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Arterial Elastance

Dinani Matoso Filho Armstrong, Gautam Sikka, Anderson da Costa Armstrong, Karen Ruggeri Saad, William Rodrigues de Freitas, Dan Ezra Berkowitz, Djalma José Fagundes, Lakshmi Santhanam, Murched Omar Taha
PURPOSE: To determine whether the absence of transglutaminase 2 enzyme (TG2) in TG2 knockout mice (TG2-/-) protect them against early age-related functional and histological arterial changes. METHODS: Pulse wave velocity (PWV) was measured using non-invasive Doppler and mean arterial pressure (MAP) was measured in awake mice using tail-cuff system. Thoracic aortas were excised for evaluation of endothelial dependent vasodilation (EDV) by wire myography, as well as histological analyses...
November 2018: Acta Cirúrgica Brasileira
Austin J Cocciolone, Elizabeth Johnson, Jin-Yu Shao, Jessica E Wagenseil
Transmural advective transport of solute and fluid was investigated in mouse carotid arteries with either a genetic knockout of Fibulin-5 (Fbln5-/-) or treatment with elastase to determine the influence of a disrupted elastic fiber matrix on wall transport properties. Fibulin-5 is an important director of elastic fiber assembly. Arteries from Fbln5-/- mice have a loose, non-continuous elastic fiber network and were hypothesized to have reduced resistance to advective transport. Experiments were carried out ex vivo at physiological pressure and axial stretch...
December 5, 2018: Journal of Biomechanical Engineering
Max L Olender, Lambros S Athanasiou, Jose M de la Torre Hernandez, Eyal Ben-Assa, Farhad Rikhtegar Nezami, Elazer R Edelman
Automated analysis of vascular imaging techniques is limited by the inability to precisely determine arterial borders. Intravascular optical coherence tomography (OCT) offers unprecedented detail of artery wall structure and composition, but does not provide consistent visibility of the outer border of the vessel due to limited penetration depth. Existing interpolation and surface fitting methods prove insufficient to accurately fill the gaps between the irregularly-spaced and sometimes unreliably-identified visible segments of the vessel outer border...
November 29, 2018: IEEE Transactions on Medical Imaging
Yu Kato, Tohru Mizutani, Naruhito Otsuka, Hiromitsu Ezure, Yuriko Inoue
In this study, the results of our previously reported technique of quantitative analysis by using microscopic image analysis of tissue image slices to calculate the proportion of the area of the tunica media occupied by of elastic fibers was compared with Janzen et al.'s technique at the carotid bifurcation. This particularly analyzed the area of transition between the common carotid and the internal carotid, to observe the quantitative changes in elastic fiber content. The data obtained from our quantitative analysis of elastic fibers were clearly at variance with those obtained by counting the number of elastic fibers...
2018: Okajimas Folia Anatomica Japonica
Leila Hadjadj, Anna Monori-Kiss, Eszter M Horváth, Andrea Heinzlmann, Attila Magyar, Réka E Sziva, Zsuzsanna Miklós, Éva Pál, János Gál, István Szabó, Zoltán Benyó, György L Nádasy, Szabolcs Várbíró
Vitamin D (VitD) hypovitaminosis and androgen excess (AE) are both risk factors for cardiovascular diseases in fertile women. However, the possible early interaction between AE and VitD status is not clear. Our goal was to describe how VitD status influences early changes in the biomechanical reactivity of small coronary arterioles in adult female rats after transdermal testosterone treatment. Forty-six adolescent, 90-110-gram-weighed female Wistar rats were randomly grouped into 4 groups. Twenty-four animals received an optimal VitD-supplemented diet, from which 12 animals underwent transdermal testosterone treatment...
November 28, 2018: Microvascular Research
R Garrett Morgan, Ashley E Walker, Daniel W Trott, Daniel R Machin, Grant D Henson, Kelly D Reihl, Richard M Cawthon, Eros L Denchi, Yu Liu, Samuel I Bloom, Tam T Phuong, Russell S Richardson, Lisa A Lesniewski, Anthony J Donato
Age-related vascular dysfunction in large elastic and resistance arteries is associated with reductions in microvascular perfusion and elevations in blood pressure. Recent evidence indicates that telomere uncapping-induced senescence in vascular cells may be an important source of oxidative stress and vascular dysfunction in aging, but the causal relationship between these processes has yet to be elucidated. To test this important unexplored hypothesis, we measured arterial senescence signaling and oxidative stress, carotid and mesenteric artery endothelium-dependent vasodilatory capacity, markers of mesenteric microvascular perfusion and endothelial glycocalyx deterioration, and blood pressure in a novel mouse model of Cre-inducible whole body Trf2 deletion and telomere uncapping...
November 28, 2018: Journal of Molecular and Cellular Cardiology
Li Bing, Chen Wei-Bing, Huang Xia, Xia Shun-Lin, Zhang Feng-Nian, Wang Shou-Qing, Wang Ye-Bo
BACKGROUND: Laparoscopic Kasai portoenterostomy (LKPE) is generally regarded to have a poorer outcome for surgical treatment of uncorrectable biliary atresia. We herein described our initial experience of some modifications to make LKPE easier in the treatment of type III biliary atresia (BA). METHODS: During the period July 2012-October 2016, a total of 25 infants with type III BA were treated with a modified LKPE technique. A percutaneous suture was introduced just below the xiphoid process to snare the round ligament and retract the liver; other percutaneous stay sutures were then introduced to the fundus and neck of the gallbladder to elevate the liver and expose the porta hepatis...
January 2019: Journal of Surgical Research
Zheng Wang, Neel A Mansukhani, Zachary M Emond, Vinit N Varu, Amy Chen, Courtney E Morgan, Janet M Vercammen, Melina R Kibbe
BACKGROUND: Current procedures to treat severe atherosclerosis are traumatic to the arterial wall and often result in restenosis due to neointimal hyperplasia. We developed a novel therapy using a specially designed double occlusion balloon catheter, ultrasonic wire, and enzymatic digestion solution to atraumatically debulk atherosclerotic plaques. MATERIALS AND METHODS: A combination of different enzymes, chemicals, and treatment conditions were evaluated for its effect at reducing atherosclerotic plaque harvested from human carotid artery endarterectomies ex vivo...
January 2019: Journal of Surgical Research
Jenny M Freij, Hanna E Burton, Daniel M Espino
PURPOSE: This study aimed to develop an objective method for the elastic characterisation of pre- and post-transitional moduli of left anterior descending (LAD) porcine coronary arteries. METHODS: Eight coronary arteries were divided into proximal, middle and distal test specimens. Specimens underwent uniaxial extension up to 3 mm. Force-displacement measurements were used to determine the induced true stress and stretch for each specimen. A local maximum of the stretch-true stress data was used to identify a transition point...
November 28, 2018: Cardiovascular Engineering and Technology
Manuel Ignacio Monge Garcia, Zhongping Jian, Jos J Settels, Charles Hunley, Maurizio Cecconi, Feras Hatib, Michael R Pinsky
BACKGROUND: Maximal left ventricular (LV) pressure rise (LV dP/dtmax ), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform measures have been proposed. We compared LV and arterial (femoral and radial) dP/dtmax to the slope of the LV end-systolic pressure-volume relationship (Ees), a load-independent measure of LV contractility, to determine the interactions between dP/dtmax and Ees as loading and LV contractility varied. METHODS: We measured LV pressure-volume data using a conductance catheter and femoral and radial arterial pressures using a fluid-filled catheter in 10 anesthetized pigs...
November 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
Run Du, Rui Yan Zhang, Lin Lu, Ying Shen, Li Jin Pu, Zheng Bin Zhu, Qi Zhang, Jian Hu, Zhen Kun Yang, Feng Hua Ding, Jian Sheng Zhang, Wei Feng Shen
BACKGROUND: Negative coronary artery remodeling is frequent in patients with diabetes, but its mechanism remains unclear. We here evaluated the association of serum levels of glycated albumin (GA) and endogenous secretory receptor for advanced glycation end products (esRAGE) with coronary artery remodeling in type 2 diabetic patients. METHODS: Serum levels of GA and esRAGE were measured and intravascular ultrasound was performed in 136 consecutive diabetic patients with 143 coronary intermediate lesions...
November 27, 2018: Cardiovascular Diabetology
Daniel von Bornstädt, Hanjay Wang, Michael J Paulsen, Andrew B Goldstone, Anahita Eskandari, Akshara Thakore, Lyndsay Stapleton, Amanda N Steele, Vi N Truong, Kevin Jaatinen, Camille Hironaka, Y Joseph Woo
BACKGROUND: Cardiovascular bypass grafting is an essential treatment for complex cases of atherosclerotic disease. Because the availability of autologous arterial and venous conduits is patient-limited, self-assembled cell-only grafts have been developed to serve as functional conduits with off-the-shelf availability. The unacceptably long production time required to generate these conduits, however, currently limits their clinical utility. Here, we introduce a novel technique to significantly accelerate the production process of self-assembled engineered vascular conduits...
November 6, 2018: Circulation
Takashi Abe, J Grant Mouser, Scott J Dankel, Zachary W Bell, Samuel L Buckner, Kevin T Mattocks, Matthew B Jessee, Jeremy P Loenneke
Blood flow restriction training using a practical (non-pneumatic) elastic-cuff has recently increased in popularity. However, a criticism of this method is that the pressure applied and the amount of blood flow restriction induced is unknown. The aim was to quantify blood flow following the application of an elastic-cuff and compare that to what is observed using a more traditional pressurized nylon-cuff. Thirty-five young participants (16 men and 19 women) visited the laboratory once for testing. In a randomized order (one condition per arm), an elastic-cuff (5cm wide) was applied to one arm and blood flow was measured following the cuff being pulled to two distinct lengths; 10% and 20% of the resting length based on arm circumference...
November 23, 2018: Scandinavian Journal of Medicine & Science in Sports
Olga Vriz, Julien Magne, Joanna Jarosh, Eduardo Bossone, Victor Aboyans, Paolo Palatini
PURPOSE: The aim was to investigate the association between blood pressure (BP), carotid stiffness, carotid-femoral pulse wave velocity (cfPWV) and left ventricular (LV) remodeling in never-treated hypertensive patients. MATERIAL AND METHODS: 178 never-treated hypertensive underwent transthoracic echocardiography, 24-hour ambulatory BP monitoring (ABPM), local carotid stiffness and regional cfPWV assessed using a high-definition echo-tracking ultrasound system and a tonometric transducer, respectively...
November 22, 2018: Blood Pressure
Pu Zhang, Ruijun Guo, Chen Wang, Dan Xiao, Haiyan Qin, Lingling Zhang
The aim of this study was to explore changes in the common carotid arterial wall elasticity after smoking cessation. Carotid artery ultrasonographic examination was performed in 136 patients, then 1 or 2 years after smoking cessation. We used echo-tracking (ET) to measure stiffness index (β), pressure-strain elasticity modulus (Ep), arterial compliance (AC), augmentation index (AI), and local pulse wave velocity (PWVβ). Patients were divided into four groups based on whether or not they successfully stopped smoking (groups M and N, respectively) and whether (groups M2 and N2, respectively) or not (groups M1 and N1, respectively) they showed comorbidities...
November 19, 2018: Journal of Clinical Ultrasound: JCU
Hans Scheers, Tim S Nawrot, Benoit Nemery, Lidia Casas
BACKGROUND: Short-term exposure to ambient air pollution triggers acute cardiovascular events. Here, we evaluate the association of exposure to ambient air pollution with two intermediate cardiovascular endpoints: blood pressure and carotid stiffness. METHODS: In a one-year panel study, we included 20 healthy volunteers (10 male-female couples aged 59-75 years) with air pollution and health parameters measured every two months at their region of residence (Leuven, Belgium) and twice during two ten-day periods in two locations, one with higher (Milan, Italy) and one with lower (Vindeln, Sweden) air pollution levels (220 observations)...
November 19, 2018: Environmental Health: a Global Access Science Source
Julie Bjerre Tarp, Maria D Radu, Ole De Backer, Annette S Jensen, David Celermajer, Keld Sørensen, Niels-Henrik Holstein-Rathlou, Thomas Engstrøm, Lars Søndergaard
AIMS: Patients with cyanotic congenital heart disease (CCHD) have been suggested to develop less atherosclerosis than the general population. This study aimed to evaluate the extent of coronary atherosclerosis in patients with CCHD using intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS). METHODS AND RESULTS: Fifteen patients with CCHD (women, 9; median age, 53 years) and 14 acyanotic controls (women, 6; median age, 53 years) were examined with IVUS-NIRS of the right coronary artery (RCA)...
November 20, 2018: EuroIntervention
Mohamed A Bahloul, Taous Meriem Laleg-Kirati
Arterial hemodynamic assessment has always been essential for clinical Cardiovascular System (CVS) diagnosis. Using Windkessel (WK) lumped parametric model as non-invasive measurement tool provides the potential of achieving a very convenient, computational inexpensive and accurate prediction of the arterial parameters. Many versions of WK models have been proposed and extensively studied, over the last century. In general, they can be classified into two categories: elastic and viscoelastic models. Recently, several studies have discussed the potential of describing the arterial wall viscoelasticity using fractional order models, reducing the number of parameters and exposing a natural response...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Ghazwan Alwan, Noah D Manring, Craig A Emter, Patrick Delafontaine, Emily Leary
Nondimensional analysis was used to develop a novel model of coronary blood flow. In addition to general hemodynamics, the model was used to study the sensitivity of the arterial flow to variations in characteristic lumped parameters. Experimental hemodynamic data obtained from four normal healthy pigs were used in the current study. The results suggest that the mean coronary arterial flow is primarily sensitive to the flow and elasticity parameters of the coronary vasculature. Other flow features were also studied, and it was shown that the sensitivities of the general flow waveforms are influenced to different extents by the perturbations of these parameters...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
R Fujita, T Kawakami, C Ichikawa, K Yamamoto, H Takao, Y Murayama, M Motosuke
Hemodynamic analysis of cerebral aneurysms is widely performed to understand the mechanism of aneurysmal rupture. Computational fluid dynamics (CFD) studies have suggested that several hemodynamic parameters are associated with such ruptures. However, a number of factors remain to be addressed to correlate these parameters with aneurysmal ruptures, especially under analytical conditions. Specifically, CFD analysis is often performed with rigid wall models due to computational cost limitations. Here, to evaluate the effects of the deformation of the aneurysmal wall, experimental flow measurement with elastic models under pulsating conditions was conducted using three-dimensional particle image velocimetry (3D PIV)...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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