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Pseudomonas aeruginosa synergies

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https://www.readbyqxmd.com/read/30298931/synergistic-antibacterial-effects-of-buddleja-albiflora-metabolites-with-antibiotics-against-listeria-monocytogenes
#1
X Zhang, L Wang, H Mu, D Wang, Y Yu
Some plants of Buddleja genus possessed antimicrobial activity. In this study, the antibacterial activities of nine compounds from B. albiflora were evaluated against Listeria monocytogenes, Staphyloccocus aureus, Escherichia coli and Pseudomonas aeruginosa, either alone or in combination with Erythromycin (Ery), Gentamycin (Gen) and Ampicillin (Amp). Checkerboard assay demonstrated that kumatakenin (Kum) elicited synergistic effects with all three antibiotics, and chrysin (Chr) displayed synergistic effect with Ery against L...
October 9, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/30295837/mechanisms-of-high-level-ceftolozane-tazobactam-resistance-in-pseudomonas-aeruginosa-from-a-severely-neutropenic-patient-and-treatment-success-from-synergy-with-tobramycin
#2
Wonhee So, James Shurko, Ralph Galega, Rod Quilitz, John N Greene, Grace C Lee
No abstract text is available yet for this article.
October 8, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30223075/synergy-of-nebulized-phage-pev20-and-ciprofloxacin-combination-against-pseudomonas-aeruginosa
#3
Yu Lin, Rachel Yoon Kyung Chang, Warwick J Britton, Sandra Morales, Elizabeth Kutter, Hak-Kim Chan
Nebulization is currently used for delivery of antibiotics for respiratory infections. Bacteriophages (or phages) are effective predators of pathogens including Pseudomonas aeruginosa commonly found in the lungs of patients with cystic fibrosis (CF). It is known that phages and antibiotics can potentially show synergistic antimicrobial effect on bacterial killing. In the present study, we investigated synergistic antimicrobial effect of phage PEV20 with five different antibiotics against three P. aeruginosa strains isolated from sputum of CF patients...
November 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30118807/screening-cloning-and-expression-of-a-novel-alginate-lyase-gene-from-p-aeruginosa-tag-48-and-its-antibiofilm-effects-on-p-aeruginosa-biofilm
#4
Hadis Tavafi, Ahya Abdi Ali, Parinaz Ghadam, Sara Gharavi
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen and utilizes several virulence factors for pathogenesis. One of the most important factors is alginate, found in the biofilm which enables P. aeruginosa to establish chronic lung infections. MATERIALS AND METHODS: In this study, 25 clinical alginate-degrading isolates were selected. Biochemical and molecular approach were carried out to identify the isolates by 16S rDNA gene amplification. Growth conditions and enzyme production were the criteria for selection...
August 15, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30118242/the-cooperation-of-pharmacologic-dose-ascorbate-with-ceftriaxone-against-staphylococcus-aureus-through-bactericidal-synergy-and-enhanced-macrophage-killing-activity
#5
Chulamartd Wirapakorn, Uthaibhorn Singkham-In, Sujittra Taratummarat, Saowapha Surawut, Peerapat Visitchanakun, Tanittha Chatsuwan, Asada Leelahavanichkul
BACKGROUND: Ascorbate is a low-cost compound with a known bactericidal-synergy to antibitics. However, the synergy depends on concentrations and organisms. Thus, the synergy test by time-kill assay might be appropriate for the screening of the synergy. OBJECTIVE: We aimed to test the adjuvant property of ascorbate with ceftriaxone, a frequently prescribed β-lactam antibiotic. METHOD: Ascorbate was tested with several bacteria from the American Type Culture Collection (ATCC) including Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli for i) bactericidal property of ascorbate, alone or with ceftriaxone-combination, by time-kill assay, ii) an influence on the killing-activity of bone -marrow-derived macrophage and iii) the attenuation of myositis mouse model...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/30104278/meropenem-combined-with-ciprofloxacin-combats-hypermutable-pseudomonas-aeruginosa-from-respiratory-infections-of-cystic-fibrosis-patients
#6
Vanessa E Rees, Rajbharan Yadav, Kate E Rogers, Jürgen B Bulitta, Veronika Wirth, Antonio Oliver, John D Boyce, Anton Y Peleg, Roger L Nation, Cornelia B Landersdorfer
Hypermutable Pseudomonas aeruginosa are prevalent in chronic respiratory infections and have been associated with reduced lung function in cystic fibrosis (CF); these isolates can become resistant to all antibiotics in monotherapy. This study aimed to evaluate the time-course of bacterial killing and resistance of meropenem and ciprofloxacin in combination against hypermutable and non-hypermutable P. aeruginosa Static concentration time-kill experiments over 72h assessed meropenem and ciprofloxacin in mono- and combination therapy against PAO1 (non-hypermutable), PAOΔ mutS (hypermutable), and hypermutable isolates CW08, CW35 and CW44 obtained from CF patients with chronic respiratory infections...
August 13, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/30101632/new-anti-pseudomonal-agents-for-cystic-fibrosis-still-needed-in-the-era-of-small-molecule-cftr-modulators
#7
REVIEW
Jane C Davies, Isaac Martin
Cystic fibrosis is characterized by bacterial lung infection, a majority of adults being chronically infected with Pseudomonas aeruginosa. Treatment is a major challenge, with frequent courses of antibiotics contributing to antimicrobial resistance. New approaches are clearly required. Over the last few years, a major shift in our approach to treating CF has occurred with the availability of the first drugs targeting the CFTR protein and leading to improvements in lung function, weight gain and frequency of exacerbations...
August 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/30100401/effect-of-sodium-mercaptoacetic-acid-on-different-antimicrobial-disks-in-the-sodium-mercaptoacetic-acid-double-disk-synergy-test-for-detection-of-imp-1-metallo-%C3%AE-lactamase-producing-pseudomonas-aeruginosa-isolates-in-japan
#8
Daisuke Sakanashi, Narimi Miyazaki, Yuzuka Kawamoto, Tomoko Ohno, Atsuko Yamada, Isao Koita, Setsuo Miyajima, Hiroyuki Suematsu, Mao Hagihara, Nobuhiro Asai, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo
We determined the optimal antimicrobial in the sodium mercaptoacetic acid double disk synergy test (SMA-DDST) for the detection of IMP-1-producing Pseudomonas aeruginosa isolates in Japan and evaluated the performance of the test. Fifty-four P. aeruginosa clinical isolates were tested, including 39 IMP-1 producers and 15 non-metallo-β-lactamase (MBL)-producing carbapenem- and ceftazidime (CAZ)-resistant isolates. The SMA-DDST was performed with CAZ, cefepime (CFPM), imipenem (IPM), meropenem (MEPM), doripenem (DRPM), or biapenem (BIPM)-containing disks...
August 9, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/30065794/in-vitro-antibacterial-interaction-of-doripenem-and-amikacin-against-multidrug-resistant-acinetobacter-baumannii-pseudomonas-aeruginosa-and-klebsiella-pneumoniae-isolates
#9
Tonny Loho, Ninik Sukartini, Dalima A W Astrawinata, Suzanna Immanuel, Diana Aulia, Ika Priatni
Evaluation of the in vitro interaction of doripenem and amikacin against Acinetobacter baumannii , Pseudomonas aeruginosa , and Klebsiella pneumoniae was done by classifying them into four groups: doripenem and amikacin sensitive (DOR-S/AMK-S), doripenem sensitive and amikacin resistant (DOR-S/AMK-R), doripenem resistant and amikacin sensitive (DOR-R/AMK-S), and both doripenem and amikacin resistant (DOR-R/AMK-R). The MIC of each antibiotic and their combination was obtained using the Etest method. The fractional inhibitory concentration index was calculated to classify the results as synergistic, additive, indifferent, or antagonistic interaction...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29973719/species-specific-activity-of-antibacterial-drug-combinations
#10
Ana Rita Brochado, Anja Telzerow, Jacob Bobonis, Manuel Banzhaf, André Mateus, Joel Selkrig, Emily Huth, Stefan Bassler, Jordi Zamarreño Beas, Matylda Zietek, Natalie Ng, Sunniva Foerster, Benjamin Ezraty, Béatrice Py, Frédéric Barras, Mikhail M Savitski, Peer Bork, Stephan Göttig, Athanasios Typas
The spread of antimicrobial resistance has become a serious public health concern, making once-treatable diseases deadly again and undermining the achievements of modern medicine1,2 . Drug combinations can help to fight multi-drug-resistant bacterial infections, yet they are largely unexplored and rarely used in clinics. Here we profile almost 3,000 dose-resolved combinations of antibiotics, human-targeted drugs and food additives in six strains from three Gram-negative pathogens-Escherichia coli, Salmonella enterica serovar Typhimurium and Pseudomonas aeruginosa-to identify general principles for antibacterial drug combinations and understand their potential...
July 2018: Nature
https://www.readbyqxmd.com/read/29928049/synergy-between-conventional-antibiotics-and-anti-biofilm-peptides-in-a-murine-sub-cutaneous-abscess-model-caused-by-recalcitrant-eskape-pathogens
#11
Daniel Pletzer, Sarah C Mansour, Robert E W Hancock
With the antibiotic development pipeline running dry, many fear that we might soon run out of treatment options. High-density infections are particularly difficult to treat due to their adaptive multidrug-resistance and currently there are no therapies that adequately address this important issue. Here, a large-scale in vivo study was performed to enhance the activity of antibiotics to treat high-density infections caused by multidrug-resistant Gram-positive and Gram-negative bacteria. It was shown that synthetic peptides can be used in conjunction with the antibiotics ciprofloxacin, meropenem, erythromycin, gentamicin, and vancomycin to improve the treatment outcome of murine cutaneous abscesses caused by clinical hard-to-treat pathogens including all ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae) pathogens and Escherichia coli...
June 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29875589/metallo-%C3%AE-lactamase-mediated-resistance-among-clinical-carbapenem-resistant-pseudomonas-aeruginosa-isolates-in-northern-iran-a-potential-threat-to-clinical-therapeutics
#12
Abdol Ahad Dogonchi, Ezzat Allah Ghaemi, Abdollah Ardebili, Sajjad Yazdansetad, Abazar Pournajaf
Objective: Carbapenems are effective agents to treat multidrug-resistant (MDR) strains of bacteria, including Pseudomonas aeruginosa . However, there is a potential threat of emergence of carbapenem-resistant P. aeruginosa (CRPA). The aim of this study was to determine antibiotic susceptibility patterns and metallo-beta-lactamase (MBL)-mediated resistance in clinical P. aeruginosa isolates. Materials and Methods: Different clinical specimens were subjected to conventional culture-based identification of P...
April 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29772761/high-concentrations-of-sodium-chloride-improve-microbicidal-activity-of-ibuprofen-against-common-cystic-fibrosis-pathogens
#13
Adrián J Muñoz, Roxana V Alasino, Ariel G Garro, Valeria Heredia, Néstor H García, David C Cremonezzi, Dante M Beltramo
Ibuprofen (IBU-H), a widely used anti-inflammatory, also shows a marked antimicrobial effect against several bacterial species, including those involved in cystic fibrosis such as Pseudomona aeruginosa , methicillin resistant Staphylococcus aureus and Burkholderia cepacia complex. Additionally, our results show significant synergy between water soluble Na-ibuprofen (IBU-Na) and ionic strength. Salt concentrations above 0.5 M modify the zeta potential promoting the action of Na-IBU; thus, with 1 M sodium chloride, IBU-Na is ten times more efficient than in the absence of ionic strength, and the minimum effective contact time is reduced from hours to minutes...
May 17, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29756762/molecular-properties-that-define-the-activities-of-antibiotics-in-escherichia-coli-and-pseudomonas-aeruginosa
#14
Sarah J Cooper, Ganesh Krishnamoorthy, David Wolloscheck, John K Walker, Valentin V Rybenkov, Jerry M Parks, Helen I Zgurskaya
The permeability barrier of Gram-negative cell envelopes is the major obstacle in the discovery and development of new antibiotics. In Gram-negative bacteria, these difficulties are exacerbated by the synergistic interaction between two biochemically distinct phenomena, the low permeability of the outer membrane (OM) and active multidrug efflux. In this study, we used Pseudomonas aeruginosa and Escherichia coli strains with controllable permeability barriers, achieved through hyperporination of the OMs and varied efflux capacities, to evaluate the contributions of each of the barriers to protection from antibacterials...
August 10, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29674848/biofilm-infections-between-scylla-and-charybdis-interplay-of-host-antimicrobial-peptides-and-antibiotics
#15
Sergey Chernysh, Natalia Gordya, Dmitry Tulin, Andrey Yakovlev
Purpose: The aim of this study is to improve the anti-biofilm activity of antibiotics. We hypothesized that the antimicrobial peptide (AMP) complex of the host's immune system can be used for this purpose and examined the assumption on model biofilms. Methods: FLIP7, the AMP complex of the blowfly Calliphora vicina containing a combination of defensins, cecropins, diptericins and proline-rich peptides was isolated from the hemolymph of bacteria-challenged maggots...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29581074/antimicrobial-susceptibility-profiles-of-bacteria-causing-urinary-tract-infections-in-mexico-single-centre-experience-with-10-years-of-results
#16
Francisco Alejandro Lagunas-Rangel
OBJECTIVES: The aim of this retrospective study was to describe urinary tract infections (UTIs) diagnosed in a single centre in Mexico through 10 years of results, with a particular emphasis on the aetiology, patterns of antimicrobial susceptibility and incidence of extended-spectrum β-lactamase (ESBL)-producing strains. METHODS: This study involved all urine samples analysed during the period March 2007 to September 2017 in a single centre in Mexico. Isolated uropathogens were identified to species level using routine laboratory methods, and antimicrobial susceptibility was determined by the disk diffusion method...
March 23, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29550930/piperacillin-and-ceftazidime-produce-the-strongest-synergistic-phage-antibiotic-effect-in-pseudomonas-aeruginosa
#17
Jumpei Uchiyama, Ryu Shigehisa, Tadahiro Nasukawa, Keijiro Mizukami, Iyo Takemura-Uchiyama, Takako Ujihara, Hironobu Murakami, Ichiro Imanishi, Koji Nishifuji, Masahiro Sakaguchi, Shigenobu Matsuzaki
The combined use of phage and antibiotics can show synergistic antimicrobial effects, so-called phage-antibiotic synergy (PAS). Here, we screened and examined PAS against Pseudomonas aeruginosa in vitro. Testing four different phages infecting P. aeruginosa, phage KPP22 classified within the family Myoviridae genus Pbunavirus showed PAS with the widest range of antibiotics, and showed PAS with anti-Pseudomonas drugs such as piperacillin and ceftazidime. Thus, evidence suggests that the combined use of phage and antibiotics is a promising therapeutic strategy against P...
July 2018: Archives of Virology
https://www.readbyqxmd.com/read/29483119/efficacy-of-human-simulated-exposures-of-ceftolozane-tazobactam-alone-and-in-combination-with-amikacin-or-colistin-against-multidrug-resistant-pseudomonas-aeruginosa-in-an-in-vitro-pharmacodynamic-model
#18
Veronica Rico Caballero, Safa Almarzoky Abuhussain, Joseph L Kuti, David P Nicolau
Combination therapy is an attractive option for the treatment of multidrug-resistant (MDR) Pseudomonas aeruginosa infections; however, limited data are available on combinations with ceftolozane-tazobactam (C-T). The in vitro pharmacodynamic chemostat model was employed to compare human-simulated exposures of C-T at 3 g every 8 h alone or in combination with amikacin at 25 mg/kg of body weight daily or colistin at 360 mg daily against four MDR P. aeruginosa isolates. C-T alone resulted in 24-h changes in the number of CFU of -0...
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29478286/key-role-of-hydrogen-peroxide-in-antimicrobial-activity-of-spring-honeydew-maquis-and-chestnut-grove-corsican-honeys-on-pseudomonas-aeruginosa-dna
#19
J-P Poli, E Guinoiseau, A Luciani, Y Yang, M-J Battesti, J Paolini, J Costa, Y Quilichini, L Berti, V Lorenzi
In honeys, several molecules have been known for their antibacterial or wound healing properties. Corsican honeys just began to be tested for their antimicrobial activity with promising results on Pseudomonas aeruginosa. So, identification of active molecules and their mode of action was determined. Hydrogen peroxide concentrations were evaluated and, in parallel, the minimal inhibitory concentrations (MIC) values were performed with and without catalase. More, the quantity of phenolic compounds and ORAC assay were measured...
May 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29459733/conditional-toxicity-and-synergy-drive-diversity-among-antibacterial-effectors
#20
Kaitlyn D LaCourse, S Brook Peterson, Hemantha D Kulasekara, Matthew C Radey, Jungyun Kim, Joseph D Mougous
Bacteria in polymicrobial habitats contend with a persistent barrage of competitors, often under rapidly changing environmental conditions 1 . The direct antagonism of competitor cells is thus an important bacterial survival strategy 2 . Towards this end, many bacterial species employ an arsenal of antimicrobial effectors with multiple activities; however, the benefits conferred by the simultaneous deployment of diverse toxins are unknown. Here we show that the multiple effectors delivered to competitor bacteria by the type VI secretion system (T6SS) of Pseudomonas aeruginosa display conditional efficacy and act synergistically...
April 2018: Nature Microbiology
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