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Polyhexamethylene biguanide

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https://www.readbyqxmd.com/read/30094541/contact-lens-related-polymicrobial-keratitis-acanthamoeba-spp-genotype-t4-and-candida-albicans
#1
Maria Luiza Carneiro Buchele, Débora Borgert Wopereis, Fabiana Casara, Jefferson Peres de Macedo, Marilise Brittes Rott, Fabíola Branco Filippin Monteiro, Maria Luiza Bazzo, Fernando Dos Reis Spada, Jairo Ivo Dos Santos, Karin Silva Caumo
A 31-year-old female daily user of contact lenses sought medical attention, reporting blurred vision and irritation of the left eye. Slit-lamp examination revealed hyperemia and an irregular corneal epithelium surface, and empirical treatment was started. A corneal scrape was obtained and examined for the presence of fungi, bacteria, and Acanthamoeba spp. The results of the microbial culture revealed growth of Acanthamoeba spp. and Candida albicans. The Acanthamoeba isolate was characterized by cyst morphology as belonging to group II according to Pussard and Pons...
August 10, 2018: Parasitology Research
https://www.readbyqxmd.com/read/30086103/polyhexanide-versus-metronidazole-for-odor-management-in-malignant-fungating-wounds-a-double-blinded-randomized-clinical-trial
#2
Diana Lima Villela-Castro, Vera Lucia Conceição de Gouveia Santos, Kevin Woo
PURPOSE: The aim of this study was to compare the effects of 0.2% polyhexamethylene biguanide (PHMB) to 0.8% metronidazole on malignant wound (MW) odor, health-related quality of life (HRQOL), and pain upon application. DESIGN: A double-blinded, randomized, clinical trial. SUBJECTS AND SETTING: Twenty-four patients with malodorous MWs hospitalized in a referral cancer center in Sao Paulo, Brazil, participated in the trial. METHODS: Participants were randomly allocated to treatment with 0...
August 6, 2018: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/30047541/antimicrobial-effectiveness-of-polyhexamethylene-biguanide-on-enterococcus-faecalis-staphylococcus-epidermidis-and-candida-albicans
#3
Ivana Medvedec Mikić, Livia Cigić, Darko Kero, Danijela Kalibović Govorko, Goranka Prpić Mehičić, Arjana Tambić Andrašević, Paris Simeon
Aim To evaluate the antimicrobial activity of 0.2% polyhexamethilene biguanide (PHMB) in root canal models infected with Enterococcus faecalis, Candida albicans and Staphylococcus epidermidis. PHMB was compared in these tests with 2.5% NaOCl and 0.2% CHX. Methods Prepared models of 50 human root canals (n=50) were immerged in mixed, four- weeks old culture that consisted of E .faecalis, S. epidermidis and C. albicans. Roots were randomly divided into three groups: one with 30 (n=30) and two with 10 (n=10) samples...
August 1, 2018: Medicinski Glasnik
https://www.readbyqxmd.com/read/30013376/effect-of-ethanol-pretreatment-in-acanthamoeba-keratitis-a-long-term-follow-up-study
#4
I-Huang Lin, Sung-Huei Tseng, Fu-Chin Huang, Yi-Hsun Huang
Purpose: The aim of this study was to evaluate the long-term outcomes of ethanol pretreatment in Acanthamoeba keratitis (AK). Patients and methods: This single-center, retrospective, interventional study included 22 patients (24 eyes) who developed AK and underwent ethanol pretreatment between 2009 and 2015. Samples for smears, polymerase chain reaction, and culture for evidence of Acanthamoeba were collected. After ethanol pretreatment, the patients were treated with corneal epithelial debridement, topical 0...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29939885/effect-of-polyhexamethylene-biguanide-solution-on-bacterial-load-and-biofilm-in-venous-leg-ulcers-a-randomized-controlled-trial
#5
Eline Lima Borges, Susiane Sucasas Frison, Kinulpe Honorato-Sampaio, Antônio Carlos Martins Guedes, Vera Lúcia de Araújo Nogueira Lima, Olga Maria Medeiros de Oliveira, Aidê Ferreira Ferraz, Ana Carolina Tyrone
PURPOSE: The purpose of this study was to investigate the effect of polyhexamethylene biguanide (PHMB) solution as a wound cleanser on bacterial load and bacterial biofilm in venous leg ulcers. DESIGN: Randomized controlled trial. SUBJECTS AND SETTING: The target population was adults attending the dermatology outpatient clinic of the Clinical Hospital of the Federal University of Minas Gerais, Brazil. The sample comprised 44 patients with venous leg ulcers recruited over a 6-month period...
June 22, 2018: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29873244/modelling-antisepsis-using-defined-populations-of-facultative-and-anaerobic-wound-pathogens-grown-in-a-basally-perfused-biofilm-model
#6
Angela Oates, Sharon Lindsay, Hitesh Mistry, Fernando Ortega, Andrew J McBain
An in vitro model was developed to assess the effects of topical antimicrobials on taxonomically defined wound biofilms. Biofilms were exposed over seven days to povidone-iodine, silver acetate or polyhexamethylene biguanide (PHMB) at concentrations used in wound dressings. The rank order of tolerance in multi-species biofilms, based on an analysis of the average bacterial counts over time was P. aeruginosa > methicillin-resistant Staphylococcus aureus (MRSA) > B. fragilis > S. pyogenes. The rank order of effectiveness for the antimicrobials in the biofilm model was povidone-iodine > PHMB > silver acetate...
May 2018: Biofouling
https://www.readbyqxmd.com/read/29772696/the-effect-of-negative-pressure-wound-therapy-with-and-without-instillation-on-mature-biofilms-in-vitro
#7
Shamaila Tahir, Matthew Malone, Honghua Hu, Anand Deva, Karen Vickery
BACKGROUND: To investigate the effect of negative pressure wound therapy (NPWT) with and without instillation (NPWTi) on in vitro mature biofilm. METHODS: Mature biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown under shear (130 rpm) on polycarbonate coupons in a CDC biofilm reactor for 3 days. Coupons containing biofilms were placed in a sterile petri dish and sealed using NPWT or NPWTi. Coupons were exposed to treatment for 24 h with NPWT alone or with instillation of: Povidone iodine solution (PVP-I) (10% w / v equivalent to 1% w / v available iodine, BETADINE® , Mundipharma, Singapore), surfactant based antimicrobial solution with polyhexamethylene biguanide (SBPHMB) (Prontosan® , B Braun Medical, Melsungen, Germany), Gentamicin 1 µg/mL (GM) (G1264 Sigma-Aldrich Pty Ltd...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29748803/hexavalent-chromium-removal-from-aqueous-solution-using-functionalized-chitosan-as-a-novel-nano-adsorbent-modeling-and-optimization-kinetic-isotherm-and-thermodynamic-studies-and-toxicity-testing
#8
Hassan Aslani, Tayebeh Ebrahimi Kosari, Simin Naseri, Ramin Nabizadeh, Mohammad Khazaei
Hexavalent chromium is a highly toxic metal that can enter drinking water sources. Chitosan, which contains amino and hydroxyl functional groups, is considered an appropriate candidate to remove heavy metals through absorption. In this study, a novel adsorbent, magnetic nanoparticles of chitosan modified with polyhexamethylene biguanide (Ch-PHMB NPs) was synthesized and was used to successfully remove chromium from aqueous solution. Quadratic models with independent variables including pH, adsorbent dosage, time, and the initial concentration of chromium were proposed through RSM to describe the behavior of both magnetic chitosan (M-Ch) and Ch-PHMB NPs in Cr(VI) removal...
July 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29705891/keratomycosis-due-to-tintelnotia-destructans-refractory-to-common-therapy-treated-successfully-with-systemic-and-local-terbinafine-in-combination-with-polyhexamethylene-biguanide
#9
Wolfgang J Behrens-Baumann, Wolfram Hofmüller, Ina Tammer, Kathrin Tintelnot
PURPOSE: To report on a wearer of rigid gas-permeable contact lenses with a keratomycosis due to Tintelnotia-a new genus of Phaeosphaeriaceae-treated with terbinafine and polyhexamethylene biguanide. METHODS: Chart review of a patient with fungal keratitis treated additionally with systemic and topical terbinafine 0.25% after symptoms increased under conventional antimycotic therapy with voriconazole. Antifungal susceptibility had been tested in vitro. RESULTS: After starting an additional treatment with systemic and topical terbinafine, the severe corneal infection was sufficiently resolved...
April 28, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29682408/stability-of-an-ophthalmic-formulation-of-polyhexamethylene-biguanide-in-gamma-sterilized-and-ethylene-oxide-sterilized-low-density-polyethylene-multidose-eyedroppers
#10
Yassine Bouattour, Philip Chennell, Mathieu Wasiak, Mireille Jouannet, Valérie Sautou
Background: Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack of validated PHMB stability data severely limits their conservation by imposing short expiration dates after preparation. In this study we aim to assess the physicochemical and microbiological stability of a 0.2 mg/mL PHMB eye drop formulation stored in two kinds of polyethylene bottles at two different temperatures...
2018: PeerJ
https://www.readbyqxmd.com/read/29666023/the-influence-of-lens-care-systems-on-eyelid-tissue-changes-during-silicone-hydrogel-contact-lens-wear
#11
Michel Guillon, Cécile Maissa, Stéphanie Wong, Trisha Patel, Renée Garofalo
PURPOSE: To compare the effects of a hydrogen peroxide (H2 O2 )-based lens care solution and a polyhexamethylene biguanide (PHMB) multi-purpose solution on the eyelids when used with silicone hydrogel (SiHy) contact lenses. METHODS: A total of 74 symptomatic wearers of ACUVUE® OASYS® (senofilcon A; n = 39) or PureVision® (balafilcon A; n = 35) contact lenses were randomised 1:1 to either CLEAR CARE® Cleaning & Disinfecting Solution or renu® fresh™ multi-purpose solution (n = 37 each)...
April 14, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29584602/effect-of-a-new-purified-collagen-matrix-with-polyhexamethylene-biguanide-on-recalcitrant-wounds-of-various-etiologies-a-case-series
#12
Dimitrios Lintzeris, Karen Vernon, Heather Percise, Andy Strickland, Kari Yarrow, Amber White, Mary Gurganus, Susan Sherrod, Kathleen Vergin, Laura Johnson
INTRODUCTION: The management of chronic, nonhealing wounds in patients with multiple comorbidities continues to be a challenge for health care practitioners. Chronic wounds typically do not progress through the normal phases of wound healing and generally remain stagnant during the inflammatory phase, resulting in an increase in proteolytic enzymes with degradation of the extracellular matrix. Bacterial biofilm has been documented to be one of the main factors delaying wound healing, resulting in the prolongation of the inflammatory phase...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29580956/the-use-of-miltefosine-in-the-management-of-refractory-acanthamoeba-keratitis
#13
Shokufeh Tavassoli, Miranda Buckle, Derek Tole, Peter Chiodini, Kieren Darcy
Acanthamoeba keratitis (AK) is a sight threatening infection most commonly affecting contact lens wearers. The authors report a case of intractable A.polyphaga and A.castellanii, with extensive intraocular spread, managed using oral miltefosine. A 59-year old male contact lens wearer was referred to the tertiary corneal service at Bristol Eye Hospital. Vision was hand movements on the left and 6/6 on the right. Clinical examination was consistent with left AK (confirmed by corneal scrape). Management included biguanide (polyhexamethylene biguanide (PHMB) 0...
March 23, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29528760/the-effect-of-antiamoebic-agents-on-viability-proliferation-and-migration-of-human-epithelial-cells-keratocytes-and-endothelial-cells-in-vitro
#14
Lei Shi, Tanja Stachon, Berthold Seitz, Stefan Wagenpfeil, Achim Langenbucher, Nóra Szentmáry
PURPOSE: To analyze the effect of diamidines (hexamidine-diisethionat (HD), propamidin-isethionate (PD), dibromopropamidine-diisethionat (DD)), and biguanides (polyhexamethylen biguanid (PHMB), chlorhexidine (CH)) on human corneal epithelial cell, keratocyte and endothelial cell viability, proliferation, and migration, in vitro. METHODS: For epithelial and endothelial cells a human cell line and for keratocytes primary cultures were used (n = 6 each). We used 3...
June 2018: Current Eye Research
https://www.readbyqxmd.com/read/29509112/effectiveness-of-a-non-medicated-wound-dressing-on-attached-and-biofilm-encased-bacteria-laboratory-and-clinical-evidence
#15
Mark G Rippon, Alan A Rogers, Laura Sellars, Kathryn M Styles, Samantha Westgate
OBJECTIVE: The objective of this study was to evaluate the ability of a non medicated, hydro-responsive wound dressing (HRWD) to effectively aid in the removal of bacteria known to reside (and cause infections) within the wound environment. METHOD: A series of in vitro studies were undertaken using Staphylococcus aureus and Pseudomonas aeruginosa biofilms to evaluate the capabilities of the HRWD to disrupt and disperse biofilms. RESULTS: Biofilms can be broken up and dispersed by HRWD and both Staphylococcus aureus and Pseudomonas aeruginosa numbers can be reduced by a greater than log2 reduction in the presence of HRWD...
March 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29363857/influence-of-human-acute-wound-fluid-on-the-antibacterial-efficacy-of-different-antiseptic-polyurethane-foam-dressings-an-in-vitro-analysis
#16
Julian-Dario Rembe, Carolin Fromm-Dornieden, Julia Böhm, Ewa K Stuermer
Treating infected acute and/or chronic wounds still represents a major challenge in medical care. Various interactions of antiseptic dressings with wound environments regarding antimicrobial efficacy remain unclear. Therefore, this work aimed to investigate the influence of human acute wound fluid (AWF) on the antimicrobial performance of different antiseptic foam dressings in vitro against typical bacterial wound pathogens. Eight antiseptic polyurethane foam dressings containing either a silver formulation or a polyhexamethylene-biguanide (PHMB) were assessed regarding their antimicrobial potency against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa using a modified time-kill assay based on ISO EN 20743...
January 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29350654/autolytic-debridement-and-management-of-bacterial-load-with-an-occlusive-hydroactive-deressing-impregnated-with-polyhexamethylene-biguanide
#17
Stefano Mancini, Roberto Cuomo, Mauro Poggialini, Carlo D'Aniello, Giuseppe Botta
BACKGROUND: Debridement and control of bacterial load are key-points of wound care. The aim of this study is to evaluate the effectiveness of autolytic debridement and management of bacterial load (bioburden) of an occlusive hydro-active dressing impregnated with polyhexamethylene biguanide (PHMB). METHODS: We used an occlusive dressing of hydro-active for leg ulcers' treatment (TenderWet-plus® - Hartmann).  Inclusion criteria were: presence of a fibrinous ulcer with multiple etiopathogenesis, in absence of clinical infection, no hypersecretion and diameter within 5 cm...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29332157/acanthamoeba-keratitis-in-porto-alegre-southern-brazil-28-cases-and-risk-factors
#18
Denise Leal Dos Santos, Sergio Kwitko, Diane Ruschel Marinho, Bruno Schneider de Araújo, Claudete Inês Locatelli, Marilise Brittes Rott
The increasing use of contact lenses worldwide has led to an increase in cases of Acanthamoeba keratitis, which are often associated with inappropriate cleaning of contact lenses and lens cases. This study aimed to retrospectively review 28 cases of Acanthamoeba keratitis in Porto Alegre (southern Brazil) and identify the risk factors and clinical outcomes of affected patients. Most patients had higher education (66.6%), all were users of contact lenses, mostly women (67.9%). Most patients were soft contact lens wearers (66...
March 2018: Parasitology Research
https://www.readbyqxmd.com/read/29305328/effect-of-polyhexamethylene-biguanide-on-rat-liver
#19
Aparajita Chowdhury, Lora L Arnold, Zemin Wang, Karen L Pennington, Puttappa Dodmane, Ana Paula Farragut-Cardoso, James E Klaunig, Daniel Cros, Edmond E Creppy, Samuel M Cohen
Polyhexamethylene biguanide (PHMB), an amphiphilic polymeric biocide, increased liver tumor incidence in male and female rats at 1000 and 1500 mg/L in drinking water, but not at 500 mg/L in previous studies. In another study, PHMB administered in diet at 4000 mg/kg was negative for hepatocellular tumors. The present studies evaluated bioavailability and distribution of PHMB administered in drinking water and diet and possible modes of action (MOA). PHMB in drinking water was unpalatable during the first 3 days, resulting in markedly decreased food consumption and decreased body weight...
March 15, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29279804/a-comparison-of-the-effects-of-topical-prolavacid-solution-a-polyhexamethylene-biguanide-based-wound-cleanser-and-medihoney-ointment-in-a-rat-model-of-cutaneous-wound
#20
Shahram Paydar, Bijan Ziaeian, Amirreza Dehghanian, Mohsen Heidarpour, Roshanak Alavi Moghadam, Behnam Dalfardi, Abbas Hallaj Karladani
Objective: This experimental work examined the healing effect and probable adverse impact of topical Prolavacid® solution (a polyhexamethylene biguanide-based wound cleanser) and topical Medihoney ointment in an animal model of cutaneous wound. Approach: We randomly divided 22 adult Sprague-Dawley rats (all were male) in two groups ( n  = 11): (1) those for which Prolavacid solution was poured on the skin wound surface; and (2) those animals for which Medihoney® ointment was applied to the wounds. These two agents were applied daily throughout the study period (21 days)...
December 1, 2017: Advances in Wound Care
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