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Breast volume measurement

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https://www.readbyqxmd.com/read/29145250/consort-independent-prognostic-value-of-asphericity-of-pretherapeutic-f-18-fdg-uptake-by-primary-tumors-in-patients-with-breast-cancer
#1
Ji-Hoon Jung, Seung Hyun Son, Do-Hoon Kim, Jeeyeon Lee, Shin Young Jeong, Sang-Woo Lee, Ho Yong Park, Jaetae Lee, Byeong-Cheol Ahn
BACKGROUND: The aim of this study was to evaluate the prognostic implication of asphericity (ASP); spatial irregularity; of pretherapeutic F 2-deoxy-2-fluoro-D-glucose (F FDG) tumor uptake in patients with invasive ductal carcinoma (IDC) of the breast. METHODS: One hundred thirty-one female IDC patients (mean age = 48.1 ± 10.4 years), with pathological tumor size greater than 2 cm were retrospectively evaluated using F FDG positron emission tomography/computed tomography (PET/CT)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144393/growth-gastrointestinal-tolerance-and-stool-characteristics-of-healthy-term-infants-fed-an-infant-formula-containing-hydrolyzed-whey-protein-63-and-intact-casein-37-a-randomized-clinical-trial
#2
Shang-Ling Wu, Ding Ding, Ai-Ping Fang, Pei-Yan Chen, Si Chen, Li-Peng Jing, Yu-Ming Chen, Hui-Lian Zhu
To investigate whether healthy term infants, fed an infant formula containing hydrolyzed whey protein (HWP-F, hydrolyzed whey/intact casein =63/37), differ in growth, gastrointestinal tolerance and stool characteristics from those fed an infant formula containing intact whey protein (IWP-F, intact whey/intact casein =61/39) or breast milk. Healthy term infants, born within 14 days of the study's commencement, were randomly assigned to be fed IWP-F or HWP-F until 13 weeks of age, and breast-fed (BF) infants were enrolled as a reference group...
November 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29143998/oxytocin-mediates-the-beneficial-effects-of-the-exercise-training-on-breast-cancer
#3
Ali Mohammad Alizadeh, Zahra Heydari, Mostafa Rahimi, Behzad Bazgir, Hossein Shirvani, Sadaf Alipour, Yassaman Heidarian, Solmaz Khalighfard, Amin Isanejad
Exercise training can affect the breast tumor growth. We hypothesized that exercise training may reduce breast tumor growth by inducing Oxytocin (OT) secretion and its related signaling pathways such as PI3K/AKT and ERK. Therefore fifty-six BALB/c mice were equally divided into seven groups to study the effects of OT and atosiban (an oxytocin receptor antagonist) together with the interval exercise training on breast tumor growth, as well as tumor related signaling pathways including PI3K/AKT and ERK. Animal weight, OT plasma level, tumor weight and volume measured at the end of study...
November 16, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29137072/volume-based-metabolic-parameter-of-breast-cancer-on-preoperative-18f-fdg-pet-ct-could-predict-axillary-lymph-node-metastasis
#4
Young-Sil An, Doo Kyoung Kang, Yongsik Jung, Tae Hee Kim
The purpose of our study was to evaluate the association between metabolic parameters on FDG PET/CT and axillary lymph node metastasis (ALNM) in patients with invasive breast cancer.From January 2012 to December 2012, we analyzed 173 patients with invasive ductal carcinoma (IDC) who underwent both initial breast magnetic resonance imaging (MRI) and F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) examinations. All metabolic parameters were measured from the tumor volume segmented by a gradient-based method...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135722/assessment-of-biological-and-clinical-aggressiveness-of-invasive-ductal-breast-cancer-using-baseline-18f-fdg-pet-ct-derived-volumetric-parameters
#5
Gul Ege Aktas, Ebru Taştekin, Ali Sarikaya
OBJECTIVE: The aim of this study was to evaluate the relationship of baseline fluorine-18-fluorodeoxyglucose PET/computed tomography (CT)-derived volumetric parameters for the primary tumor with clinicopathological risk factors and molecular subtypes in patients with invasive ductal breast carcinoma (IDBC). PATIENTS AND METHODS: We evaluated 65 patients who underwent fluorine-18-fluorodeoxyglucose PET/CT for initial breast cancer staging. The association of maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume, and total lesion glycolysis (TLG) with clinicopathological risk factors and molecular subtypes was investigated and the discriminative power of significant features was assessed...
November 10, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29134542/influence-of-the-menstrual-cycle-on-compression-induced-pain-during-mammography-correlation-with-the-thickness-and-volume-of-the-mammary-gland
#6
Hitomi Kitaoka, Hiroko Kawashima
In mammography, breast compression is necessary and an important factor influencing image quality. The purpose of this study was to determine the influence of the menstrual cycle on compression-induced pain during mammography and to evaluate the association between the thickness and volume of the mammary gland and pain. We examined basal body temperature and categorized the menstrual cycle into five phases. We executed breast compression in the craniocaudal view using a customized compression plate, to which we introduced an opening...
November 13, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29134472/real-time-wireless-tumor-tracking-during-breast-conserving-surgery
#7
Natasja Janssen, Roeland Eppenga, Marie-Jeanne Vrancken Peeters, Frederieke van Duijnhoven, Hester Oldenburg, Jos van der Hage, Emiel Rutgers, Jan-Jakob Sonke, Koert Kuhlmann, Theo Ruers, Jasper Nijkamp
PURPOSE: To evaluate a novel surgical navigation system for breast conserving surgery (BCS), based on real-time tumor tracking using the Calypso[Formula: see text] 4D Localization System (Varian Medical Systems Inc., USA). Navigation-guided breast conserving surgery (Nav-BCS) was compared to conventional iodine seed-guided BCS ([Formula: see text]I-BCS). METHODS: Two breast phantom types were produced, containing spherical and complex tumors in which wireless transponders (Nav-BCS) or a iodine seed ([Formula: see text]I-BCS) were implanted...
November 13, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29128583/patients-experiences-with-decisions-on-timing-of-chemotherapy-for-breast-cancer
#8
K M de Ligt, P E R Spronk, A C M van Bommel, M T F D Vrancken Peeters, S Siesling, C H Smorenburg
INTRODUCTION: Despite potential advantages, application of chemotherapy in the neo-adjuvant (NAC) instead of adjuvant (AC) setting for breast cancer (BC) patients varies among hospitals. The aim of this study was to gain insight in patients' experiences with decisions on the timing of chemotherapy for stage II and III BC. MATERIALS AND METHODS: A 35-item online questionnaire was distributed among female patients (age>18) treated with either NAC or AC for clinical stage II/III invasive BC in 2013-2014 in the Netherlands...
November 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29127528/changes-in-volume-and-incidence-of-lymphedema-during-and-after-treatment-with-docetaxel-doxorubicin-and-cyclophosphamide-tac-in-patients-with-breast-cancer
#9
Janine T Hidding, Carien H G Beurskens, Philip J van der Wees, Wilmy C A M Bos, Maria W G Nijhuis-van der Sanden, Hanneke W M van Laarhoven
PURPOSES: The purposes of this study were to investigate the incidence of lymphedema in patients with breast cancer during and after adjuvant treatment with docetaxel, doxorubicin, and cyclophosphamide (TAC), to identify predictors for development of lymphedema, and to describe consequences in daily life in relation to lymphedema. METHODS: This is a prospective study with measurements before chemotherapy (T0), during chemotherapy before cycle 2 (T1), cycle 4 (T2), and 1 month after completion of treatment (T3)...
November 10, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29113931/neurobiological-mechanisms-of-chemotherapy-induced-cognitive-impairment-in-a-transgenic-model-of-breast-cancer
#10
Gordon Winocur, Hal Berman, Mary Nguyen, Malcolm A Binns, Mark Henkelman, Matthijs van Eede, Micheline Piquette-Miller, Melanie J Sekeres, J Martin Wojtowicz, Johnson Yu, Haibo Zhang, Ian F Tannock
Animal studies have reinforced clinical reports of cognitive impairment in cancer survivors following chemotherapy but, until now, all pre-clinical research in this area has been conducted on normal rodents. The present study investigated the effects of chemotherapy on cognition and underlying biological mechanisms in the FVB/N-Tg (MMTV-neu) 202 Mul/J mouse, a well-characterized transgenic model of breast cancer that has similarities to the tumorigenesis which occurs in humans. Tumor-bearing and control mice received three weekly injections of a combination of methotrexate + 5-fluorouracil, or an equal volume of saline...
November 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/29106497/effect-of-candesartan-and-metoprolol-on-myocardial-tissue-composition-during-anthracycline-treatment-the-prada-trial
#11
Siri Lagethon Heck, Geeta Gulati, Pavel Hoffmann, Florian von Knobelsdorff-Brenkenhoff, Tryggve Holck Storås, Anne Hansen Ree, Berit Gravdehaug, Helge Røsjø, Kjetil Steine, Jürgen Geisler, Jeanette Schulz-Menger, Torbjørn Omland
Aims: Anthracycline treatment may cause myocyte loss and expansion of the myocardial extracellular volume (ECV) fraction by oedema and fibrosis. We tested the hypotheses that adjuvant treatment for early breast cancer with the anthracycline epirubicin is dose dependently associated with increased ECV fraction and total ECV, as well as reduced total myocardial cellular volume, and that these changes could be prevented by concomitant angiotensin or beta-adrenergic blockade. Methods and results: PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA) was a 2 × 2 factorial, placebo-controlled, double-blinded trial of candesartan and metoprolol...
June 29, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29101985/acr-appropriateness-criteria-%C3%A2-monitoring-response-to-neoadjuvant-systemic-therapy-for%C3%A2-breast-cancer
#12
Priscilla J Slanetz, Linda Moy, Paul Baron, Roberta M diFlorio, Edward D Green, Samantha L Heller, Anna I Holbrook, Su-Ju Lee, Alana A Lewin, Ana P Lourenco, Bethany Niell, Ashley R Stuckey, Sunita Trikha, Nina S Vincoff, Susan P Weinstein, Monica M Yepes, Mary S Newell
Patients with locally advanced invasive breast cancers are often treated with neoadjuvant chemotherapy prior to definitive surgical intervention. The primary aims of this approach are to: 1) reduce tumor burden thereby permitting breast conservation rather than mastectomy; 2) promptly treat possible metastatic disease, whether or not it is detectable on preoperative staging; and 3) potentially tailor future chemotherapeutic decisions by monitoring in-vivo tumor response. Accurate radiological assessment permits optimal management and planning in this population...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29101445/integrated-18-f-fdg-pet-mri-in-breast-cancer-early-prediction-of-response-to-neoadjuvant-chemotherapy
#13
Nariya Cho, Seock-Ah Im, Gi Jeong Cheon, In-Ae Park, Kyung-Hun Lee, Tae-Yong Kim, Young Seon Kim, Bo Ra Kwon, Jung Min Lee, Hoon Young Suh, Koung Jin Suh
PURPOSE: To explore whether integrated (18)F-FDG PET/MRI can be used to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with breast cancer. METHODS: Between November 2014 and April 2016, 26 patients with breast cancer who had received NAC and subsequent surgery were prospectively enrolled. Each patient underwent (18)F-FDG PET/MRI examination before and after the first cycle of NAC. Qualitative MRI parameters, including morphological descriptors and the presence of peritumoral oedema were assessed...
November 4, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29098437/breast-compression-parameters-and-mammographic-density-in-the-norwegian-breast-cancer-screening-programme
#14
Nataliia Moshina, Marta Roman, Gunvor G Waade, Sofie Sebuødegård, Giske Ursin, Solveig Hofvind
OBJECTIVES: To investigate possible associations between breast compression parameters, including compression force, pressure and compressed breast thickness, and mammographic density assessed by an automated software. METHODS: We obtained data on breast compression parameters, breast volume, absolute and percentage dense volume, and body mass index for 14,698 women screened with two-view (craniocaudal, CC, and mediolateral oblique, MLO) digital mammography, in the Norwegian Breast Cancer Screening Programme, 2014-2015...
November 2, 2017: European Radiology
https://www.readbyqxmd.com/read/29097916/a-method-for-manufacturing-oncological-phantoms-for-the-quantification-of-18f-fdg-pet-and-dw-mri-studies
#15
Francesca Gallivanone, Irene Carne, Matteo Interlenghi, Daniela D'Ambrosio, Maurizia Baldi, Daniele Fantinato, Isabella Castiglioni
The aim of this work was to develop a method to manufacture oncological phantoms for quantitation purposes in 18F-FDG PET and DW-MRI studies. Radioactive and diffusion materials were prepared using a mixture of agarose and sucrose radioactive gels. T2 relaxation and diffusion properties of gels at different sucrose concentrations were evaluated. Realistic oncological lesions were created using 3D-printed plastic molds filled with the gel mixture. Once solidified, gels were extracted from molds and immersed in a low-radioactivity gel simulating normal background tissue...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29094880/disorders-of-puberty-an-approach-to-diagnosis-and-management
#16
David A Klein, Jill E Emerick, Jillian E Sylvester, Karen S Vogt
Disorders of puberty can profoundly impact physical and psychosocial well-being. Precocious puberty is pubertal onset before eight years of age in girls and before nine years of age in boys. Patients with early isolated pubertal changes, prepubertal linear growth, and no worrisome neurologic symptoms typically have a benign pattern of development and should be monitored in the appropriate clinical context. Among patients with true precocious puberty, or full activation of the hypothalamic-pituitary-gonadal axis, most girls have an idiopathic etiology, whereas it is commonly due to identifiable pathology on imaging in boys...
November 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29094744/oral-administration-of-lyophilized-dunaliella-salina-a-carotenoid-rich-marine-alga-reduces-tumor-progression-in-mammary-cancer-induced-rats
#17
Ramachandran Srinivasan, Amballa Chaitanyakumar, Anbazhagan Mageswari, Ajitha Gomathi, J G S Pavan Kumar, Mathiyazhagan Jayasindu, Gunasekaran Bharath, Jagannathan Sampathkumar Shravan, K M Gothandam
Dunaliella salina is a photosynthetic cell factory used for the commercial production of food additives, cattle stock feed and cosmetics as well as active ingredients for pharmaceutical industries. The investigation of the in vivo antitumor activity of D. salina lyophilized powder (DSLP) against 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis in female Wistar rats indicated a dose-dependent effect of DSLP. We studied the effect of DSLP at two different dosages of 500 and 1000 mg per kg bw on DMBA induced mammary cancer in rats by measuring the status of antioxidant enzymes, phase I and phase II detoxification enzymes, lipid peroxidation, and glycoconjugated proteins and by investigating the expression pattern of cell proliferation (Ki-67), hormonal receptor (ER, PR and HER2) status by immunohistochemical analysis, and apoptotic (caspase-3 and -9) and pro-inflammatory (COX-2) markers by colorimetric analysis...
November 2, 2017: Food & Function
https://www.readbyqxmd.com/read/29091003/american-college-of-radiology-compliant-short-protocol-breast-mri-for-high-risk-breast-cancer-screening-a-prospective-feasibility-study
#18
Basak E Dogan, Marion E Scoggins, Jong Bum Son, Wei Wei, Rosalind Candelaria, Wei T Yang, Jingfei Ma
OBJECTIVE: The purpose of this study was to assess the feasibility of a short protocol for screening breast MRI that is noninferior to standard-of-care (SOC) MRI in image quality that complies with American College of Radiology accreditation requirements. SUBJECTS AND METHODS: In a prospective feasibility trial, 23 women at high risk underwent both an initial SOC MRI examination that included axial iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) and T1-weighted volume imaging for breast assessment (VIBRANT) dynamic contrast-enhanced sequences and a separate short breast MRI protocol comprising a fast spin-echo (FSE) triple-echo Dixon T2 sequence for T2-weighted imaging and a 3D dual-echo fast spoiled gradient-echo two-point Dixon sequence for dynamic contrast-enhanced imaging from October 1, 2015, through May 2, 2016...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29083315/dosimetric-feasibility-of-using-tungsten-based-functional-paper-for-flexible-chest-wall-protectors-in-intraoperative-electron-radiotherapy-for-breast-cancer
#19
Takeshi Kamomae, Hajime Monzen, Mariko Kawamura, Kuniyasu Okudaira, Takayoshi Nakaya, Takashi Mukouyama, Yoshikazu Miyake, Yoshitomo Ishihara, Yoshiyuki Itoh, Shinji Naganawa
Intraoperative electron radiotherapy (IOERT), which is an accelerated partial breast irradiation method, has been used for early-stage breast cancer treatment. In IOERT, a protective disk is inserted behind the target volume to minimize the dose received by normal tissues. However, to use such a disk, the surgical incision must be larger than the field size because the disk is manufactured from stiff and unyielding materials. In this study, the applicability of newly developed tungsten-based functional paper (TFP) was assessed as an alternative to the existing protective disk...
October 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29074857/methods-to-evaluate-cell-growth-viability-and-response-to-treatment-in-a-tissue-engineered-breast-cancer-model
#20
Kayla F Goliwas, Jillian R Richter, Hawley C Pruitt, Lita M Araysi, Nicholas R Anderson, Rajeev S Samant, Susan M Lobo-Ruppert, Joel L Berry, Andra R Frost
The use of in vitro, engineered surrogates in the field of cancer research is of interest for studies involving mechanisms of growth and metastasis, and response to therapeutic intervention. While biomimetic surrogates better model human disease, their complex composition and dimensionality make them challenging to evaluate in a real-time manner. This feature has hindered the broad implementation of these models, particularly in drug discovery. Herein, several methods and approaches for the real-time, non-invasive analysis of cell growth and response to treatment in tissue-engineered, three-dimensional models of breast cancer are presented...
October 26, 2017: Scientific Reports
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