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ibuprofen and kidney damage

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https://www.readbyqxmd.com/read/30158028/protective-effect-of-commercial-green-tea-on-ibuprofen-induced-glomerular-atrophy-in-kidney-of-adult-rat
#1
Afnan Gul, Khadija Qamar, Tassaduq Hussain
OBJECTIVE: To determine the effect of commercial green tea on ibuprofen-induced glomerular atrophy in kidney of adult rat by using transvertical glomerular diameter as the determining parameter. STUDY DESIGN: Laboratory-based experimental study. PLACE AND DURATION OF STUDY: Department of Anatomy, Army Medical College Rawalpindi in collaboration with National Institute of Health (NIH) Islamabad from December 2016 to January 2017. METHODOLOGY: Thirty Sprague-dawley rats, males and females, were selected and divided into three groups...
September 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29461420/the-effect-of-ibuprofen-on-muscle-hematological-and-renal-function-hydric-balance-pain-and-performance-during-intense-long-distance-running
#2
Raphael Fabricio de Souza, Dihogo Gama de Matos, Alexandre Reis Pires Ferreira, Philip Chilibeck, Natalie de Almeida Barros, Alan Santos de Oliveira, Luana Mendonça Cercato, Danielle Soares da Silva, Felipe José Aidar
The aim of this study was to investigate the effect of prophylactic use of nonsteroidal anti-inflammatory drugs (NSAID, i.e. Ibuprofen) on physical performance, vertical jump, muscle biomarkers, liver, kidney, acute pain and hydration status of participants in the 42 km Trail Running Challenge, a long-distance race integrated over mountain routes. The sample consisted of 20 males randomly divided into two groups: a control group (CG) and an experimental group (EG) with 12 completing the race (41.1±8.8 y; 75...
February 14, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27901208/gastric-and-renal-effects-of-cox-2-selective-and-non-selective-nsaids-in-rats-receiving-low-dose-aspirin-therapy
#3
Marcella Goetz Moro, Paula Katherine Vargas Sanchez, Mayara Vitorino Gevert, Emeline Maria Baller, Ana Flávia Tostes, Ana Caroline Lupepsa, Sinvaldo Baglie, Gilson Cesar Nobre Franco
The consumption of low-dose aspirin (LDA) to prevent cardiovascular disease continues to increase worldwide. Consequently, the number of chronic LDA users seeking dental procedures that require complementary acute anti-inflammatory medication has also grown. Considering the lack of literature evaluating this interaction, we analyzed the gastric and renal effects caused by a selective COX-2 inhibitor (etoricoxib) and a non-selective COX-2 inhibitor (ibuprofen) nonsteroidal anti-inflammatory drug (NSAID) in rats receiving chronic LDA therapy...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/25119863/silver-nanoparticles-ibuprofen-loaded-poly-l-lactide-fibrous-membrane-anti-infection-and-anti-adhesion-effects
#4
Shuai Chen, Guangda Wang, Tianyi Wu, Xin Zhao, Shen Liu, Gang Li, Wenguo Cui, Cunyi Fan
Infection caused by bacteria is one of the crucial risk factors for tendon adhesion formation. Silver nanoparticles (AgNP)-loaded physical barriers were reported to be effective in anti-infection and anti-adhesion. However, high silver load may lead to kidney and liver damages. This study was designed for Ibuprofen (IBU)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes containing a low dosage of Ag to evaluate its potential in maintaining suitable anti-infection and good anti-adhesion effects. The in vitro drug release study showed a sustained release of Ag ions and IBU from the membrane...
August 12, 2014: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/25038277/effects-of-anti-inflammatory-drugs-in-primary-kidney-cell-culture-of-a-freshwater-fish
#5
João Luiz Coelho Ribas, Cesar A da Silva, Lucas de Andrade, Gabrieli Limberger Galvan, Marta Margarete Cestari, Edvaldo S Trindade, Aleksander R Zampronio, Helena C Silva de Assis
The non-steroidal anti-inflammatory drugs are emerging contaminants in aquatic ecosystems. This study aimed to evaluate toxic effects of some representative drugs of this pharmaceutical group on primary culture of monocytic lineage of Hoplias malabaricus anterior kidney. The effects of diclofenac, acetaminophen and ibuprofen in cell viability, lipopolysaccharide (LPS)-induced NO production and genotoxicity were evaluated. Cytometry analysis CD11b(+) cells showed 71.5% of stem cells, 19.5% of macrophages and 9% of monocytes...
September 2014: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/24074058/zizyphus-jujuba-protects-against-ibuprofen-induced-nephrotoxicity-in-rats
#6
Dalal S Awad, Reem M Ali, Nizar M Mhaidat, Ali M Shotar
CONTEXT: Zizyphus jujuba Mill. (Rhamnaceae) has long been used for the treatment of anxiety and insomnia in Chinese traditional medicine. The edible part is the fruit. Different parts of Z. jujuba possess medicinal properties such as anti-inflammatory, anticancer and antifertility. OBJECTIVES: This study evaluated the therapeutic effect of Z. jujuba fruit aqueous extract (ZE) on nephrotoxicity induced by ibuprofen (IBP) in rats. MATERIALS AND METHODS: Male Sprague-Dawley rats were grouped as normal saline (control), ZE (500 mg/kg), IBP (400 mg/kg) and ZE + IBP-treated groups...
February 2014: Pharmaceutical Biology
https://www.readbyqxmd.com/read/23243929/-toxicity-of-analgesics-in-the-family-doctor-practice
#7
REVIEW
Justyna Kuźniar-Placek, Jarosław Szponar, Lech Panasiuk
Analgesic usage without any consultation with a physician is very common in Poland. It increases the risk of occurrence of the harmful effect or harmful interaction with other medicaments taken by the patient. The abuse of painkillers applies not only to opioid but also to nonopioid analgesics. The largest group of commonly available medicaments are NSAIDs. The most frequent undesirable effect of NSAIDs' is dyspepsia. Among the most dangerous, and very often the ones without any symptoms, are gastric and duodenum ulceration for which the bleeding and perforation may be the first manifestation...
2012: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/21924358/the-role-of-nonsteroidal-anti-inflammatory-drugs-in-pediatric-patients
#8
REVIEW
Robin Dills, Leigh A Anderson, Catherine A Pierce
Like in the adult population, nonsteroidal anti-inflammatory drugs (NSAIDS) are commonly used agents for their anti-inflammatory, anti-pyretic and analgesic effects in pediatrics. They are also used for some distinct indications in pediatrics such as Kawasaki disease, patent ductus arteriosus (PDA) closure, and Juvenile Idiopathic Arthritis (JIA). The primary mechanism thought to cause their therapeutic effects is the inhibition of prostaglandin synthesis. NSAIDs inhibit cyclooxygenase (COX) which is an enzyme that is necessary for the formation of prostaglandins...
January 2012: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/21636647/p38-map-kinase-is-a-therapeutic-target-for-hepatic-encephalopathy-in-rats-with-portacaval-shunts
#9
Ana Agusti, Omar Cauli, Regina Rodrigo, Marta Llansola, Vicente Hernández-Rabaza, Vicente Felipo
OBJECTIVE: Inflammation plays a role in neurological alterations in patients with hepatic encephalopathy (HE). Animal models of HE show neuroinflammation. Treatment with ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), reduces neuroinflammation and restores cognitive and motor function in rats with HE due to portacaval shunts (PCS). This suggests that reducing neuroinflammation would improve neurological status in patients with minimal or clinical HE. NSAID induce kidney damage in patients with cirrhosis and PCS rats and are not suitable for clinical use...
November 2011: Gut
https://www.readbyqxmd.com/read/20926620/toxicological-evaluation-of-acyl-glucuronides-of-nonsteroidal-anti-inflammatory-drugs-using-human-embryonic-kidney-293-cells-stably-expressing-human-udp-glucuronosyltransferase-and-human-hepatocytes
#10
Toshihisa Koga, Ryoichi Fujiwara, Miki Nakajima, Tsuyoshi Yokoi
The chemical reactivity of acyl glucuronide (AG) has been thought to be associated with the toxic properties of drugs containing carboxylic acid moieties, but there has been no direct evidence that AG formation was related to the toxicity. In the present study, the cytotoxicity and genotoxicity of AGs were investigated. Human embryonic kidney (HEK) 293 cells stably expressing UDP-glucuronosyltransferase (UGT) 1A3 (HEK/UGT1A3) were constructed to assess the cytotoxicity of AGs, and HEK/UGT1A4 cells were also used as a negative reference...
January 2011: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/19800206/evaluation-of-analgesic-efficacy-gastrotoxicity-and-nephrotoxicity-of-fixed-dose-combinations-of-nonselective-preferential-and-selective-cyclooxygenase-inhibitors-with-paracetamol-in-rats
#11
Gaurav Kumar, Debasish Hota, Uma Nahar Saikia, Promila Pandhi
Nonsteroidal anti-inflammatory drugs (NSAIDs) are combined with paracetamol (PCM) with a view to enhance analgesic efficacy and reduce gastric toxicity. However, there are reports of enhanced nephrotoxicity with nonselective NSAID with PCM combinations. The present study investigated the analgesic efficacy, gastrotoxicity and nephrotoxicity of nonselective, preferential and selective cyclooxygenase inhibitors and their combination with PCM in rats. Graded doses of ibuprofen, meloxicam and celecoxib alone and their combination with fixed dose of PCM were administered to the rats by gavage for 14 days...
November 2010: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/17949535/persistence-of-nsaids-at-effect-sites-and-rapid-disappearance-from-side-effect-compartments-contributes-to-tolerability
#12
REVIEW
Kay Brune
BACKGROUND: Non-steroidal, anti-inflammatory drugs (NSAIDs) are still the most widely used drugs worldwide. The introduction of selective cyclooxygenase (COX)-2 inhibitors has led to compounds which appear less damaging to the gastrointestinal tract, but possibly more risky to the cardiovascular system than older drugs. None has as yet reached OTC-status. OBJECTIVE: This situation necessitates an analysis of the characteristics of those older ones which - due to their relative safety - have achieved over-the-counter (OTC) status...
December 2007: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/17695142/exploring-effects-of-different-nonsteroidal-antiinflammatory-drugs-on-lipid-peroxidation-part-ii-4-hne-profile
#13
Santanu Chakraborty, Kunal Roy, Chandana Sengupta
Non-steroidal anti-inflammatory drugs (NSAIDs) are common in alleviating pain, pyrexia and inflammation, in patients with rheumatoid arthritis and osteoarthritis. As these drugs are associated with high incidence of gastrointestinal ulceration, bleeding and kidney damage which may be linked with lipid peroxidation. our study was aimed to examine lipid peroxidation induction capacity of NSAIDs (diclofenac sodium, ibuprofen, flurbiprofen, paracetamol, nimesulide, celecoxib and indomethacin) by determining 4-hydroxy-2-nonenal (4-HNE) concentration as an index of lipid peroxidation and to see the suppressive potential of ascorbic acid on NSAID induced lipid peroxidation...
May 2007: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/17608647/over-the-counter-medication-use-for-childhood-fever-a-cross-sectional-study-of-australian-parents
#14
Anne Walsh, Helen Edwards, Jenny Fraser
AIM: To report Australian parents' medication (paracetamol, ibuprofen and homeopathic) use in childhood fever management. METHODS: A cross-sectional survey of 401 Queensland parents of children aged between 6 months and 5 years recruited through advertising (48.4%), face-to-face (26.4%) and snowball (24.4%) methods was conducted. A 17-item instrument was developed; construct and content validity were determined by an expert panel; and item reliability by test-retest with nine parents...
September 2007: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/17166604/changes-in-the-timing-of-reproduction-following-chronic-exposure-to-ibuprofen-in-japanese-medaka-oryzias-latipes
#15
COMPARATIVE STUDY
Jennifer L Flippin, Duane Huggett, Christy M Foran
Effluents from wastewater treatment plants and untreated sewage constitute a low concentration but continuous source of pharmaceutical products to the aquatic environment. One such drug, ibuprofen, is a non-steroidal anti-inflammatory agent that primarily acts through inhibition of cyclooxygenase (COX) activity. Oryzias latipes (Japanese medaka) were exposed for 6 weeks via water to three concentrations of ibuprofen (1-100 microg/L nominal concentrations) and a water control. Reproductive parameters, including frequency of spawning, fecundity, egg size, and rate of fertilization, were measured for each pair of adult medaka following 6 weeks of exposure...
February 15, 2007: Aquatic Toxicology
https://www.readbyqxmd.com/read/15495777/nonprescription-analgesics-and-their-use-in-solid-organ-transplantation-a-review
#16
REVIEW
Steven Gabardi, Linh Luu
OBJECTIVE: To review the pharmacology, adverse events, drug interactions, and use of the nonprescription analgesics in solid-organ transplant recipients. STUDY SELECTION AND DATA EXTRACTION: Studies evaluating nonprescription analgesics in solid-organ transplantation were considered for evaluation. English-language studies were selected for inclusion. DATA SYNTHESIS: Nonprescription analgesics (aspirin, choline salicylate, magnesium salicylate, sodium salicylate, ibuprofen, ketoprofen, naproxen sodium, and acetaminophen) are the most commonly purchased over-the-counter agents in the United States...
September 2004: Progress in Transplantation
https://www.readbyqxmd.com/read/15364641/inhibition-of-cox-isoforms-by-nutraceuticals
#17
Ben Seaver, Jerry Robert Smith
Humans have two isoforms of Prostaglandin H Synthase or cyclooxygenase: COX-1 and COX-2. COX-1 is cytoprotective. COX-2 inhibitors reduce inflammation without the risk of ulceration and kidney damage. The ideal nutraceutical would inhibit COX-2 synthesis while preserving COX-1 synthesis. The hypothesis for this research was that COX inhibitors would fall primarily into three categories: COX-2 specific inhibition, non-specific inhibition (COX-1 and COX-2), and minimal inhibition. The human Cayman COX inhibitor screening assay was used to determine the inhibitory concentration 50 (IC50) of COX-1/ COX-2 activity of each nutraceutical...
2004: Journal of Herbal Pharmacotherapy
https://www.readbyqxmd.com/read/12705061/-pharmacology-of-cyclooxygenase-2-inhibition
#18
COMPARATIVE STUDY
Eckhard Beubler
Prostaglandins are important modulators of pain and inflammation. Both, pain and inflammation can be inhibited either at the level of the phospholipase A2 by corticosteroids or at the level of the cyclooxygenase (COX) by non steroidal anti-inflammatory drugs (NSAIDs). Formally, "cyclooxygenase" in general was thought to be responsible for the synthesis of prostaglandins involved in pain, inflammation and fever as well as cytoprotection in the stomach, hemostasis and blood flow in the kidneys. Later, two isoenzymes, cyclooxygenase-1 and cyclooxygenase-2 were discovered...
2003: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/11153163/renal-damage-induced-by-the-treatment-with-non-opioid-analgesics-theoretical-assumption-or-clinical-significance
#19
D Fackovcova, V Kristova, M Kriska
Non-opioid analgesics are some of the most widely used therapeutic agents in clinical practice today. The number of patients at risk for adverse events related to the use of these agents is rapidly expanding. While the gastrointestinal toxicity of these medications is well known, it has become increasingly apparent that the kidney is also an important target for untoward clinical events. Evidence of the nephrotoxicity of analgesic preparations is not sufficiently completed and available in our region. Analgesic-related renal injury has been classified based on mechanism of action into "classic" analgesic nephropathy and NSAID-related renal toxicity...
2000: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/10487161/i-take-ibuprofen-regularly-for-my-arthritis-but-i-ve-heard-that-it-may-lead-to-kidney-damage-can-you-tell-me-more
#20
(no author information available yet)
No abstract text is available yet for this article.
August 1999: Mayo Clinic Health Letter
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