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Thyroid Bone

Tin Sui Ko, Michael Siu Hei Tse, Kam Kwong Wong, Wing Cheung Wong
Study Design: Observational study. Purpose: To assess the correlational accuracy between the traditional anatomic landmarks of the neck and their corresponding vertebral levels in Southern Chinese patients. Overview of Literature: Recent studies have demonstrated discrepancies between traditional anatomic landmarks of the neck and their corresponding cervical vertebra. Methods: The center of the body of the hyoid bone, the upper limit of the lamina of the thyroid cartilage, and the lower limit of the cricoid cartilage were selected as representative surface landmarks for this investigation...
October 16, 2018: Asian Spine Journal
Susanna C Larsson, Karl Michaëlsson, Stephen Burgess
Identification of causative risk factors amenable for modification is essential for the prevention and treatment of osteoporosis. Observational studies have identified associations between several potentially modifiable risk factors and osteoporosis. However, observational studies are susceptible to confounding, reverse causation bias, and measurement error, all of which limit their ability to provide causal estimates of the effect of exposures on outcomes, thereby reducing their ability to inform prevention and treatment strategies against bone loss and fractures...
October 12, 2018: Bone
Amrit Kaur, Monika Kucheria, Rekha Gupta, Gurvinder Pal Thami, Reetu Kundu
Extrapulmonary tuberculosis is uncommon and has an insidious onset with slow evolution and a paucibacillary nature. Here, we present a case of disseminated tuberculosis in an adult immunocompetent man presenting with morphologically different types of cutaneous lesions (i.e., multiple subcutaneous abcesses and multiple noduloulcerative lesions with discharging sinuses with seropurulent fluid). Extensive screening in the form of routine blood investigations, serologies, skin biopsy, Montoux test, sputum examination, chest and skull roentgenogram, noncontrast computed tomography chest and abdomen, contrast-enhanced computed tomography of the skull, and magnetic resonance imaging of lumbosacral spine with screening of the whole spine revealed extensive involvement of the skin, subcutaneous tissue, lungs, lymph nodes, skull bone, mandible, ribs, scapula, pelvis and Pott's spine, and thyroid...
September 2018: Journal of Clinical and Aesthetic Dermatology
Dilyara S Ismailova, Irina M Belovalova, Yaroslav O Grusha, Natalya Y Sviridenko
Orbital decompression is a surgical procedure aimed at increasing the orbital volume and/or decreasing the volume of the orbital fat. The indications for orbital decompression are determined in the course of thorough eye examination. An important objective of examination of a patient with thyroid eye disease (TED) is determination of inflammation activity and severity. Orbital decompression is a surgical procedure that can be performed in both the active and nonactive stages of the disease. However, the indications for the surgery in these cases are different...
2018: International Medical Case Reports Journal
Aylin Oral, Bülent Yazıcı, Cenk Eraslan, Zeynep Burak
Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. In this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients’ clinical outcomes and the contribution of SPECT/CT imaging...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
Farzaneh Amini Nezhad, Moloud Payab, Sara Nayebandi, Shirin Hasani-Ranjbar
BACKGROUND: Brown tumor may present as uni/multilocular osteolytic lesions with bone expansion, bone pain or pathologic fracture in primary, secondary and tertiary hyperparathyroidism. However, recently, such presentation is rare due to early detection using blood screening techniques before symptomatic bone lesions appear. CASE REPORT: A 65-year-old woman was admitted to our hospital with generalized bone pain and a progressive painless mass in her jaw appeared since 6 months ago...
October 4, 2018: International Journal of Surgery Case Reports
Roberto Luigi Cazzato, Pierre Auloge, Pierre De Marini, Chloé Rousseau, Jeanie Betsy Chiang, Guillaume Koch, Jean Caudrelier, Pramod Rao, Julien Garnon, Afshin Gangi
INTRODUCTION: Percutaneous image-guided cryo- (CA) and radiofrequency- (RFA) ablations have been widely used in the treatment of painful bone metastases (BM). However, paucity of data is available for the performance of these treatments when used with a curative intent. The aim of this study is to investigate the local progression free-survival (LPFS) after radical percutaneous image-guided ablation of BM in oligometastatic patients, and to identify predictive factors associated with local tumor progression...
October 11, 2018: International Journal of Hyperthermia
Catherine Cormier
A genetic disorder should be suspected in patients with hypercalcemia, notably those who are young; have family members with hypercalcemia; or have had a tumor of the endocrine pancreas, thyroid, pituitary, adrenal gland, or jaw bone. All forms of hypercalcemia should be interpreted according to the serum level of parathyroid hormone (PTH). Genetic forms are thus classified as related or unrelated to a parathyroid gland disorder. When the PTH level is elevated or is not depressed despite the hypercalcemia, findings that suggest hyperparathyroidism due to a genetic cause include syndromic manifestations in the patient or family members, parathyroid cancer (either suspected before surgery or confirmed during parathyroidectomy), multiple or recurrent parathyroid tumors, a family history of primary hyperparathyroidism, and the onset of primary hyperthyroidism before 50 years of age...
October 6, 2018: Joint, Bone, Spine: Revue du Rhumatisme
Sebastian Hoberück, Enrico Michler, Danilo Seppelt, Jörg Kotzerke, Claudia Brogsitter
A 68-year-old woman who underwent a thyroidectomy for bilateral goiter 20 years ago was referred to our department. The examination revealed a newly occurred thyroid nodule in the right central lobe. Unexpectedly the Tc-pertechnetate scan revealed several extrathyroidal foci right-sided supraclavicular, beside a cold thyroid nodule in the right lower lobe. Consecutive surgery and histology confirmed the suspected diagnosis of follicular thyroid cancer with multiple bone metastases. Whole-body scintigraphy performed after the following radioiodine therapy indicated disseminated osseous metastases...
October 8, 2018: Clinical Nuclear Medicine
Mohammad Abuqbeitah, Mustafa Demir, İffet Çavdar, Handan Tanyildizi, Nami Yeyin, Lebriz Uslu-Beşli, Levent Kabasakal, Nazenin İpek Işıkcı, Kerim Sönmezoğlu
The aim of the present study was to review the available models developed for calculating red bone marrow dose in radioiodine therapy using clinical data. The study includes 18 patients (12 females and six males) with metastatic differentiated thyroid cancer. Radioiodine tracer of 73 ± 16 MBq 131 I was orally administered, followed by blood sampling (2 ml) and whole-body scans (WBSs) done at several time points (2, 6, 24, 48, 72, and ≥ 96 h). Red bone marrow dose was estimated using the OLINDA/EXM 1...
October 8, 2018: Radiation and Environmental Biophysics
Shilpa Shah, Sarah Berry, Laura Bingham, Gillian Rea
An 8-month-old boy presented with a week's history of left lower limb swelling. He was apyrexic, well and developmentally age appropriate. He was born at 35+5 via by C-section for breech presentation, weighing 3.47 kg (97th centile).His left calf measured 21.5 cm and the right calf 19.5 cm. The overlying skin showed mild eczema. There was no circulatory compromise of the left leg, and he was systemically well.X-rays of the left tibia and fibula were normal. He received oral antibiotics for presumed cellulitis...
October 8, 2018: Archives of Disease in Childhood. Education and Practice Edition
M M Uygur, T Yoldemir, D G Yavuz
The interpretation of thyroid function tests should be cautiously made during the perimenopause and postmenopause period bearing in mind that physiologic changes do exist in this group of women in terms of secretion and metabolism of thyrotropin and thyroid hormones. Moreover the incidence of thyroid disorders increases in postmenopausal and elderly women. There is no consensus for screening postmenopausal women even though there is well-known evidence about the effect of thyroid status on cognitive function, cardiovascular risk, bone turnover, and longevity...
October 8, 2018: Climacteric: the Journal of the International Menopause Society
Ali Erhan Kayalar, Eylem Eren Eyupoglu, Seda Akyildiz, Askin Esen Hasturk, Abdurrahman Bakir
Calvarial and dural metastases of papillary thyroid carcinomas (PTC) are rarely reported in the medical literature. Most frequent calvarial metastases are seen to originate from lung, breast, and prostate cancers. Thyroid cancer metastases are generally well vascularized and cause destruction in the bone tissues. First choice of treatment in distant metastases of PTC is surgery and radioactive iodine treatment for the primary cause. Postsurgical radiotherapy is used in accepted and suitable patients.
October 2018: Journal of Craniofacial Surgery
Maxi Wass, Marcus Bauer, Roald Pfannes, Kerstin Lorenz, Andreas Odparlik, Lutz P Müller, Claudia Wickenhauser
BACKGROUND: Chronic active Epstein-Barr virus (EBV) infection (CAEBV) of the T-/NK-cell type, systemic form is a rare and potentially life-threatening illness caused by persistent EBV infection. The highest incidence is found in children and adolescents with increased frequency among Asians and Native Americans, while the disease is uncommon in Western countries. Typically patients present with unspecific symptoms, like fever, lymphadenopathy, hepatosplenomegaly and liver dysfunction...
October 3, 2018: BMC Cancer
Hiroaki Ogawa, Kei Ito, Takuya Shimizuguchi, Tomohisa Furuya, Keiji Nihei, Katsuyuki Karasawa
PURPOSE: Stereotactic body radiotherapy (SBRT) is expected to achieve safe and effective re-irradiation for painful bone metastases. This study aimed to clarify the efficacy of re-irradiation using SBRT for painful bone metastases. METHODS: Prospective database at our institution for the period between September 2013 and December 2017 were retrospectively reviewed for patients with: (1) painful bone metastases; (2) history of radiotherapy to the metastasis; and (3) SBRT performed as re-irradiation...
October 3, 2018: Acta Oncologica
Yun-Jie Zhang, Yu-Shui Ma, Qing Xia, Fei Yu, Zhong-Wei Lv, Cheng-You Jia, Xiao-Xin Jiang, Liang Zhang, Yun-Chao Shao, Wen-Ting Xie, Gai-Xia Lu, Xia-Qing Yv, Peng Zhong, Da Fu, Xiao-Feng Wang
The incidence of well‑differentiated thyroid cancer (WDTC) is rapidly increasing. Poor survival follows distant metastasis (DM) and recurrence. In the present study, we aimed to analyze the expression alterations in different stages of WDTC and the regulatory mechanism of DM and the recurrence of DM. A male patient diagnosed with follicular thyroid cancer and distant metastasis in the eleventh thoracic vertebrae received total thyroidectomy and the removal of a metastatic lesion. A local relapse was found in the vertebrae after four‑time iodine‑131 treatment...
September 26, 2018: Oncology Reports
Jordy P W Burger, Jouke J H van der Laan, Tom A Jansen, Joost P H Drenth, Elisabeth A Roovers, Margreet M S Wessels, Peter J Wahab
AIM: To evaluate the yield of routine laboratory tests and Dual Energy X-ray Absorptiometry (DEXA) scans in coeliac disease. METHODS: A retrospective analysis of medical files of all followed-up patients with coeliac disease attending Rijnstate Hospital in 2016 was conducted with respect to blood tests of hemoglobin, vitamin B12, folate acid, iron status, calcium, vitamin D, glucose, thyroid function, DEXA-scans and related symptoms or signs of abnormalities. All patients had positive coeliac serology and/or biopsy-proven coeliac disease and attended regular visits after diagnosis...
September 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
Francisca Caimari, Stephen Keddie, Michael P Lunn, Shirley D'Sa, Stephanie E Baldeweg
Context: POEMS syndrome is a rare multisystem disorder characterised by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes among other features. Objective: To describe the prevalence and course of the endocrine dysfunction in the context of POEMS. Design: Cohort study with systematic review of the endocrinopathy in POEMS. Setting: 75 patients with POEMS were evaluated by the multidisciplinary team at our tertiary specialist centre...
September 17, 2018: Journal of Clinical Endocrinology and Metabolism
Linxin Xu, Yi Ren, Jianhong Yin, Jing Yang, Yunfeng Liu, Jin Zhang, Yi Zhang, Chenyu Xiang, Luyang Yang
RATIONALE: Mucopolysaccharidosis IVA (Morquio A) is a catabolic mucopolysaccharide disorder caused by galactose-6-sulfate sulfatase deficiency. It is an autosomal recessive inherited disease. Previous reports on clinical characteristics of Morquio A mainly focused on growth retardation, skeletal deformities, and organ damage in children and adolescents, while the effects of mucopolysaccharide metabolism disorders on endocrine hormone metabolism level have not been reported. Herein, we reported the endocrine hormone metabolism in a case diagnosed as Morquio A...
September 2018: Medicine (Baltimore)
Gisele M Martins, Marília B C G Teixeira, Marcos V Silva, Bianca Neofiti-Papi, Manuela Miranda-Rodrigues, Patricia C Brum, Cecilia H A Gouveia
Evidence shows that sympathetic nervous system (SNS) activation inhibits bone formation and activates bone resorption leading to bone loss. Because thyroid hormone (TH) interacts with the SNS to control several physiological processes, we raised the hypothesis that this interaction also controls bone remodeling. We have previously shown that mice with double-gene inactivation of α2A- and -adrenoceptors (α2A/2C-AR-/- ) present high bone mass (HBM) phenotype and resistance to thyrotoxicosis-induced osteopenia, which supports a TH-SNS interaction to control bone mass and suggests that it involves α2-AR signaling...
2018: Frontiers in Endocrinology
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