidates from the components that contained 90% of the variance of the data...
July 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28673203/bra-band-size-measurements-derived-from-three-dimensional-scans-are-not-accurate-in-women-with-large-ptotic-breasts
#16
Deirdre E McGhee, Lauren Ramsay, Celeste E Coltman, Sheridan A Gho, Julie R Steele
This study investigated differences in standard measurements used to determine bra size, under-bust chest circumference (UBCC) and over-bust chest circumference (OBCC), measured from a three-dimensional scan (hand-held scanner) compared to the direct measurement in 111 women (age 21-56 years; right breast volume 57-1672 mL; bra size 10A-18G). Bland-Altman plots of UBCC measurements showed a large positive bias and wide limits of agreement (12 cm; -4.6 to 28 cm), which increased as band size increased but decreased when the breasts were digitally removed from the scan prior to the UBCC measurement...
July 3, 2017: Ergonomics
https://www.readbyqxmd.com/read/28668405/local-breast-density-assessment-using-reacquired-mammographic-images
#17
Eloy García, Oliver Diaz, Robert Martí, Yago Diez, Albert Gubern-Mérida, Melcior Sentís, Joan Martí, Arnau Oliver
PURPOSE: The aim of this paper is to evaluate the spatial glandular volumetric tissue distribution as well as the density measures provided by Volpara™ using a dataset composed of repeated pairs of mammograms, where each pair was acquired in a short time frame and in a slightly changed position of the breast. MATERIALS AND METHODS: We conducted a retrospective analysis of 99 pairs of repeatedly acquired full-field digital mammograms from 99 different patients...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28666904/actual-target-coverage-after-setup-verification-using-surgical-clips-compared-with-external-skin-markers-in-postoperative-breast-cancer-radiation-therapy
#18
Anke van der Salm, Lars Murrer, Inge Steenbakkers, Ruud Houben, Liesbeth J Boersma
PURPOSE: After changing from offline setup verification to online setup verification using external skin markers in breast cancer patients, we noticed an increase in localized acute skin toxicity beneath the markers. Also, in vivo 3-dimensional dose measurements showed deviations between the delivered and the planned dose distributions; therefore, we investigated the accuracy of setup verification using surgical clips in the tumor bed, with a focus on target coverage of whole breast and tumor bed...
April 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28661075/mri-reveals-increased-tumorigenesis-following-high-fat-feeding-in-a-mouse-model-of-triple-negative-breast-cancer
#19
Devkumar Mustafi, Sully Fernandez, Erica Markiewicz, Xiaobing Fan, Marta Zamora, Jeffrey Mueller, Matthew J Brady, Suzanne D Conzen, Gregory S Karczmar
High animal fat consumption is associated with an increase in triple-negative breast cancer (TNBC) risk. Based on previous MRI studies demonstrating the feasibility of detecting very early non-palpable mammary cancers in simian virus 40 large T antigen (SV40TAg) mice, we examined the effect of dietary fat fed from weaning to young adulthood in this model of TNBC. Virgin female C3(1)SV40TAg mice (n = 16) were weaned at 3-4 weeks of age and then fed either a low fat diet (LFD) (n = 8, 3.7 kcal/g; 17.2% kcal from vegetable oil) or a high animal fat diet (HAFD) (n = 8, 5...
June 29, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28658472/association-of-fat-grafting-with-patient-reported-outcomes-in-postmastectomy-breast-reconstruction
#20
Katelyn G Bennett, Ji Qi, Hyungjin M Kim, Jennifer B Hamill, Edwin G Wilkins, Babak J Mehrara, Jeffrey H Kozlow
Importance: Fat grafting has proven to be a useful adjunct to breast reconstruction for the treatment of contour irregularities and volume deficits, but the proposed US Food and Drug Administration regulations may severely limit the ability of plastic surgeons to continue its use in this clinical context. Objective: To determine whether fat grafting is associated with patient-reported outcomes (PROs) in patients undergoing breast reconstruction. Design, Setting, and Participants: A longitudinal, multicenter, prospective cohort study was conducted between February 1, 2012, and July 31, 2016, at the 11 sites associated with the Mastectomy Reconstruction Outcomes Consortium Study...
June 28, 2017: JAMA Surgery
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