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Asprosin

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https://www.readbyqxmd.com/read/30037606/asprosin-possible-target-in-connection-with-ghrelin-and-cytokine-network-expression-in-the-post-burn-treatment
#1
Mustafa Metin Donma, Orkide Donma
Burn injury is a severe form of trauma associated with pain, metabolic abnormalities, susceptibility to infections, muscle loss, mental and emotional distress. Conventional therapies as well as some recent approaches for the treatment of burned patients are currently in use. Nutritional therapy is also suggested as a supplementary option in major burns. Within this context, hormones involved in the regulation of appetite will have a paramount importance. The aim is to evaluate the interactions among ghrelin, some inflammatory parameters and the burn injury...
September 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29743813/plasma-asprosin-concentrations-are-increased-in-individuals-with-glucose-dysregulation-and-correlated-with-insulin-resistance-and-first-phase-insulin-secretion
#2
Yuren Wang, Hua Qu, Xin Xiong, Yuyang Qiu, Yong Liao, Yingchun Chen, Yi Zheng, Hongting Zheng
Background: Adipokines are reported to participate in many common pathologic processes of glucose dysregulation, such as insulin resistance, β -cell dysfunction, and chronic inflammation. Objective: To detect the concentrations of plasma asprosin in subjects with impaired glucose regulation (IGR) and newly diagnosed type 2 diabetes (nT2DM) and its relationship to parameters of glucose and lipid metabolism, insulin resistance, and pancreatic β -cell function. Methods: 143 eligible participants were included and were divided into three groups including normal glucose regulation (NGR, n = 52), IGR ( n = 40), and nT2DM group ( n = 51)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29615900/peripheral-cb1-receptor-neutral-antagonist-am6545-ameliorates-hypometabolic-obesity-and-improves-adipokine-secretion-in-monosodium-glutamate-induced-obese-mice
#3
Haiming Ma, Guina Zhang, Chunrong Mou, Xiujuan Fu, Yadan Chen
Effect of peripheral cannabinoid receptor 1 (CB1R) blockade by AM6545 in the monosodium glutamate (MSG)-induced hypometabolic and hypothalamic obesity was observed, and the impact on intraperitoneal adipose tissue and adipokines was investigated. The MSG mice is characterized by excessive abdominal obesity, and combined with dyslipidemia and insulin resistance. 3-Week AM6545 treatment dose-dependently decreased the body weight, intraperitoneal fat mass, and rectified the accompanied dyslipidemia include elevated serum triglyceride, total cholesterol, free fatty acids, and lowered LDLc level...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29470967/a-spotlight-on-appetite
#4
Lisa R Beutler, Zachary A Knight
Remarkably few hormones have been identified that stimulate appetite. The recent discovery of asprosin, a hormone that activates AgRP neurons to increase food intake and body weight, begins to fill this gap (Duerrschmid et al., 2017; Romere et al., 2016).
February 21, 2018: Neuron
https://www.readbyqxmd.com/read/29106398/asprosin-is-a-centrally-acting-orexigenic-hormone
#5
Clemens Duerrschmid, Yanlin He, Chunmei Wang, Chia Li, Juan C Bournat, Chase Romere, Pradip K Saha, Mark E Lee, Kevin J Phillips, Mahim Jain, Peilin Jia, Zhongming Zhao, Monica Farias, Qi Wu, Dianna M Milewicz, V Reid Sutton, David D Moore, Nancy F Butte, Michael J Krashes, Yong Xu, Atul R Chopra
Asprosin is a recently discovered fasting-induced hormone that promotes hepatic glucose production. Here we demonstrate that asprosin in the circulation crosses the blood-brain barrier and directly activates orexigenic AgRP+ neurons via a cAMP-dependent pathway. This signaling results in inhibition of downstream anorexigenic proopiomelanocortin (POMC)-positive neurons in a GABA-dependent manner, which then leads to appetite stimulation and a drive to accumulate adiposity and body weight. In humans, a genetic deficiency in asprosin causes a syndrome characterized by low appetite and extreme leanness; this is phenocopied by mice carrying similar mutations and can be fully rescued by asprosin...
December 2017: Nature Medicine
https://www.readbyqxmd.com/read/29104036/circulating-asprosin-concentrations-are-increased-in-type-2-diabetes-mellitus-and-independently-associated-with-fasting-glucose-and-triglyceride
#6
Lei Zhang, Chao Chen, Nan Zhou, Yuming Fu, Xingbo Cheng
BACKGROUND: Asprosin has been identified as a novel hormone enriched in white adipose tissue and is pathologically increased in insulin-resistant mice and humans. However, information regarding the role of asprosin in type 2 diabetes mellitus (T2DM) remains unavailable. Via conducting a hospital-based study, we purposed to ascertain the potential relationship between circulating asprosin concentrations and T2DM. METHODS: The study recruited 84 adults with T2DM and 86 controls with normal glucose tolerance...
November 3, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27125501/liver-asprosin-new-hormone-involved-in-hepatic-glucose-release
#7
COMMENT
Claire Greenhill
No abstract text is available yet for this article.
June 2016: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/27087445/asprosin-a-fasting-induced-glucogenic-protein-hormone
#8
Chase Romere, Clemens Duerrschmid, Juan Bournat, Petra Constable, Mahim Jain, Fan Xia, Pradip K Saha, Maria Del Solar, Bokai Zhu, Brian York, Poonam Sarkar, David A Rendon, M Waleed Gaber, Scott A LeMaire, Joseph S Coselli, Dianna M Milewicz, V Reid Sutton, Nancy F Butte, David D Moore, Atul R Chopra
Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that precisely regulate plasma glucose levels. We have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and we name it Asprosin. Asprosin is secreted by white adipose, circulates at nanomolar levels, and is recruited to the liver, where it activates the G protein-cAMP-PKA pathway, resulting in rapid glucose release into the circulation...
April 21, 2016: Cell
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