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Nicholas A Swanson, Gino Cingolani
In this issue of Structure, Dunne et al. (2018) unveil the architecture of Salmonella phage S16 adhesin. The structure unravels a beads-on-a-string topology consisting of three domains of which the C-terminal glycine-rich PGII domain, located at the distal tip of the long tail fiber, mediates cell surface attachment and host recognition.
December 4, 2018: Structure
Turgay Saritas, Victor G Puelles, Xiao-Tong Su, James A McCormick, Paul A Welling, David H Ellison
Distal nephron remodeling contributes to the pathophysiology of many clinically relevant scenarios, including diuretic resistance and certain Mendelian disorders of blood pressure. However, constitutive genetic disruptions are likely to have substantial developmental effects in this segment, and whether tubule remodeling upon physiological stimuli is a normal homeostatic mechanism is not known. Since the distal nephron acts as a potassium sensor, we assessed proliferation and tubule length in three dimensions upon dietary or inducible genetic manipulation by using optical clearing of adult mouse kidneys, whole-mount immunolabeling, and advanced light microscopy...
December 4, 2018: Cell Reports
Paul T Ogink, Frederik R Teunissen, Julie R Massier, Kevin A Raskin, Joseph H Schwab, Santiago A Lozano-Calderon
BACKGROUND AND OBJECTIVES: Allograft reconstruction of the humerus after resection is preferred by many because of bone stock restoration and biologic attachment of ligaments and muscles to the allograft, theoretically obtaining superior stability and functionality. Our aim was to assess the prevalence of complications and the incidence and etiology for revision surgery in humeral allograft reconstructions. METHODS: We included patients 18 years and older who underwent wide resection and allograft reconstruction of the humerus for primary and metastatic lesions at our institution between 1990 and 2013...
December 5, 2018: Journal of Surgical Oncology
Kiyoko Taniai, Toru Arakawa, Taro Maeda
Traumatic insemination (TI) is an extraordinary style of mating behavior wherein the female integument is pierced by the male extragenital structure to transfer the spermatozoa into the female's body through wounding. Flower bugs of the genus Orius belong to the family Anthocoridae (Heteroptera), which is referred to as the "TI family". Males possess sharp shaped extragenitalia, and females receive the extragenitalia using the copulatory tubes, which are specialized extragenital structures in Orius species...
2018: PloS One
Erich Michel, Oliver Zerbe, Andreas Plückthun
Designed armadillo repeat proteins (dArmRPs) are modular peptide binders composed of N- and C-terminal capping repeats Y and A and a variable number of internal modules M that each specifically recognize two amino acids of the target peptide. Complementary fragments of dArmRPs obtained by splitting the protein between helices H1 and H2 of an internal module show conditional and specific assembly only in presence of a target peptide (Michel et al., 2018). Here, we investigate dArmRP fragments that already spontaneously assemble with high affinity, e...
December 1, 2018: Biological Chemistry
Jacquie Baker, Kurt Kimpinski
BACKGROUND: In evaluating autonomic dysfunction, the autonomic reflex screen (ARS) is an established set of standardized tests to evaluate the presence and severity of autonomic dysfunction. Our laboratory previously reported normative data on 121 healthy individuals; however, the sample size in older individuals was reduced compared to other age groups. Therefore, the objective of the current study was to provide updated normative values representative of young, middle aged and older individuals from Southwestern Ontario...
December 5, 2018: Canadian Journal of Physiology and Pharmacology
Makoto Taguchi, Kenji Yoshida, Motohiko Sugi, Hidefumi Kinoshita, Tadashi Matsuda
PURPOSE: To investigate a method to determine the appropriate length of ureteral stents, given that the stent length may lead to exacerbation of urinary symptoms if the stent crosses the bladder midline. MATERIALS AND METHODS: We retrospectively reviewed the position of the distal curl of the ureteral stent using kidney/ureter/bladder (KUB) radiographs after ureteroscopic lithotripsy in 165 patients who underwent placement of 24- or 26-cm ureteral stents. According to the KUB findings, we categorized the position of the distal curl of the ureteral stent into two groups...
November 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Satoru Kikuchi, Shinji Kuroda, Masahiko Nishizaki, Takashi Matsusaki, Kazuya Kuwada, Yoshikazu Kimura, Shunsuke Kagawa, Hiroshi Morimatsu, Toshiyoshi Fujiwara
PURPOSE: Epidural analgesia (EDA) is an imperative modality for postoperative pain relief after major open abdominal surgery. However, whether EDA has benefits in laparoscopic surgery has not been clear. In this study, the effects of EDA and patient-controlled intravenous analgesia (PCIA) after laparoscopic distal gastrectomy (LDG) were compared. METHODS: This was a retrospective study that included 82 patients undergoing LDG for gastric cancer. Patients received either EDA (n=67) or PCIA (n=15) for postoperative pain relief...
December 3, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Rueben Ganeshalingam, Paul Roach, Geoffrey Paul Schembri
Two patients with diffuse large B-cell lymphoma relapsing as neurolymphomatosis diagnosed on FDG PET/CT are presented. Both patients were treated initially with chemotherapy and had a complete metabolic response. Patient 1 represented with lower-limb pain. An FDG PET/CT demonstrated intense uptake throughout the sciatic nerves bilaterally extending distally with relapse confirmed on biopsy. Patient 2 represented to hospital with worsening mobility, neuropathic pain, and facial asymmetry. An FDG PET/CT demonstrated relapse within the spinal cord, left sciatic nerve, and facial nerve branches...
December 3, 2018: Clinical Nuclear Medicine
Marc-Antoine Hubaut, Alice Jaillard, Capucine Eloy, Gregory Petyt
We report the case of a 31-year-old woman with left foot bones located epithelioid hemangioendothelioma. It is a rare type of vascular tumor, locally aggressive with metastatic potential. It was revealed by a chronic isolated left foot pain. Conventional imaging showed multiple osteolytic lesions of the bones, appearing aggressive. Both bone scintigraphy and F-FDG PET showed an increased uptake of these lesions and confirmed the limited extent to distal extremity of the left lower limb. Final diagnosis was given on a surgical biopsy...
December 3, 2018: Clinical Nuclear Medicine
Christopher P Beauchamp
No abstract text is available yet for this article.
November 27, 2018: Clinical Orthopaedics and related Research
Christopher J Dy, Alison L Antes, Daniel A Osei, Charles A Goldfarb, James M DuBois
BACKGROUND: Overlapping surgery is attracting increased scrutiny. The American College of Surgeons states that the attending surgeon must be present for all critical portions of a surgical procedure; however, critical portions of surgical procedures are not defined. We hypothesized that a Delphi panel process would measure consensus on critical portions of 3 common hand surgical procedures. METHODS: We used a Delphi process to achieve consensus on the critical portions of carpal tunnel release, ulnar nerve transposition, and open reduction and internal fixation of the distal part of the radius...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
Yakup Balaban, Ali Hıdır Kayışoğlu, Altuğ Tokatlı, Aykut Tantan
Presently described is a case with a twisted catheter in the radial artery during coronary angiography and was removed after stretching it with an external needle tip inserted into the brachial artery. A 77-year-old male patient had undergone coronary artery bypass surgery 10 years earlier and implantation of a permanent pacemaker 2 years prior. He had presented with typical angina and a regional wall motion defect had been observed on echocardiography. Coronary angiography was scheduled. A 5-F sheath (Terumo Corp...
December 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Hyo-Jin Park, Sung-Hwan Choi, Yoon Jeong Choi, Young-Bum Park, Kwang-Mahn Kim, Hyung-Seog Yu
OBJECTIVES: To determine whether the success rate and primary stability of surface-treated miniscrews differ from those of nontreated miniscrews. MATERIALS AND METHODS: Patients who required one or more miniscrews for the same reason in each quadrant were recruited into a single-blinded, split-mouth, randomized, controlled trial with a 1:1 allocation ratio. Self-drilling miniscrews with two surface types were used: those with no surface treatment, and those with an acid-etched surface treatment...
December 5, 2018: Angle Orthodontist
Kinan G Zeno, Samah J El-Mohtar, Samir Mustapha, Joseph G Ghafari
OBJECTIVE: To evaluate stresses on maxillary teeth during alignment of a palatally impacted canine (PIC) under different loading conditions with forces applied in vertical and buccal directions. MATERIALS AND METHODS: A three-dimensional finite element model of the maxilla was developed from a cone beam computed tomographic scan of a patient with a left PIC. Traction was simulated under different setups: (1) palatal spring extending from a transpalatal bar (TPB) anchored on the first molars (M1) and alternatively combined with different archwires (0...
December 5, 2018: Angle Orthodontist
Mats Hall, Jörgen Wenner, Peter Scherman, Stefan Öberg
OBJECTIVE: Studies of the etiology of intestinal metaplasia (IM) at a normal appearing gastroesophageal junction (GEJ) are conflicting as associations with both H. Pylori (HP) infection and gastroesophageal reflux has been reported. The aim of this study was to investigate whether IM at the GEJ is associated with gastroesophageal reflux or HP infection. MATERIAL AND METHODS: Fifty asymptomatic volunteers and 149 patients with reflux symptoms underwent endoscopy with biopsies obtained from the gastric antrum and the squamocolumnar junction (SCJ)...
December 5, 2018: Scandinavian Journal of Gastroenterology
Nicolas Clementy, Yann Ancedy, Arnaud Bisson, Clémentine Andre, Bertrand Pierre, Laurent Fauchier, Dominique Babuty
INTRODUCTION: Ablation of premature ventricular contractions has emerged as a safe and effective treatment in patients experiencing a high premature ventricular contractions burden. Mapping of premature ventricular contractions origin may sometimes be challenging. We sought to evaluate the accuracy of a new electrophysiological criterion, the Distal-to-Proximal Delay, at localizing the optimal site for ablation of ventricular ectopic foci. METHODS AND RESULTS: Consecutive patients with ablation attempts of symptomatic premature ventricular contractions were included...
December 5, 2018: Journal of Cardiovascular Electrophysiology
Xiaomei Yu, Wenbo He, Jing Xie, Bo He, Da Luo, Xiaoying Wang, Hong Jiang, Zhibing Lu
INTRODUCTION: Our recent study found that selective ablation of the distal part of the ligament of Marshall (LOMLSPV ) could suppress ventricular arrhythmias (VAs) during acute myocardial infarction (AMI). This study was to investigate the possible underlying mechanisms. METHODS: Dogs were randomly subjected into the sham operated group (SO, n=6), AMI group (AMI, n=8) and the group undergoing LOMLSPV ablation ahead of AMI (LOMD+AMI, n=8). Incidence of VAs, serum levels of malondialdehyde (MDA) and superoxide diamutas (SOD), expression of connexin (Cx43), Bcl-2, Bax, Caspase-3, tumor necrosis factor (TNF)-α, IL-6 and high mobility group box (HMGB)1 were compared...
December 5, 2018: Journal of Cardiovascular Electrophysiology
Tzevat Tefik, Salvatore Buttice, Bhaskar Somani, Selçuk Erdem, Tayfun Oktar, Faruk Özcan, Taner Koçak, İsmet Nane, Olivier Traxer
BACKGROUND: Ureteral access sheaths (UASs) are commonly used in retrograde intra-renal surgery (RIRS). Despite their advantages, there is a risk of ureteral trauma during their placement and subsequent stricture following surgery. The aim of this study was to evaluate the UAS force of insertion (FOI) during placement and its impact on ureteral trauma. METHODS: Seven female patients who underwent RIRS for kidney stones were included in the study. A digital force gauge (Chatillon DFX II; Ametek Test and Calibration Instruments, Largo, Florida, USA) was connected to the distal end of the UAS and the UAS FOI was continuously measured during insertion...
November 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Svetlana Filimonova
Silk spinning is widely-spread in trombidiform mites, yet scarse information is available on the morphology of their silk glands. Thus this study describes the fine structure of the prosomal silk glands in a small parasitic mite, Ornithocheyletia sp. (Cheyletidae). These are paired acinous glands incorporated into the podocephalic system, as typical of the order. Combined secretion of the coxal and silk glands is released at the tip of the gnathosoma. Data obtained show Ornithocheyletia silk gland belonging to the class 3 arthropod exocrine gland...
December 5, 2018: Journal of Morphology
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