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Polyhexamethylene biguanide

Amanda de Oliveira Melo, Daniela Braz Dos Santos, Luciana Damacena Silva, Thiago Lopes Rocha, José Clecildo Barreto Bezerra
Schistosomiasis is a disease that affects tropical and subtropical areas and is considered the second most prevalent parasitic disease in the world. One of the ways of combating this disease is the use of molluscicidal agents to eliminate or reduce the population of intermediate host snails. Polyhexamethylene biguanide hydrochloride (PHMB) is a chemical biocide commonly used as a disinfectant and antiseptic in the food industry and very successfully for the disinfection of swimming pools. The US Environmental Protection Agency (USEPA) indicated the PHMB as low environmental risk...
February 2019: Chemosphere
Mark G Rippon, Alan A Rogers, Laura Sellars, Liam E J Purcell, Samantha Westgate
OBJECTIVE: The aim of this in vitro study was to investigate the transfer of viable Pseudomonas aeruginosa biofilm microorganisms following treatment with debridement tools. METHOD: The level of viable biofilm microorganisms transferred by debridement tools was compared following treatment that reflected the clinical practice of each product. RESULTS: A significant level of microorganism transfer was seen in response to the mechanical debridement tool...
October 2, 2018: Journal of Wound Care
Ojan Assadian, Gerhard Kammerlander, Claudia Geyrhofer, Gerlinde Luch, Stefan Doppler, Felix Tuchmann, Thomas Eberlein, David Leaper
OBJECTIVE: The influence of different irrigation solutions, in conjunction with wet-to-moist cleansing, on the reduction of sessile, non-planktonic bacteria which colonise wounds, has not been investigated. In this study, the antibacterial effect of different irrigation solutions, during a 20-minute wet-to-moist cleansing, has been evaluated in chronic wounds. METHODS: This study was designed as a prospective cohort study with 12 study arms and was conducted between June 2011 and April 2016...
October 1, 2018: Journal of Wound Care
Abhiram Arunkumar, Mark R Etzel
Fractionation of the bovine glycomacropeptide (GMP) from the other proteins in cheese whey was examined using ultrafiltration membranes surface modified to contain positively charged polymer brushes made of polyhexamethylene biguanide. By placing a strong positive charge on a 1000 kDa ultrafiltration membrane and adjusting the pH of whey close to the isoelectric point of GMP, a 14-fold increase in selectivity was observed compared to unmodified membranes. A one stage membrane system gave 90% pure GMP and a three-stage rectification system gave 97% pure GMP...
October 9, 2018: Foods (Basel, Switzerland)
Supamas Napavichayanun, Sumate Ampawong, Tavornchai Harnsilpong, Apichai Angspatt, Pornanong Aramwit
Bacterial cellulose wound dressings containing silk sericin and PHMB (BCSP) were developed in our previous studies. It had good physical properties, efficacy, and safety. For further use as a medical material, this dressing was investigated for its efficacy and safety in split-thickness skin graft (STSG) donor-site wound treatment compared to Bactigras® (control). Moreover, the inflammatory responses to both dressings were also deeply investigated. For in vivo study, expressions of anti-inflammatory cytokines were intensely considered in the tissue interfacing area...
October 9, 2018: Archives of Dermatological Research
Cecilia Zorzi Bueno, Ângela Maria Moraes
This work is a continuation of a previous study which described the development of dense and porous chitosan-alginate polyelectrolyte complexes through the addition of different amounts of Pluronic F68 to the polymeric mixture. The present study consisted in the incorporation of an antimicrobial agent, polyhexamethylene biguanide (PHMB), to the previously developed system. PHMB was incorporated at 1 and 10% (w/w) with high incorporation efficiencies, varying from 72 to 86%. Release profiles in phosphate buffered saline were evaluated using the Korsmeyer-Peppas equation, which suggested a quasi-Fickian diffusion mechanism for all obtained formulations...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Masashi Yamamoto, Reiko Matsumura, Yoshihiko Hirata, Hideaki Nagamune
New bis-quaternary ammonium compounds (bis-QACs) 3-(3-hydroxy-2-(hydroxymethyl)-2-{[(1-dodecylpyridinium-3-yl)oxy]methyl}propoxy)-1-dodecylpyridinium dibromide (3HHDMP-12) and 3,3'-[1,4-phenylenebis(oxy)]bis(1-dodecylpyridinium) dibromide (3PHBO-12) were compared with commonly-used antiseptics such as benzalkonium chloride (BAC), octenidine dihydrochloride (OCT), chlorhexidine digluconate (CHG) and polyhexamethylene biguanide (PHMB), to evaluate their potential to cause skin irritation. The cytotoxicity of these compounds in various cultured cells, as well as their effect on the expression of inflammatory cytokine genes such as IL-1α were evaluated...
September 18, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Rohan Bir Singh, Priti Batta
A 36-year-old male, soft contact lens wearer was referred by his primary ophthalmologist for corneal ulcer of the right eye (OD), which was persistent despite topical fluoroquinolone therapy for 1 month. A ring-shaped infiltrate typically seen in Acanthamoeba infection was noted, and topical therapy with chlorhexidine and polyhexamethylene biguanide was initiated. However, the patient's condition deteriorated over the next several weeks; thus, diagnostic and therapeutic penetrating keratoplasty was performed...
September 19, 2018: BMJ Case Reports
Mikel Gray
No abstract text is available yet for this article.
September 2018: Journal of Wound, Ostomy, and Continence Nursing
Maria Luiza Carneiro Buchele, Débora Borgert Wopereis, Fabiana Casara, Jefferson Peres de Macedo, Marilise Brittes Rott, Fabíola Branco Filippin Monteiro, Maria Luiza Bazzo, Fernando Dos Reis Spada, Jairo Ivo Dos Santos, Karin Silva Caumo
A 31-year-old female daily user of contact lenses sought medical attention, reporting blurred vision and irritation of the left eye. Slit-lamp examination revealed hyperemia and an irregular corneal epithelium surface, and empirical treatment was started. A corneal scrape was obtained and examined for the presence of fungi, bacteria, and Acanthamoeba spp. The results of the microbial culture revealed growth of Acanthamoeba spp. and Candida albicans. The Acanthamoeba isolate was characterized by cyst morphology as belonging to group II according to Pussard and Pons...
November 2018: Parasitology Research
Diana Lima Villela-Castro, Vera Lucia Conceição de Gouveia Santos, Kevin Woo
PURPOSE: The aim of this study was to compare the effects of 0.2% polyhexamethylene biguanide (PHMB) to 0.8% metronidazole on malignant wound (MW) odor, health-related quality of life (HRQOL), and pain upon application. DESIGN: A double-blinded, randomized, clinical trial. SUBJECTS AND SETTING: Twenty-four patients with malodorous MWs hospitalized in a referral cancer center in Sao Paulo, Brazil, participated in the trial. METHODS: Participants were randomly allocated to treatment with 0...
September 2018: Journal of Wound, Ostomy, and Continence Nursing
Ivana Medvedec Mikić, Livia Cigić, Darko Kero, Danijela Kalibović Govorko, Goranka Prpić Mehičić, Arjana Tambić Andrašević, Paris Simeon
Aim To evaluate the antimicrobial activity of 0.2% polyhexamethilene biguanide (PHMB) in root canal models infected with Enterococcus faecalis, Candida albicans and Staphylococcus epidermidis. PHMB was compared in these tests with 2.5% NaOCl and 0.2% CHX. Methods Prepared models of 50 human root canals (n=50) were immerged in mixed, four- weeks old culture that consisted of E .faecalis, S. epidermidis and C. albicans. Roots were randomly divided into three groups: one with 30 (n=30) and two with 10 (n=10) samples...
August 1, 2018: Medicinski Glasnik
I-Huang Lin, Sung-Huei Tseng, Fu-Chin Huang, Yi-Hsun Huang
Purpose: The aim of this study was to evaluate the long-term outcomes of ethanol pretreatment in Acanthamoeba keratitis (AK). Patients and methods: This single-center, retrospective, interventional study included 22 patients (24 eyes) who developed AK and underwent ethanol pretreatment between 2009 and 2015. Samples for smears, polymerase chain reaction, and culture for evidence of Acanthamoeba were collected. After ethanol pretreatment, the patients were treated with corneal epithelial debridement, topical 0...
2018: Infection and Drug Resistance
Eline Lima Borges, Susiane Sucasas Frison, Kinulpe Honorato-Sampaio, Antônio Carlos Martins Guedes, Vera Lúcia de Araújo Nogueira Lima, Olga Maria Medeiros de Oliveira, Aidê Ferreira Ferraz, Ana Carolina Tyrone
PURPOSE: The purpose of this study was to investigate the effect of polyhexamethylene biguanide (PHMB) solution as a wound cleanser on bacterial load and bacterial biofilm in venous leg ulcers. DESIGN: Randomized controlled trial. SUBJECTS AND SETTING: The target population was adults attending the dermatology outpatient clinic of the Clinical Hospital of the Federal University of Minas Gerais, Brazil. The sample comprised 44 patients with venous leg ulcers recruited over a 6-month period...
September 2018: Journal of Wound, Ostomy, and Continence Nursing
Angela Oates, Sharon Lindsay, Hitesh Mistry, Fernando Ortega, Andrew J McBain
An in vitro model was developed to assess the effects of topical antimicrobials on taxonomically defined wound biofilms. Biofilms were exposed over seven days to povidone-iodine, silver acetate or polyhexamethylene biguanide (PHMB) at concentrations used in wound dressings. The rank order of tolerance in multi-species biofilms, based on an analysis of the average bacterial counts over time was P. aeruginosa > methicillin-resistant Staphylococcus aureus (MRSA) > B. fragilis > S. pyogenes. The rank order of effectiveness for the antimicrobials in the biofilm model was povidone-iodine > PHMB > silver acetate...
May 2018: Biofouling
Shamaila Tahir, Matthew Malone, Honghua Hu, Anand Deva, Karen Vickery
BACKGROUND: To investigate the effect of negative pressure wound therapy (NPWT) with and without instillation (NPWTi) on in vitro mature biofilm. METHODS: Mature biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown under shear (130 rpm) on polycarbonate coupons in a CDC biofilm reactor for 3 days. Coupons containing biofilms were placed in a sterile petri dish and sealed using NPWT or NPWTi. Coupons were exposed to treatment for 24 h with NPWT alone or with instillation of: Povidone iodine solution (PVP-I) (10% w / v equivalent to 1% w / v available iodine, BETADINE® , Mundipharma, Singapore), surfactant based antimicrobial solution with polyhexamethylene biguanide (SBPHMB) (Prontosan® , B Braun Medical, Melsungen, Germany), Gentamicin 1 µg/mL (GM) (G1264 Sigma-Aldrich Pty Ltd...
May 16, 2018: Materials
Hassan Aslani, Tayebeh Ebrahimi Kosari, Simin Naseri, Ramin Nabizadeh, Mohammad Khazaei
Hexavalent chromium is a highly toxic metal that can enter drinking water sources. Chitosan, which contains amino and hydroxyl functional groups, is considered an appropriate candidate to remove heavy metals through absorption. In this study, a novel adsorbent, magnetic nanoparticles of chitosan modified with polyhexamethylene biguanide (Ch-PHMB NPs) was synthesized and was used to successfully remove chromium from aqueous solution. Quadratic models with independent variables including pH, adsorbent dosage, time, and the initial concentration of chromium were proposed through RSM to describe the behavior of both magnetic chitosan (M-Ch) and Ch-PHMB NPs in Cr(VI) removal...
July 2018: Environmental Science and Pollution Research International
Wolfgang J Behrens-Baumann, Wolfram Hofmüller, Ina Tammer, Kathrin Tintelnot
PURPOSE: To report on a wearer of rigid gas-permeable contact lenses with a keratomycosis due to Tintelnotia-a new genus of Phaeosphaeriaceae-treated with terbinafine and polyhexamethylene biguanide. METHODS: Chart review of a patient with fungal keratitis treated additionally with systemic and topical terbinafine 0.25% after symptoms increased under conventional antimycotic therapy with voriconazole. Antifungal susceptibility had been tested in vitro. RESULTS: After starting an additional treatment with systemic and topical terbinafine, the severe corneal infection was sufficiently resolved...
April 28, 2018: International Ophthalmology
Yassine Bouattour, Philip Chennell, Mathieu Wasiak, Mireille Jouannet, Valérie Sautou
Background: Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack of validated PHMB stability data severely limits their conservation by imposing short expiration dates after preparation. In this study we aim to assess the physicochemical and microbiological stability of a 0.2 mg/mL PHMB eye drop formulation stored in two kinds of polyethylene bottles at two different temperatures...
2018: PeerJ
Michel Guillon, Cécile Maissa, Stéphanie Wong, Trisha Patel, Renée Garofalo
PURPOSE: To compare the effects of a hydrogen peroxide (H2 O2 )-based lens care solution and a polyhexamethylene biguanide (PHMB) multi-purpose solution on the eyelids when used with silicone hydrogel (SiHy) contact lenses. METHODS: A total of 74 symptomatic wearers of ACUVUE® OASYS® (senofilcon A; n = 39) or PureVision® (balafilcon A; n = 35) contact lenses were randomised 1:1 to either CLEAR CARE® Cleaning & Disinfecting Solution or renu® fresh™ multi-purpose solution (n = 37 each)...
April 14, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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