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Pseudomonas aeruginosa resistant synergies

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https://www.readbyqxmd.com/read/30487502/laboratory-diagnosis-of-bacterial-vaginosis-and-potential-pathogens-other-than-group-b-streptococcus-in-vaginal-swab-of-pregnant-women-in-dhaka-medical-college-hospital
#1
M N Tarana, S M Shamsuzzaman
Pathogenic microorganisms are important cause of maternal and neonatal infections which are transmitted from colonized vagina of mother. The purpose of the present study was to detect the potential pathogens other than Group B Streptococcus in vaginal swab of pregnant women. This prospective cross sectional study was conducted from July 2013 to June 2014 at Dhaka Medical College Hospital, Dhaka, Bangladesh. A total of 224 vaginal swab samples were studied. Gram stain Nugent score was applied for all vaginal smear to detect bacterial vaginosis...
October 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/30381056/esculentin-1a-derived-antipseudomonal-peptides-limited-induction-of-resistance-and-synergy-with-aztreonam
#2
Bruno Casciaro, Maria Rosa Loffredo, Vincenzo Luca, Walter Verrusio, Mauro Cacciafesta, Maria Luisa Mangoni
BACKGROUND: The massive use of antibiotics has led to the selection of resistant bacterial strains that are difficult to eradicate. Among these, Pseudomonas aeruginosa most frequently colonizes and infects the airways of cystic fibrosis patients. Cationic Antimicrobial Peptides (AMPs) represent interesting molecules for the development of new antimicrobial agents. Thanks to their mechanism of action that involves the permeabilization of the bacterial cytoplasmic membrane, the induction of resistance is quite limited...
October 31, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/30376073/fosfomycin-in-severe-infections-due-to-genetically-distinct-pan-drug-resistant-gram-negative-microorganisms-synergy-with-meropenem
#3
Lauro Vieira Perdigão Neto, Maura S Oliveira, Roberta Cristina Ruedas Martins, Ana Paula Marchi, Juliana Januário Gaudereto, Lucianna Auxi Teixeira Josino da Costa, Lia Fernandes Alves de Lima, Christianne Fernandes Valente Takeda, Silvia F Costa, Anna S Levin
Background: In vitro and clinical studies using parenteral fosfomycin have suggested the possibility of using this drug against infections caused by MDR microorganisms. The aim of this study was to describe a case series of patients treated with fosfomycin who had severe infections caused by pan-drug-resistant Gram-negative bacteria. Methods: We describe a prospective series of cases of hospitalized patients with infections caused by Gram-negative bacteria resistant to β-lactams and colistin, treated with 16 g of fosfomycin daily for 10-14 days...
October 29, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30368151/diversity-and-metallo-%C3%AE-lactamase-producing-genes-in-pseudomonas-aeruginosa-strains-isolated-from-filters-of-household-water-treatment-systems
#4
Sara Mombini, Seyedeh Elham Rezatofighi, Laleh Kiyani, Hossein Motamedi
The microbiological quality of drinking water has long been a critical element in public health. Considering the high clinical relevance of Pseudomonas aeruginosa, we examined the filters of household water treatment systems for its presence and characteristics to determine the systems' efficiency in eliminating the bacteria. In total, filters of 50 household water treatment systems were examined. Microbiological and molecular methods were used for the detection and confirmation of P. aeruginosa isolates. Random Amplification of Polymorphic DNA-polymerase chain reaction (RAPD-PCR) was performed to detect similarities and differences among P...
October 24, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/30298931/synergistic-antibacterial-effects-of-buddleja-albiflora-metabolites-with-antibiotics-against-listeria-monocytogenes
#5
X Zhang, L Wang, H Mu, D Wang, Y Yu
Some plants of Buddleja genus possessed antimicrobial activity. In this study, the antibacterial activities of nine compounds from B. albiflora were evaluated against Listeria monocytogenes, Staphyloccocus aureus, Escherichia coli and Pseudomonas aeruginosa, either alone or in combination with Erythromycin (Ery), Gentamycin (Gen) and Ampicillin (Amp). Checkerboard assay demonstrated that kumatakenin (Kum) elicited synergistic effects with all three antibiotics, and chrysin (Chr) displayed synergistic effect with Ery against L...
October 9, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/30295837/mechanisms-of-high-level-ceftolozane-tazobactam-resistance-in-pseudomonas-aeruginosa-from-a-severely-neutropenic-patient-and-treatment-success-from-synergy-with-tobramycin
#6
Wonhee So, James Shurko, Ralph Galega, Rod Quilitz, John N Greene, Grace C Lee
No abstract text is available yet for this article.
October 8, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30223075/synergy-of-nebulized-phage-pev20-and-ciprofloxacin-combination-against-pseudomonas-aeruginosa
#7
Yu Lin, Rachel Yoon Kyung Chang, Warwick J Britton, Sandra Morales, Elizabeth Kutter, Hak-Kim Chan
Nebulization is currently used for delivery of antibiotics for respiratory infections. Bacteriophages (or phages) are effective predators of pathogens including Pseudomonas aeruginosa commonly found in the lungs of patients with cystic fibrosis (CF). It is known that phages and antibiotics can potentially show synergistic antimicrobial effect on bacterial killing. In the present study, we investigated synergistic antimicrobial effect of phage PEV20 with five different antibiotics against three P. aeruginosa strains isolated from sputum of CF patients...
November 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30118807/screening-cloning-and-expression-of-a-novel-alginate-lyase-gene-from-p-aeruginosa-tag-48-and-its-antibiofilm-effects-on-p-aeruginosa-biofilm
#8
Hadis Tavafi, Ahya Abdi Ali, Parinaz Ghadam, Sara Gharavi
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen and utilizes several virulence factors for pathogenesis. One of the most important factors is alginate, found in the biofilm which enables P. aeruginosa to establish chronic lung infections. MATERIALS AND METHODS: In this study, 25 clinical alginate-degrading isolates were selected. Biochemical and molecular approach were carried out to identify the isolates by 16S rDNA gene amplification. Growth conditions and enzyme production were the criteria for selection...
August 15, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30118242/the-cooperation-of-pharmacologic-dose-ascorbate-with-ceftriaxone-against-staphylococcus-aureus-through-bactericidal-synergy-and-enhanced-macrophage-killing-activity
#9
Chulamartd Wirapakorn, Uthaibhorn Singkham-In, Sujittra Taratummarat, Saowapha Surawut, Peerapat Visitchanakun, Tanittha Chatsuwan, Asada Leelahavanichkul
BACKGROUND: Ascorbate is a low-cost compound with a known bactericidal-synergy to antibitics. However, the synergy depends on concentrations and organisms. Thus, the synergy test by time-kill assay might be appropriate for the screening of the synergy. OBJECTIVE: We aimed to test the adjuvant property of ascorbate with ceftriaxone, a frequently prescribed β-lactam antibiotic. METHOD: Ascorbate was tested with several bacteria from the American Type Culture Collection (ATCC) including Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli for i) bactericidal property of ascorbate, alone or with ceftriaxone-combination, by time-kill assay, ii) an influence on the killing-activity of bone -marrow-derived macrophage and iii) the attenuation of myositis mouse model...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/30104278/meropenem-combined-with-ciprofloxacin-combats-hypermutable-pseudomonas-aeruginosa-from-respiratory-infections-of-cystic-fibrosis-patients
#10
Vanessa E Rees, Rajbharan Yadav, Kate E Rogers, Jürgen B Bulitta, Veronika Wirth, Antonio Oliver, John D Boyce, Anton Y Peleg, Roger L Nation, Cornelia B Landersdorfer
Hypermutable Pseudomonas aeruginosa organisms are prevalent in chronic respiratory infections and have been associated with reduced lung function in cystic fibrosis (CF); these isolates can become resistant to all antibiotics in monotherapy. This study aimed to evaluate the time course of bacterial killing and resistance of meropenem and ciprofloxacin in combination against hypermutable and nonhypermutable P. aeruginosa Static concentration time-kill experiments over 72 h assessed meropenem and ciprofloxacin in mono- and combination therapies against PAO1 (nonhypermutable), PAOΔ mutS (hypermutable), and hypermutable isolates CW8, CW35, and CW44 obtained from CF patients with chronic respiratory infections...
November 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/30101632/new-anti-pseudomonal-agents-for-cystic-fibrosis-still-needed-in-the-era-of-small-molecule-cftr-modulators
#11
REVIEW
Jane C Davies, Isaac Martin
Cystic fibrosis is characterized by bacterial lung infection, a majority of adults being chronically infected with Pseudomonas aeruginosa. Treatment is a major challenge, with frequent courses of antibiotics contributing to antimicrobial resistance. New approaches are clearly required. Over the last few years, a major shift in our approach to treating CF has occurred with the availability of the first drugs targeting the CFTR protein and leading to improvements in lung function, weight gain and frequency of exacerbations...
August 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/30100401/effect-of-sodium-mercaptoacetic-acid-on-different-antimicrobial-disks-in-the-sodium-mercaptoacetic-acid-double-disk-synergy-test-for-detection-of-imp-1-metallo-%C3%AE-lactamase-producing-pseudomonas-aeruginosa-isolates-in-japan
#12
Daisuke Sakanashi, Narimi Miyazaki, Yuzuka Kawamoto, Tomoko Ohno, Atsuko Yamada, Isao Koita, Setsuo Miyajima, Hiroyuki Suematsu, Mao Hagihara, Nobuhiro Asai, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo
We determined the optimal antimicrobial in the sodium mercaptoacetic acid double disk synergy test (SMA-DDST) for the detection of IMP-1-producing Pseudomonas aeruginosa isolates in Japan and evaluated the performance of the test. Fifty-four P. aeruginosa clinical isolates were tested, including 39 IMP-1 producers and 15 non-metallo-β-lactamase (MBL)-producing carbapenem- and ceftazidime (CAZ)-resistant isolates. The SMA-DDST was performed with CAZ, cefepime (CFPM), imipenem (IPM), meropenem (MEPM), doripenem (DRPM), or biapenem (BIPM)-containing disks...
August 9, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/30065794/in-vitro-antibacterial-interaction-of-doripenem-and-amikacin-against-multidrug-resistant-acinetobacter-baumannii-pseudomonas-aeruginosa-and-klebsiella-pneumoniae-isolates
#13
Tonny Loho, Ninik Sukartini, Dalima A W Astrawinata, Suzanna Immanuel, Diana Aulia, Ika Priatni
Evaluation of the in vitro interaction of doripenem and amikacin against Acinetobacter baumannii , Pseudomonas aeruginosa , and Klebsiella pneumoniae was done by classifying them into four groups: doripenem and amikacin sensitive (DOR-S/AMK-S), doripenem sensitive and amikacin resistant (DOR-S/AMK-R), doripenem resistant and amikacin sensitive (DOR-R/AMK-S), and both doripenem and amikacin resistant (DOR-R/AMK-R). The MIC of each antibiotic and their combination was obtained using the Etest method. The fractional inhibitory concentration index was calculated to classify the results as synergistic, additive, indifferent, or antagonistic interaction...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29973719/species-specific-activity-of-antibacterial-drug-combinations
#14
Ana Rita Brochado, Anja Telzerow, Jacob Bobonis, Manuel Banzhaf, André Mateus, Joel Selkrig, Emily Huth, Stefan Bassler, Jordi Zamarreño Beas, Matylda Zietek, Natalie Ng, Sunniva Foerster, Benjamin Ezraty, Béatrice Py, Frédéric Barras, Mikhail M Savitski, Peer Bork, Stephan Göttig, Athanasios Typas
The spread of antimicrobial resistance has become a serious public health concern, making once-treatable diseases deadly again and undermining the achievements of modern medicine1,2 . Drug combinations can help to fight multi-drug-resistant bacterial infections, yet they are largely unexplored and rarely used in clinics. Here we profile almost 3,000 dose-resolved combinations of antibiotics, human-targeted drugs and food additives in six strains from three Gram-negative pathogens-Escherichia coli, Salmonella enterica serovar Typhimurium and Pseudomonas aeruginosa-to identify general principles for antibacterial drug combinations and understand their potential...
July 2018: Nature
https://www.readbyqxmd.com/read/29928049/synergy-between-conventional-antibiotics-and-anti-biofilm-peptides-in-a-murine-sub-cutaneous-abscess-model-caused-by-recalcitrant-eskape-pathogens
#15
Daniel Pletzer, Sarah C Mansour, Robert E W Hancock
With the antibiotic development pipeline running dry, many fear that we might soon run out of treatment options. High-density infections are particularly difficult to treat due to their adaptive multidrug-resistance and currently there are no therapies that adequately address this important issue. Here, a large-scale in vivo study was performed to enhance the activity of antibiotics to treat high-density infections caused by multidrug-resistant Gram-positive and Gram-negative bacteria. It was shown that synthetic peptides can be used in conjunction with the antibiotics ciprofloxacin, meropenem, erythromycin, gentamicin, and vancomycin to improve the treatment outcome of murine cutaneous abscesses caused by clinical hard-to-treat pathogens including all ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae) pathogens and Escherichia coli...
June 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29875589/metallo-%C3%AE-lactamase-mediated-resistance-among-clinical-carbapenem-resistant-pseudomonas-aeruginosa-isolates-in-northern-iran-a-potential-threat-to-clinical-therapeutics
#16
Abdol Ahad Dogonchi, Ezzat Allah Ghaemi, Abdollah Ardebili, Sajjad Yazdansetad, Abazar Pournajaf
Objective: Carbapenems are effective agents to treat multidrug-resistant (MDR) strains of bacteria, including Pseudomonas aeruginosa . However, there is a potential threat of emergence of carbapenem-resistant P. aeruginosa (CRPA). The aim of this study was to determine antibiotic susceptibility patterns and metallo-beta-lactamase (MBL)-mediated resistance in clinical P. aeruginosa isolates. Materials and Methods: Different clinical specimens were subjected to conventional culture-based identification of P...
April 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29772761/high-concentrations-of-sodium-chloride-improve-microbicidal-activity-of-ibuprofen-against-common-cystic-fibrosis-pathogens
#17
Adrián J Muñoz, Roxana V Alasino, Ariel G Garro, Valeria Heredia, Néstor H García, David C Cremonezzi, Dante M Beltramo
Ibuprofen (IBU-H), a widely used anti-inflammatory, also shows a marked antimicrobial effect against several bacterial species, including those involved in cystic fibrosis such as Pseudomona aeruginosa , methicillin resistant Staphylococcus aureus and Burkholderia cepacia complex. Additionally, our results show significant synergy between water soluble Na-ibuprofen (IBU-Na) and ionic strength. Salt concentrations above 0.5 M modify the zeta potential promoting the action of Na-IBU; thus, with 1 M sodium chloride, IBU-Na is ten times more efficient than in the absence of ionic strength, and the minimum effective contact time is reduced from hours to minutes...
May 17, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29483119/efficacy-of-human-simulated-exposures-of-ceftolozane-tazobactam-alone-and-in-combination-with-amikacin-or-colistin-against-multidrug-resistant-pseudomonas-aeruginosa-in-an-in-vitro-pharmacodynamic-model
#18
Veronica Rico Caballero, Safa Almarzoky Abuhussain, Joseph L Kuti, David P Nicolau
Combination therapy is an attractive option for the treatment of multidrug-resistant (MDR) Pseudomonas aeruginosa infections; however, limited data are available on combinations with ceftolozane-tazobactam (C-T). The in vitro pharmacodynamic chemostat model was employed to compare human-simulated exposures of C-T at 3 g every 8 h alone or in combination with amikacin at 25 mg/kg of body weight daily or colistin at 360 mg daily against four MDR P. aeruginosa isolates. C-T alone resulted in 24-h changes in the number of CFU of -0...
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29438821/molecular-characterisation-of-extended-spectrum-%C3%AE-lactamase-producing-gram-negative-bacterial-isolates-from-surgical-wounds-of-patients-at-a-hospital-in-north-central-nigeria
#19
Ahmed Olowo-Okere, Yakubu Kokori Enevene Ibrahim, Busayo Olalekan Olayinka
OBJECTIVES: This study aimed to characterise extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacterial isolates from patients with surgical site infections (SSIs) at a tertiary healthcare facility in Abuja, Nigeria. METHODS: Consecutive, non-duplicate wound swabs were collected over a 3-month period from wounds of patients with SSI and were cultured appropriately. Bacterial isolates were identified using rapid identification kits. The modified agar disk diffusion method was used for antimicrobial susceptibility testing, and phenotypic ESBL activity of the isolates was determined using the double-disk synergy test (DDST)...
February 10, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29432937/detection-of-vim-2-imp-1-and-ndm-1-producing-multidrug-resistant-pseudomonas-aeruginosa-in-malaysia
#20
Siew Mun Liew, Ganeswrei Rajasekaram, Savithri D Puthucheary, Kek Heng Chua
OBJECTIVES: The increasing incidence of carbapenem-resistant Pseudomonas aeruginosa along with the discovery of novel metallo-β-lactamases (MBLs) is of concern. In this study, the isolation of MBL-producing P. aeruginosa clinical strains in Malaysia was investigated. METHODS: A total of 53 P. aeruginosa clinical strains were isolated from different patients in Sultanah Aminah Hospital (Johor Bahru, Malaysia) in 2015. Antimicrobial susceptibility testing was performed, and minimum inhibitory concentrations (MICs) of imipenem and meropenem were determined by Etest...
June 2018: Journal of Global Antimicrobial Resistance
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