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Shaktivel Manavalan, Umamaheswari Rajaji, Shen-Ming Chen, Mani Govindasamy, S Steplin Paul Selvin, Tse-Wei Chen, M Ajmal Ali, Fahad M A Al-Hemaid, M S Elshikh
Herein, we report an efficient electrochemical sensor strategy for determination of epinephrine based on Bi2 O3 nanoparticle decorated reduced graphene oxide nanocomposite (Bi2 O3 @RGO). The Bi2 O3 @RGO was prepared by simple ultrasonic method and then it's morphological and crystal structure aspects were well characterized by physiological instruments. The electrode-electrolyte interfacial properties were examined to ensure the catalytic ability of composite sensing towards EP. The composite was deposited on the multi-conventional screen-printed electrode and was found to be desirable performance toward EP oxidation...
March 2019: Ultrasonics Sonochemistry
Kobra Foroughi, Mehdi Khaksari, Asghar Shayannia
BACKGROUND: The catecholamines such as dopamine, norepinephrine, and epinephrine are neurotransmitters that regulate different physiological functions of the central nervous system. Some evidence suggest that the degeneration of dopamine neurons in the substantia nigra contributes in Parkinson's disease (PD), which is a neurodegenerative disorder and it is responsible for the major symptoms of PD. It is suggested that replenishment of striatal dopamine through the oral administration of the dopamine precursor, levodopa, can compensate the lack of endogenously produced dopamine...
December 4, 2018: Current Computer-aided Drug Design
(no author information available yet)
No abstract text is available yet for this article.
December 4, 2018: Prehospital Emergency Care
Megan O'reilly, Georg M Schmölzer
An estimated 0.1% of term infants and up to 15% of preterm infants (2-3 million worldwide) need extensive resuscitation, defined as chest compression and 100% oxygen with or without epinephrine in the delivery room. Despite these interventions, infants receiving extensive resuscitation in the DR have a high incidence of mortality and neurologic morbidity. Successful resuscitation from neonatal cardiac arrest requires the delivery of high-quality chest compression using the most effective vasopressor with the optimal dose, timing, and route of administration during CPR...
December 3, 2018: Minerva Pediatrica
Yuji Odagaki, Masakazu Kinoshita, Toshio Ota, J Javier Meana, Luis F Callado, Jesús A García-Sevilla
The biochemical abnormalities in transmembrane signal transduction mediated through G protein-coupled receptors (GPCRs) have been postulated as underlying pathophysiology of psychiatric diseases such as schizophrenia and mood disorders. In the present study, the experimental conditions of agonist-induced [35 S]GTPγS binding in postmortem human brain membranes were optimized, and the responses induced by a series of agonists were pharmacologically characterized. The [35 S]GTPγS binding assay was performed in postmortem human prefrontal cortical membranes by means of filtration techniques, and standardized as to GDP concentration, membrane protein content, MgCl2 and NaCl concentrations in assay buffer, incubation period, and effect of white matter contamination...
December 3, 2018: Basic & Clinical Pharmacology & Toxicology
Ersöz Gonca, Duygu Çatlı
Objective: Bupivacaine, a local anaesthetic substance, is used as a regional-anaesthesia agent. Lidocaine, a sodium channel blocker, is used in combination with epinephrine for regional anaesthesia. We aimed to evaluate the effects of lidocaine with epinephrine (LE) at different doses on bupivacaine-induced cardiotoxicity in rats. Methods: In our study, 24 Wistar albino rats were divided into four groups: I) Control; II) LE, 1 mg kg-1 ; III) LE, 3 mg kg-1 and IV) LE, 6 mg kg-1 ...
December 2018: Turkish Journal of Anaesthesiology and Reanimation
Jae-Sung Yoo, Kang Heo, Soon-Min Kwon, Dong-Ho Lee, Joong-Bae Seo
Background: Surgical-site, multimodal drug injection has recently evolved to be a safe and useful method for multimodal pain management even in patients with musculoskeletal trauma. Methods: Fifty consecutive patients who underwent plating for mid-shaft and distal clavicular fractures were included in the study. To evaluate whether surgical-site injections (SIs) have pain management benefits, the patients were divided into two groups (SI and no-SI groups). The injection was administered between the deep and superficial tissues prior to wound closure...
December 2018: Clinics in Orthopedic Surgery
Matthieu Masureel, Yaozhong Zou, Louis-Philippe Picard, Emma van der Westhuizen, Jacob P Mahoney, João P G L M Rodrigues, Thomas J Mildorf, Ron O Dror, David E Shaw, Michel Bouvier, Els Pardon, Jan Steyaert, Roger K Sunahara, William I Weis, Cheng Zhang, Brian K Kobilka
In the version of this paper originally published, the structure for epinephrine shown in Figure 1a was redrawn with an extra carbon. The structure has been replaced in the HTML and PDF versions of the article. The original and corrected versions of the structure are shown below.
November 30, 2018: Nature Chemical Biology
Benjamin P Tooke, Hui Yu, Jessica M Adams, Graham L Jones, Talisha Sutton-Kennedy, Lakshmi Mundada, Nathan R Qi, Malcolm J Low, Kavaljit H Chhabra
OBJECTIVE: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses remain unclear. Given the established roles of the hypothalamic proopiomelanocortin (POMC)/melanocortin 4 receptor (MC4R) circuit in regulating sympathetic nervous system (SNS) activity and the SNS in stimulating counterregulatory responses to hypoglycemia, we hypothesized that hypothalamic POMC as well as MC4R, a receptor for POMC derived melanocyte stimulating hormones, is required for normal hypoglycemia counterregulation...
November 20, 2018: Molecular Metabolism
Piotr Lacwik, Adam J Bialas, Marzena Wielanek, Maria Sklodowska, Maciej Kupczyk, Pawel Gorski, Piotr Kuna
No abstract text is available yet for this article.
November 27, 2018: Journal of Allergy and Clinical Immunology in Practice
Milad Modabber, Andrei F Dan, Razek G Coussa, Michael Flanders
OBJECTIVE: To characterize the ocular response to retrobulbar anaesthesia and to evaluate the efficacy of retrobulbar anaesthesia for adjustable strabismus surgery in adults. DESIGN: Prospective observational study. PARTICIPANTS: Adult patients undergoing adjustable strabismus surgery under retrobulbar anaesthesia. METHODS: Surgical success was defined by ocular alignment within 10 prism diopters (PD) of orthotropia for horizontal rectus surgery and within 5 PD for vertical rectus surgery...
December 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
L I Pyshkina, A R Abieva, A N Yasamanova, N A Darvish, P R Kamchatnov, A A Kabanov, A A Tyazhelnikov, E V Silina, S N Shurygin, Z H Osmaeva
AIM: To study the state of cerebral hemodynamics and platelet hemostasis in patients with carotid stenosis (CS). MATERIAL AND METHODS: The prospective study included 123 patients with atherosclerotic CS. The 1st group included 53 patients (mean age 52±12.5 yrs) who underwent carotid endarterectomy (CEA); the 2nd group - 70 patients who were treated conservatively (mean age 58.5±15.9 yrs). The state of blood flow through the main arteries of the head (Doppler flowmetry), platelet aggregation induced by adrenaline, the frequency of acute cardiovascular events that occurred during 12 months were evaluated...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Utkarsh Kohli, Karen L Pumphrey, Aziez Ahmed, Srikant Das
A 13 kg, 20 month-old, Caucasian girl, presented with cardiomyopathy, biventricular dysfunction and pre-excitation on electrocardiogram. She had normal intracardiac anatomy with severely dilated left ventricle and severely diminished biventricular function (Fig. 1). She was treated with milrinone and epinephrine infusions, mechanical ventilation and listed for heart transplant. She underwent Berlin Heart EXCOR biventricular assist device (BiVAD) placement (30 ml LVAD and 25 ml RVAD pumps). No supraventricular tachycardia (SVT) was inducible or noted during her hospitalization...
November 2018: Journal of Electrocardiology
Matti Korppi
Bronchiolitis in infancy is the most common infectious reason for hospitalization of infants without any chronic underlying illness. Areas covered: This review focuses on the role of racemic epinephrine, systemic corticosteroids, hypertonic saline and high-flow oxygen therapy (HFOT) in the treatment of infants with bronchiolitis. Literature was searched from Pubmed covering the years 2009-2018 using the entries of bronchiolitis or viral bronchiolitis, and epinephrine, adrenaline, racemic epinephrine, racemic adrenaline, corticosteroids, hypertonic saline, high-flow oxygen therapy or high-flow oxygen cannula...
November 29, 2018: Expert Review of Respiratory Medicine
Keiichi Tozawa, Yukako Ono-Uruga, Masaki Yazawa, Taisuke Mori, Mitsuru Murata, Shinichiro Okamoto, Yasuo Ikeda, Yumiko Matsubara
The clinical needs for platelet transfusions are increasing. Donor-dependent platelet transfusions are, however, associated with practical problems, such as the limited supply and the risk of infection. Thus, we developed a manufacturing system for platelets from donor-independent cell source, human adipose-derived mesenchymal stromal/stem cell line (ASCL). ASCL was obtained by upside-down culture flask method. ASCL satisfied the minimal criteria for defining mesenchymal stem cell (MSC) by The International Society for Cellular Therapy...
November 28, 2018: Blood
Michelle Le, Sofianne Gabrielli, Ann Clarke, Harley Eisman, Judy Morris, Jocelyn Gravel, Edmond S Chan, Rod Lim, Andrew O'Keefe, Greg Shand, Moshe Ben-Shoshan
BACKGROUND: Anaphylaxis due to Unknown Trigger (AUT) is anaphylaxis not explained by a proved or presumptive cause or stimulus at the time of the reaction. Research describing the management and follow-up of AUT is limited. OBJECTIVE: This study assesses and compares the demographics, clinical characteristics and management of adult and pediatric AUT cases across Canada. METHODS: Participants were identified between 2011 and 2018 in emergency departments at eight centers across Canada as part of the Cross-Canada Anaphylaxis Registry...
November 23, 2018: Journal of Allergy and Clinical Immunology in Practice
Hisatsugu Koshimizu, Nao Hirata, Keizo Takao, Keiko Toyama, Takashi Ichinose, Shigeki Furuya, Tsuyoshi Miyakawa
AIM: Tryptophan hydroxylase 2 (Tph2) is a rate-limiting enzyme for the biosynthesis of 5-hydroxytryptamine (5-HT, serotonin). Previous studies have reported that C1473G polymorphism of the murine Tph2 gene leads to decreased 5-HT levels in the brain and abnormal behavioral phenotypes, such as impaired anxiety- and depression-like behaviors. In this study, to confirm the effect of the C1473G polymorphism on mouse phenotypes, we conducted a comprehensive battery of behavioral tests and measured the amounts of brain free amino acids involved in the production of 5-HT...
November 24, 2018: Neuropsychopharmacology reports
M S Chae, Y Kim, S A Oh, Y Jeon, H J Choi, Y H Kim, S H Hong, C S Park, J Huh
BACKGROUND: Combined liver and kidney transplant is a very complex surgery. To date, there has been no report on the intraoperative management of patients with impaired cardiac function undergoing simultaneous ABO-compatible liver and ABO-incompatible kidney transplant from 2 living donors. CASE REPORT: A 60-year-old man underwent simultaneous ABO-compatible liver and ABO-incompatible kidney transplant from 2 living donors because of IgA nephropathy and alcoholic liver cirrhosis...
September 7, 2018: Transplantation Proceedings
Shu Guo Xing, Jin Bo Tang
The authors' experience demonstrates that wide-awake flap surgery in the hand is safe. The authors used this approach in 4 commonly used flaps in the hand in 27 patients: the extended Segmuller flap, the homo-digital reverse digital artery flap, the dorsal metacarpal artery perforator flap, and the Atasoy advancement flap. Wide-awake flap surgery works very well and safely achieved excellent anesthetic and vasoconstrictive effects in the authors' cases. The authors found that vasoconstriction caused by epinephrine mainly affects the capillaries and does not affect digital arteries and their major branches in the hand...
February 2019: Hand Clinics
Saori Araki, Toshiki Kijima, Yuma Waseda, Yoshinobu Komai, Yasukazu Nakanishi, Sho Uehara, Yosuke Yasuda, Soichiro Yoshida, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Kazunori Kihara, Yujiro Nakano, Takanobu Yoshimoto, Tokujiro Uchida, Yasuhisa Fujii
OBJECTIVES: To determine the incidence and preoperative risk factors of post-excisional hypoglycemia in patients undergoing pheochromocytoma resection. METHODS: Patients who underwent surgical resection of pheochromocytoma at a single institution were retrospectively enrolled in the present study. The primary end-point was the development of post-excisional hypoglycemia; that is, a serum glucose level <70 mg/dL. The serum levels of immunoreactive insulin and glucose levels during the preoperative oral glucose-tolerance test and surgery were analyzed to elucidate the mechanism of hypoglycemia...
November 22, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
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