Ruth Flümann, Julia Hansen, Jörn Meinel, Pauline Pfeiffer, Hannah Goldfarb Wittkopf, Anna Lütz, Jessica Wirtz, Michael Möllmann, Tanja Zhou, Areya Tabatabai, Tim Lohmann, Maximilian Jauch, Filippo Beleggia, Benedikt Pelzer, Fabian Ullrich, Svenja Höfmann, Aastha Arora, Thorsten Persigehl, Reinhard Buettner, Bastian von Tresckow, Sebastian Klein, Ron D Jachimowicz, H Christian Reinhardt, Gero Knittel
Diffuse large B cell lymphoma (DLBCL) is the most common aggressive lymphoma and constitutes a highly heterogenous disease. Recent comprehensive genomic profiling revealed the identity of numerous molecularly-defined DLBCL subtypes, including a cluster which is characterized by recurrent aberrations in MYD88, CD79B and BCL2, as well as various lesions promoting a block in plasma cell differentiation, including PRDM1, TBL1XR1 and SPIB. Here, we generated a series of autochthonous mouse models to mimic this DLBCL cluster and specifically focused on the impact of Cd79b mutations in this setting...
December 7, 2023: Blood Advances