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https://www.readbyqxmd.com/read/30547432/surgery-for-locally-advanced-git-cancers-has-potentially-good-postoperative-outcomes-in-a-tertiary-hospital
#1
Anwar Tawfik Amin, Ahmed A S Salem, Abeer Ibrahim
BACKGROUND: Adhesions and infiltration into adjacent tissues are present in about 12% of gastrointestinal (GIT) cancers. These adhesions have high potential risk of malignancy. Free resection margin is a predictor of good survival in such patients. This study aims at evaluating the post-operative outcomes after multi-visceral resection of locally advanced gastrointestinal cancers. PATIENTS AND METHODS: Ninety patients who underwent extended and multi-visceral resection for GIT cancers invading or adhering to adjacent organs have been included...
December 14, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/30547202/prediction-of-sorafenib-treatment-related-gene-expression-for-hepatocellular-carcinoma-preoperative-mri-and-histopathological-correlation
#2
Zhi Dong, Kun Huang, Bing Liao, Huasong Cai, Yu Dong, Mengqi Huang, Xiaoqi Zhou, Yingmei Jia, Ling Xu, Yanji Luo, Zi-Ping Li, Shi-Ting Feng
PURPOSE: To investigate the feasibility of prediction for targeted therapy-related gene expression in hepatocellular carcinoma (HCC) using preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Ninety-one patients (81 men, mean age 53.9 ± 12 years) with solitary HCC who underwent preoperative enhanced MRI were retrospectively analyzed. Features including tumor size, signal homogeneity, tumor capsule, tumor margin, intratumoral vessels, peritumor enhancement, peritumor hypointensity, signal intensity ratio on DWI, T1 relaxation times, and the reduction rate between pre- and post-contrast enhancement images were assessed...
December 13, 2018: European Radiology
https://www.readbyqxmd.com/read/30547197/predictors-of-thrombosis-in-testicular-cancer-during-platinum-based-chemotherapy
#3
Pia Paffenholz, Katharina Grein, Isabel Heidegger, Tim Nestler, Markus Grabbert, Johannes Salem, Martin Hellmich, David Pfister, Axel Heidenreich
PURPOSE: To identify potential risk factors for the development of venous thromboembolic events in testicular cancer patients receiving platinum-based chemotherapy. METHODS: We performed a retrospective analysis including 255 patients with testicular germ cell tumors who received platinum-based chemotherapy from 2003 to 2018 as a multi-center observational cohort study. Patient and tumor characteristics of patients with and without a thromboembolic event were analyzed...
December 13, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/30547118/chronic-obstructive-pulmonary-disease-is-an-independent-predictor-for-30-day-readmissions-following-1-to-2-level-posterior-lumbar-fusions
#4
Azeem Tariq Malik, Nikhil Jain, Jeffery Kim, Safdar N Khan, Elizabeth Yu
Background: Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and mortality worldwide. Past literature has demonstrated that patients with COPD are at an increased risk of post-operative complications. We assessed the impact of COPD on 30-day outcomes following a 1- to 2-level posterior lumbar fusion (PLF). Methods: The 2012-2016 American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) database was queried using current procedural terminology (CPT) codes 22612, 22630 and 22633 to identify patients undergoing PLFs...
September 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/30546938/genetic-associations-of-t-cell-cancer-immune-response-with-tumor-aggressiveness-in-localized-prostate-cancer-patients-and-disease-reclassification-in-an-active-surveillance-cohort
#5
Qinchuan Wang, Justin R Gregg, Jian Gu, Yuanqing Ye, David W Chang, John W Davis, Timothy C Thompson, Jeri Kim, Christopher J Logothetis, Xifeng Wu
Determining prostate cancer (PCa) aggressiveness and reclassification are critical events during the treatment of localized disease and for patients undergoing active surveillance (AS). Since T cells play major roles in cancer surveillance and elimination, we aimed to identify genetic biomarkers related to T cell cancer immune response which are predictive of aggressiveness and reclassification risks in localized PCa. The genotypes of 3,586 single nucleotide polymorphisms (SNPs) from T cell cancer immune response pathways were analyzed in 1762 patients with localized disease and 393 who elected AS...
2019: Oncoimmunology
https://www.readbyqxmd.com/read/30546452/association-between-the-expression-levels-of-il-6-and-il-6r-in-the-hepatocellular-carcinoma-microenvironment-and-postoperative-recurrence
#6
Mao Zhang, Shun Zhang, Zhenjie Yang, Jie Hu, Weiyu Hu, Peng Sun, Liqun Wu, Bing Han
The tumor microenvironment of hepatocellular carcinoma (HCC) is a complex system, involving mutual promotion and inhibition between cells and molecules. It results in alterations to inflammatory-associated factors, including a decrease in interleukin (IL)-2 and an increase in tumor necrosis factor, together with a characteristic elevation of IL-6. Following the synthesis and release of IL-6, HCC is stimulated through IL-6 binding to the IL-6 receptor (IL-6R). In the present study, immunohistochemistry was performed to investigate the expression levels of IL-6 and IL-6R in 92 patients with HCC, and the association between IL-6/IL-6R expression levels and tumor recurrence was examined...
December 2018: Oncology Letters
https://www.readbyqxmd.com/read/30546396/correlation-between-coronary-atherosclerosis-calcification-and-epicardial-adipose-tissue-volume-in-patients-with-nephropathy
#7
Hong Zuo, Ying Zhang, Qiaojuan Ma
Correlation between coronary atherosclerosis calcification and epicardial adipose tissue (EAT) volume in patients with nephropathy was investigated. A total of 529 patients with high risk of coronary atherosclerotic nephropathy were selected from August 2013 to September 2016 in Xianyang Central Hospital to serve as research subjects, and their clinical data were retrospectively analyzed. All patients underwent coronary artery and EAT examination using dual-source CT. Correlation between EAT and severity of coronary atherosclerosis, calcification, lesions, and BMI were analyzed...
December 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30546124/determinants-of-environmental-styrene-exposure-in-gulf-coast-residents
#8
Emily J Werder, Dale P Sandler, David B Richardson, Michael E Emch, Richard K Kwok, Lawrence S Engel
BACKGROUND: In a previous study of exposure to oil-related chemicals in Gulf coast residents, we measured blood levels of volatile organic compounds. Levels of styrene were substantially elevated compared to a nationally representative sample. We sought to identify factors contributing to these levels, given the opportunities for styrene exposure in this community. METHODS: We measured blood styrene levels in 667 Gulf coast residents and compared participants' levels of blood styrene to a nationally representative sample...
December 13, 2018: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/30546032/predictors-of-developing-mycobacterium-kansasii-pulmonary-disease-within-1-year-among-patients-with-single-isolation-in-multiple-sputum-samples-a-retrospective-longitudinal-multicentre-study
#9
Hung-Ling Huang, Meng-Hsuan Cheng, Po-Liang Lu, Chia-Jung Liu, Inn-Wen Chong, Jann-Yuan Wang
The clinical significance of a single Mycobacterium kansasii (MK) isolation in multiple sputum samples remains unknown. We conducted this study to evaluate the outcome and predictors of developing MK-pulmonary disease (PD) within 1 year among these patients. Patients with a single MK isolation from ≥3 sputum samples collected within 3 months and ≥2 follow-up sputum samples and chest radiography in the subsequent 9 months between 2008 and 2016 were included. The primary outcome was development of MK-PD within 1 year, with its predictors explored using multivariate logistic regression analysis...
December 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30545659/first-trimester-ferritin-screening-for-pre-delivery-anaemia-as-a-patient-blood-management-strategy
#10
Philip Crispin, Benjamin Stephens, Evelyn McArthur, Farah Sethna
OBJECTIVES: To determine the optimum approach and timing to screen for iron deficiency in pregnancy. BACKGROUND: There is a lack of consensus on identifying and treating iron deficiency during pregnancy. Patient blood management programs may be refined by evaluating outcomes. METHODS: Retrospective data collection on women delivering prior to and following implementation of patient blood management interventions. Ferritin, transferrin saturation and haemoglobin levels were evaluated in first and second trimesters as predictors of pre-delivery anaemia...
December 5, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/30545655/is-operative-time-a-predictor-for-post-operative-infection-in-primary-total-knee-arthroplasty
#11
Hiba K Anis, Nipun Sodhi, Alison K Klika, Michael A Mont, Wael K Barsoum, Carlos A Higuera, Robert M Molloy
BACKGROUND: The purpose of this study is to identify factors affecting operative times and to evaluate the associations of operative times with prosthetic joint infections (PJIs) and surgical site infections (SSIs) in primary total knee arthroplasty. METHODS: A total of 11,840 primary total knee arthroplasties with a mean 2-year post-operative follow-up were studied. Operative times were analyzed both as categorical and continuous variables. Associations with PJIs and SSIs were evaluated with univariate and multivariate analyses to adjust for gender, age, body mass index, Charlson Comorbidity Index, year of surgery, antibiotic cement use, and hospital/surgeon volume...
November 22, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30545411/using-a-birth-cohort-to-study-brain-health-and-preclinical-dementia-recruitment-and-participation-rates-in-insight-46
#12
Sarah-Naomi James, Christopher A Lane, Thomas D Parker, Kirsty Lu, Jessica D Collins, Heidi Murray-Smith, Michelle Byford, Andrew Wong, Ashvini Keshavan, Sarah Buchanan, Sarah E Keuss, Diana Kuh, Nick C Fox, Jonathan M Schott, Marcus Richards
OBJECTIVE: Identifying and recruiting people with early pre-symptomatic Alzheimer's disease to neuroimaging research studies is increasingly important. The extent to which results of these studies can be generalised depends on the recruitment and representativeness of the participants involved. We now report the recruitment and participation patterns from a neuroscience sub-study of the MRC National Survey of Health and Development, "Insight 46". This study aimed to recruit 500 participants for extensive clinical and neuropsychological testing, and neuroimaging...
December 13, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/30545385/atherogenic-index-of-plasma-is-a-novel-predictor-of-non-alcoholic-fatty-liver-disease-in-obese-participants-a-cross-sectional-study
#13
Qian Wang, Dongmei Zheng, Jia Liu, Li Fang, Qiu Li
BACKGROUND: The atherogenic index of plasma showed to be related with some chronic disease like cardiovascular diseases and atherosclerosis. Body mass index which was commonly used in clinical practice is not an accurate index to predict non-alcoholic fatty liver disease. The aim of this study is to investigate the relationship between atherogenic index of plasma and non-alcoholic fatty liver disease in obese participants. METHODS: 538 obese subjects were included in this cross sectional study...
December 13, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/30545342/infection-free-rates-and-sequelae-predict-factors-in-bone-transportation-for-infected-tibia-a-systematic-review-and-meta-analysis
#14
Zhen Zhang, W Benton Swanson, Yan-Hong Wang, Wei Lin, Guanglin Wang
BACKGROUND: Tibia infected nonunion and chronic osteomyelitis are challenging clinical presentations. Bone transportation with external or hybrid fixators (combined external and internal fixators) is versatile to solve these problems. However, the infection-free rates of these fixator systems are unknown. Additionally, the prognosis factors for results of bone transportation are obscure. Therefore, this systematic review and meta-analysis was conducted to answer these questions. METHODS: A systematic review was conducted following the PRISMA-IPD guidelines...
December 13, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30545302/when-pitch-adds-to-volume-coregulation-of-transcript-diversity-predicts-gene-function
#15
Alejandro Cáceres, Juan R González
BACKGROUND: Genes corregulate their overall transcript volumes to perform their physiological functions. However, it is unknown if they additionally coregulate their transcript diversities. We studied the reliability, consistency and functional associations of co-splicing correlations of genes of interest, across two independent studies, multiple tissues and two statistical methods. We thoroughly investigated the reproducibility of co-splicing correlations of APP, the candidate gene of Azheimer's disease (AD)...
December 13, 2018: BMC Genomics
https://www.readbyqxmd.com/read/30545270/cochrane-corner-platinum-induced-hearing-loss-after-treatment-for-childhood-cancer
#16
Christopher G Brennan-Jones, Courtney McMahen, Elvira C Van Dalen
This Cochrane Corner features the review entitled "Platinum-induced hearing loss after treatment for childhood cancer" published in 2016. In their review, van As et al. identified 13 cohort studies including 2837 participants with a hearing test after treatment with a platinum-based therapy for different types of childhood cancers. All studies had problems related to quality of the evidence. The reported frequency of hearing loss varied between 1.7% and 90.1% for studies that included a definition of hearing loss; none of the studies provided data on tinnitus...
December 13, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/30545258/stroke-after-percutaneous-coronary-intervention-in-the-era-of-transradial-intervention
#17
Satoshi Shoji, Shun Kohsaka, Hiraku Kumamaru, Mitsuaki Sawano, Yasuyuki Shiraishi, Ikuko Ueda, Shigetaka Noma, Masahiro Suzuki, Yohei Numasawa, Kentaro Hayashida, Shinsuke Yuasa, Hiroaki Miyata, Keiichi Fukuda
BACKGROUND: Periprocedural stroke is a rare but life-threatening complication of percutaneous coronary intervention (PCI). Transradial intervention (TRI) is more beneficial than transfemoral intervention for periprocedural bleeding and acute kidney injuries, but its effect on periprocedural stroke has not been fully investigated. Our study aimed to assess risk predictors of periprocedural stroke according to PCI access site. METHODS AND RESULTS: Between 2008 and 2016, 17 966 patients undergoing PCI were registered in a prospective multicenter database...
December 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30545257/prognostic-impact-of-periprocedural-myocardial-infarction-in-patients-undergoing-elective-percutaneous-coronary-interventions
#18
Konstantinos C Koskinas, Gjin Ndrepepa, Lorenz Räber, Alexios Karagiannis, Sebastian Kufner, Thomas Zanchin, Julia Hieber, Lukas Hunziker, Katharina Mayer, Robert A Byrne, Dik Heg, Stephan Windecker, Adnan Kastrati
BACKGROUND: The magnitude of prognostically relevant myocardial injury after percutaneous coronary interventions remains poorly defined. The Society for Cardiovascular Angiography and Interventions (SCAI) proposed marked biomarker elevations to define periprocedural myocardial infarction (PMI). These consensus-based thresholds have not been validated in the era of high-sensitivity cardiac troponins. We sought to assess the prognostic impact of SCAI-defined PMI and explore optimal prognostic thresholds of high-sensitivity cardiac troponin T (hs-cTnT) after elective percutaneous coronary interventions...
December 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30545039/effect-of-road-safety-education-on-road-risky-behaviors-of-spanish-children-and-adolescents-findings-from-a-national-study
#19
Francisco Alonso, Cristina Esteban, Sergio Useche, Natura Colomer
BACKGROUND: Road Safety Education (RSE) is widely known as a reliable determinant of the future results for what concerns health and welfare and as an undisputable factor which contributes to the social behavior of individuals and to their mid- and long-term road safety outcomes. However, its development has been relatively scarce in most countries, a fact which has contributed to letting matters as delicate as traffic crashes, largely explained by road misbehaviors, continue to be a prevalent problem, thus affecting the health of the community...
December 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30544670/venous-thromboembolism-in-asian-patients-with-pancreatic-cancer-following-palliative-chemotherapy-low-incidence-but-a-negative-prognosticator-for-those-with-early-onset
#20
Jen-Shi Chen, Chia-Yen Hung, Hung Chang, Chien-Ting Liu, Yen-Yang Chen, Chang-Hsien Lu, Pei-Hung Chang, Yu-Shin Hung, Wen-Chi Chou
BACKGROUND: Few studies have reported the epidemiology and clinical outcome of venous thromboembolism (VTE) in Asian patients with pancreatic cancer. This study investigated the incidence, risk factors, and clinical outcome of VTE in patients with pancreatic cancer following palliative chemotherapy. METHODS: The medical records of 838 patients with newly diagnosed locally advanced or metastatic pancreatic cancer who underwent palliative chemotherapy between 2010 and 2016 at four institutes in Taiwan were retrospectively reviewed...
December 10, 2018: Cancers
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