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Endometrial disease

Naveena Singh, Lynn Hirschowitz, Richard Zaino, Isabel Alvarado-Cabrero, Maire A Duggan, Rouba Ali-Fehmi, Elizabeth Euscher, Jonathan L Hecht, Lars-Christian Horn, Olga Ioffe, Xavier Matias-Guiu, W Glenn McCluggage, Yoshiki Mikami, Jaume Ordi, Vinita Parkash, M Ruhul Quddus, Charles M Quick, Annette Staebler, Charles Zaloudek, Marisa Nucci, Anais Malpica, Esther Oliva
Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The aim of accurate prognostication is to ensure that patients receive optimal treatment and are neither overtreated nor undertreated, thereby improving patient outcomes overall. Patients with EC can be categorized into prognostic risk groups based on clinicopathologic findings. Other than tumor type and grade, groupings and recommended management algorithms may take into account age, body mass index, stage, and presence of lymphovascular space invasion...
January 2019: International Journal of Gynecological Pathology
Anais Malpica, Elizabeth D Euscher, Jonathan L Hecht, Rouba Ali-Fehmi, Charles M Quick, Naveena Singh, Lars-Christian Horn, Isabel Alvarado-Cabrero, Xavier Matias-Guiu, Lynn Hirschowitz, Máire Duggan, Jaume Ordi, Vinita Parkash, Yoshiki Mikami, M Ruhul Quddus, Richard Zaino, Annette Staebler, Charles Zaloudek, W Glenn McCluggage, Esther Oliva
Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during the surgical treatment of patients affected by this disease. This article presents recommendations on how to gross and submit sections for microscopic examination of hysterectomy specimens and other tissues removed during the surgical management of endometrial cancer such as salpingo-oophorectomy, omentectomy, and lymph node dissection-including sentinel lymph nodes...
January 2019: International Journal of Gynecological Pathology
Alessandro Villanucci, Ketty Tavella, Laura Vannini, Virginia Rossi, Stefania Nobili, Gianni Amunni, Teresita Mazzei, Enrico Mini
The majority of patients with ovarian cancer will experience relapse and thus require second-line therapy. While platinum-based therapies are the primary treatments for refractory disease other options are required, particularly for those with partially platinum-sensitive disease as their response rates are lower. Agents that can resensitize relapsed ovarian cancers to platinum, including trabectedin, are therefore of increasing interest. Trabectedin is a multitarget agent that has a complex, novel mechanism of action and has exhibited promising results in platinum-sensitive ovarian cancer when in combination with pegylated liposomal doxorubicin (PLD)...
December 2018: Molecular and Clinical Oncology
Raffaele Hellweg, Ashley Mooneyham, Martina Bazzaro
Here we describe a method for identifying genes and genetic pathways responsible for chemoresistance in cancer cells. The method is based on generation and characterization of matched pairs of chemotherapy-sensitive/chemotherapy-resistant cancer cell lines. In this protocol we are using endometrial cancer cell lines treated with carboplatin and paclitaxel, which are first-line chemotherapies for gynecologic malignancies. The chemoresistant cells and their chemosensitive counterparts are used for downstream applications including bulk RNA-sequencing analysis to identify a set of genes and pathways that are associated with chemoresistance...
2019: Methods in Molecular Biology
Victor D Li, Karen H Li, John T Li
PURPOSE: Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers. METHODS: Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP53 Database were analyzed to determine the distribution of germline and somatic mutations in the TP53 gene. Subsequently, 7,893 cancer cases were compiled in cBioPortal for Cancer Genomics from the 33 most recent The Cancer Genome Atlas (TCGA) studies to determine the prevalence of TP53 mutations in cancers and their effects on survival and disease-free survival times...
December 12, 2018: Journal of Cancer Research and Clinical Oncology
Hee-Jin Choi, Tae-Wook Chung, Hee-Jung Choi, Jung Ho Han, Jung-Hye Choi, Cheorl-Ho Kim, Ki-Tae Ha
Endometriosis is a disease characterized by implants of endometrial tissue outside the uterine cavity and is strongly associated with infertility. Focal adhesion of endometrial tissue to the peritoneum is an indication of incipient endometriosis. In this study, we examined the effect of various cytokines that are known to be involved in the pathology of endometriosis on endometrial cell adhesion. Among the investigated cytokines, transforming growth factor-β1 (TGF-β1) increased adhesion of endometrial cells to the mesothelium through induction of α2-6 sialylation...
December 12, 2018: Experimental & Molecular Medicine
Anastasios Kyriazoglou, Michael Liontos, Dimitrios C Ziogas, Flora Zagouri, Kostantinos Koutsoukos, Giorgos Tsironis, Anna Tsiara, Maria Kaparelou, Roubini Zakopoulou, Nikolaos Thomakos, Dimitrios Haidopoulos, Irene Papaspyrou, Alexandros Rodolakis, Aristotelis Bamias, Meletios Athanasios Dimopoulos
BACKGROUND: Uterine sarcomas consist a heterogeneous group of mesenchymal gynecological malignancies with unclear therapeutic recommendations and unspecific but poor prognosis, since they usually metastasize and tend to recur very often, even in early stages. METHODS: We retrospectively analyzed all female patients with uterine sarcomas treated in our institution over the last 17 years. Clinico-pathological data, treatments and outcomes were recorded. Kaplan-Meier curves were plotted and time-to-event analyses were estimated using Cox regression...
December 13, 2018: BMC Cancer
Aharon Feldman, Sadaf Chaugle, Charlotte Burmeister, Adnan Munkarah, Mohamed A Elshaikh
OBJECTIVE: To compare survival endpoints between African American (AA) and non-AA (NAA) women with endometrial carcinoma (EC) stage I-II using a robust matching analysis. METHODS AND MATERIALS: Patients were matched by stage, grade, adjuvant management (surveillance, vaginal brachytherapy or pelvic radiation treatment), age, and year of hysterectomy. Recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) were calculated. RESULTS: A total of 758 patients were included...
December 12, 2018: Gynecologic and Obstetric Investigation
Ashraf Ishak Fawzy Tawadros, Mohamed Mohamed Mohamed Khalafalla
Background: Programmed death-ligand 1 (PD-L1) and hypoxia-inducible factor-1α (HIF-1α) proteins mediate major alterations of tumor microenvironment including generation of immunosuppressive microenvironment and tumor hypoxia, respectively. These alterations play a crucial role in carcinogenesis and tumor progression. Aims: The present study was designed to investigate the correlation between the expression of PD-L1 and HIF-1α proteins and the clinicopathologic variables in endometrial carcinoma...
December 2018: Journal of Cancer Research and Therapeutics
L Del Pup, F A Peccatori, P E Levi-Setti, G Codacci-Pisanelli, P Patrizio
OBJECTIVE: Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. The delay or the inability to achieve a pregnancy is an important risk factor for breast, endometrial and ovarian cancer...
November 2018: European Review for Medical and Pharmacological Sciences
N Galazis, S Mappouridou, A Mavrou
No abstract text is available yet for this article.
November 2018: Gynecologic Oncology Reports
German Cano-Sancho, Stéphane Ploteau, Komodo Matta, Evdochia Adoamnei, Germaine Buck Louis, Jaime Mendiola, Emile Darai, Jean Squifflet, Bruno Le Bizec, Jean-Philippe Antignac
BACKGROUND: Endometriosis is a gynaecological disease characterized by the presence of ectopic endometrial tissue that affects women during their reproductive years, having a strong impact on their lives, fertility and healthcare costs. The aetiology remains largely unknown, but current evidence suggests that it is multi-causal and oestrogen-dependent. Many epidemiologic studies have explored associations between organochlorine chemicals (OCCs) and endometriosis, but the findings are inconsistent...
December 6, 2018: Environment International
Philippe R Koninckx, Anastasia Ussia, Leila Adamyan, Arnaud Wattiez, Victor Gomel, Dan C Martin
OBJECTIVE: To study the pathophysiology of endometriosis. DESIGN: Overview of observations on endometriosis. SETTING: Not applicable. PATIENT(S): None. INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): The hypothesis is compatible with all observations. RESULT(S): Endometriosis, endometrium-like tissue outside the uterus, has a variable macroscopic appearance and a poorly understood natural history...
December 6, 2018: Fertility and Sterility
Mohamed Gamal Ibrahim, Martin Sillem, Johanna Plendl, Eliane T Taube, Andreas Schüring, Martin Götte, Vito Chiantera, Jalid Sehouli, Sylvia Mechsner
PURPOSE: Superficial peritoneal endometriotic (pEM) lesions are composed of endometrial glands and stroma, in addition to a third component-myofibroblasts and smooth muscles (SM)-like cells. The latter develops secondary to a metaplasia. In this study, we characterised the third component cells in pEM according to differentiation markers in different micro-compartments. Furthermore, a possible effect of TGFβ1 on myofibroblastic metaplasia in endometriotic epithelial cells was studied...
December 7, 2018: Archives of Gynecology and Obstetrics
Rosa M Polan, Emma C Rossi, Emma L Barber
BACKGROUND: In patients with endometrial cancer sentinel lymphadenectomy is used to accurately prognosticate extent of disease and has been proposed as a method to decrease the incidence of medical and surgical complications associated with more extensive lymphadenectomy. It is unknown if patients who undergo traditional lymphadenectomy experience major postoperative complications at the same rates as those who undergo sentinel lymphadenectomy or those who do not undergo lymphadenectomy...
December 3, 2018: American Journal of Obstetrics and Gynecology
Lois Salamonsen
The focus of my life in science, has been to improve reproductive health for women, with an emphasis on the endometrium, the most dynamic tissue in the human body: its remarkable cyclical remodelling is essential for establishment of pregnancy. The most notable events in a woman's endometrial cycle are menstruation and endometrial repair, regeneration of the endometrium during the proliferative phase, attainment of receptivity by the mid-secretory phase of the cycle and the embryo-maternal interactions that initiate peri-implantation events within the microenvironment of the uterine cavity...
December 1, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Qiongrong Chen, Manxiang Wang, Zhigao Xu, Mingwei Wang, Su Jin, Sufang Tian, Shuyuan Xiao
Muir-Torre syndrome is a rare subtype of Lynch syndrome characterized by coincidence of skin neoplasm and visceral malignancies. Here, we report a case of this rare disease, whose diagnosis of the syndrome was first suspected by the pathologist. This was a 60-yr-old woman who presented with an axillary skin nodule, which was diagnosed as basal cell carcinoma. Further inquiry revealed that she was hospitalized for evaluation of a recurrent vaginal stump endometrial carcinoma. Histologic workup and immunohistochemistry for mismatch repair proteins of both the skin and vaginal tumor suggested the possibility of Muir-Torre syndrome...
December 3, 2018: International Journal of Gynecological Pathology
Stefania Rizzo, Marco Femia, Valentina Buscarino, Dorella Franchi, Annalisa Garbi, Vanna Zanagnolo, Maria Del Grande, Lucia Manganaro, Sarah Alessi, Caterina Giannitto, Francesca Ruju, Massimo Bellomi
Endometrial cancer is the most common gynaecologic malignancy in developed countries and its incidence is increasing. First-level treatment, if no contraindicated, is based on surgery. Pre-operative imaging is needed for evaluation of local extent and detection of distant metastases in order to guide treatment planning. Radiological evaluation, based on transvaginal ultrasound, MR and CT, can make the difference in disease management, paying special attention to assessment of entity of myometrial invasion, cervical stromal extension, and assessment of lymph nodal involvement and distant metastases...
December 4, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Lifeng Zhang, Xinmei Zhang
In addition to regulating calcium and phosphorus metabolism to maintain strong bones, vitamin D also has immune regulating and anti-inflammatory effects. Moreover, it is related to chronic inflammatory diseases, autoimmune diseases and cancer. Many studies indicate the roles of vitamin D in the development and progression of endometriosis including the effects on modulation of immune responses, inflammation reactions, cell proliferation and apoptosis, angiogenesis, adhesion and invasion. Vitamin D supplementation can relieve pain and improve endometrial receptivity associated with endometriosis and play a preventive and therapeutic role...
February 25, 2018: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
A Ray, J Fornsaglio, S Dogan, S Hedau, D Naik, A De
Obesity has an influence on the risk and prognosis of different types of cancers of the female reproductive tract. In the uterus, a common site for neoplasms is the endometrium, the inner lining tissue. Generally, obesity has been documented to be involved in endometrioid carcinoma of the endometrium. Obesity may influence the cancer risk by various mechanisms such as chronic inflammation, dysregulation of sex hormones and abnormal secretion of hormone-like cytokines or adipokines from adipose tissue. One of the important pro-inflammatory adipokines is leptin, which acts via its transmembrane receptors (Ob-R)...
March 2018: Facts, Views & Vision in ObGyn
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