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Eva Asselmann, Johannes Hertel, Carsten-Oliver Schmidt, Georg Homuth, Matthias Nauck, Christiane A Pané-Farré, Beesdo-Baum Katja, Hans-Jörgen Grabe
BACKGROUND: It remains unresolved whether childhood adversities interact with genetic variation in regulator of G-protein signaling 2 (RGS2) rs4606 in predicting various anxiety and depressive disorders and whether diagnostic specificity exists in these interactions. METHODS: The genotype of RGS2 rs4606 was determined for N = 2,263 adults with European ancestry from the Study of Health in Pomerania. Lifetime anxiety and depressive disorders according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, were assessed with the Munich Composite International Diagnostic Interview (DIA-X/M-CIDI)...
August 14, 2018: Depression and Anxiety
Pablo Elpidio García-Granja, Javier López, Isidre Vilacosta, Cristina Sarriá, Raquel Ladrón, Carmen Olmos, Carmen Sáez, Luis Maroto, Salvatore Di Stefano, Itziar Gómez, J Alberto San Román
Background: The culture of removed cardiac tissues during cardiac surgery of left-sided infective endocarditis (LSIE) helps guiding antibiotic treatment. Nevertheless, the prognostic information of a positive valve culture has never been explored. Methods: Among 1078 cases of LSIE consecutively diagnosed in three tertiary centres we selected those with positive blood cultures, who underwent surgery during the active period of infection and in whom surgical biological tissues were cultured (n=429)...
August 11, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Maya Gopalakrishnan, Kolar Vishwanath Vinod, Tarun Kumar Dutta, Kusha Kumar Shaha, Magadi Gopalakrishna Sridhar, Suman Saurabh
Background: Viper envenomation contributes to nearly 50% of snake-bite deaths in India, chiefly due to circulatory shock. The mechanisms leading to circulatory shock include bleeding, capillary leak syndrome (CLS) and myocardial depression. Pituitary-adrenal axis involvement in circulatory shock, though described, has not been fully elucidated. Aims: To identify predictors of circulatory shock and mortality in viper envenomation and explore the role of pituitary-adrenal axis in circulatory shock...
August 13, 2018: QJM: Monthly Journal of the Association of Physicians
Michael Asamoah-Boaheng, Eric Y Tenkorang, Osei Sarfo-Kantanka
Background: Type 2 diabetes affects an increasing number of Ghanaians. The timing of the onset of diabetes is linked to several other co-morbid conditions, yet no study has examined the timing of the onset of type 2 diabetes in Ghana. Methods: To fill this gap in the literature, this study applied logit models to data extracted from the medical records at the Diabetes Clinic of the Komfo Anokye Teaching Hospital in Kumasi, Ghana. Gender-specific models were also estimated...
August 11, 2018: International Health
Thomas R McCarty, Thomas J Abramo, Robert T Maxson, Gregory Albert, Mallikarjuna R Rettiganti, Marie E Saylors, Jonathan W Orsborn, Amanda I Hollingsworth
OBJECTIVE: Hypothermia is an independent risk factor for mortality in adult trauma patients. Two small studies have shown similar results in pediatric trauma patients. Temperature is not included in any pediatric trauma assessment scores. This study sought to compare mortality and various descriptive outcomes between pediatric hypothermic and normothermic trauma patients. METHODS: Data were obtained from the National Trauma Database from 2009 to 2012. Patients meeting inclusion criteria were stratified by presence of isolated head injury, head injury with multiple trauma, and absence of head injury...
August 13, 2018: Pediatric Emergency Care
Leman Akcan Yildiz, Ayse Gultekingil, Selman Kesici, Benan Bayrakci, Ozlem Teksam
OBJECTIVE: Carbon monoxide (CO) is a gas, which is produced by incomplete combustion of hydrocarbon-containing substances, and causes significant tissue and organ damage in the common event of CO poisoning. This study aims to evaluate the demographic, clinical, and laboratory characteristics of patients diagnosed with CO poisoning in the emergency department and to determine the factors associated with severe course in the acute phase of poisoning. METHODS: A total of 331 patients diagnosed with CO poisoning in Hacettepe University Children's Hospital, Pediatric Emergency Unit, between January 2004 and March 2014 were included in the study...
August 13, 2018: Pediatric Emergency Care
Ming Song, Ying Yang, Jianghong He, Zhengyi Yang, Shan Yu, Qiuyou Xie, Xiaoyu Xia, Yuanyuan Dang, Qiang Zhang, Xinhuai Wu, Yue Cui, Bing Hou, Ronghao Yu, Ruxiang Xu, Tianzi Jiang
Disorders of consciousness are a heterogeneous mixture of different diseases or injuries. Although some indicators and models have been proposed for prognostication, any single method when used alone carries a high risk of false prediction. This study aimed to develop a multidomain prognostic model that combines resting state functional MRI with three clinical characteristics to predict one year outcomes at the single-subject level. The model discriminated between patients who would later recover consciousness and those who would not with an accuracy of around 88% on three datasets from two medical centers...
August 14, 2018: ELife
Andrea L Axtell, Amy G Fiedler, David C Chang, Heidi Yeh, Gregory D Lewis, Mauricio A Villavicencio, David A D'Alessandro
Hearts from older donors are increasingly utilized for transplantation due to unmet demand. Conflicting evidence exists regarding the prognosis of recipients of advanced age donor hearts, especially in young recipients. A retrospective analysis was performed on 11,433 patients aged 18-45 who received a cardiac transplant from 2000-2017. Overall 10,279 patients received hearts from donors less than 45 and 1,145 from donors greater than 45. Recipients of older donors were older (37 vs 34 years, p<0.01) and had higher rates of inotropic dependence (48% vs 42%, p<0...
August 14, 2018: American Journal of Transplantation
G Marchegiani, S Andrianello, G Morbin, E Secchettin, M D'Onofrio, R De Robertis, G Malleo, C Bassi, R Salvia
BACKGROUND: The association between risk of pancreatic cancer and a dilated main pancreatic duct (MPD) in intraductal papillary mucinous neoplasm (IPMN) is debated. The aim of this study was to assess the role of MPD size in predicting pancreatic cancer in resected IPMNs and those kept under surveillance. METHODS: All patients with IPMN referred to the Pancreas Institute, University of Verona Hospital Trust, from 2006 to 2016 were included. The primary endpoint was the occurrence of malignancy detected at surgery or during follow-up...
August 14, 2018: British Journal of Surgery
I-Wen Penn, Yue-Cune Chang, Eric Chuang, Chi-Ming Chen, Chi-Feng Chung, Chia-Yu Kuo, Tien-Yow Chuang
PURPOSE: Breast-cancer-related lymphedema (BCRL) can be a transient or persistent condition. The aims of this study were to (1) identify and weigh the risk factors for persistent lymphedema (PLE) among all patients with BCRL and (2) establish a prediction model for the occurrence of PLE. METHODS: A cohort of 342 patients with BCRL with a median follow-up of 5 years after the onset of swelling was analyzed. PLE was defined as a hardening of the subcutaneous tissue, the persistence of the circumferential difference (CD) between arms, or a flare-up of swelling during follow-up...
August 14, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Ana Pinto-Bastos, Eva Conceição, Marta de Lourdes, Filipa Arrojado, Isabel Brandão, Paulo P P Machado
BACKGROUND: Problematic eating behaviors and general psychopathology have been associated with poor weight loss after bariatric surgery. However, little is known about how these aspects impact weight loss outcomes for the increasing number of patients undergoing reoperative surgeries. This study compares disordered eating and weight-related outcomes before and 6 months after surgery in patients undergoing primary (P-Group) and reoperative bariatric surgery (R-Group). METHODS: This longitudinal study assessed 122 P-Group and 116 R-Group patients before and 6 months after surgery...
August 13, 2018: Obesity Surgery
Viktor Rotbain Curovic, Tine W Hansen, Mie K Eickhoff, Bernt Johan von Scholten, Henrik Reinhard, Peter Karl Jacobsen, Frederik Persson, Hans-Henrik Parving, Peter Rossing
AIMS: Urinary levels of kidney injury molecule 1 (u-KIM-1) and neutrophil gelatinase-associated lipocalin (u-NGAL) reflect proximal tubular pathophysiology and have been proposed as risk markers for development of complications in patients with type 2 diabetes (T2D). We clarify the predictive value of u-KIM-1 and u-NGAL for decline in eGFR, cardiovascular events (CVE) and all-cause mortality in patients with T2D and persistent microalbuminuria without clinical cardiovascular disease. METHODS: This is a prospective study that included 200 patients...
August 14, 2018: Acta Diabetologica
Sevcan A Bakkaloğlu, Yaşar Kandur, Erkin Serdaroğlu, Aytül Noyan, Aysun Karabay Bayazıt, Mehmet Taşdemir, Sare Gülfem Özlü, Gül Özçelik, İsmail Dursun, Caner Alparslan, Meltem Akcaboy, Yeşim Özdemir Atikel, Gönül Parmaksız, Bahriye Atmış, Lale Sever
BACKGROUND: During erythropoietin-stimulating agent (ESA) treatment, hemoglobin (Hb) levels usually fluctuate; this phenomenon is known as "Hb cycling (HC)." In this study, we aimed to evaluate the predictors of HC and its impact on left ventricular hypertrophy (LVH) as a patient-important outcome parameter in pediatric dialysis patients. METHODS: Records of patients followed up in nine pediatric nephrology centers between 2008 and 2013 were reviewed. More than 1 g/dL decrease or increase in Hb level was considered as HC...
August 13, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
James Kohler, Natalie Glass, Nicolas O Noiseux, John J Callaghan, Benjamin J Miller
Background: Many clinical factors are known to increase an individual patient's risk of perioperative complications and hospital readmission. Several novel risk calculators have been created to predict the risk of postoperative complications for specific procedures that rely entirely on objective measurements. Our goal was to determine if surgeon intuition (an estimate of the percent likelihood of minor and major medical and surgical complications and 30-day readmission) could provide an additional source of data in the preoperative setting that may enhance the prediction of complications after surgery...
2018: Iowa Orthopaedic Journal
Elisa Torselli, Marcella Ottonello, Emilio Franceschina, Emanuele Palagi, Giorgio Bertolotti, Elena Fiabane
Purpose: The aims of this pilot study were to examine cognitive factors (brooding and craving) together with positive/negative metacognitive beliefs about alcohol during a residential program for alcohol addiction and to explore relationships with psychological variables at discharge, with the scope of identifying predictive factors of psychological outcome and patients at greatest risk of relapse. Methods: Thirty patients underwent a brief semistructured interview on admission to a 28-day rehabilitation program for alcohol addiction, and completed at admission and discharge the following five self-report questionnaires: 1) brooding (Brooding subscale of Ruminative Response Scale [B-RRS]), 2) craving (Penn Alcohol Craving Scale [PACS]), 3) positive beliefs about alcohol use (Positive Alcohol Metacognitions Scale [PAMS]), 4) negative beliefs about alcohol use (Negative Alcohol Metacognitions Scale [NAMS]), and 5) the psychophysical state of health (Cognitive Behavioral Assessment - Outcome Evaluation [CBA-OE])...
2018: Neuropsychiatric Disease and Treatment
Amit V Khera, Mark Chaffin, Krishna G Aragam, Mary E Haas, Carolina Roselli, Seung Hoan Choi, Pradeep Natarajan, Eric S Lander, Steven A Lubitz, Patrick T Ellinor, Sekar Kathiresan
A key public health need is to identify individuals at high risk for a given disease to enable enhanced screening or preventive therapies. Because most common diseases have a genetic component, one important approach is to stratify individuals based on inherited DNA variation1 . Proposed clinical applications have largely focused on finding carriers of rare monogenic mutations at several-fold increased risk. Although most disease risk is polygenic in nature2-5 , it has not yet been possible to use polygenic predictors to identify individuals at risk comparable to monogenic mutations...
August 13, 2018: Nature Genetics
Hongyan Ren, Chiara Fabbri, Rudolf Uher, Marcella Rietschel, Ole Mors, Neven Henigsberg, Joanna Hauser, Astrid Zobel, Wolfgang Maier, Mojca Z Dernovsek, Daniel Souery, Annamaria Cattaneo, Gerome Breen, Ian W Craig, Anne E Farmer, Peter McGuffin, Cathryn M Lewis, Katherine J Aitchison
A key feature of major depressive disorder (MDD) is anhedonia, which is a predictor of response to antidepressant treatment. In order to shed light on its genetic underpinnings, we conducted a genome-wide association study (GWAS) followed by investigation of biological pathway enrichment using an anhedonia dimension for 759 patients with MDD in the GENDEP study. The GWAS identified 18 SNPs associated at genome-wide significance with the top one being an intronic SNP (rs9392549) in PRPF4B (pre-mRNA processing factor 4B) located on chromosome 6 (P = 2...
August 13, 2018: Translational Psychiatry
Rachel A Kennedy, Kate Carroll, Graham Hepworth, Kade L Paterson, Monique M Ryan, Jennifer L McGinley
OBJECTIVE: To prospectively study falls in children and adolescents with Charcot-Marie-Tooth disease (CMT). DESIGN: Prospective cohort study. SETTING: Neuromuscular outpatient clinic of a tertiary paediatric hospital. PATIENTS: Sixty children and adolescents ('children') aged 4-18 years, 30 with CMT and 30 typically developing (TD). MAIN OUTCOME MEASURES: Falls rate over 6 months and falls characteristics questionnaire...
August 13, 2018: Archives of Disease in Childhood
Helen Sherrell, Vicky Clifton, Sailesh Kumar
INTRODUCTION: Intrapartum complications are a major contributor to adverse perinatal outcomes, including stillbirth, hypoxic-ischaemic brain injury and subsequent longer term disability. In many cases, hypoxia develops as a gradual process due to the inability of the fetus to tolerate the stress of parturition suggesting reduced fetoplacental reserve before labour commences. The fetal cerebroplacental ratio (CPR) is an independent predictor of intrapartum fetal compromise, poor acid base status at birth and of neonatal unit admission at term...
August 13, 2018: BMJ Open
Konstantinos Syrigos, Dimitra Grapsa, Rabiatou Sangare, Ilias Evmorfiadis, Annette K Larsen, Patrick Van Dreden, Paraskevi Boura, Andriani Charpidou, Elias Kotteas, Theodoros N Sergentanis, Ismail Elalamy, Anna Falanga, Grigoris T Gerotziafas
BACKGROUND: The aim of this prospective study was to identify the most clinically relevant hypercoagulability biomarkers in lung adenocarcinoma patients for elaboration of an improved risk assessment model (RAM) for venous thromboembolism (VTE). SUBJECTS, MATERIALS, AND METHODS: One hundred fifty ambulatory patients with lung adenocarcinoma were prospectively enrolled. Thrombin generation, procoagulant phospholipid-dependent clotting time (Procoag-PPL), tissue factor activity (TFa), factor VIIa (FVIIa), factor V (FV), antithrombin, D-Dimers, P-selectin, and heparanase levels were assessed in platelet-poor plasma at inclusion (baseline) and at the end of the third chemotherapy cycle (third chemotherapy)...
August 13, 2018: Oncologist
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