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Developmental assessment

Jyothsna Chitturi, Ying Li, Vijayalakshmi Santhakumar, Sridhar S Kannurpatti
Pathophysiology of developmental traumatic brain injury (TBI) is unique due to intrinsic differences in the developing brain. Energy metabolic studies of the brain during early development (P13 to P30) have indicated acute oxidative energy metabolic decreases below 24 h after TBI, which generally recovered by 48 h. However, marked neurodegeneration and altered neural functional connectivity have been observed at later stages into adolescence. As secondary neurodegeneration is most prominent during the first week after TBI in the rat model, we hypothesized that the subacute TBI-metabolome may contain predictive markers of neurodegeneration...
August 9, 2018: Neurochemistry International
Liana Shvachiy, Vera Geraldes, Ângela Amaro-Leal, Isabel Rocha
BACKGROUND: Exposures to lead (Pb) during developmental phases can alter the normal course of development, with lifelong health consequences. Permanent Pb exposure leads to behavioral changes, cognitive impairment, sympathoexcitation, tachycardia, hypertension and autonomic dysfunction. However, the effects of an intermittent lead exposure are not yet studied. This pattern of exposure has been recently increasing due to migrations, implementation of school exchange programs and/or residential changes...
August 8, 2018: Neurotoxicology
Toshiyuki Hata, Kenji Kanenishi, Nobuhiro Mori, Mohamed Ahmed Mostafa AboEllail, Uiko Hanaoka, Kosuke Koyano, Ikuko Kato, Takashi Kusaka
Objective To assess the usefulness of the antenatal fetal neurodevelopmental test for the prediction of postnatal developmental disabilities. Methods Fetal behavior was assessed with Kurjak's antenatal neurodevelopmental test (KANET) using four-dimensional ultrasound between 28 and 38 weeks of gestation. A score range of 0-5 was characterized as abnormal, from 6 to 9 was considered borderline, and 10-16 was normal. After birth, follow-up was conducted for at least 2 years in all fetuses. Results There were 337 normal (95...
August 11, 2018: Journal of Perinatal Medicine
Jin-Hua Liao, Rong-Fang Hu, Li-Jing Su, Shuo Wang, Qin Xu, Xiao-Fang Qian, Hong-Gu He
BACKGROUND: Nonpharmacological interventions are often used to promote sleep among preterm infants in the neonatal intensive care unit (NICU). However, there is a lack of synthesis in the evidence of their effectiveness. AIM: To synthesize the evidence on the effectiveness of nonpharmacological interventions on NICU preterm infants' sleep during hospital stay. METHODS: Seven databases were searched, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Wan-fang database, China National Knowledge Infrastructure, China Biological Medicine Database, and VIP Journal Integration Platform from their inceptions to August 2017...
August 11, 2018: Worldviews on Evidence-based Nursing
Anna-Lena Kolb, Duen-Wei Hsu, Ana B A Wallis, Seiji Ura, Alina Rakhimova, Catherine J Pears, Nicholas D Lakin
The amoeba Dictyostelium discoideum is a single-cell organism that can undergo a simple developmental program, making it an excellent model to study the molecular mechanisms of cell motility, signal transduction, and cell-type differentiation. A variety of human genes that are absent or show limited conservation in other invertebrate models have been identified in this organism. This includes ADP-ribosyltransferases, also known as poly-ADP-ribose polymerases (PARPs), a family of proteins that catalyze the addition of single or poly-ADP-ribose moieties onto target proteins...
2018: Methods in Molecular Biology
Kuang Zhang, Zhen Xu, Hui-Xia Chen, Ning Guo, Liang Li
The yellow goosefish Lophius litulon is a commercially important marine fish species. However, our present knowledge of the occurrence of nematode parasites in L. litulon remains incomplete. A total of 42 L. litulon collected from the East China Sea were investigated for the presence of ascaridoid nematodes. Eight ascaridoid species with different developmental stages were identified using morphological and molecular methods, including Anisakis pegreffii (L3s), Raphidascaris lophii (L3s), Hysterothylacium fabri (L3s, L4s), H...
August 3, 2018: International Journal of Food Microbiology
Evelin M Cotella, Antonela Scarponi Gomez, Paige Lemen, Carrie Chen, Guillermo Fernández, Christian Hansen, James P Herman, María Gabriela Paglini
Adolescence is a period of active development of stress regulatory neurocircuitry. As a consequence, mechanisms that control the responses to stress are not fully matured during this developmental period, which may result in vulnerability to chronic stress. We hypothesized that adolescent chronic stress would have negative consequences on stress adaptation later in life. Male Wistar rats (PND40) were subjected to chronic variable stress (CVS) for 2 weeks, with 2 daily stressors randomly presented and overnight social stressors twice a week...
August 7, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Kathryn E Worley, Jennifer Rico-Varela, Dominic Ho, Leo Q Wan
Birth defects are a common occurrence in the United States and worldwide. Currently, evaluation of potential developmental toxicants (i.e., teratogens) relies heavily on animal-based models which do not always adequately mimic human development. In order to address this, researchers are developing in vitro human-based models which utilize human pluripotent stem cells (hPSCs) to assess the teratogenic potential of chemical substances. The field of human developmental toxicity assays includes a variety of platforms including monolayer, micropattern, embryoid body, and 3D organoid cultures...
August 10, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
Rachel C Heenan, Thomas Volkman, Simon Stokes, Shidan Tosif, Hamish Graham, Andrea Smith, David Tran, Georgia Paxton
AIM: To examine refugee health assessments in Syrian and Iraqi children in the context of changes to offshore immigration screening, updated Australian refugee health guidelines and the primary care refugee health model in Victoria. METHODS: This is a retrospective audit of Syrian and Iraqi children aged 0-17 years attending a specialist immigrant health service from January 2015 to September 2017. RESULTS: We saw 128 children (7 months-16 years, 64...
August 9, 2018: Journal of Paediatrics and Child Health
Rafaella R Sâmia, Pablo C Gontijo, Rodrigo L Oliveira, Geraldo A Carvalho
BACKGROUND: Thiamethoxam, when applied as a seed treatment, can contaminate plant products, such as extrafloral nectar, causing non-target effects on beneficial arthropods. This study assessed non-target effects of thiamethoxam applied to cotton seed on life history parameters of the predators Chrysoperla externa (Neuroptera: Chrysopidae) and Harmonia axyridis (Coleoptera: Coccinellidae). RESULTS: Exposure of C. externa larvae to plants grown from thiamethoxam treated seeds caused sublethal and transgenerational effects...
August 9, 2018: Pest Management Science
Christof Schaefer
Drug safety in pregnancy is of utmost importance because prenatal exposure to the unborn child may result in side effects with life-long consequences. Data on their risks in pregnancy are scarce for many drugs. Furthermore, there is often uncertainty how to translate risk data into practice.This article aims to identify tools to improve data ascertainment on exposed pregnancies and their outcome. Using the example of the German Embryotox institute, it is demonstrated how to disseminate drug safety knowledge to healthcare professionals and patients for clinical decision-making...
August 9, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Rhian L Clissold, Jon Fulford, Michelle Hudson, Beverley M Shields, Timothy J McDonald, Sian Ellard, Andrew T Hattersley, Coralie Bingham
Background: Heterozygous mutations in the HNF1B gene are the most common monogenic cause of developmental kidney disease. Extrarenal phenotypes frequently occur, including diabetes mellitus and pancreatic hypoplasia; the latter is associated with subclinical exocrine dysfunction. We measured faecal elastase-1 in patients with HNF1B-associated disease regardless of diabetes status and assessed the degree of symptoms associated with pancreatic exocrine deficiency. Methods: Faecal elastase-1 was measured in 29 patients with a known HNF1B mutation...
August 2018: Clinical Kidney Journal
Bilal Ahmad Bhat, Arshad Hussain, Mansoor Ahmad Dar, Shabir Ahmad Dar, Nusrat Jabeen, Sumaya Rasool, Shabnum Shafi
Background: Psychiatric disorders are ubiquitous and affect not only adults but also children and adolescents. The age factor plays an important role in the pattern of these psychiatric disorders. The objective of our study was to find the pattern of psychiatric morbidity in children and adolescents at the child and adolescent outpatient service of a tertiary care hospital. Materials and Methods: A semi-structured questionnaire was used to record the sociodemographic status...
July 2018: Indian Journal of Psychological Medicine
Erin Kang, Cara M Keifer, Emily J Levy, Jennifer H Foss-Feig, James C McPartland, Matthew D Lerner
BACKGROUND: Autism spectrum disorder (ASD) is associated with impaired face processing. The N170 event-related potential (ERP) has been considered a promising neural marker of this impairment. However, no quantitative review to date has integrated the literature to assess whether the N170 response to faces in individuals with ASD differs from that of typically developing (TD) individuals. METHODS: This meta-analysis examined the corpus of literature investigating difference in N170 response to faces in individuals with ASD and without ASD...
August 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Mahmoud Moussa, Meng-Qi Li, Hai-Ying Zheng, Chun-Yan Yang, Sheng-Fei Yan, Nong-Qi Yu, Jia-Xiang Huang, Jiang-Hua Shang
The objectives of the present study were to evaluate the developmental competence of buffalo denuded oocytes (DOs) cocultured with cumulus cells (CCs) during in vitro maturation, and to investigate the mechanisms by which CCs promote oocyte maturation and development. Buffalo oocytes were matured in vitro for 24 h in three groups: (1) intact cumulus-oocyte complexes (COCs) (2) DOs cocultured with CCs (DOsCC), and (3) DOs cultured alone (DOs). Matured oocytes were used to determine the relative mRNA abundance of Gdf-9, Bmp15, Zar1, Caspase-3, Bcl-2, Zp2, Zp3, Cd9 and Pde3a by Rt-qPCR and CASPASE-3 protein expression by immunofluorescence...
July 29, 2018: Theriogenology
Razieh Habibi, Sayyed Morteza Hosseini, Faezeh Ghazvini Zadegan, Mehdi Hajian, Somayyeh Ostadhosseini, Nima Tanhaei Vash, Azadeh Naddafpour, Mohammad Hossein Nasr Esfahani
Nanog as a novel pluripotent cell-specific gene plays important roles in regulation of signaling pathways for maintenance and induction of pluripotency in inner cell mass (ICM) and embryonic stem cells (ESC) in mouse. The molecular features and transcription regulation of NANOG gene in domestic animals are not well defined. In this study, we performed knockdown of NANOG mRNA in goat embryos and examined its effect on early embryonic development. Presumptive zygotes were injected with a volume of 8-10 pl NANOG or scrambled (SCR) siRNA, and subsequently cleavage and blastocyst formation rate were assessed...
July 29, 2018: Theriogenology
Marion E Rice, Romeo R Galang, Nicole M Roth, Sascha R Ellington, Cynthia A Moore, Miguel Valencia-Prado, Esther M Ellis, Aifili John Tufa, Livinson A Taulung, Julia M Alfred, Janice Pérez-Padilla, Camille A Delgado-López, Sherif R Zaki, Sarah Reagan-Steiner, Julu Bhatnagar, John F Nahabedian, Megan R Reynolds, Marshalyn Yeargin-Allsopp, Laura J Viens, Samantha M Olson, Abbey M Jones, Madelyn A Baez-Santiago, Philip Oppong-Twene, Kelley VanMaldeghem, Elizabeth L Simon, Jazmyn T Moore, Kara D Polen, Braeanna Hillman, Ruta Ropeti, Leishla Nieves-Ferrer, Mariam Marcano-Huertas, Carolee A Masao, Edlen J Anzures, Ransen L Hansen, Stephany I Pérez-Gonzalez, Carla P Espinet-Crespo, Mildred Luciano-Román, Carrie K Shapiro-Mendoza, Suzanne M Gilboa, Margaret A Honein
INTRODUCTION: Zika virus infection during pregnancy causes serious birth defects and might be associated with neurodevelopmental abnormalities in children. Early identification of and intervention for neurodevelopmental problems can improve cognitive, social, and behavioral functioning. METHODS: Pregnancies with laboratory evidence of confirmed or possible Zika virus infection and infants resulting from these pregnancies are included in the U.S. Zika Pregnancy and Infant Registry (USZPIR) and followed through active surveillance methods...
August 10, 2018: MMWR. Morbidity and Mortality Weekly Report
Tamar Heller, Haleigh M Scott, Matthew P Janicki
Introduction: A specially commissioned working group produced a report on caregiving, intellectual and developmental disabilities (IDDs), and dementia for the National Institutes of Health-located National Research Summit on Care, Services, and Supports for Persons with Dementia and Their Caregivers. Methods: Experts in caregiving, dementia, and IDDs examined the current state of research, policy, and practice related to caregiving and supports; identified the similarities and dissimilarities between IDD-related care and services and the general population affected by dementia; and considered how these findings might contribute to the conversation on developing a dementia care research and services development agenda...
2018: Alzheimer's & Dementia: Translational Research & Clinical Interventions
Alessio Facchin, Silvio Maffioletti
The developmental eye movement (DEM) test is a practical and simple method for assessing and quantifying ocular motor skills in children. Different studies have previously assessed the reliability of the DEM test and they have generally found high values for vertical and horizontal time, whereas those for Ratio and Errors were medium and low, respectively. In the second application of test were found an improvement in performance in all subtests. Our aim was to evaluate the reliability of the DEM test using seconds and percentile scoring and looking in depth at the improvement in performance when the test is repeated...
2018: Frontiers in Psychology
Ponson Laura, Gomot Marie, Blanc Romuald, Barthelemy Catherine, Roux Sylvie, Munnich Arnold, Romana Serge, Aguillon-Hernandez Nadia, Malan Valérie, Bonnet-Brilhault Frédérique
Phelan-McDermid syndrome is related to terminal 22q13 deletions of various sizes affecting the SHANK3 gene. In this neurodevelopmental disorder, behavioural symptoms of autism spectrum disorder (ASD) are reported in half of cases. Extensive clinical and neurophysiological characterization is lacking to understand the genotype-phenotype correlation. Eighteen patients (8 males, mean age 12.7 years, SD = 9.2) with known 22q13 deletions were fully explored with determination of deletion size, along with behavioural, language and cognitive standardized assessments...
August 8, 2018: Translational Psychiatry
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