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Thyroid Bone

Aikaterini Lavrentaki, Asad Ali, Brendan Cooper, Abd Tahrani
Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious co-morbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA...
December 1, 2018: European Journal of Endocrinology
Andrea Porzionato, Veronica Macchi, Cristina Mazzarolo, Aldo Morra, Jose Sanudo, Raffaele De Caro
Differential diagnosis between normal/variant anatomy and pathological/traumatic findings represents one of the main matters of investigation of the so-called forensic clinical anatomy. In the literature, many anatomical variations of the laryngeal thyroid cartilage have been reported, with potential implications in forensic pathology. They include triticeal cartilages, foramen thyroideum, asymmetry, segmentation or agenesis of the superior thyroid horns, bone connections with the hyoid bone, absence of cricothyroid facets, hypertrophy of the inferior thyroid tubercle, and asymmetries in the thyroid notch, isthmus, or length of the inferior horn...
December 6, 2018: American Journal of Forensic Medicine and Pathology
Nobutoshi Kumagai, Yukiko Enomoto, Masafumi Miyai, Yusuke Egashira, Noriyuki Nakayama, Toru Iwama
BACKGROUND: Bony structures around the carotid artery such as the styloid process and hyoid bone can cause dissection, compression, plaque formation, and plaque rupture of the carotid artery. To the best of our knowledge, this case is the first finding of thyroid cartilage being the cause of a lesion corresponding to adjacent common carotid artery (CCA) atherosclerosis. CASE DESCRIPTION: A 51-year-old man with a history of hypertension and dyslipidemia suddenly experienced right facial numbness and dysphasia while front crawl swimming, which he usually did 3 times weekly...
December 6, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Seiji Kakiuchi, Kimikazu Yakushijin, Rina Sakai, Koji Kawaguchi, Ako Higashime, Keiji Kurata, Hiroya Ichikawa, Shigeki Nagao, Junpei Rikitake, Naomi Kiyota, Hiroshi Matsuoka, Hironobu Minami
A 69-year-old woman who had been diagnosed with unresectable papillary thyroid cancer was referred to our hospital. We initially treated her with sorafenib, but she subsequently developed erythema multiforme, which was suspected to be a drug rush due to sorafenib; therefore, sorafenib was discontinued. At the time of discontinuation, immature blast cells were detected in her peripheral blood. Approximately two weeks later, her skin rash improved substantially, but the proportion of blasts in the peripheral blood increased...
December 4, 2018: Journal of Oncology Pharmacy Practice
Ufuk Çakır, Cuneyt Tayman
Background It is known that thyroid hormones have effects on bone development. In particular, the effect of thyroid hormones on osteopenia of prematurity (OOP) has not been examined in preterm infants. Our study aimed to examine the relationship between OOP and congenital hypothyroidism (CH) in preterm infants. Methods Very low birth weight infants (VLBW, <1500 g) were included in the study. Thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels were measured on postnatal day 5. Serum calcium, phosphorus and alkaline phosphatase (ALP) levels were studied as standard screening parameters for OOP at postnatal week 4...
December 4, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Mehdi Dehghani, Saranaz Jangjoo, Ahmad Monabati, Dena Masoomi Bandari, Nasrin Namdari
The standard therapy for thyroid cancer is total or near total thyroidectomy, followed by the administration of radioactive iodine for remnant ablation or residual disease. Patients with radioiodine therapy are predisposed to second malignant neoplasms in organs such as central nervous system (CNS), breast, prostate, kidney, bone marrow, salivary gland, and digestive tract. Exposure to carcinogen including occupational and therapy related hazard, aging and genetic susceptibility are other causes of second primary cancers...
November 2018: Iranian Journal of Medical Sciences
Sayed Esmaeil Mousavi, Heresh Amini, Pouria Heydarpour, Fatemeh Amini Chermahini, Lode Godderis
Beyond vitamin D (VD) effect on bone homeostasis, numerous physiological functions in human health have been described for this versatile prohormone. In 2016, 95% of the world's population lived in areas where annual mean ambient particulate matter (<2.5 μm) levels exceeded the World Health Organization guideline value (Shaddick et al., 2018). On the other hand, industries disperse thousands of chemicals continually into the environment. Further, considerable fraction of populations are exposed to tobacco smoke...
November 30, 2018: Environment International
John R Nesiba, Courtney Caplin, Erik J Nuveen
This case report details a 21-year-old transgender female patient who underwent a concomitant trichophyllic brow lift with frontal bone reduction, tracheal shave (also known as thyroid chondroplasty), and rhinoplasty for facial feminization in conjunction with her transitioning process. During rhinoplasty (similarly to many other procedures), harvesting cartilage for structural grafting is often necessary, and this is typically done from a distant, unrelated surgical site. During this case, cartilage from the thyroid lamina was used in structural grafting in the form of a columellar strut...
November 2, 2018: Journal of Oral and Maxillofacial Surgery
Junko Ajimi, Junichi Nishiyama, Ritsuko Masuda, Sadanori Hosoi, Reinii Sakamoto, Tomohiko Murata, Masaaki Miura, Toshiyasu Suzuki
OBJECTIVE: The Universal Adapter for Smartphones® c an record s till images and movies during intubation using the monitor display and recording functions of a smartphone. Here, we describe the successful use of the Airtraq Double Lumen® with the Universal Adapter for Smartphones® for airway management during anesthesia in a patient with intubation difficulty. METHODS: A 78-year-old man required thoracoscopic upper lobectomy for a pulmonary tumor. Preoperative examination revealed micrognathia, mouth opening equivalent to a three-finger width, Mallampati Class II, mentum-hyoid bone distance equal to a 2...
December 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Akihiro Yasoda
Thyrotoxicosis, commonly seen in a condition with Graves' disease, causes increased bone absorption and results in osteoporosis with increased bone turnover. The osteoporotic state is dominant in cortical bones with slight impairment of calcium-homeostasis, although the precise mechanism is still elusive. It ought to be recovered in accordance with the amelioration of thyroid hormone status, but past history of thyrotoxicosis might cause bone fragility, especially in post-menopausal or senile patients.
2018: Clinical Calcium
Grzegorz Mieczysław Rudzki, Monika Lenart-Lipińska, Agata Smoleń, Beata E Chrapko, Beata Matyjaszek-Matuszek
Introduction Subclinical hyperthyroidism (SCH) also known as mildly symptomatic has recently been diagnosed more frequently. One of the main endogenous causes of this disorder is autonomously functioning thyroid nodule (AFTN). Despite the fact that it is usually asymptomatic SCH entails repercussions on the cardiovascular system and bone as well as carries a risk of progression to overt hyperthyroidism with a typical clinical picture. Treatment is still controversial and its benefits are widely debated in literature...
November 27, 2018: Endokrynologia Polska
Pon Ramya Sivaperumal, Sneha Magatha Latha, Sowmiya Narayani, Julius Scott
Purpose: Acute lymphoblastic leukemia (ALL), a common hematological malignancy observed in children, typically presents with fever, pallor, easy bruising, hepatosplenomegaly and lymphadenopathy. However, when ALL manifests with unusual signs and the blood counts and peripheral smears are normal, it causes a diagnostic dilemma. Case Report: We report a 5-year-old boy who presented with bilateral proptosis as the initial manifestation of ALL. He presented with fever and bilateral knee pain attributed to a fall while playing...
October 2018: Journal of Ophthalmic & Vision Research
Vikram Haridas, Kiran Haridas
Aim: To evaluate the prevalence of anti-thyroid antibodies in a cohort of rheumatoid arthritis (RA) patients from south India and their clinical use. Methods: A cross-sectional epidemiological study was conducted including 1217 patients aged more than 14 years with fever and thrombocytopenia admitted in the medical wards from October 2013 to September 2014. Detailed clinical examination and routine investigations were done; specific investigations like blood culture, widal test, antigen test for malaria, IgM ELISA leptospira, IgM ELISA dengue, bone marrow aspiration/biopsy etc...
May 2018: Journal of the Association of Physicians of India
Jaime Fornetti, Alana L Welm, Sheila A Stewart
The bone is the third most common site of metastasis for a wide range of solid tumors including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of metastatic prostate and breast cancer patients harboring bone metastasis. Unfortunately, once cancer spreads to the bone, it is rarely cured and is associated with a wide range of morbidities including pain, increased risk of fracture, and hypercalcemia. This fact has driven experts in the fields of bone and cancer biology to study the bone, and has revealed that there is a great deal that each can teach the other...
November 26, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Judith Gebauer, Claire Higham, Thorsten Langer, Christian Denzer, Georg Brabant
The number of patients surviving five or more years after initial cancer diagnosis has significantly increased over the last decades due to considerable improvements in the treatment of many cancer entities. A negative consequence of this is the emergence of long-term sequelae and endocrine disorders account for a high proportion of these. These late effects can occur decades after cancer treatment and affect up to 50% of childhood cancer survivors. Multiple predisposing factors for endocrine late effects have been identified; including radiation, gender and age at the time of diagnosis...
November 23, 2018: Endocrine Reviews
Debasis Gochhait, Ramkumar Govindarajalou, Rakhee Kar, Vidhyalakshmi Rangarajan, Priyadarshini Dehuri, Biswajit Dubashi
Plasma cell neoplasms may have a spectrum of clinical presentation ranging from asymptomatic proliferation to single/multiple mass lesions in medullary/ extramedullary sites. Extramedullary plasmacytoma (EMP) is a rare tumor of the soft tissue without theinvolvement of bone marrow which most commonly affects the head and neck region and may precede multiple myeloma (MM) (1). Thyroid can rarely be a site for EMP or may be infiltrated by systemic multiple myeloma. These patients are predominantly males and are usually well beyond middle age...
November 21, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Kexin Meng, Wanyuan Chen, Wei Tian, Kewang Sun, Hailong Chen
RATIONALE: Medullary thyroid carcinoma (MTC) is an aggressive subtype of thyroid cancer with frequent hematogenous metastasis. While its metastasis is usually observed in the lung, liver, or bone, it rarely migrates to the breast. PATIENT CONCERNS: Here we report 2 cases with a complaint of breast lump after initial treatment of MTC. DIAGNOSES: In both patients, the MTC characteristics of breast nodules were confirmed by pathologic analysis of biopsy specimens...
November 2018: Medicine (Baltimore)
Firdevs Baş, Zehra Yavaş Abalı, Güven Toksoy, Şükran Poyrazoğlu, Rüveyde Bundak, Çağrı Güleç, Zehra Oya Uyguner, Feyza Darendeliler
Central precocious puberty (CPP) or early puberty (EP) is a rare entity in combined pituitary hormone deficiency (CPHD), the latter caused by mutations in pituitary transcription factor genes. The early onset of puberty in two patients with CPHD with POU1F1 gene mutation was evaluated. A 3-month-old boy was diagnosed with central hypothyroidism, and L-thyroxine was commenced. He was referred for the evaluation of short stature at 20 months of age. Anthropometric evaluation revealed severe short stature (- 6...
November 20, 2018: Hormones: International Journal of Endocrinology and Metabolism
Stella Bernardi, Andrea Michelli, Deborah Bonazza, Veronica Calabrò, Fabrizio Zanconati, Gabriele Pozzato, Bruno Fabris
BACKGROUND: Thyroid lymphomas are an exceptional finding in patients with thyroid nodules. Burkitt's lymphoma is one of the rarest and most aggressive forms of thyroid lymphomas, and its prognosis depends on the earliness of medical treatment. Given the rarity of this disease, making a prompt diagnosis can be challenging. For instance, fine-needle aspiration (FNA) cytology, which is the first-line diagnostic test that is performed in patients with thyroid nodules, is often not diagnostic in cases of thyroid lymphomas, with subsequent delay of the start of therapy...
November 19, 2018: BMC Endocrine Disorders
Jenny J Ko, Jasleen Grewal, Tony Ng, Jean-Michel Lavoie, My Linh Thibodeau, Yaoqing Shen, Andrew J Mungall, Greg Taylor, Kasmintan A Schrader, Steven J M Jones, Christian Kollmannsberger, Janessa Laskin, Marco A Marra
INTRODUCTION: Thyroid-like follicular renal cell carcinoma (TLFRCC) is a rare cancer with few reports of metastatic disease. Little is known regarding genomic characteristics and therapeutic targets. We present the clinical, pathologic, genomic and transcriptomic analyses of a case of a 27-year-old male with TLFRCC who presented initially with bone metastases of unknown primary. METHODS: Genomic DNA from peripheral blood and metastatic tumor samples were sequenced...
November 16, 2018: Cold Spring Harbor Molecular Case Studies
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