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Lymphocytic alveolitis

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https://www.readbyqxmd.com/read/27758997/spontaneous-resolution-of-a-tumor-like-pulmonary-sarcoidosis
#1
Zied Moatemri, Ghassen Soussi, Salsabil Dabboussi, Samira Mhamdi, Chiraz Aichaouia, Mohsen Khadraoui, Rezaik Cheikh
We report a case of thoracic sarcoidosis in a 72-year-old female, snuff taker, who presented with multinodular pulmonary lesions on chest x-ray. Clinical and biological findings were poor. Thoracic imaging showed soft tissue density nodules with irregular borders. The diagnosis of 'cannon ball' metastases was suspected. A thorough investigation strategy could not prove malignancy. A complete radiologic clearing was obtained spontaneously within three months. A rereading of pathology slides performed afterwards showed multinucleated giant cells on hemorrhagic background with a lymphocytic alveolitis...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27599705/osimertinib-induced-interstitial-lung-disease-after-treatment-with-anti-pd1-antibody
#2
Nobuaki Mamesaya, Hirotsugu Kenmotsu, Mineo Katsumata, Takashi Nakajima, Masahiro Endo, Toshiaki Takahashi
We report a case of a 38-year-old woman who was diagnosed with stage IV lung adenocarcinoma, harboring an epidermal growth factor receptor (EGFR) L858R mutation on exon 21 and a T790 M mutation on exon 20. The patient was treated with osimertinib, a third-generation EGFR tyrosine kinase inhibitor (EGFR-TKI) following treatment with nivolumab, an anti-Programmed Cell Death 1 (anti-PD1) antibody. After initiating osimertinib treatment, the patient began to complain of low-grade fever and shortness of breath without hypoxemia, and her chest radiograph and a CT scan revealed a remarkable antitumor response, although faint infiltrations were observed in the bilateral lung field...
September 6, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27471881/the-diagnostic-importance-of-the-bronchoalveolar-lavage-in-lymphocytic-alveolitis
#3
Mona Mlika, Nourane Kria, Emna Braham, Chokri Chebbi, Faouzi El Mezni
BACKGROUND: Multidisciplinary concertation is mandatory in order to assess interstitial pneumonias. The study of the bronchoalveolar lavage helps evoking a diagnosis according to the lavage profile. In lymphocytic alveolitis, immunocytochemistry or in flux cytometry are necessary in order to identify the different clusters of lymphocytes implicated. AIM: Our objective was to evaluate the profile of 31 lymphocytic alveolitis using 2 different techniques which are the immunocytochemistry and the in flow cytometry in order to evaluate the efficacy of each technique and to compare the different results to the final diagnoses...
July 29, 2016: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/27390897/functional-tlr9-expression-and-cxcr3-ligand-release-in-pulmonary-sarcoidosis
#4
Jasmin Schnerch, Antje Prasse, Dimitrios Vlachakis, Katrin L Schuchardt, Dmitri V Pechkovsky, Torsten Goldmann, Karoline I Gaede, Joachim Müller-Quernheim, Gernot Zissel
BACKGROUND: Sarcoidosis is a granulomatous disease characterized by a Th1-cell dominated alveolitis. As a role of bacteria in the pathogenesis of sarcoidosis has been discussed, toll-like receptors (TLR) may be involved in the initiation of a first immune reaction. OBJECTIVES: We analysed expression and functional relevance of several TLRs in broncho-alveolar lavage (BAL) cells from patients with pulmonary sarcoidosis. In parallel, we determined the release of CXCL9, CXCL10, and CXCL11 by BAL cells from patients with pulmonary sarcoidosis...
July 8, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27230039/diagnostic-value-of-the-cd103-cd4-cd4-ratio-to-differentiate-sarcoidosis-from-other-causes-of-lymphocytic-alveolitis
#5
Lisa Bretagne, Ibrahima-Dina Diatta, Mohamed Faouzi, Antoine Nobile, Massimo Bongiovanni, Laurent P Nicod, Romain Lazor
BACKGROUND: The CD103 integrin is present on CD4+ lymphocytes of the bronchial mucosa, but not on peripheral blood CD4+ lymphocytes. It has been hypothesized that CD4+ lymphocytes in pulmonary sarcoidosis originate from redistribution from the peripheral blood to the lung, and therefore do not bear the CD103 integrin. Some data suggest that a low CD103+ percentage among bronchoalveolar lavage fluid (BALF) CD4+ lymphocytes discriminates between sarcoidosis and other diagnoses. OBJECTIVE: To determine the diagnostic value of BALF CD103+ to identify sarcoidosis among other causes of alveolar lymphocytosis in a large retrospective case series...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27218212/-the-role-of-bronchoalveolar-lavage-in-the-diagnosis-of-idiopathic-pulmonary-fibrosis-an-investigation-of-the-relevance-of-the-protein-content
#6
J Schildge, J Frank, B Klar
Although bronchoalveolar lavage (BAL) is often used in the diagnosis of interstitial lung diseases (ILDs), its importance in investigating, in particular, idiopathic pulmonary fibrosis (IPF) is controversial. The cell distributions in the BAL are taken into account in the clinical routine, non-cellular characteristics of the BAL play no role.Using mathematical modeling of data, the present work investigated the extent to which BAL features enable drawing conclusions about the underlying ILK or help exclude IPF...
July 2016: Pneumologie
https://www.readbyqxmd.com/read/27126427/benzylthiouracil-induced-anca-associated-glomerulonephritis-in-patients-with-graves-disease
#7
Hayet Kaaroud, Ibtissem Oueslati, Amel Harzallah, Ibtissem Ben Nacef, Karima Khiari, Fethi Ben Hamida
BACKGROUND: Renal complications in Graves' disease are rare and may be related either to the disease itself or secondary to antithyroid drugs. AIM: We report 6 cases of renal damage in patients with Graves' disease treated with Benzylthiouracil collected over a period of 14 years. METHODS: There were 6 women with a mean age of 37.86 ± 14.25 years. All patients developed renal vasculitis associated with ANCA. The signs were dominated by renal proteinuria and renal failure associated with hematuria in all cases...
November 2015: La Tunisie Médicale
https://www.readbyqxmd.com/read/26974294/human-immunodeficiency-virus-infection-and-host-defense-in-the-lungs
#8
Tysheena P Charles, Judd E Shellito
Immunosuppression associated with human immunodeficiency virus (HIV) infection impacts all components of host defense against pulmonary infection. Cells within the lung have altered immune function and are important reservoirs for HIV infection. The host immune response to infected lung cells further compromises responses to a secondary pathogenic insult. In the upper respiratory tract, mucociliary function is impaired and there are decreased levels of salivary immunoglobulin A. Host defenses in the lower respiratory tract are controlled by alveolar macrophages, lymphocytes, and polymorphonuclear leukocytes...
April 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26719148/chronic-hypersensitivity-pneumonitis-caused-by-saccharopolyspora-rectivirgula-is-not-associated-with-a-switch-to-a-th2-response
#9
Kelly Andrews, Manik C Ghosh, Andreas Schwingshackl, Gabriel Rapalo, Charlean Luellen, Christopher M Waters, Elizabeth A Fitzpatrick
Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease that develops following repeated exposure to inhaled environmental antigens. The disease results in alveolitis and granuloma formation and may progress to a chronic form associated with fibrosis; a greater understanding of the immunopathogenic mechanisms leading to chronic HP is needed. We used the Saccharopolyspora rectivirgula (SR) mouse model of HP to determine the extent to which a switch to a Th2-type immune response is associated with chronic HP...
March 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/26448865/lymphangiogenic-factors-are-associated-with-the-severity-of-hypersensitivity-pneumonitis
#10
Masahiro Yamashita, Takashi Mouri, Miyuki Niisato, Hiroo Nitanai, Hitoshi Kobayashi, Masahito Ogasawara, Ryujin Endo, Kazuki Konishi, Tamotsu Sugai, Takashi Sawai, Kohei Yamauchi
BACKGROUND: Antigen presenting cells play a pivotal role in the adaptive immune response in hypersensitivity pneumonitis (HP). It was hypothesised that lymphangiogenesis is involved in the pathophysiology of HP via cell transport. OBJECTIVE: To determine the clinical significance of lymphangiogenic factors in HP. METHODS: Levels of vascular endothelial growth factors (VEGF)-A, VEGF-C, VEGF-D and CCL21 in the serum and bronchoalveolar lavage fluid (BALF) were measured in 29 healthy volunteers, 14 patients with idiopathic pulmonary fibrosis (IPF) and 26 patients with HP by ELISA...
2015: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/26200268/crizotinib-associated-with-ground-glass-opacity-predominant-pattern-interstitial-lung-disease-a-retrospective-observational-cohort-study-with-a-systematic-literature-review
#11
Perrine Créquit, Marie Wislez, Jocelyne Fleury Feith, Nathalie Rozensztajn, Laurence Jabot, Sylvie Friard, Armelle Lavole, Valérie Gounant, Julie Fillon, Martine Antoine, Jacques Cadranel
BACKGROUND: Crizotinib, an oral tyrosine kinase inhibitor that targets anaplastic lymphoma kinase, has proven to offer sustained progression-free survival in anaplastic lymphoma kinase-rearranged non-small-cell lung cancers. Occurrence of severe interstitial lung disease (ILD) was one of the crucial adverse events reported in randomized clinical trials and case reports. METHODS: In September 2011, we observed a crizotinib-associated ILD case. Following this index case, we reviewed the clinical and computed tomographic scan features of all patients treated with crizotinib in our department, between October 2010 and July 2013, comparing patients with and without ILD...
August 2015: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/26101656/migratory-eosinophilic-alveolitis-caused-by-radiation-therapy
#12
Jun Hyeok Lim, Hae-Seong Nam, Hun Jung Kim, Chang-Hwan Choi, In-Suh Park, Jae Hwa Cho, Jeong-Seon Ryu, Seung Min Kwak, Hong Lyeol Lee
Although radiation pneumonitis is usually confined to irradiated areas, some studies have reported that radiation-induced lymphocytic alveolitis can also spread to the non-irradiated lung. However, there have been few reports of radiation-induced eosinophilic alveolitis. We report the case of a 27-year-old female with radiation pneumonitis, occurring 4 months after radiation therapy for cancer of the left breast. Clinical and radiological relapse followed withdrawal of corticosteroids. Examination of bronchoalveolar lavage (BAL) in patchy airspace consolidations revealed increased eosinophil counts...
May 2015: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26090114/histamine-h1-antagonist-levocetirizine-as-a-potential-cause-of-lung-injury
#13
Satoshi Endo, Yasushi Yamamoto, Yoshinori Minami, Shunsuke Okumura, Takaaki Sasaki, Yoshinobu Ohsaki
Histamine H1 antagonists rarely cause drug-induced lung injury (DLI). A woman in her 60s, who had been taking antihistaminic levocetirizine for 2 months, presented with progressive cough and shortness of breath. A chest radiograph showed patchy infiltrations on both lower lung fields. Chest computed tomography findings were consistent with non-specific interstitial pneumonia. Serum markers associated with interstitial pneumonias were elevated. Room air arterial blood gas analysis revealed hypoxemia. Restrictive ventilatory impairment was noted with reduced diffusing capacity...
June 2015: Respirology Case Reports
https://www.readbyqxmd.com/read/26027241/-pulmonary-paecilomycosis-diagnosis-and-treatment
#14
A V Strelyaeva, A A Svistunov, R Al Dzhomaa, S A Sapozhnikov, N V Chebyshev, A A Ashurov, M L Maksimov, N B Lazareva, A K Gabchenko, V M Sadykov
AIM: To represent the advances of Russia and Uzbekistan in studying the problem of paecilomycosis. The goal of the investigation was to develop the diagnosis and treatment of pulmonary paecilomycosis (PP). SUBJECTS AND METHODS: Two hundred and twenty-five people, including 200 patients with bronchopulmonary infection with fungi of the Paecilomyces genus and 25 clinically healthy individuals (a control group), were examined. Clinico-anamnestic, laboratory diagnostic, mycological, and immunological studies were conducted; a lymphocyte antigen-binding test was used for differential diagnosis...
2015: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/25847206/-chronic-farmer-s-lung-disease-with-emphysema
#15
T Soumagne, B Degano, J C Dalphin
INTRODUCTION: Farmer's lung (FL) is the most common type of hypersensitivity pneumonitis (HP), with an estimated prevalence of between 0.5 and 1.5% in dairy farmers. In chronic FL, fibrotic sequelae are widely described in the literature although our experience and occasional epidemiological studies emphasize an increased risk of developing emphysema in these patients. CASE REPORT: We report a case of FL in a 37-year-old patient with typical clinical features (exertional dyspnoea, lymphocytic alveolitis and computed tomography appearances) together with proven allergen exposure...
March 2015: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/25835470/phenotypic-features-and-phylogenetic-background-of-extraintestinal-hemolytic-escherichia-coli-responsible-of-mortality-in-puppies
#16
Sara Turchetto, Martina Ustulin, Carlo Vittorio Citterio, Claudia Zanardello, Marta Vascellari, Denis Vio, Gabriella Conedera, Nicola Maria Ferro Milone, Monia Cocchi
A 10-day-old litter of five puppies of Bracco Italiano dog breed showed weakness and diarrhea and, 2 days later, four of them died. At the same time, the bitch showed high hyperthermia (40 °C) and endometritis. The necropsy of a puppy revealed a severe lobar pneumonia accompanied with a bilateral nephrosis. No gross lesions were detected in other organs. Histopathology of the lung revealed severe multifocal fibrino-suppurative necrotizing bronchiolar-alveolitis associated with rod-shaped bacterial aggregates and diffuse interstitial lymphocytic infiltration...
August 31, 2015: Veterinary Microbiology
https://www.readbyqxmd.com/read/25697336/studies-of-hepatocyte-growth-factor-in-bronchoalveolar-lavage-fluid-in-chronic-interstitial-lung-diseases
#17
Grzegorz Przybylski, Joanna Chorostowska-Wynimko, Andrzej Dyczek, Ewelina Wędrowska, Marek Jankowski, Adam Szpechciński, Agata Giżycka, Joanna Golińska, Piotr Kopiński
INTRODUCTION:  Previous studies have suggested that hepatocyte growth factor (HGF) inhibits lung fibrosis as an antagonist of transforming growth factor β (TGF‑β). OBJECTIVES:  We assessed HGF expression levels in the lower airways of patients with selected interstitial lung diseases. PATIENTS AND METHODS:  HGF levels were examined by an enzyme‑linked immunosorbent assay in bronchoalveolar lavage (BAL) fluid supernatants from patients with pulmonary sarcoidosis (PS, n = 52), idiopathic pulmonary fibrosis (IPF, n = 23), nonspecific interstitial pneumonia (NSIP, n = 14), extrinsic allergic alveolitis (EAA, n = 6), bronchiolitis obliterans organizing pneumonia (BOOP, n = 8), chronic eosinophilic pneumonia (EP, n = 6), and in control subjects (n = 13)...
2015: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/25536276/lymphocytic-alveolitis-is-associated-with-the-accumulation-of-functionally-impaired-hiv-specific-t-cells-in-the-lung-of-antiretroviral-therapy-naive-subjects
#18
C Preston Neff, Jennifer L Chain, Samantha MaWhinney, Allison K Martin, Derek J Linderman, Sonia C Flores, Thomas B Campbell, Brent E Palmer, Andrew P Fontenot
RATIONALE: Lymphocytic alveolitis in HIV-1-infected individuals is associated with multiple pulmonary complications and a poor prognosis. Although lymphocytic alveolitis has been associated with viremia and an increased number of CD8(+) T cells in the lung, its exact cause is unknown. OBJECTIVES: To determine if HIV-1-specific T cells are associated with lymphocytic alveolitis in HIV-1-infected individuals. METHODS: Using blood and bronchoalveolar lavage (BAL) cells from normal control subjects and untreated HIV-1-infected individuals, we examined the frequency and functional capacity of HIV-1-specific T cells...
February 15, 2015: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/24989247/chronic-granulomatous-disease-with-pulmonary-mass-like-opacities-secondary-to-hypersensitivity-pneumonitis-a-case-report
#19
Yuki Katsuya, Masayuki Hojo, Shigeo Kawai, Toshinao Kawai, Masafumi Onodera, Haruhito Sugiyama
INTRODUCTION: Chronic granulomatous disease, one of the primary immunodeficiency syndromes, is characterized by failure of phagocytic capacity due to loss of reactive oxygen species production, as well as formation of granulomas in organs. Clinically, dysregulated inflammation by excessive cytokine production due to loss of reactive oxygen species production is suggested as a cause of noninfectious inflammatory problems such as chronic granulomatous disease colitis. We experienced a rare case of a patient with chronic granulomatous disease with unique pathological and radiological presentations of hypersensitive pneumonitis, which to our knowledge has never been previously reported...
July 2, 2014: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/24942974/bronchoalveolar-lavage-cellular-patterns-in-monoclonal-antibody-induced-lung-disease
#20
Shikha Gupta, Patricia Smith, Homer L Twigg Iii, Chadi A Hage
BACKGROUND: The increase in the use of monoclonal antibodies (mAB) as a targeted therapy for a variety of diseases has been accompanied by an increase in reports of interstitial lung abnormalities in treated patients. OBJECTIVE: Bronchoalveolar lavage (BAL) is routinely performed in these patients to rule out infection, so we sought to determine the BAL cellular pattern in individuals with mAB-induced lung disease (mAB-ILD). METHODS: We utilized a case-control study design...
2014: Respiration; International Review of Thoracic Diseases
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