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Breast volume measurement

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https://www.readbyqxmd.com/read/28104715/detailed-echocardiographic-phenotyping-in-breast-cancer-patients-associations-with-ejection-fraction-decline-recovery-and-heart-failure-symptoms-over-3-years-of-followup
#1
Hari K Narayan, Brian S Finkelman, Benjamin French, Theodore Plappert, David Hyman, Amanda M Smith, Kenneth B Margulies, Bonnie Ky
BACKGROUND: -Cardiovascular disease in breast cancer patients is of growing concern. The longitudinal effects of commonly used therapies, including doxorubicin and trastuzumab, on cardiac remodeling and function remain unknown in this population. We sought to define the changes in echocardiographic parameters of structure, function, and ventricular-arterial (VA) coupling, and their associations with left ventricular ejection fraction (LVEF) and heart failure (HF) symptoms. METHODS: -In a longitudinal prospective cohort study of 277 breast cancer participants receiving doxorubicin (Dox), trastuzumab (Tras), or both (Dox+Tras), we obtained 1,249 echocardiograms over a median followup of 2...
January 19, 2017: Circulation
https://www.readbyqxmd.com/read/28097499/automating-perforator-flap-mra-and-cta-reporting
#2
Christopher J Lange, Nanda Deepa Thimmappa, Srikanth R Boddu, Silvina P Dutruel, Mengchao Pei, Zerwa Farooq, Ashkan Heshmatzadeh Behzadi, Yi Wang, Ramin Zabih, Martin R Prince
Surgical breast reconstruction after mastectomy requires precise perforator coordinates/dimensions, perforator course, and fat volume in a radiology report. Automatic perforator reporting software was implemented as an OsiriX Digital Imaging and Communications in Medicine (DICOM) viewer plugin. For perforator analysis, the user identifies a reference point (e.g., umbilicus) and marks each perforating artery/vein bundle with multiple region of interest (ROI) points along its course beginning at the muscle-fat interface...
January 17, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28089082/backcasting-to-identify-food-waste-prevention-and-mitigation-opportunities-for-infant-feeding-in-maternity-services
#3
Yvonne Ryan-Fogarty, Genevieve Becker, Richard Moles, Bernadette O'Regan
Food waste in hospitals is of major concern for two reasons: one, healthcare needs to move toward preventative and demand led models for sustainability and two, food system sustainability needs to seek preventative measures such as diet adaptation and waste prevention. The impact of breast-milk substitute use on health services are well established in literature in terms of healthcare implications, cost and resourcing, however as a food demand and waste management issue little has been published to date. This paper presents the use of a desk based backcasting method to analyse food waste prevention, mitigation and management options within the Irish Maternity Service...
January 6, 2017: Waste Management
https://www.readbyqxmd.com/read/28075192/loss-of-monocyte-chemoattractant-protein-1-expression-delays-mammary-tumorigenesis-and-reduces-localized-inflammation-in-the-c3-1-sv40tag-triple-negative-breast-cancer-model
#4
Taryn L Cranford, Kandy T Velázquez, Reilly T Enos, Jackie E Bader, Meredith S Carson, Ioulia Chatzistamou, Mitzi Nagarkatti, E Angela Murphy
Monocyte chemoattractant protein 1 (MCP-1) has been implicated as a major modulator in the progression of mammary tumorigenesis, largely due to its ability to recruit macrophages to the tumor microenvironment. Macrophages are key mediators in the connection between inflammation and cancer progression and have been shown to play an important role in tumorigenesis. Thus, MCP-1 may be a potential therapeutic target in inflammatory and difficult-to-treat cancers such as triple negative breast cancer (TNBC). We examined the effect of MCP-1 depletion on mammary tumorigenesis in a model of TNBC...
January 11, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28074018/evaluation-of-dose-homogeneity-in-cone-beam-breast-computed-tomography
#5
Giovanni Mettivier, Matilde Costa, Nico Lanconelli, Anna Ianiro, Mariagabriella Pugliese, Maria Quarto, Paolo Russo
The aim of this study is to determine, via measurements on phantoms and Monte Carlo (MC) simulations, the dose distribution of absorbed dose in a cone-beam breast computed tomography scan. The absorbed dose volume distribution was measured inside a polyethylene cylindrical phantom, simulating adipose breast tissue, using LiF:Mg,Ti thermoluminescence dosimeters. A reasonable agreement (between 2 and 8%) between the simulated and measured data was observed. The 3D distribution of absorbed dose was evaluated at 40, 60 and 80 kV in a phantom simulating a pendant breast...
January 10, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28068349/influence-of-anthropogenic-disturbances-on-stand-structural-complexity-in-andean-temperate-forests-implications-for-managing-key-habitat-for-biodiversity
#6
Julián Caviedes, José Tomás Ibarra
Forest attributes and their abundances define the stand structural complexity available as habitat for faunal biodiversity; however, intensive anthropogenic disturbances have the potential to degrade and simplify forest stands. In this paper we develop an index of stand structural complexity and show how anthropogenic disturbances, namely fire, logging, livestock, and their combined presence, affect stand structural complexity in a southern Global Biodiversity Hotspot. From 2011 to 2013, we measured forest structural attributes as well as the presence of anthropogenic disturbances in 505 plots in the Andean zone of the La Araucanía Region, Chile...
2017: PloS One
https://www.readbyqxmd.com/read/28066808/effect-of-mr-imaging-contrast-thresholds-on-prediction-of-neoadjuvant-chemotherapy-response-in-breast-cancer-subtypes-a-subgroup-analysis-of-the-acrin-6657-i-spy-1-trial
#7
Wen Li, Vignesh Arasu, David C Newitt, Ella F Jones, Lisa Wilmes, Jessica Gibbs, John Kornak, Bonnie N Joe, Laura J Esserman, Nola M Hylton
Functional tumor volume (FTV) measurements by dynamic contrast-enhanced magnetic resonance imaging can predict treatment outcomes for women receiving neoadjuvant chemotherapy for breast cancer. Here, we explore whether the contrast thresholds used to define FTV could be adjusted by breast cancer subtype to improve predictive performance. Absolute FTV and percent change in FTV (ΔFTV) at sequential time-points during treatment were calculated and investigated as predictors of pathologic complete response at surgery...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28062965/patient-satisfaction-and-clinical-outcomes-following-414-breast-reductions-application-of-breast-q
#8
A Cogliandro, M Barone, G Cassotta, S Tenna, B Cagli, P Persichetti
BACKGROUND: The aim of this study was to measure breast satisfaction and quality of life using the BREAST-Q Reduction Module in a large sample of postoperative patients having breast reduction using the inverted T technique. METHODS: With due approval from the ethics committee of our university, 414 patients who were seen in consultation for breast reduction surgery between 2005 and 2015 performed by the same team were asked to fill out BREAST-Q surveys. The patient factors collected for all those undergoing breast reduction included age, body mass index, incision pattern, areola complex pedicle used, amount of tissue resected, concurrent procedures, and complications...
January 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28058719/segmented-separable-footprint-projector-for-digital-breast-tomosynthesis-and-its-application-for-subpixel-reconstruction
#9
Jiabei Zheng, Jeffrey A Fessler, Heang-Ping Chan
PURPOSE: Digital forward and back projectors play a significant role in iterative image reconstruction. The accuracy of the projector affects the quality of the reconstructed images. Digital breast tomosynthesis (DBT) often uses the ray-tracing (RT) projector that ignores finite detector element size. This paper proposes a modified version of the separable footprint (SF) projector, called the segmented separable footprint (SG) projector, that calculates efficiently the Radon transform mean value over each detector element...
January 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28057031/-18-fdg-pet-ct-for-predicting-the-outcome-in-er-her2-breast-cancer-patients-comparison-of-clinicopathological-parameters-and-pet-image-derived-indices-including-tumor-texture-analysis
#10
David Groheux, Antoine Martineau, Luis Teixeira, Marc Espié, Patricia de Cremoux, Philippe Bertheau, Pascal Merlet, Charles Lemarignier
BACKGROUND: This study investigated the value of some clinicopathological parameters and 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography ((18)FDG-PET/CT) indices, including textural features, to predict event-free survival (EFS) in estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) locally advanced breast cancer (BC) patients. METHODS: FDG-PET/CT indices and clinicopathological parameters were assessed before neoadjuvant chemotherapy (NAC)...
January 5, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28056551/hepatitis-b-x-interacting-protein-promotes-cisplatin-resistance-and-regulates-cd147-via-sp1-in-ovarian-cancer
#11
Wei Zou, Xiangdong Ma, Hong Yang, Wei Hua, Biliang Chen, Guoqing Cai
Ovarian cancer is the highest mortality rate of all female reproductive malignancies. Drug resistance is a major cause of treatment failure in malignant tumors. Hepatitis B X-interacting protein acts as an oncoprotein, regulates cell proliferation, and migration in breast cancer. We aimed to investigate the effects and mechanisms of hepatitis B X-interacting protein on resistance to cisplatin in human ovarian cancer cell lines. The mRNA and protein levels of hepatitis B X-interacting protein were detected using RT-PCR and Western blotting in cisplatin-resistant and cisplatin-sensitive tissues, cisplatin-resistant cell lines A2780/CP and SKOV3/CP, and cisplatin-sensitive cell lines A2780 and SKOV3...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28048929/su-c-207b-04-automated-segmentation-of-pectoral-muscle-in-mr-images-of-dense-breasts
#12
E Verburg, S N de Waard, W B Veldhuis, C H van Gils, Kga Gilhuijs
PURPOSE: To develop and evaluate a fully automated method for segmentation of the pectoral muscle boundary in Magnetic Resonance Imaging (MRI) of dense breasts. METHODS: Segmentation of the pectoral muscle is an important part of automatic breast image analysis methods. Current methods for segmenting the pectoral muscle in breast MRI have difficulties delineating the muscle border correctly in breasts with a large proportion of fibroglandular tissue (i.e., dense breasts)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048744/su-f-t-119-development-of-heart-prediction-model-to-increase-accuracy-of-dose-reconstruction-for-radiotherapy-patients
#13
E Mosher, M Choi, E Jones, C Lee
PURPOSE: To assess individual variation in heart volume and location in order to develop a prediction model of the heart. This heart prediction model will be used to calculate individualized heart doses for radiotherapy patients in epidemiological studies. METHODS: Chest CT images for 30 adult male and 30 adult female patients were obtained from NIH Clinical Center. Image-analysis computer programs were used to segment the whole heart and 8 sub-regions and to measure the volume of each sub- region and the dimension of the whole heart...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048639/tu-h-209-02-quality-assurance-and-qmp-for-brachytherapy-treatment-delivery-and-treatment-planning-system
#14
M Chilukuri
Learnings Objectives: 1. Although brachytherapy is the oldest form of radiation therapy, the rapid advancement of the methods of dose calculation, treatment planning and treatment delivery pushes us to keep updating our knowledge and experience to new procedures all the time. Our purpose is to present the newest applicators used in Accelerated Partial Breast Irradiation (APBI) and the techniques of using them for a maximum effective treatment. Our objective will be to get the user familiar with the Savi, Contura and ML Mammosite from the detailed description and measurements to cavity eval and choice or size, to acceptance tests and use of each...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048359/su-f-j-121-dosimetric-evaluation-of-active-breathing-coordinator-response-gating-system-linked-to-linear-accelerator-in-volumetric-modulated-arc-therapy
#15
S Lee, Y Zheng, D Albani, V Colussi, J Dorth, J Sohn
PURPOSE: To reduce internal target volume (ITV), respiratory management is a must in imaging and treatment for lung, liver, and breast cancers. We investigated the dosimetric accuracy of VMAT treatment delivery with a Response™ gating system linked to linear accelerator. METHODS: The Response™ gating module designed to directly control radiation beam by breath-holding with a ABC system (Elekta AB, Stockholm, Sweden) was tested for VMAT treatments. Seven VMAT plans including three conventional and four stereotactic body radiotherapy (SBRT) cases were evaluated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048313/we-de-207b-10-library-based-x-ray-scatter-correction-for-dedicated-cone-beam-breast-ct-clinical-validation
#16
L Shi, S Vedantham, A Karellas, L Zhu
PURPOSE: Scatter contamination is detrimental to image quality in dedicated cone-beam breast CT (CBBCT), resulting in cupping artifacts and loss of contrast in reconstructed images. Such effects impede visualization of breast lesions and the quantitative accuracy. Previously, we proposed a library-based software approach to suppress scatter on CBBCT images. In this work, we quantify the efficacy and stability of this approach using datasets from 15 human subjects. METHODS: A pre-computed scatter library is generated using Monte Carlo simulations for semi-ellipsoid breast models and homogeneous fibroglandular/adipose tissue mixture encompassing the range reported in literature...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048291/su-f-i-01-normalized-mean-glandular-dose-values-for-dedicated-breast-ct-using-realistic-breast-shaped-phantoms
#17
A Hernandez, J Boone
PURPOSE: To estimate normalized mean glandular dose values for dedicated breast CT (DgN-CT) using breast CT-derived phantoms and compare to estimations using cylindrical phantoms. METHODS: Segmented breast CT (bCT) volume data sets (N=219) were used to measure effective diameter profiles and were grouped into quintiles by volume. The profiles were averaged within each quintile to represent the range of breast sizes found clinically. These profiles were then used to generate five voxelized computational phantoms (V1, V2, V3, V4, V5 for the small to large phantom sizes, respectively), and loaded into the MCNP6 lattice geometry to simulate normalized mean glandular dose coefficients (DgN-CT) using the system specifications of the Doheny-prototype bCT scanner in our laboratory...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048059/tu-ab-202-06-quantitative-evaluation-of-deformable-image-registration-in-mri-guided-adaptive-radiation-therapy
#18
K Mooney, T Zhao, Y Duan, M Zhang, O Green, S Mutic, D Yang
PURPOSE: To assess the performance of the deformable image registration algorithm used for MRI-guided adaptive radiation therapy using image feature analysis. METHODS: MR images were collected from five patients treated on the MRIdian (ViewRay, Inc., Oakwood Village, OH), a three head Cobalt-60 therapy machine with an 0.35 T MR system. The images were acquired immediately prior to treatment with a uniform 1.5 mm resolution. Treatment sites were as follows: head/neck, lung, breast, stomach, and bladder...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048008/su-f-t-289-mlc-fluence-sonogram-based-delivery-quality-assurance-for-bilateral-breast-irradiation
#19
Rajesh Thiyagarajan, K P Karrthick, Tejinder Kataria, N Arunai, Nambi Raj, Ramu Mahendran, Tamil Selvan, Palani Duraikannu
PURPOSE: Performing DQA for Bilateral (B-L) breast tomotherapy is a challenging task due to the limitation of any commercially available detector array or film. Aim of this study is to perform DQA for B-L breast tomotherapy plan using MLC fluence sinogram. METHODS: Treatment plan was generated on Tomotherapy system for B-L breast tumour. B-L breast targets were given 50.4 Gy prescribed over 28 fractions. Plan is generated with 6 MV photon beam & pitch was set to 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047974/tu-h-209-03-planning-and-treatment-delivery-for-apbi-using-savi-contura-and-ml-mammosite
#20
S Pella
Learnings Objectives: 1. Although brachytherapy is the oldest form of radiation therapy, the rapid advancement of the methods of dose calculation, treatment planning and treatment delivery pushes us to keep updating our knowledge and experience to new procedures all the time. Our purpose is to present the newest applicators used in Accelerated Partial Breast Irradiation (APBI) and the techniques of using them for a maximum effective treatment. Our objective will be to get the user familiar with the Savi, Contura and ML Mammosite from the detailed description and measurements to cavity eval and choice or size, to acceptance tests and use of each...
June 2016: Medical Physics
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