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Interleukin-15

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https://www.readbyqxmd.com/read/27910764/metabolic-regulation-of-natural-killer-cell-ifn-%C3%AE-production
#1
Annelise Y Mah, Megan A Cooper
Metabolism is critical for a host of cellular functions and provides a source of intracellular energy. It has been recognized recently that metabolism also regulates differentiation and effector functions of immune cells. Although initial work in this field has focused largely on T lymphocytes, recent studies have demonstrated metabolic control of innate immune cells, including natural killer (NK) cells. Here, we review what is known regarding the metabolic requirements for NK cell activation, focusing on NK cell production of interferon-gamma (IFN-γ)...
2016: Critical Reviews in Immunology
https://www.readbyqxmd.com/read/27881938/are-interleukin-15-and-22-a-new-pathogenic-factor-in-pustular-palmoplantar-psoriasis
#2
Aleksandra Lesiak, Igor Bednarski, Marta Pałczyńska, Ewelina Kumiszcza, Marzena Kraska-Gacka, Anna Woźniacka, Joanna Narbutt
INTRODUCTION: Pustular palmoplantar psoriasis (PPP) is a rare type of psoriasis affecting mainly distal parts of the limbs. Despite numerous theories about etiology of PPP, the pathogenesis still remains unclear. Recent data indicate that interleukin (IL)-15, IL-17 and IL-22 enhance a proinflammatory response in certain skin inflammatory diseases such as psoriasis and atopic dermatitis. There is also evidence that anti-endomysial (anti-EMA) and anti-gliadin (AGA) antibodies are engaged in PPP development...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27880829/interleukin-15-il-15-strongly-correlates-with-increasing-hiv-1-viremia-and-markers-of-inflammation
#3
Sanjay Swaminathan, Ju Qiu, Adam W Rupert, Zonghui Hu, Jeanette Higgins, Robin L Dewar, Randy Stevens, Catherine A Rehm, Julia A Metcalf, Brad T Sherman, Michael W Baseler, H Clifford Lane, Tomozumi Imamichi
OBJECTIVE: IL-15 has been postulated to play an important role in HIV-1 infection, yet there are conflicting reports regarding its expression levels in these patients. We sought to measure the level of IL-15 in a large, well characterised cohort of HIV-1 infected patients and correlate this with well known markers of inflammation, including CRP, D-dimer, sCD163 and sCD14. DESIGN AND METHODS: IL-15 levels were measured in 501 people (460 patients with HIV-1 infection and 41 uninfected controls)...
2016: PloS One
https://www.readbyqxmd.com/read/27847409/effect-of-interleukin-15-on-cd11b-cd54-and-cd62l-expression-on-natural-killer-cell-and-natural-killer-t-like-cells-in-systemic-lupus-erythematosus
#4
Syh-Jae Lin, Ji-Yih Chen, Ming-Ling Kuo, Hsiu-Shan Hsiao, Pei-Tzu Lee, Jing-Long Huang
Adhesion molecules may play an important role in systemic lupus erythematosus (SLE) pathogenesis. We investigated the effect of interleukin- (IL-) 15 on CD11b, CD54, and CD62L expression on natural killer (NK) cells, T cells, and CD56(+)CD3(+) NKT-like cells from SLE subjects and healthy controls. SLE patients had decreased circulating NK cells and NKT-like cells compared to controls. NK cells from SLE patients showed higher CD11b and CD62L expression compared to controls. IL-15 enhanced CD11b and CD54 but downregulated CD62L expression on NK cells from SLE patients...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27837366/hippocampus-specific-deficiency-of-il-15r%C3%AE-contributes-to-greater-anxiety-like-behaviors-in-mice
#5
Linda Nguyen, Joseph Bohlen, Janelle Stricker, Ikttesh Chahal, Hanting Zhang, Emidio E Pistilli
A hippocampus-specific IL15RαKO mouse (hipIl15ra (fl/fl) /Cre(+)) was generated to test the hypothesis that the targeted deletion of interleukin-15 receptor alpha (IL-15Rα) in the hippocampus contributes to altered behavior, including greater levels of anxiety and ambulatory activity. Using Cre-loxP, exons 2 and 3 of the IL-15Rα gene were excised within the hippocampus, while normal expression was maintained within the rest of the brain. In the open field test (OFT), hipIl15ra (fl/fl) /Cre(+) spent a greater amount of time in the periphery and less time in the central portions of the chamber, and there was also a noticeable trend for decreased rearing activity; these behaviors are consistent with greater levels of anxiety-like behavior in these mice...
November 11, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27830278/molecular-communication-from-skeletal-muscle-to-bone-a-review-for-muscle-derived-myokines-regulating-bone-metabolism
#6
REVIEW
Baosheng Guo, Zong-Kang Zhang, Chao Liang, Jie Li, Jin Liu, Aiping Lu, Bao-Ting Zhang, Ge Zhang
Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN)...
November 9, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27824945/correction-deficiency-of-interleukin-15-confers-resistance-to-obesity-by-diminishing-inflammation-and-enhancing-the-thermogenic-function-of-adipose-tissues
#7
Gregory Lacraz, Volatiana Rakotoarivelo, Sebastien M Labbé, Mathieu Vernier, Christophe Noll, Marian Mayhue, Jana Stankova, Adel Schwertani, Guillaume Grenier, André Carpentier, Denis Richard, Gerardo Ferbeyre, Julie Fradette, Marek Rola-Pleszczynski, Alfredo Menendez, Marie-France Langlois, Subburaj Ilangumaran, Sheela Ramanathan
[This corrects the article DOI: 10.1371/journal.pone.0162995.].
2016: PloS One
https://www.readbyqxmd.com/read/27776794/oncolytic-influenza-a-virus-expressing-interleukin-15-decreases-tumor-growth-in%C3%A2-vivo
#8
Karin Hock, Johannes Laengle, Irina Kuznetsova, Andrej Egorov, Balazs Hegedus, Balazs Dome, Thomas Wekerle, Monika Sachet, Michael Bergmann
BACKGROUND: Interleukin-15 has become a promising molecule in the context of eliciting an effective, antitumor immune response because it is able to stimulate cells of the innate and adaptive immune system. METHODS: We generated an interleukin-15-expressing oncolytic influenza A virus for the treatment of an established murine tumor model. RESULTS: Our oncolytic influenza A virus produced large amounts of interleukin-15 and induced proliferation and activation of human T cells in vitro...
October 21, 2016: Surgery
https://www.readbyqxmd.com/read/27738421/il-15-mediates-mitochondrial-activity-through-a-ppar%C3%AE-dependent-ppar%C3%AE-independent-mechanism-in-skeletal-muscle-cells
#9
Shantaé M Thornton, James E Krolopp, Marcia J Abbott
Molecular mediators of metabolic processes, to increase energy expenditure, have become a focus for therapies of obesity. The discovery of cytokines secreted from the skeletal muscle (SKM), termed "myokines," has garnered attention due to their positive effects on metabolic processes. Interleukin-15 (IL-15) is a myokine that has numerous positive metabolic effects and is linked to the PPAR family of mitochondrial regulators. Here, we aimed to determine the importance of PPARα and/or PPARδ as targets of IL-15 signaling...
2016: PPAR Research
https://www.readbyqxmd.com/read/27686372/interleukin-15-enhances-the-proliferation-stimulatory-phenotype-and-antitumor-effector-functions-of-human-gamma-delta-t-cells
#10
Heleen H Van Acker, Sébastien Anguille, Yannick Willemen, Johan M Van den Bergh, Zwi N Berneman, Eva Lion, Evelien L Smits, Viggo F Van Tendeloo
BACKGROUND: Adoptive immunotherapy is gaining momentum to fight malignancies, whereby γδ T cells have received recent attention as an alternative cell source as to natural killer cells and αβ T cells. The advent of γδ T cells is largely due to their ability to recognize and target tumor cells using both innate characteristic and T cell receptor (TCR)-mediated mechanisms, their capacity to enhance the generation of antigen-specific T cell responses, and their potential to be used in an autologous or allogeneic setting...
September 29, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27684068/deficiency-of-interleukin-15-confers-resistance-to-obesity-by-diminishing-inflammation-and-enhancing-the-thermogenic-function-of-adipose-tissues
#11
Gregory Lacraz, Volatiana Rakotoarivelo, Sebastien M Labbé, Mathieu Vernier, Christophe Noll, Marian Mayhue, Jana Stankova, Adel Schwertani, Guillaume Grenier, André Carpentier, Denis Richard, Gerardo Ferbeyre, Julie Fradette, Marek Rola-Pleszczynski, Alfredo Menendez, Marie-France Langlois, Subburaj Ilangumaran, Sheela Ramanathan
OBJECTIVE: IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exercise by skeletal muscle and has been reported to reduce weight gain in mice. Contrarily, our findings on IL-15 knockout (KO) mice indicate that IL-15 promotes obesity. The aim of this study is to investigate the mechanisms underlying the pro-obesity role of IL-15 in adipose tissues. METHODS: Control and IL-15 KO mice were maintained on high fat diet (HFD) or normal control diet...
2016: PloS One
https://www.readbyqxmd.com/read/27683210/a-novel-self-cleavable-tag-zbasic-%C3%A2-i-cm-and-its-application-in-the-soluble-expression-of-recombinant-human-interleukin-15-in-escherichia-coli
#12
Siwei Shi, Huanhuan Chen, Hua Jiang, Yueqing Xie, Lei Zhang, Ninghuan Li, Chencen Zhu, Junsheng Chen, Han Luo, Jiaxian Wang, Lei Feng, Huili Lu, Jianwei Zhu
Soluble expression of recombinant therapeutic proteins in Escherichia coli (E. coli) has been a challenging task in biopharmaceutical development. In this study, a novel self-cleavable tag Zbasic-intein has been constructed for the soluble expression and purification of a recombinant cytokine, human interleukin-15 (IL-15). We screened several solubilizing tags fused with the self-cleavable Mycobacterium tuberculosis recA mini-intein ∆I-CM and demonstrated that Zbasic tag can significantly improve the solubility of the product with correspondent to the intein activity...
September 28, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27676149/acute-effect-of-cluster-and-traditional-set-configurations-on-myokines-associated-with-hypertrophy
#13
J M Oliver, S C Jenke, J D Mata, A Kreutzer, M T Jones
This study compared the acute cytokine response, and kinetic and kinematic profile following back squat exercise in resistance-trained men. In a randomized, cross-over design, 10 resistance-trained men (27±4 y, 1.80±0.07 m, 82.8±6.7 kg, 16.3±3.5% fat) performed the back squat exercise using traditional and cluster set configurations. Kinetic and kinematic data were sampled throughout each condition. Venous blood was sampled prior, immediately post, 30 min, 60 min, 24 h, and 48 h post-exercise for plasma interleukin-6 (IL-6) and interleukin-15 (IL-15)...
December 2016: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/27671547/active-immunization-with-human-interleukin-15-induces-neutralizing-antibodies-in-non-human-primates
#14
Yunier Rodríguez-Álvarez, Yanelys Morera-Díaz, Haydee Gerónimo-Pérez, Jorge Castro-Velazco, Rafael Martínez-Castillo, Pedro Puente-Pérez, Vladimir Besada-Pérez, Eugenio Hardy-Rando, Araceli Chico-Capote, Klaudia Martínez-Cordovez, Alicia Santos-Savio
BACKGROUND: Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune and inflammatory diseases such as Rheumatoid Arthritis, psoriasis and ulcerative colitis; thus, inhibition of IL-15-induced signaling could be clinically beneficial in these disorders. Our approach to neutralize IL-15 consisted in active immunization with structurally modified human IL-15 (mhIL-15) with the aim to induce neutralizing antibodies against native IL-15. In the present study, we characterized the antibody response in Macaca fascicularis, non-human primates that were immunized with a vaccine candidate containing mhIL-15 in Aluminum hydroxide (Alum), Montanide and Incomplete Freund's Adjuvant...
September 26, 2016: BMC Immunology
https://www.readbyqxmd.com/read/27648810/interleukin-15-promotes-intestinal-dysbiosis-with-butyrate-deficiency-associated-with-increased-susceptibility-to-colitis
#15
Marlies Meisel, Toufic Mayassi, Hannah Fehlner-Peach, Jason C Koval, Sarah L O'Brien, Reinhard Hinterleitner, Kathryn Lesko, Sangman Kim, Romain Bouziat, Li Chen, Christopher R Weber, Sarkis K Mazmanian, Bana Jabri, Dionysios A Antonopoulos
Dysbiosis resulting in gut-microbiome alterations with reduced butyrate production are thought to disrupt intestinal immune homeostasis and promote complex immune disorders. However, whether and how dysbiosis develops before the onset of overt pathology remains poorly defined. Interleukin-15 (IL-15) is upregulated in distressed tissue and its overexpression is thought to predispose susceptible individuals to and have a role in the pathogenesis of celiac disease and inflammatory bowel disease (IBD). Although the immunological roles of IL-15 have been largely studied, its potential impact on the microbiota remains unexplored...
September 20, 2016: ISME Journal
https://www.readbyqxmd.com/read/27621026/oscillatory-flow-suppression-improves-inflammation-in-chronic-venous-disease
#16
Paolo Zamboni, Paolo Spath, Veronica Tisato, Mirko Tessari, Patrizia Dalla Caneva, Erica Menegatti, Savino Occhionorelli, Sergio Gianesini, Paola Secchiero
BACKGROUND: To assess if suppression of the oscillatory component of reflux may improve the inflammatory phenotype in chronic venous disease (CVD). MATERIALS AND METHODS: From 193 CVD patients, we selected 54 (13 males, 41 females, CEAP C2-4EpAsPr) for a blinded, case-control prospective investigation. All of them underwent echo-color-Doppler assessment of reflux parameters. In the same patients a blood systemic assessment of 19 inflammatory cytokines was obtained...
September 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27615504/interleukin-15-enhances-cytokine-induced-killer-cik-cytotoxic-potential-against-epithelial-cancer-cell-lines-via-an-innate-pathway
#17
Paola Iudicone, Daniela Fioravanti, Elisabetta Cicchetti, Ilaria Grazia Zizzari, Annino Pandolfi, Rita Scocchera, Raffaella Fazzina, Luca Pierelli
CIK cells are a subset of effector lymphocytes endowed with a non-MHC restricted anti-tumor activity making them an appealing and promising cell population for adoptive immunotherapy. CIK are usually generated ex-vivo by initial priming with Interferon-γ (IFN-γ) and monoclonal antibody against CD3 (anti-CD3), followed by culture in medium containing Interleukin-2 (IL-2). Interleukin-15 (IL-15) shares with IL-2 similar biological functions and recently it has been reported to induce CIK with increased anti-leukemic potential...
September 8, 2016: Human Immunology
https://www.readbyqxmd.com/read/27612641/interleukin-15-dependent-t-cell-like-innate-intraepithelial-lymphocytes-develop-in-the-intestine-and-transform-into-lymphomas-in-celiac-disease
#18
Julien Ettersperger, Nicolas Montcuquet, Georgia Malamut, Nicolas Guegan, Silvia Lopez-Lastra, Ségolène Gayraud, Christian Reimann, Elodie Vidal, Nicolas Cagnard, Patrick Villarese, Isabelle Andre-Schmutz, Rita Gomes Domingues, Cristina Godinho-Silva, Henrique Veiga-Fernandes, Ludovic Lhermitte, Vahid Asnafi, Elizabeth Macintyre, Christophe Cellier, Kheira Beldjord, James P Di Santo, Nadine Cerf-Bensussan, Bertrand Meresse
The nature of gut intraepithelial lymphocytes (IELs) lacking antigen receptors remains controversial. Herein we showed that, in humans and in mice, innate intestinal IELs expressing intracellular CD3 (iCD3(+)) differentiate along an Id2 transcription factor (TF)-independent pathway in response to TF NOTCH1, interleukin-15 (IL-15), and Granzyme B signals. In NOTCH1-activated human hematopoietic precursors, IL-15 induced Granzyme B, which cleaved NOTCH1 into a peptide lacking transcriptional activity. As a result, NOTCH1 target genes indispensable for T cell differentiation were silenced and precursors were reprogrammed into innate cells with T cell marks including intracellular CD3 and T cell rearrangements...
September 20, 2016: Immunity
https://www.readbyqxmd.com/read/27608420/il-15-and-rankl-play-a-synergistically-important-role-in-osteoclastogenesis
#19
Iichiro Okabe, Takeshi Kikuchi, Makio Mogi, Hiroaki Takeda, Makoto Aino, Yosuke Kamiya, Takeki Fujimura, Hisashi Goto, Kousuke Okada, Yoshiaki Hasegawa, Toshihide Noguchi, Akio Mitani
Interleukin-15 (IL-15), a cytokine secreted by several cell types, has important physiological roles in the activity, proliferation, and viability of immune cells.It has both chemoattractant and proinflammatory properties, and may promote bone destruction. Aprevious study has shown that IL-15alone exertsno effect on osteoclastogenesis. Therefore,thecurrent study addressed the synergistic effect of IL-15 on osteoclast formation using RAW264.7(RAW) cellsby co-stimulation with receptor activator of nuclear factor (NF)-κB ligand (RANKL)that has a majorrole inosteoclastogenesis involving the pathogenesis of rheumatoid arthritis and periodontal disease...
September 8, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27567226/interleukin-15-as-a-potential-new-target-in-sj%C3%A3-gren-s-syndrome-associated-inflammation
#20
Margherita Sisto, Loredana Lorusso, Sabrina Lisi
IL-15 is a key regulatory cytokine that shares many biological properties with IL-2. Recently, it has been shown that IL-15 could be up-regulated in T cell-mediated inflammatory disorders, such as rheumatoid arthritis and inflammatory bowel diseases. However, the role and expression of IL-15 in the inflammatory autoimmune disease Sjögren's syndrome (SS) has not been investigated. In the present study we evaluated the expression of IL-15 mRNA and protein in minor salivary gland (MSG) biopsy specimens and in human salivary gland epithelial cell (SGEC) cultures obtained from patients with primary SS (pSS) and compared their expression with that seen in normal healthy control subjects...
October 2016: Pathology
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