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Breast volume measurement

Yujin Myung, Heeyeon Kwon, Changsik Pak, Hobin Lee, Jae Hoon Jeong, Chan Yeong Heo
BACKGROUND: Breast augmentation with fat transfer does not bear the risks associated with silicone implantation. The method can potentially be especially useful in Asian women, who often reject augmentation mammoplasty with implants. This prospective clinical trial evaluated the effects of external breast expansion on breast density and vessel count using magnetic resonance imaging. METHODS: Thirty-four enrolled patients were instructed to apply one of two devices, the conventional BRAVA device (used in the AESTES trial) or a novel external expansion device (EVERA) designed for Asian women, continuously for 8 h per day for 12 weeks...
September 28, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Katie M Parkins, Amanda M Hamilton, Ashley V Makela, Yuanxin Chen, Paula J Foster, John A Ronald
Cellular MRI involves sensitive visualization of iron-labeled cells in vivo but cannot differentiate between dead and viable cells. Bioluminescence imaging (BLI) measures cellular viability, and thus we explored combining these tools to provide a more holistic view of metastatic cancer cell fate in mice. Human breast carcinoma cells stably expressing Firefly luciferase were loaded with iron particles, injected into the left ventricle, and BLI and MRI were performed on days 0, 8, 21 and 28. The number of brain MR signal voids (i...
October 21, 2016: Scientific Reports
Sungheon Gene Kim, Melanie Freed, Ana Paula Klautau Leite, Jin Zhang, Claudia Seuss, Linda Moy
PURPOSE: To assess the diagnostic utility of contrast kinetic analysis for breast lesions and background parenchyma of women undergoing MRI-guided biopsies, for whom standard clinical analysis had failed to separate benign and malignant lesions. MATERIALS AND METHODS: This study included 115 women who had indeterminate lesions based on routine diagnostic breast MRI exams and underwent an MRI (3 Tesla) -guided biopsy of one or more lesions suspicious for breast cancer...
October 20, 2016: Journal of Magnetic Resonance Imaging: JMRI
D D Correa, J C Root, M Kryza-Lacombe, M Mehta, S Karimi, M L Hensley, N Relkin
Women with ovarian cancer often undergo chemotherapy involving multiple agents. However, little is known about treatment-related central neurotoxicity in this population. The goal of this cross-sectional study was to assess brain structure and function and neurocognitive abilities in patients with ovarian cancer following first-line chemotherapy. Eighteen patients with ovarian, peritoneal and fallopian tube cancer and eighteen healthy controls matched for gender, age and education participated in the study...
October 20, 2016: Brain Imaging and Behavior
Ingunn Holen, Diane V Lefley, Sheila E Francis, Sarah Rennicks, Steven Bradbury, Robert E Coleman, Penelope Ottewell
BACKGROUND: We have recently identified interleukin 1B (IL-1B) as a potential biomarker for predicting breast cancer patients at increased risk for developing bone metastasis. In mouse models, IL-1B and its receptor (IL-1R1) are upregulated in breast cancer cells that metastasise to bone compared with cells that do not. We have now investigated the functional role of IL-1 by blocking IL-1R signalling with the clinically licensed antagonist, anakinra. METHODOLOGY: 6-week old female BALB/c mice received a subcutaneous or intra-venous injection of MDA-MB-231-IV or MCF7 cells...
September 27, 2016: Oncotarget
Peter V Glovinski, Mikkel Herly, Felix C Müller, Jens J Elberg, Stig-Frederik T Kølle, Anne Fischer-Nielsen, Carsten Thomsen, Krzysztof T Drzewiecki
Several techniques for measuring breast volume (BV) are based on examining the breast on magnetic resonance imaging. However, when techniques designed to measure total BV are used to quantify BV changes, for example, after fat grafting, a systematic error is introduced because BV changes lead to contour alterations of the breast. The volume of the altered breast includes not only the injected volume but also tissue previously surrounding the breast. Therefore, the quantitative difference in BV before and after augmentation will differ from the injected volume...
September 2016: Plastic and Reconstructive Surgery. Global Open
Fanny Orlhac, Christophe Nioche, Michael Soussan, Irene Buvat
INTRODUCTION: The use of texture indices (TI) to characterize tumor heterogeneity from Positron Emission Tomography (PET) images is increasingly investigated in retrospective studies. Yet, the interpretation of PET-derived TI values has not been thoroughly reported. Furthermore, the calculation of TI lacks a standardized methodology, making it difficult to compare published results. To allow for TI value interpretation, we investigated the changes in value of six TI computed from simulated and real patient data...
October 6, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Andrew Gratzon, Jerette Schultz, Kristine Secrest, Kenneth Lee, Jeffrey Feiner, Richard D Klein
ABSTARCT: BACKGROUND: Secondary lymphedema following breast cancer therapy remains a major problem. Vascularized lymph node transfer (VLNT) is a surgical treatment for lymphedema that has shown promising results, but limited studies in the United States have investigated outcomes for single-stage VLNT to the axilla. The goal of this prospective, ongoing study was to investigate the clinical, psychosocial, and functional outcomes of patients who underwent VLNT for the treatment of upper extremity lymphedema after breast cancer therapy...
October 12, 2016: Annals of Surgical Oncology
Allen Gabriel, G Patrick Maxwell, Leah Griffin, Manish C Champaneria, Mousam Parekh, David Macarios
BACKGROUND: Centrifugation (Cf) is a common method of fat processing but may be time consuming, especially when processing large volumes. OBJECTIVES: To determine the effects on fat grafting time, volume efficiency, reoperations, and complication rates of Cf vs an autologous fat processing system (Rv) that incorporates fat harvesting and processing in a single unit. METHODS: We performed a retrospective cohort study of consecutive patients who underwent autologous fat grafting during reconstructive breast surgery with Rv or Cf...
October 11, 2016: Aesthetic Surgery Journal
Alessandra D Fisher, Giovanni Castellini, Jiska Ristori, Helen Casale, Emanuele Cassioli, Carolina Sensi, Egidia Fanni, Anna Maria Letizia Amato, Eva Bettini, Maddalena Mosconi, Davide Dèttore, Valdo Ricca, Mario Maggi
CONTEXT: To date, there are few studies investigating the impact of body changes induced by cross-sex hormonal treatment (CHT) on psychobiological well-being in gender-dysphoric persons (GDs). OBJECTIVE: The objective of the study was to assess whether CHT-related body changes affect psychobiological well-being in GDs. METHODS: A consecutive series of 359 GDs was considered for a cross-sectional section of the study. In addition, 54 GDs were studied in a 2-year follow-up...
October 4, 2016: Journal of Clinical Endocrinology and Metabolism
Gül Alço, Sefik Igdem, Sait Okkan, Maktav Dincer, Dauren Sarsenov, Ahmet Serkan Ilgun, Filiz Agacayak, Filiz Elbüken, Tulay Ercan, Derya Selamoglu, Vahit Ozmen
The aim of the present study was to evaluate the geographic variability of the tumor bed following oncoplastic breast-conserving surgery (OP-BCS), and to assess its relevance for radiotherapy planning. In this prospective study, pre- and postoperative computerized tomography (CT) scans of 22 patients with early-stage breast cancer were fused. The preoperative gross tumor volume or excisional biopsy cavity were contoured under the guidance of preoperative radiological images. Postoperative lumpectomy cavities were contoured under the guidance of surgical clips...
October 2016: Molecular and Clinical Oncology
Ladan Delphi, Houri Sepehri
PURPOSE: Increase in the number of cancer related deaths has made the study on developing new drugs and treatments essential. One of the main aims in developing new therapies is to use natural resources which have the ability to induce apoptosis. Pectin is one of these natural compounds, a complex polysaccharide found in apples with anti-cancer properties. The aim of this study was to examine anti-cancer properties of pectic acid both in vitro in 4T1 breast cancer cells and in vivo using an animal model of breast cancer...
September 30, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Marijn Hameeteman, Arico C Verhulst, Thomas J J Maal, Dietmar J O Ulrich
BACKGROUND: Volume of the breast can be objectively measured by three-dimensional (3D) photographs. This study describes the analysis of three different positions of the patient in image acquisition, in order to find the best pose for reproducible 3D photographs of the breasts. METHOD: Twenty-four patients were included between February and September 2014 in a consecutive way. Data were collected prospectively. 3D photographs were acquired using a stereophotogrammetry system...
September 17, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Mark Sak, Neb Duric, Peter Littrup, Lisa Bey-Knight, Haythem Ali, Patricia Vallieres, Mark E Sherman, Gretchen L Gierach
A population of 165 women with negative mammographic screens also received an ultrasound tomography (UST) examination at the Karmanos Cancer Institute in Detroit, MI. Standard statistical techniques were employed to measure the associations between the various mammographic- and UST-related density measures and various participant characteristics such as age, weight and height. The mammographic percent density (MPD) was found to have similar strength associations with UST mean sound speed (Spearman coefficient, rs = 0...
September 29, 2016: Ultrasound in Medicine & Biology
Woo Yeon Lee, Min Jung Kim, Dae Hyun Lew, Seung Yong Song, Dong Won Lee
BACKGROUND: Accurate breast volume assessment is a prerequisite to preoperative planning, as well as intraoperative decision making in breast reconstruction surgery. The use of three-dimensional surface imaging (3D scanning) to assess breast volume has many advantages. However, before employing 3D scanning in the field, the tool's validity should be demonstrated. The purpose of this study was to confirm the validity of 3D-scanning technology for evaluating breast volume. METHODS: We reviewed the charts of 25 patients who underwent breast reconstruction surgery immediately after total mastectomy...
September 2016: Archives of Plastic Surgery
Karolien Verhoeven, Stéphanie Peeters, Katrien Erven, Hilde Janssen, Isabelle Kindts, Erik Van Limbergen, Annouschka Laenen, Saskia Petillion, Caroline Weltens
PURPOSE: The purpose of this article is to compare isotropic and anisotropic margin expansion with regard to the size of the clinical target volume boost (CTVboost) and the interobserver variability (IOV). METHODS AND MATERIALS: Lumpectomy cavities marked with 3 or more surgical clips were delineated by 6 radiation oncologists who specialized in breast radiation therapy. CTVboost anisotropic was created by manually expanding the tumor bed with an anisotropic margin of 15 mm (20 mm in case of extensive intraductal component) minus the surgical free margins in 6 directions (anteroposterior, craniocaudal, and superoinferior)...
March 19, 2016: Practical Radiation Oncology
Jan Hering, Frederik Bernd Laun, Wolfgang Lederer, Heidi Daniel, Tristan Anselm Kuder, Anne Stieber, Stefan Delorme, Klaus H Maier-Hein, Heinz-Peter Schlemmer, Sebastian Bickelhaupt
INTRODUCTION: To evaluate the feasibility and accuracy of a semiautomatic, three-dimensional volume of interest (3D sphere) for measuring the apparent diffusion coefficient (ADC) in suspicious breast lesions compared to conventional single-slice two-dimensional regions of interest (2D ROIs). METHOD: This institutional-review-board-approved study included 56 participants with Breast Imaging Reporting and Data System 4/5 lesion. All received diffusion-weighted imaging magnetic resonance imaging prior to biopsy (b=0-1500 s/mm(2))...
September 4, 2016: Clinical Imaging
Genevieve E Becker, Hazel A Smith, Fionnuala Cooney
BACKGROUND: Breastfeeding is important, however not all infants can feed at the breast and methods of expressing milk need evaluation. OBJECTIVES: To assess acceptability, effectiveness, safety, effect on milk composition, contamination and costs of methods of milk expression. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (21 March 2016), handsearched relevant journals and conference proceedings, and contacted experts in the field to seek additional published or unpublished studies...
September 29, 2016: Cochrane Database of Systematic Reviews
Kana Takahashi, Madoka Morota, Yoshikazu Kagami, Hiroyuki Okamoto, Shuhei Sekii, Koji Inaba, Naoya Murakami, Hiroshi Igaki, Yoshinori Ito, Takashi Uno, Jun Itami
BACKGROUND: This prospective study aimed to compare dose volume histograms (DVH) of the breasts and organs at risk (OARs) of whole breast radiotherapy in the supine and prone positions, and frequency and severity of acute and late toxicities were analyzed. METHODS: Early-stage breast cancer patients with large breasts (Japanese bra size C or larger, or the widest measurements of the bust ≥ 95 cm) undergoing partial mastectomy participated in this study. CT-based treatment plans were made in each position, and various dosimetric parameters for the breast and OARs were calculated to compare the supine and prone radiotherapy plans...
September 29, 2016: BMC Cancer
Jessica K R Boult, Marco Borri, Alexa Jury, Sergey Popov, Gary Box, Lara Perryman, Suzanne A Eccles, Chris Jones, Simon P Robinson
High grade and metastatic brain tumours exhibit considerable spatial variations in proliferation, angiogenesis, invasion, necrosis and oedema. Vascular heterogeneity arising from vascular co-option in regions of invasive growth (in which the blood-brain barrier remains intact) and neoangiogenesis is a major challenge faced in the assessment of brain tumours by conventional MRI. A multiparametric MRI approach, incorporating native measurements and both Gd-DTPA (Magnevist) and ultrasmall superparamagnetic iron oxide (P904)-enhanced imaging, was used in combination with histogram and unsupervised cluster analysis using a k-means algorithm to examine the spatial distribution of vascular parameters, water diffusion characteristics and invasion in intracranially propagated rat RG2 gliomas and human MDA-MB-231 LM2-4 breast adenocarcinomas in mice...
September 27, 2016: NMR in Biomedicine
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