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https://www.readbyqxmd.com/read/30102396/sp140-regulates-the-expression-of-immune-related-genes-associated-with-multiple-sclerosis-and-other-autoimmune-diseases-by-nf-%C3%AE%C2%BAb-inhibition
#1
Mohamad Karaky, María Fedetz, Victor Potenciano, Eduardo Andrés-León, Anna Esteve Codina, Cristina Barrionuevo, Antonio Alcina, Fuencisla Matesanz
SP140 locus has been associated with multiple sclerosis (MS) as well as other autoimmune diseases by genome-wide association studies (GWAS). The causal variant of these associations (rs28445040-T) alters the splicing of the SP140 gene transcripts reducing the protein expression. We aimed to understand why the reduction of SP140 expression produced by the risk variant can increase the susceptibility to MS. To this end, we determined by RNA-seq analysis the differentially expressed genes after SP140 silencing in lymphoblastoid cell lines (LCLs)...
August 8, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/30099999/immunosuppressive-autoimmune-disorders
#2
REVIEW
Angela Richard-Eaglin, Benjamin A Smallheer
Autoimmune disorders are a category of diseases in which the immune system attacks healthy cells as a result of a dysfunction of the acquired immune system. Clinical presentation and diagnosis are disease specific and often correspond with the degree of inflammation, as well as the systems involved. Treatment varies based on the specific disease, its stage of presentation, and patient symptoms. The primary goal of treatment is to decrease inflammation, minimize symptoms, and lessen the potential for relapse...
September 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/30091313/generation-characteristics-and-clinical-trials-of-ex-vivo-generated-tolerogenic-dendritic-cells
#3
REVIEW
Sang Hyun Kim, Ho Hyun Jung, Chong Kil Lee
Dendritic cells (DCs) play a key role not only in the initiation of primary immune responses, but also in the development and maintenance of immune tolerance. Numerous protocols have been developed to generate tolerogenic DCs (tolDCs) ex vivo, and the therapeutic efficacy of ex vivo-generated tolDCs has been demonstrated in autoimmune disease animal models. Based on successes in small animal models, several clinical trials have been completed or are on-going in patients with autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, multiple sclerosis, and Crohn's disease...
September 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/30072560/autologous-haematopoietic-stem-cell-transplantation-ahsct-for-severe-resistant-autoimmune-and-inflammatory-diseases-a-guide-for-the-generalist
#4
John A Snowden, Basil Sharrack, Mohammed Akil, David G Kiely, Alan Lobo, Majid Kazmi, Paolo A Muraro, James O Lindsay
Autologous haematopoietic stem cell transplantation (aHSCT) is commonly used for the treatment of haematological cancers, but is increasingly used in the treatment of patients severely affected by autoimmune diseases (ADs). In fact, ADs have become the fastest growing indication for aHSCT. A wide range of diseases have been treated, but the field has focused on three areas: multiple sclerosis, diffuse cutaneous systemic sclerosis and Crohn's disease, where there are populations of patients for whom disease control remains unsatisfactory despite the advent of biological and targeted small molecule therapies...
August 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/30065768/construction-and-characterization-of-human-embryonic-kidney-hek-293t-cell-overexpressing-truncated-%C3%AE-4-integrin
#5
Azam Fatahi, Ilnaz Rahimmanesh, Mina Mirian, Fattah Rohani, Maryam Boshtam, Azam Gheibi, Laleh Shariati, Hossein Khanahmad, Shirin Kouhpayeh
Blockade of α4 integrin by antibodies could be an appropriate treatment strategy in multiple sclerosis and Crohn's disease. Considering disadvantages of antibodies, other elements (e.g. aptamers) have been proposed for antibodies replacement. Isolation of aptamers through cell-SELEX (systematic evolution of ligands by exponential enrichment) method requires positive and negative expressing α4 integrin cell lines. For a better isolation, we intended to construct a negative cell line lacking of specific ligand binding site of α4 integrin...
August 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29995817/clinical-adverse-effects-of-natalizumab-protocol-for-a-meta-analysis-of-randomized-double-blind-placebo-controlled-clinical-trails
#6
REVIEW
Hao Li, Fang-Hong Shi, Shi-Ying Huang, Shun-Guo Zhang, Zhi-Chun Gu, Ji-Fu Wei
BACKGROUND: Natalizumab (NAT), a humanized monoclonal antibody, which binds in both α4β1 integrins and α4β7 integrins, is approved for the treatment of multiple sclerosis (MS) and Crohn's disease (CD). An uncommon but serious adverse event from NAT treatment is known as progressive multifocal leukoencephalopathy (PML). However, clinical comprehensive safety evidence of NAT is limited. METHODS: We will search Medline, Embase, Cochrane library, and ClinicalTrials...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29976222/assessing-patients-acceptance-of-their-medication-to-reveal-unmet-needs-results-from-a-large-multi-diseases-study-using-a-patient-online-community
#7
Jérémy Lambert, Michael Chekroun, Hélène Gilet, Catherine Acquadro, Benoit Arnould
BACKGROUND: Patients with chronic conditions are required to take long-term treatments for their disease itself or to prevent any potential health risks. Measuring patient acceptance of their medication should help to better understand and predict patients' behavior toward treatment. This study aimed to describe the level of patient acceptance toward various long-term treatments in real life using an online patient community. METHODS: This was an observational, cross-sectional study conducted through the French Carenity platform...
July 6, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29911021/-mycobacterium-avium-subspecies-paratuberculosis-a-possible-causative-agent-in-human-morbidity-and-risk-to-public-health-safety
#8
REVIEW
Mary Garvey
Mycobacterium avium subspecies paratuberculosis is a bacterial parasite and the causative agent of paratuberculosis, a disease predominately found in cattle and sheep. Infection with this microorganism results in substantial farming economic losses and animal morbidity. The link between infection with this pathogen and human disease has been theorised for many years with Crohn's disease being one of many suspected resultant conditions. Mycobacterium avium may be spread from animal to human hosts by water and foodborne transmission routes, where the foodborne route of exposure represents a significant risk for susceptible populations, namely children and the immune-compromised...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29875003/current-status-and-future-prospects-of-small-molecule-protein-protein-interaction-ppi-inhibitors-of-tumor-necrosis-factor-tnf-and-receptor-activator-of-nf-%C3%AE%C2%BAb-ligand-rankl
#9
Georgia Melagraki, Georgios Leonis, Evangelos Ntougkos, Vagelis Rinotas, Christos Papaneophytou, Thomas Mavromoustakos, George Kontopidis, Eleni Douni, George Kollias, Antreas Afantitis
The overexpression of Tumor Necrosis Factor (TNF) is directly related to the development of several autoimmune diseases, such as rheumatoid and psoriatic arthritis, inflammatory bowel disease, Crohn's disease, refractory asthma, and multiple sclerosis. Receptor Activator of Nuclear Factor Kappa- B Ligand (RANKL) belongs to the TNF family and is the primary mediator of osteoclast-induced bone resorption through interaction with its receptor RANK. The function of RANKL is physiologically inhibited by the action of osteoprotegerin (OPG), which is a decoy receptor that binds to RANKL and prevents the process of osteoclastogenesis...
2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29760920/serum-lipidomics-of-bovine-paratuberculosis-disruption-of-choline-containing-glycerophospholipids-and-sphingolipids
#10
Paul L Wood, Erdal Erol, Glen F Hoffsis, Margaret Steinman, Jeroen DeBuck
Objectives: Bovine paratuberculosis is a devastating infection with Mycobacterium avium subspecies paratuberculosis that ultimately results in death from malnutrition. While the infection is characterized by a long (2-4 years) subclinical phase with immune activation, ultimately host defense mechanisms fail and the bacteria spread from the small intestine to other organs. Since both the gastrointestinal tract and liver are essential for the biosynthesis of structural glycerophospholipids, we investigated the circulating levels of these lipids in field infections and experimentally infected cattle...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29740348/could-sodium-chloride-be-an-environmental-trigger-for-immune-mediated-diseases-an-overview-of-the-experimental-and-clinical-evidence
#11
REVIEW
Eric Toussirot, Matthieu Béreau, Charline Vauchy, Philippe Saas
Immune mediated diseases (IMDs) are complex chronic inflammatory diseases involving genetic and environmental factors. Salt intake has been proposed as a diet factor that can influence the immune response. Indeed, experimental data report the influence of sodium chloride on the differentiation of naive CD4+ T cells into IL-17 secreting T helper (Th) cells (Th17 cells), by a mechanism involving the serum glucocorticoid kinase-1 (SGK1) that promotes the expression of the IL-23 receptor (IL-23R). The IL-23/IL-23R is critical for pathogenic inflammatory Th17 cell differentiation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29708072/a-review-on-clinical-pharmacokinetics-pharmacodynamics-and-pharmacogenomics-of-natalizumab-a-humanized-anti-%C3%AE-4-integrin-monoclonal-antibody
#12
Li Hao, Shi Fang-Hong, Huang Shi-Ying, Zhang Shun-Guo, Chen Min-Ling
Natalizumab (Tysabri®, Biogen-Idec Inc., NAT), a humanized anti-α4 integrin monoclonal antibody, binds in both α4β1 (Very Late Antigen 4, VLA-4) and α4β7 (lymphocytes Peyer's patch adhesion molecule 1, LPAM-1) integrins, is approved for the treatment of Multiple sclerosis (MS) and Crohn's disease (CD). NAT has been well tolerated in pivotal trials. Progressive multifocal leukoencephalopathy (PML) is an uncommon but serious complications resulting from NAT treatment. It is not confirmed that higher NAT concentration increases the risk of PML...
April 27, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29701842/the-emerging-immunogenetic-architecture-of-schizophrenia
#13
Jennie G Pouget
Schizophrenia is a severe psychiatric disorder of complex etiology. Immune processes have long been proposed to contribute to the development of schizophrenia, and accumulating evidence supports immune involvement in at least a subset of cases. In recent years, large-scale genetic studies have provided new insights into the role of the immune system in this disease. Here, we provide an overview of the immunogenetic architecture of schizophrenia based on findings from genome-wide association studies (GWAS). First, we review individual immune loci identified in secondary analyses of GWAS, which implicate over 30 genes expressed in both immune and brain cells...
April 26, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29629902/humanized-mouse-model-of-rasmussen-s-encephalitis-supports-the-immune-mediated-hypothesis
#14
Hania Kebir, Lionel Carmant, François Fontaine, Kathie Béland, Ciprian M Bosoi, Nathalie T Sanon, Jorge I Alvarez, Sébastien Desgent, Camille L Pittet, David Hébert, Marie-Josée Langlois, Rose-Marie Rébillard, Dang K Nguyen, Cécile Cieuta-Walti, Gregory L Holmes, Howard P Goodkin, John R Mytinger, Mary B Connolly, Alexandre Prat, Elie Haddad
Rasmussen's encephalitis (RE) is a chronic inflammatory brain disorder that causes frequent seizures and unilateral hemispheric atrophy with progressive neurological deficits. Hemispherectomy remains the only treatment that leads to seizure freedom for this refractory epileptic syndrome. The absence of an animal model of disease has been a major obstacle hampering the development of effective therapies. Here, we describe an experimental mouse model that shares several clinical and pathological features with the human disease...
May 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29593681/intestinal-microbiota-influences-non-intestinal-related-autoimmune-diseases
#15
REVIEW
Maria C Opazo, Elizabeth M Ortega-Rocha, Irenice Coronado-Arrázola, Laura C Bonifaz, Helene Boudin, Michel Neunlist, Susan M Bueno, Alexis M Kalergis, Claudia A Riedel
The human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin, gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contributes to balancing the immune system to maintain host homeostasis. The gut is a vital organ where microbiota can influence and determine the function of cells of the immune system and contributes to preserve the wellbeing of the individual...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29431301/seroepidemiological-study-of-epstein-barr-virus-in-different-population-groups-in-croatia
#16
Nataša Beader, Branko Kolarić, Domagoj Slačanac, Irena Tabain, Tatjana Vilibić-Čavlek
BACKGROUND: The Epstein-Barr virus (EBV) is one of the most common viruses found in humans, causing lifelong infection in up to 95% of the world population. OBJECTIVES: To analyze the seroprevalence of EBV infection in different population groups in Croatia. METHODS: During a 2 year period (2015-2016), a total of 2022 consecutive serum samples collected from Croatian residents were tested for the presence of EBV-specific viral capsid antigen (VCA) immunoglobulin M (IgM) and IgG antibodies using an enzyme-linked immunoassay...
February 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29377216/the-safety-and-efficacy-of-low-dose-naltrexone-in-the-management-of-chronic-pain-and-inflammation-in-multiple-sclerosis-fibromyalgia-crohn-s-disease-and-other-chronic-pain-disorders
#17
REVIEW
Denise K Patten, Bob G Schultz, Daniel J Berlau
Chronic inflammatory diseases are complex to treat and have an impact on a large number of patients. Due to the difficulty of treating these diseases and the great impact on quality of life, patients often seek off-label, complimentary, or alternative medicines to gain relief from symptoms. Low-dose naltrexone has been used off-label for treatment of pain and inflammation in multiple sclerosis, Crohn's disease, fibromyalgia, and other diseases. Naltrexone is a mu-opioid receptor antagonist indicated by the U...
March 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29296926/evolution-trends-outcomes-and-economics-of-hematopoietic-stem-cell-transplantation-in-severe-autoimmune-diseases
#18
John A Snowden, Manuela Badoglio, Myriam Labopin, Sebastian Giebel, Eoin McGrath, Zora Marjanovic, Joachim Burman, John Moore, Montserrat Rovira, Nico M Wulffraat, Majid Kazmi, Raffaella Greco, Emilian Snarski, Tomas Kozak, Kirill Kirgizov, Tobias Alexander, Peter Bader, Riccardo Saccardi, Dominique Farge
Hematopoietic stem cell transplantation (HSCT) has evolved for >20 years as a specific treatment of patients with autoimmune disease (AD). Using European Society for Blood and Marrow Transplantation registry data, we summarized trends and identified factors influencing activity and outcomes in patients with AD undergoing first autologous HSCT (n = 1951; median age, 37 years [3-76]) and allogeneic HSCT (n = 105; median age, 12 years [<1-62]) in 247 centers in 40 countries from 1994 to 2015. Predominant countries of activity were Italy, Germany, Sweden, the United Kingdom, The Netherlands, Spain, France, and Australia...
December 26, 2017: Blood Advances
https://www.readbyqxmd.com/read/29251350/engineered-cell-migration-to-lesions-linked-to-autoimmune-disease
#19
Abdullah Al Mosabbir, Anam Qudrat, Kevin Truong
The damaging and degenerative effects in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and Crohn's disease often manifests as the formation of lesions that feature a high local concentration of granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF along with other pro-inflammatory factors form a positive feedback loop that ultimately perpetuate the lesions. Hence, to engineer chemotaxis to GM-CSF, we created a new chimeric GM-CSF receptor alpha subunit (GMRchi) that was coupled with a previously engineered Ca2+ -activated RhoA...
April 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29119385/intestinal-permeability-in-relapsing-remitting-multiple-sclerosis
#20
REVIEW
M C Buscarinu, S Romano, R Mechelli, R Pizzolato Umeton, M Ferraldeschi, A Fornasiero, R Reniè, B Cerasoli, E Morena, C Romano, N D Loizzo, R Umeton, M Salvetti, G Ristori
Changes of intestinal permeability (IP) have been extensively investigated in inflammatory bowel diseases (IBD) and celiac disease (CD), underpinned by a known unbalance between microbiota, IP and immune responses in the gut. Recently the influence of IP on brain function has greatly been appreciated. Previous works showed an increased IP that preceded experimental autoimmune encephalomyelitis development and worsened during disease with disruption of TJ. Moreover, studying co-morbidity between Crohn's disease and MS, a report described increased IP in a minority of cases with MS...
January 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
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