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Tropisetron

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https://www.readbyqxmd.com/read/30053687/quantification-of-ondansetron-granisetron-and-tropisetron-in-goat-plasma-using-hydrophilic-interaction-liquid-chromatography-solid-phase-extraction-coupled-with-hydrophilic-interaction-liquid-chromatography-triple-quadrupole-tandem-mass-spectrometry
#1
Cunying Huang, Huihui Wan, Jing Zhang, Hongmin Zhong, Juan Li, YuMing Sun, Qing Wang, Hua Zhang
An assay method to quantify ondansetron (OND), granisetron (GRA) and tropisetron (TRO) in goat plasma has been successfully developed and validated. This method procedure for the analysis of OND, GRA and TRO was involved of extracting samples with hydrophilic interaction liquid chromatography (HILIC) solid phase extraction (SPE) and determination by liquid chromatography coupled to tandem mass spectroscopy. An SPE method for the simultaneous extraction of OND, GRA and TRO with high efficiency and selectivity was developed...
July 11, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29977907/nephrotoxicity-evaluation-on-cisplatin-combined-with-5-ht-3-receptor-antagonists-a-retrospective-study
#2
Wen Kou, Hongyan Qin, Shahbaz Hanif, Xinan Wu
Objective: 5-HT3 receptor antagonist (ondansetron) has been reported to have nephrotoxic effect when combined with cisplatin in mice; however, little evidence exists in explaining its nephrotoxic effects on patients. The aim of this present study was to investigate whether 5-HT3 receptor antagonist could enhance or aggravate the incidence of cisplatin-induced nephrotoxicity in patients. Methods: We retrospectively reviewed 600 tumor patients which were treated with cisplatin ( ⩾ 60 mg/m2 ) as a first-time chemotherapy and combined with 5-HT3 receptor antagonist (i...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29858776/pain-inhibits-pain-an-ascending-descending-pain-modulation-pathway-linking-mesolimbic-and-classical-descending-mechanisms
#3
Glaucia Tobaldini, Natalia F Sardi, Vinicius A Guilhen, Luana Fischer
The ability to modulate pain perception is as critical to survival as pain itself. The most known pain modulation pathway is the PAG-RVM (periaqueductal gray-rostral ventromedial medulla) descending system. In this study, we hypothesized that it is functionally linked to the ascending nociceptive control, which is a form of pain-induced analgesia dependent on mesolimbic mechanisms. To test this hypothesis, we used a pharmacological approach, in which the antinociception induced by noxious stimulation (forepaw injection of capsaicin) was detected in a standard rat model of inflammatory pain (hindpaw injection of carrageenan)...
June 1, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29759144/tropisetron-attenuates-lipopolysaccharide-induced-neuroinflammation-by-inhibiting-nf-%C3%AE%C2%BAb-and-sp-nk1r-signaling-pathway
#4
Yan Yu, Wanhu Zhu, Qing Liang, Jing Liu, Xu Yang, Guangchun Sun
Tropisetron, an antagonist of serotonin type 3 receptors (5-HT3 Rs), has been investigated in colonic inflammatory process. Since substance P/neurokinin 1 receptor (SP/NK1R) signaling pathway plays a key role in several sensory neuronal inflammatory. We evaluated the anti-inflammatory activity of tropisetron in mice cerebral cortex, and discovered that it was a potential inhibitor in LPS-mediated neuron inflammation through SP/NK1R signaling pathway. We found that tropisetron significantly reduced the increased number of iba-1 positive microglia, down-regulated the gene transcription and protein expression of IL-1β,IL-6 and TNF-α in LPS stimulated cerebral cortex...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29577093/evaluation-of-a-neurokinin-1-antagonist-in-preventing-multiple-day-cisplatin-induced-nausea-and-vomiting
#5
Quanfu Li, Wenjuan Wang, Gang Chen, Shuqin Deng, Caihong Jiang, Feng Chen, Jun Zhao, Hui Li, Xiaojun Bai, Yuliang Hu, Lenggaowa Da, Yungaowa Wu, Gaowa Jin
Objective: To perform a prospective non-randomized comparison of the effectiveness and safety of combined neurokinin-1 antagonist aprepitant treatment with the standard multiple-day cisplatin regimen for the prevention of cisplatin-induced nausea and vomiting (CINV). Methods: Patients being administered 3-day cisplatin-based chemotherapy (25 mg/m2 /d) who had never received aprepitant were given either the standard regimen (tropisetron and dexamethasone) or the aprepitant regimen (aprepitant plus tropisetron and dexamethasone)...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29228438/analgesic-effect-of-dezocine-in-different-doses-on-elderly-patients-undergoing-abdominal-operation-under-general-anesthesia-and-its-influence-on-stress-response-to-postoperative-tracheal-extubation
#6
RANDOMIZED CONTROLLED TRIAL
Z-Y Yao, Z Jia, Y-H Xie, L-L Zhang, H-S Zhang, W-Q Wu, C-K Zhang, L-J Gan
OBJECTIVE: To study the analgesic effect of dezocine in different doses on elderly patients undergoing abdominal operation under general anesthesia and to investigate the influence of dezocine on stress response to postoperative tracheal extubation. PATIENTS AND METHODS: A total of 76 elderly patients undergoing abdominal operation under general anesthesia and postoperative analgesia in our hospital from January 2015 to January 2016 were selected, and patients treated with fentanyl were selected as the control group (fentanyl: 10 μg/kg, n=19)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29175423/tropisetron-enhances-recognition-memory-in-rats-chronically-treated-with-risperidone-or-quetiapine
#7
Indrani Poddar, Patrick M Callahan, Caterina M Hernandez, Xiangkun Yang, Michael G Bartlett, Alvin V Terry
While impairments of cognition in schizophrenia have the greatest impact on long-term functional outcome, the currently prescribed treatments, antipsychotic drugs (APDs), do not effectively improve cognition. Moreover, while more than 20 years have been devoted to the development of new drugs to treat cognitive deficits in schizophrenia, none have been approved to date. One area that has not been given proper attention at the preclinical or clinical stage of drug development is the chronic medication history of the test subject...
May 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29139251/-clinical-application-features-of-fufang-kushen-injection-in-treating-malignant-esophageal-tumor%C3%AF-real-world-study-based-on-hospital-information-system
#8
Ya-Xin Liu, Zhi-Fei Wang, Yan-Ming Xie, Yin Zhang, Cen Chen, Yan Zhuang
To analyze the clinical application features of Fufang Kushen injection in treating malignant esophageal tumors in the real world by using hospital information system database, and provide reference for clinical application of Fufang Kushen injection. The electronic medical data from 2 550 patients with malignant esophageal tumors using Fufang Kushen injection from 22 large-scale hospitals nationwide were extracted based on the hospital information system (HIS) established by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29090823/the-serotonergic-system-modulates-the-cocaine-induced-expression-of-the-immediate-early-genes-egr-1-and-c-fos-in-rat-brain
#9
N Humblot, N Thiriet, S Gobaille, D Aunis, J Zwiller
Transcription regulatory factors are rapidly induced in brain by a wide variety of stimuli and may be important in coordinating changes in gene expression underlying neuronal plasticity. Using in situ hybridization, we found that acute cocaine administration (20 mg/kg, intraperitoneally (i.p.)) produced a robust induction of both c-fos and egr-1 immediate early genes. Egr-1 messenger RNA induction was highest in the caudate putamen and in the shell of the nucleus accumbens. No significant induction was noticed after injection of fluoxetine, a selective inhibitor of serotonin uptake...
May 1998: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28818674/effects-of-electroacupuncture-administered-24hours-prior-to-surgery-on-postoperative-nausea-and-vomiting-and-pain-in-patients-undergoing-gynecologic-laparoscopic-surgery-a-feasibility-study
#10
Sha Li, Man Zheng, Wenzhong Wu, Jie Guo, Fangbin Ji, Zhen Zheng
OBJECTIVE: Our study aimed to investigate the feasibility and effectiveness of preoperative electroacupuncture (EA), delivered 24hours before surgery, on postoperative nausea and vomiting (PONV) and postoperative pain in patients undergoing gynecologic laparoscopic surgery. METHODS: In this randomized controlled trial, 40 patients scheduled for elective gynecologic laparoscopic surgery were randomly assigned to the usual care (UC) group and the EA group (n = 20 each)...
June 30, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28686973/protective-effects-of-tropisetron-on-cerulein-induced-acute-pancreatitis-in-mice
#11
Reza Rahimian, Mohammad Reza Zirak, Mohammad Seyedabadi, Mojtaba Keshavarz, Amir Rashidian, Sareh Kazmi, Amir Hossein Jafarian, Gholamreza Karimi, Kazem Mousavizadeh
Acute pancreatitis (AP) causes morbidity and mortality. The aim of the present study was to investigate the protective effect of tropisetron against AP induced by cerulein. Cerulein (50μg/kg, 5 doses) was used to induce AP in mice. Six hours after final cerulein injection, animals were decapitated. Hepatic/pancreatic enzymes in the serum, pancreatic content of malondialdehyde (MDA), pro-inflammatory cytokines and myeloperoxidase (MPO) activity were measured. Tropisetron significantly attenuated pancreatic injury markers and decreased the amount of elevated serum amylase, lipase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), MPO activities and pro-inflammatory cytokines levels caused by AP in mice...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28501575/the-anti-asthmatic-drug-pranlukast-suppresses-the-delayed-phase-vomiting-and-reverses-intracellular-indices-of-emesis-evoked-by-cisplatin-in-the-least-shrew-cryptotis-parva
#12
Nissar A Darmani, Seetha Chebolu, Weixia Zhong, William D Kim, Matthew Narlesky, Joia Adams, Fanglong Dong
The introduction of second generation serotonin 5-HT3 receptor (5-HT3 ) antagonist palonosetron combined with long-acting substance P neurokinin NK1 receptor (NK1 ) antagonists (e.g. netupitant) has substantially improved antiemetic therapy against early- and delayed-phases of emesis caused by highly emetogenic chemotherapeutics such as cisplatin. However, the improved efficacy comes at a cost that many patients cannot afford. We introduce a new class of antiemetic, the antiasthmatic leukotriene CysLT1 receptor antagonist pranlukast for the suppression of cisplatin-evoked vomiting...
August 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28439683/genistein-modulation-of-seizure-involvement-of-estrogen-and-serotonin-receptors
#13
Saeed Amiri Gheshlaghi, Razieh Mohammad Jafari, Mohammad Algazo, Nastaran Rahimi, Hussein Alshaib, Ahmad Reza Dehpour
Genistein, a major source of phytoestrogen exposure for humans and animals, has been shown to mediate neuroprotection in Alzheimer's disease and status epilepticus. In the present study, we investigated the effect of genistein on pentylenetetrazole-induced seizures in ovariectomized mice and the possible involvement of estrogenic and serotonergic pathways in the probable effects of genistein. Intraperitoneal (i.p.) administration of genistein (10 mg/kg) significantly increased the seizure threshold 30 min prior to induction of seizures 14 days after ovariectomy surgery...
July 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28259598/tropisetron-sensitizes-%C3%AE-7-containing-nicotinic-receptors-to-low-levels-of-acetylcholine-in-vitro-and-improves-memory-related-task-performance-in-young-and-aged-animals
#14
Patrick M Callahan, Daniel Bertrand, Sonia Bertrand, Marc R Plagenhoef, Alvin V Terry
Tropisetron, a 5-HT3 receptor antagonist commonly prescribed for chemotherapy-induced nausea and vomiting also exhibits high affinity, partial agonist activity at α7 nicotinic acetylcholine receptors (α7 nAChRs). α7 nAChRs are considered viable therapeutic targets for neuropsychiatric disorders such as Alzheimer's disease (AD). Here we further explored the nAChR pharmacology of tropisetron to include the homomeric α7 nAChR and recently characterized heteromeric α7β2 nAChR (1:10 ratio) and we evaluated its cognitive effects in young and aged animals...
May 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28243846/protective-effect-of-tropisetron-on-high-glucose-induced-apoptosis-and-oxidative-stress-in-pc12-cells-roles-of-jnk-p38-mapks-and-mitochondria-pathway
#15
Azadeh Aminzadeh
Tropisetron, a selective 5-HT3 receptor (5-HT3R) antagonist, is widely used to counteract chemotherapy-induced emesis. There is growing interest concerning the beneficial effects of tropisetron on the treatment of several diseases. This study was carried out to examine effects of tropisetron on high glucose (HG) induced apoptosis in PC12 cells as a suitable culture model for studying neuronal functions. Apoptosis was induced by HG, and cells were treated with HG in the absence and presence of tropisetron for varying periods of time...
June 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28168082/simultaneous-determination-of-dexamethasone-ondansetron-granisetron-tropisetron-and-azasetron-in-infusion-samples-by-hplc-with-dad-detection
#16
Fu-Chao Chen, Lin-Hai Wang, Jun Guo, Xiao-Ya Shi, Bao-Xia Fang
A simple and rapid high-performance liquid chromatography with diode array detector (HPLC-DAD) method has been developed and validated for simultaneous quantification of five antiemetic agents in infusion samples: dexamethasone, ondansetron, granisetron, tropisetron, and azasetron. The chromatographic separation was achieved on a Phenomenex C18 column (4.6 mm × 150 mm, 5 μm) using acetonitrile-50 mM KH2PO4 buffer-triethylamine (25 : 74 : 1; v/v; pH 4.0). Flow rate was 1.0 mL/min with a column temperature of 30°C...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28137449/the-binding-orientations-of-structurally-related-ligands-can-differ-a%C3%A2-cautionary-note
#17
Marc-David Ruepp, Hao Wei, Michele Leuenberger, Martin Lochner, Andrew J Thompson
Crystal structures can identify ligand-receptor interactions and assist the development of novel therapeutics, but experimental challenges sometimes necessitate the use of homologous proteins. Tropisetron is an orthosteric ligand at both 5-HT3 and α7 nACh receptors and its binding orientation has been determined in the structural homologue AChBP (pdbid: 2WNC). Co-crystallisation with a structurally-related ligand, granisetron, reveals an almost identical orientation (pdbid; 2YME). However, there is a >1000-fold difference in the affinity of tropisetron at 5-HT3 versus α7 nACh receptors, and α7 nACh receptors do not bind granisetron...
June 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28121196/nanoethosomes-for-transdermal-delivery-of-tropisetron-hcl-multi-factorial-predictive-modeling-characterization-and-ex-vivo-skin-permeation
#18
Hanaa A Abdel Messih, Rania A H Ishak, Ahmed S Geneidi, Samar Mansour
OBJECTIVE: The aim of the present work is to exclusively optimize and model the effect of phospholipid type either egg phosphatidylcholine (EPC) or soybean phosphatidylcholine (SPC), together with other formulation variables, on the development of nano-ethosomal systems for transdermal delivery of a water-soluble antiemetic drug. Tropisetron HCl (TRO) is available as hard gelatin capsules and IV injections. The transdermal delivery of TRO is considered as a novel alternative route supposing to improve BAV as well as patient convenience...
June 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28007031/comparative-safety-and-effectiveness-of-serotonin-receptor-antagonists-in-patients-undergoing-chemotherapy-a-systematic-review-and-network-meta-analysis
#19
REVIEW
Andrea C Tricco, Erik Blondal, Areti Angeliki Veroniki, Charlene Soobiah, Afshin Vafaei, John Ivory, Lisa Strifler, Roberta Cardoso, Emily Reynen, Vera Nincic, Huda Ashoor, Joanne Ho, Carmen Ng, Christy Johnson, Erin Lillie, Jesmin Antony, Derek J Roberts, Brenda R Hemmelgarn, Sharon E Straus
BACKGROUND: Although serotonin (5-HT3) receptor antagonists are effective in reducing nausea and vomiting, they may be associated with increased cardiac risk. Our objective was to examine the comparative safety and effectiveness of 5-HT3 receptor antagonists (e.g., dolasetron, granisetron, ondansetron, palonosetron, tropisetron) alone or combined with steroids for patients undergoing chemotherapy. METHODS: We searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from inception until December 2015 for studies comparing 5-HT3 receptor antagonists with each other or placebo in chemotherapy patients...
December 23, 2016: BMC Medicine
https://www.readbyqxmd.com/read/28002639/clinical-pharmacogenetics-implementation-consortium-cpic-guideline-for-cyp2d6-genotype-and-use-of-ondansetron-and-tropisetron
#20
G C Bell, K E Caudle, M Whirl-Carrillo, R J Gordon, K Hikino, C A Prows, A Gaedigk, Jag Agundez, S Sadhasivam, T E Klein, M Schwab
No abstract text is available yet for this article.
August 2017: Clinical Pharmacology and Therapeutics
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