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Arterial Elastance

Donald R Dengel, Aaron S Kelly, Lei Zhang, Qi Wang, James S Hodges, Julia Steinberger, K Scott Baker
This study examined the effects of hematopoietic cell transplantation (HCT) and associated preparative regimens on vascular structure and function. Measures of carotid artery stiffness as well as brachial artery endothelial-dependent-dilation were obtained in patients who had survived ≥2 yrs after HCT for hematologic malignancy and were diagnosed at ≤21 yrs. HCT (n=108) survivors were examined; 66 received TBI alone or with a low dose cranial radiation boost (TBI+/-LD-CRT), 19 received TBI plus high dose cranial radiation (TBI+HD-CRT), and 23 received a chemotherapy-only preparative regimen (CHEMO)...
August 10, 2018: Biology of Blood and Marrow Transplantation
David B Hanna, Jee-Young Moon, Sabina A Haberlen, Audrey L French, Frank J Palella, Stephen J Gange, Mallory D Witt, Seble Kassaye, Jason M Lazar, Phyllis C Tien, Matthew J Feinstein, Lawrence A Kingsley, Wendy S Post, Robert C Kaplan, Howard N Hodis, Kathryn Anastos
OBJECTIVE: Among people with HIV, there are few long-term studies of non-invasive ultrasound-based measurements of the carotid artery predicting major health events. We hypothesized that such measurements are associated with 10-year mortality in the Women's Interagency HIV Study (WIHS) and Multicenter AIDS Cohort Study (MACS), and that associations differ by HIV serostatus. DESIGN: Nested cohort study. METHODS: Participants without coronary heart disease underwent B-mode carotid artery ultrasound, with measurement of common carotid artery intima-media thickness (CCA-IMT); carotid artery plaque (focal IMT > 1...
August 9, 2018: AIDS
Francesco Signorelli, Cyril Pailler-Mattei, Benjamin Gory, Pierre Larquet, Philip Robinson, Roberto Vargiolu, Hassan Zahouani, Paul-Emile Labeyrie, Jacques Guyotat, Isabelle Pelissou-Guyotat, Julien Berthiller, Francis Turjman
OBJECT: Aneurysm wall biomechanics are not yet integral part of aneurysm rupture risk evaluation. We aimed to develop a new technique describing the biomechanical properties of aneurysm wall and correlating them to rupture status. METHODS: Aneurysm wall samples collected during surgery were submitted before and after freezing to tensile tests or as fresh samples to indentation tests. The lateral stiffness or the Young's modulus of the different samples were determined as function of the mechanical test used...
August 9, 2018: World Neurosurgery
Ewa Podolecka, Grzegorz Wystrychowski, Władysław Grzeszczak, Ewa Żukowska-Szczechowska
BACKGROUND: LDL-cholesterol is a risk factor for the development of cardiovascular diseases. Atherosclerosis is a chronic inflammatory process, initiated by the damage of the vascular endothelium, which leads to remodelling the artery wall. AIM: The aim of the study was to evaluate the correlation between LDL-cholesterol and arterial wall elasticity indices. METHODS: The study group comprised of 315 men and women at mean age of 55.84 ± 9...
August 9, 2018: Kardiologia Polska
Thomas D Stuckey, Roger S Gammon, Robi Goswami, Jeremiah P Depta, John A Steuter, Frederick J Meine, Michael C Roberts, Narendra Singh, Shyam Ramchandani, Tim Burton, Paul Grouchy, Ali Khosousi, Ian Shadforth, William E Sanders
BACKGROUND: Artificial intelligence (AI) techniques are increasingly applied to cardiovascular (CV) medicine in arenas ranging from genomics to cardiac imaging analysis. Cardiac Phase Space Tomography Analysis (cPSTA), employing machine-learned linear models from an elastic net method optimized by a genetic algorithm, analyzes thoracic phase signals to identify unique mathematical and tomographic features associated with the presence of flow-limiting coronary artery disease (CAD). This novel approach does not require radiation, contrast media, exercise, or pharmacological stress...
2018: PloS One
Simone Marques Dos Santos, Eneida Rejane Rabelo-Silva, Graziella Badin Aliti, Paola Severo Romero, Camille Lacerda Corrêa, Felipe Homem Valle, Sandro Cadaval Gonçalves, Marco Vugman Wainstein, Rodrigo Vugman Wainstein
OBJECTIVE: Randomized clinical trial protocol to evaluate the incidence of radial artery occlusion with two different arterial compression devices after transradial procedures. METHODS: Barbeau's test will be performed in adults scheduled to undergo transradial interventional procedures. Those with A, B, or C plethysmographic patterns will be selected. At the end of the procedure, patients will be randomly assigned (1:1) to receive patent haemostasis with TR Band™ device or conventional haemostasis with an elastic adhesive bandage...
August 2, 2018: Revista Gaúcha de Enfermagem
Elif Erolu, Figen Akalın, Nilüfer Çetiner, Berna Ç Şaylan
AimWe investigated dimensions and elasticity of whole aorta in patients with bicuspid aortic valve and influence of valve phenotype. METHOD: The study group included 44 patients and 42 controls. Patients were divided into groups according to the type of valve opening as horizontal - fusion between right and left coronary cusps - and vertical - fusion between right-non-coronary cusps; according to age they were divided into younger (5-10 years) and older patients (11-16 years). Our study did not include valve phenotype with fusion between left and non-coronary cusps...
August 6, 2018: Cardiology in the Young
A Rahman Rasyada, Munirah Sha'ban, Azran Azhim
INTRODUCTION: The aim of this study was to evaluate the impact of different visceral fat (VF) and blood pressure (BP) levels on changes in blood flow velocity (BFV) among non-obese subjects, using a cross-sectional study approach. METHODS: A total of 110 putatively healthy and non-obese subjects were divided into three groups according to their level of VF and BP. Common carotid artery BFV was measured using a developed portable Doppler ultrasound measurement system...
May 2018: Cardiovascular Journal of Africa
Elisabetta Bianchini, Rosa Maria Bruno, Nicole Di Lascio, Alessandra Vezzoli, Simona Mrakic-Sposta, Anca Irina Corciu, Mario Comassi, Lorenza Pratali
OBJECTIVES: The aim of this study was to evaluate the acute effects of participation in an Ironman distance triathlon competition on arterial function by ultrasound, in relation to cardiac function and body water content. METHODS: Twenty-eight male triathletes participating in an Ironman distance competition underwent carotid, femoral, and cardiac ultrasound examinations. Moreover, the presence of extravascular lung water was identified by lung echo B-lines (echogenic coherent wedge-shaped signal with a narrow origin from the hyperechoic pleural line) at rest and within 20 minutes of arrival...
July 29, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Felix S Seibert, Fabian Bernhard, Ulrik Stervbo, Sinthuya Vairavanathan, Frederic Bauer, Benjamin Rohn, Nikolaos Pagonas, Nina Babel, Joachim Jankowski, Timm H Westhoff
Background: Blood pressure has been traditionally measured at peripheral arteries. In the past decade evidence has grown, that central aortic blood pressure may be a more powerful predictor for cardiovascular events, but data on its regulation are rare. The present work examines the impact of microgravity on central blood pressure for the first time. Methods: We performed seven parabolic flights with 22 seconds of weightlessness in each parabola. Hemodynamic parameters including central systolic blood pressure were measured non-invasively in a free-floating position in 20 healthy subjects (19-43 years of age)...
July 25, 2018: American Journal of Hypertension
Michael B Avery, Ahmed Alaqeel, Amy B Bromley, Yong-Xiang Chen, John H Wong, Muneer Eesa, Alim P Mitha
OBJECTIVE Reliable animal models are an important aspect of translational research, especially for relatively uncommon clinical entities such as fusiform aneurysms. While several animal models exist, very few are tailored to cerebral fusiform aneurysms, which have unique attributes compared to abdominal fusiform aneurysms. The authors aimed to build from previous models to create a cerebral fusiform aneurysm model that is simple to use and reliable. METHODS Twelve female New Zealand White rabbits were assigned to 3 groups: group E, elastase only; group C, CaCl2 only; group EC, elastase + CaCl2 ...
July 27, 2018: Journal of Neurosurgery
Peter L M Kerkhof, Richard A Peace, Guy R Heyndrickx, Lilian J Meijboom, Ralf W Sprengers, Neal Handly
Cardiac function is best described by investigating the pressure-volume relationships. This information permits description in terms of the ventricular volume regulation graph (VRG), estimation of systolic elastance, evaluation of lusitropic properties, and assessment of ventriculo-arterial coupling. Current techniques yield noninvasive determination of cardiac compartmental volumes, along with systolic/diastolic arterial pressure, while ventricular end-diastolic pressure can be inferred from an echocardiography-based surrogate measure...
2018: Advances in Experimental Medicine and Biology
John K-J Li
The properties of arterial walls are dictated by their underlying structure, which is responsible for the adequate perfusion of conduit branching arteries and their vascular beds. Beginning with the mechanobiology of arteries in terms of their composition and individual contributions to overall viscoelastic behavior in men and women, pressure-flow relations are analyzed and noted in terms of sex differences. Hemodynamic function in terms of indices of vascular stiffness-such as pressure-strain elastic modulus, pulse wave velocity, augmentation index, and cardio-ankle vascular index-are evaluated...
2018: Advances in Experimental Medicine and Biology
Susumu Yamaguchi, Junpei Hamabe, Nobutaka Horie, Aya Yamashita, Junji Irie, Yoshihiro Tokuda, Kazuo Mutsukura, Nobuhiro Yagi, Kazuhiko Suyama
BACKGROUND: Mechanical thrombectomy improves functional outcomes in patients with acute ischemic stroke. However, stent retrievers have the risk of vascular damage. CASE DESCRIPTION: We present two cases of patients with acute internal carotid artery occlusion who experienced removal of the intima by a stent retriever. In both patients, a 6 × 30-mm Solitairetm stent was fully deployed from the M2 portion, and slowly withdrawn. White membranes were retrieved outside the strut in both patients...
July 23, 2018: World Neurosurgery
Naoki Kaneko, Yutaro Komuro, Hajime Yokota, Satoshi Tateshima
INTRODUCTION: Tortuous vascular anatomy is one of the greatest challenges in mechanical thrombectomy. This study examines the impact of vascular tortuosity on the performance of stent retrievers and evaluates the efficacy of the newer generation stent retrievers with segmented design. MATERIALS AND METHODS: Models with mild, moderate, and severe tortuosity with an internal carotid artery (ICA) and a middle cerebral artery (MCA) were created. An elastic and cohesive clot was placed in the MCA lying from distal M1 and proximal M2...
July 24, 2018: Journal of Neurointerventional Surgery
Daniele Pezzoli, Joseph Di Paolo, Heena Kumra, Giulia Fois, Gabriele Candiani, Dieter P Reinhardt, Diego Mantovani
One of the tightest bottlenecks in vascular tissue engineering (vTE) is the lack of strength and elasticity of engineered vascular wall models caused by limited elastic fiber deposition. In this study, flat and tubular collagen gel-based scaffolds were cellularised with vascular smooth muscle cells (SMCs) and supplemented with human plasma fibronectin (FN), a known master organizer of several extracellular matrix (ECM) fiber systems. The consequences of FN on construct maturation was investigated in terms of geometrical contraction, viscoelastic mechanical properties and deposition of core elastic fiber proteins...
October 2018: Biomaterials
Tomonori Iwata, Takahisa Mori, Yuhei Tanno, Shigen Kasakura, Kazuhiro Yoshioka
BACKGROUND AND PURPOSE: Spontaneous intracranial arterial dissections are characterized by the sudden disruption of the internal elastic lamina in the intracranial arteries. The purpose of our retrospective study was to investigate whether patients with nontraumatic intracranial arterial dissections had normal endothelial function. METHODS: The study included symptomatic patients with nontraumatic intracranial arterial dissections who underwent an endothelial function test...
July 19, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Hasan Tuzun, Emire Seyahi, Gul Guzelant, Buge Oz, Sebnem Batur, Ozkan Demirhan, Vedat Hamuryudan
We described disease characteristics, management and outcome of a group of Behçet's syndrome (BS) patients who underwent pulmonary lobectomy, segmentectomy or various pleura interventions for complications due to pulmonary artery or descending aorta involvement. There were 9 patients with BS (8 M/1 F; mean age: 24.8 ± 7.5 and mean disease duration: 4.3 ± 3.8 years) who underwent lung surgery from 2000 to 2017. Their medical files including operation details and radiological and pathological studies were reviewed retrospectively...
July 19, 2018: Seminars in Thoracic and Cardiovascular Surgery
Han Wen, Alejandro Morales Martinez, Houxun Miao, Thomas C Larsen, Catherine P Nguyen, Eric E Bennett, Kellan P Moorse, Zu-Xi Yu, Alan T Remaley, Manfred Boehm, Ahmed M Gharib
Histopathology protocols often require sectioning and processing of numerous microscopy slides to survey a sample. Trade-offs between workload and sampling density means that small features can be missed. Aiming to reduce the workload of routine histology protocols and the concern over missed pathology in skipped sections, we developed a prototype x-ray tomographic scanner dedicated to rapid scouting and identification of regions of interest in pathology specimens, thereby allowing targeted histopathology analysis to replace blanket searches...
July 20, 2018: Scientific Reports
Daphne Meza, David A Rubenstein, Wei Yin
A fluid structure interaction model of a left anterior descending (LAD) coronary artery was developed, incorporating transient blood flow, cyclic bending motion of the artery, and myocardial contraction. The 3D geometry was constructed based on a patient's computed tomography angiography data. To simulate disease conditions, a plaque was placed within the LAD to create a 70% stenosis. The bending motion of the blood vessel was prescribed based on the LAD spatial information. The pressure induced by myocardial contraction was applied to the outside of the blood vessel wall...
July 5, 2018: Journal of Biomechanical Engineering
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