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Pediatric encephalitis

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https://www.readbyqxmd.com/read/30095300/two-case-reports-of-neuropsychological-outcomes-following-pediatric-anti-n-methyl-d-aspartate-receptor-autoimmune-encephalitis
#1
Natalia Moss, Christine L Petranovich, Lauren Parks, Andrea Sherwood
Anti-NMDAR autoimmune encephalitis is a rare neurological condition. Limited existing pediatric case studies have shown mild, but persisting, neuropsychological impairments. This report described neuropsychological functioning in two patients treated for anti-NMDAR autoimmune encephalitis. Patient A is a 16-year-old male (10 months after symptom onset) and Patient B is a 5-year-old female (45 months after symptom onset). Contrary to expectations, their cognitive profiles were largely intact, raising the possibility of minimal cognitive implications for some pediatric patients with this condition...
August 10, 2018: Developmental Neuropsychology
https://www.readbyqxmd.com/read/30090761/anti-nmdar-encephalitis-in-a-13-year-old-female-a-24-month-clinical-follow-up
#2
Eunsil Kim, Eu Gene Park, Jiwon Lee, Munhyang Lee, Jihye Kim, Jeehun Lee
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare autoimmune disorder manifesting as seizures, movement disorders, and psychiatric changes. However, there have been few case reports concerning this disorder in South Korean children. The current case report describes a pediatric patient with anti-NMDAR encephalitis. A 13-year-old female patient developed clonic movements of the right arm followed by aphasia, paresthesia, and right-sided hemiparesis. The electroencephalogram (EEG) results indicated electroclinical seizures arising from the left temporal area...
June 2018: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/30067953/high-incidence-of-early-human-herpes-virus-6-infection-in-children-undergoing-haploidentical-manipulated-stem-cell-transplantation-for-haematological-malignancies
#3
Katia Perruccio, Luisa Sisinni, Antonio Perez-Martinez, Jaime Valentin, Ilaria Capolsini, Maria Speranza Massei, Maurizio Caniglia, Simone Cesaro
BACKGROUND: Human herpesvirus (HHV-6) infection is increasingly recognized among allogeneic hematopoietic stem cell transplantation (HSCT) recipients, 30% being the risk of reactivation in the haploidentical setting. It has been associated with encephalitis, acute graft-versus-host disease (GvHD) and graft failure. Here we report two cohorts of pediatric haploidentical manipulated HSCT in which, despite many differences, HHV-6 reactivation and disease occurred with very high incidence compared to data reported in literature, and represented the main early post-transplant infectious complication compared to other viral, bacterial or fungal infections...
July 29, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30063654/epidemiology-of-disease-and-mortality-from-a-picu-in-mozambique
#4
Maria Punchak, Kaitlin Hall, Amir Seni, W Chris Buck, Daniel A DeUgarte, Emily Hartford, Robert B Kelly, Valéria I Muando
OBJECTIVES: Delivery of pediatric critical care in low-income countries is limited by a lack of infrastructure, resources, and providers. Few studies have analyzed the epidemiology of disease associated with a PICU in a low-income country. The aim of this study was to document the primary diagnoses and the associated mortality rates of patients presenting to a tertiary PICU in Mozambique in order to formulate quality improvement projects through an international academic partnership. We hypothesized that the PICU mortality rate would be high and that sepsis would be a common cause of death...
July 30, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/30046856/arterial-spin-labeling-perfusion-imaging-of-childhood-encephalitis-correlation-with-seizure-and-clinical-outcome
#5
Alex Mun-Ching Wong, Chih-Hua Yeh, Jainn-Jim Lin, Ho-Ling Liu, I-Jun Chou, Kuang-Lin Lin, Huei-Shyong Wang
PURPOSE: In childhood encephalitis, perfusion abnormalities have been infrequently reported to associate with clinical status. We investigated whether perfusion abnormalities correlated with seizure and clinical outcome in encephalitis. METHODS: We retrospectively analyzed the MR studies of 77 pediatric patients with encephalitis. Pseudo-continuous arterial spin-labeling (ASL) imaging was performed on a 3-T scanner. The patients were divided into five groups according to ASL perfusion imaging pattern: normal perfusion (NP), focal hypoperfusion (Lf), extreme global hypoperfusion (LE), focal hyperperfusion (Hf), and extreme global hyperperfusion (HE)...
July 25, 2018: Neuroradiology
https://www.readbyqxmd.com/read/30031939/unexpected-high-incidence-of-human-herpesvirus-6-encephalitis-after-naive-t-cell-depleted-graft-of-haploidentical-stem-cell-transplantation-in-pediatric-patients
#6
Sisinni L, M Gasior, R de Paz, S Querol, D Bueno, L Fernández, J Marsal, A Sastre, R Gimeno, L Alonso, I Badell, E López-Granados, J Torres, L Medina, M Torrent, C Diaz de Heredia, A Escudero, A Pérez-Martínez
The CD45RA T cell depletion (TCD) method has been used to deplete naïve T cells, preventing graft-versus-host disease (GvHD) but preserving memory cells, providing immediate functional T cells with anti-infection, anti-leukemia and anti-rejection effects. We describe a series of 25 consecutive high-risk patients with leukemia who received haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with CD45RA TCD. Each patient received two cell products: one created by CD34 positive selection and the other through CD45RA depletion from the CD34 negative fraction by a CliniMACS device...
July 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30014832/hypoglycemic-toxins-and-enteroviruses-as-causes-of-outbreaks-of-acute-encephalitis-like-syndrome-in-children-bac-giang-province-northern-vietnam
#7
Nga Thi Phan, Meriadeg Ar Gouilh, Juliette Paireau, Loan Phuong, Justine Cheval, Nghia Duy Ngu, Charles Hébert, Tuan Hai Nguyen, Olivier Lortholary, Laura Tondeur, Jean-Claude Manuguerra, Robert Barouki, Johannes Sander, Nils Janzen, Hien Tran Nguyen, Paul T Brey, Arnaud Fontanet, Marc Eloit
We investigated the cause of seasonal outbreaks of pediatric acute encephalitis-like syndrome associated with litchi harvests (May-July) in northern Vietnam since 2008. Nineteen cerebrospinal fluid samples were positive for human enterovirus B, and 8 blood samples were positive for hypoglycemic toxins present in litchi fruits. Patients who were positive for hypoglycemic toxins had shorter median times between disease onset and admission, more reports of seizures, more reports of hypoglycemia (glucose level <3 mmol/L), lower median numbers of leukocytes in cerebrospinal fluid, and higher median serum levels of alanine aminotransferase and aspartate transaminase than did patients who were positive for enteroviruses...
August 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29979382/analysis-and-discussion-of-the-rare-complication-of-autoimmune-encephalitis-two-case-reports
#8
Rong Li, Li Jiang, Xiu-Juan Li, Si-Qi Hong, Min Zhong, Yue Hu
RATIONALE: Autoimmune encephalitis related to many antibodies against neuronal cell surface or synaptic proteins, it is increasingly recognized as the cause of a variety of neuropsychiatric syndromes. PATIENT CONCERNS: The two pediatric cases were about autoimmune encephalitis with rare complication. One patient was a 11-year-old girl and was diagnosed with Voltage-Gated Potassium Channel complex (VGKC) antibody-mediated encephalitis with rhabdomyolysis; the other was also a 11-year-old girl and was diagnosed with anti- N-methyl-D-aspartate receptor (NMDAR) encephalitis...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29910555/adult-influenza-a-h1n1-related-encephalitis-a-case-report
#9
Devinder Midha, Arun Kumar, Pratibha Vasudev, Zafar Ahmad Iqbal, Amit Kumar Mandal
The year 2009-2010 saw H1N1 influenza outbreaks occurring in almost all countries of the world, causing the WHO to declare it a pandemic of an alert level of 6. In India, H1N1 influenza outbreaks were again reported in late 2014 and early 2015. Since then, sporadic cases of H1N1 influenza have been reported. H1N1 influenza usually presents itself with respiratory tract symptoms. In a minority of patients, abdominal symptoms may occur as well. Acute influenza-associated encephalopathy/encephalitis mostly occurs in the pediatric population, whereas in adults, it is a rare complication...
May 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29899790/pediatric-n-methyl-d-aspartate-receptor-autoimmune-encephalitis
#10
N A Uvais
No abstract text is available yet for this article.
January 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29891405/long-term-outcomes-in-motor-and-cognitive-impairment-with-acute-encephalopathy
#11
Yuri Matsubara, Hitoshi Osaka, Takanori Yamagata, Ryusuke Ae, Jun Shimizu, Noriko Oguro
BACKGROUND: Acute encephalopathy causes various sequelae, including motor disabilities and intellectual delays. Previous studies reported that cognitive impairments can also occur after acute encephalitis. Although the incidence of acute encephalopathy is high in Japan, there have been few reports on its sequelae. OBJECTIVE: To characterize the neurological outcomes of pediatric patients who sought motor rehabilitation for motor dysfunction after acute encephalopathy...
June 8, 2018: Brain & Development
https://www.readbyqxmd.com/read/29891404/influenza-associated-neurological-complications-during-2014-2017-in-taiwan
#12
Li-Wen Chen, Chao-Ku Teng, Yi-Shan Tsai, Jieh-Neng Wang, Yi-Fang Tu, Ching-Fen Shen, Ching-Chuan Liu
INTRODUCTION: Seasonal influenza-associated neurological complications had high mortality and morbidity rates in recent studies. We reported influenza-associated encephalitis/encephalopathy in children during 2014-2017 in Taiwan, focusing on neurological presentations, neuroimaging correlations, and critical care managements. MATERIALS/SUBJECTS: During January 1st 2014 to June 30th 2017, pediatric patients reported to the Taiwan Centers for Disease Control surveillance system for severe complicated influenza infections in the hospital were retrospectively reviewed...
June 8, 2018: Brain & Development
https://www.readbyqxmd.com/read/29882008/overview-of-therapeutic-plasma-exchange-in-pediatric-neurology-a-single-center-experience
#13
Murat Özkale, Ilknur Erol, Yasemin Özkale, İlknur Kozanoğlu
Therapeutic plasma exchange (TPE) is used in the treatment of neurological, hematological, renal and autoimmune diseases with known or suspected immune pathogenesis. In comparison with neurological diseases of adults, knowledge about the use of TPE in children is incomplete. We report our experience on TPE in children with neurological diseases in a single institution and describe the underlying etiology, clinical course, treatment and outcome. We retrospectively evaluated 22 consecutive children (12 girls, 10 boys, aged 2-16 years) who underwent TPE in the pediatric intensive care unit between January 2010 and January 2017...
June 7, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29871023/effectiveness-of-homeopathic-medicines-as-add-on-to-institutional-management-protocol-for-acute-encephalitis-syndrome-in-children-an-open-label-randomized-placebo-controlled-trial
#14
Praveen Oberai, Roja Varanasi, Maya Padmanabhan, Alok Upadhyaya, Supriya Singh, Samarendra Pratap Singh, Deepika Vikram, Tariq Khan, Ramesh Prasad, A K Gupta, J R Singh, Raj K Manchanda
BACKGROUND:  Acute encephalitis syndrome (AES) is endemic to certain parts of India, with limited treatment options. In our initial exploratory comparative observational study of 151 patients with AES, there was significantly reduced mortality with adjunctive homeopathy compared to institutional management protocol (IMP). The present randomized placebo-controlled trial brings more statistical rigor to this research program. METHODS:  This study was conducted at a pediatric unit from 2013 to 2015...
June 5, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29780690/an-update-on-the-treatment-of-pediatric-autoimmune-encephalitis
#15
Cory Stingl, Kathleen Cardinale, Heather Van Mater
Purpose of review: Autoimmune encephalitis (AE) is an increasingly recognized etiology for neuropsychiatric deficits that are highly responsive to immunotherapy. As a result, rheumatologists are often called upon to help with the diagnosis and treatment of these conditions. The purpose of this review is to provide an update on the pharmacologic treatment of AE. Recent findings: To date, there are no prospective randomized placebo-controlled trials to guide treatment recommendations for AE...
March 2018: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/29753677/multicenter-phase-1-2-application-of-adenovirus-specific-t-cells-in-high-risk-pediatric-patients-after-allogeneic-stem-cell-transplantation
#16
Winnie Ip, Juliana M F Silva, Hubert Gaspar, Arindam Mitra, Shreenal Patel, Kanchan Rao, Robert Chiesa, Persis Amrolia, Kimberly Gilmour, Gul Ahsan, Mary Slatter, Andrew R Gennery, Robert F Wynn, Paul Veys, Waseem Qasim
BACKGROUND: Adenovirus (ADV) reactivation can cause significant morbidity and mortality in children after allogeneic stem cell transplantation. Antiviral drugs can control viremia, but viral clearance requires recovery of cell-mediated immunity. METHOD: This study was an open-label phase 1/2 study to investigate the feasibility of generating donor-derived ADV-specific T cells (Cytovir ADV, Cell Medica) and to assess the safety of pre-emptive administration of ADV-specific T cells in high-risk pediatric patients after allogeneic hematopoietic stem cell transplantation (HSCT) to treat adenoviremia...
June 2018: Cytotherapy
https://www.readbyqxmd.com/read/29743771/cervical-myelopathy-in-a-child-a-rare-cause-of-hypoventilation-syndrome-presenting-with-type-2-respiratory-failure
#17
Alolika Mondal, Prabhas Prasun Giri
Hypoventilation syndrome leading to Type 2 respiratory failure is not a rare cause of Pediatric Intensive Care Unit admission and mechanical ventilation. Common causes in pediatric population are Guillain-Barre syndrome and various central nervous system disorders such as encephalitis, traumatic brain injury, and drugs. Any injury or disease in the cervical cord can also produce respiratory paralysis causing respiratory failure. Here, we present two cases of mixed cerebral palsy with cervical myelopathy due to compression effect of fractured segments of first and second cervical vertebrae...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29741721/update-from-the-advisory-committee-on-immunization-practices
#18
Sean T O'Leary, David W Kimberlin, Yvonne A Maldonado
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, each of whom is appointed to a 4-year term. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. The ACIP met on October 25 and 26, 2017, to discuss herpes zoster vaccine, the child/adolescent and adult vaccination schedules, Japanese encephalitis (JE) epidemiology and vaccines, pneumococcal vaccines, anthrax vaccines and disaster preparedness, hepatitis A outbreaks, influenza surveillance and vaccination coverage, vaccine safety, and considerations for a potential third dose of measles-mumps-rubella (MMR) vaccine to combat ongoing mumps outbreaks...
May 15, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29703768/long-term-neuropsychological-outcome-following-pediatric-anti-nmdar-encephalitis
#19
Marienke A A M de Bruijn, Femke K Aarsen, Marielle P van Oosterhout, Marieke M van der Knoop, Coriene E Catsman-Berrevoets, Marco W J Schreurs, Danielle E M Bastiaansen, Peter A E Sillevis Smitt, Rinze F Neuteboom, Maarten J Titulaer
OBJECTIVE: To provide detailed long-term outcome data of children and adolescents following pediatric anti- N -methyl-d-aspartate receptor (anti-NMDAR) encephalitis, to identify neuropsychological impairments, and to evaluate the influence of these factors on quality of life (QoL). METHODS: All Dutch children diagnosed with anti-NMDAR encephalitis were identified. Patients currently aged 4 years or older were included in the follow-up study, consisting of a visit to our clinic for a detailed interview and a standardized neuropsychological assessment...
May 29, 2018: Neurology
https://www.readbyqxmd.com/read/29670575/mog-igg-associated-optic-neuritis-encephalitis-and-myelitis-lessons-learned-from-neuromyelitis-optica-spectrum-disorder
#20
REVIEW
Giordani Rodrigues Dos Passos, Luana Michelli Oliveira, Bruna Klein da Costa, Samira Luisa Apostolos-Pereira, Dagoberto Callegaro, Kazuo Fujihara, Douglas Kazutoshi Sato
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been found in some cases diagnosed as seronegative neuromyelitis optica spectrum disorder (NMOSD). MOG-IgG allowed the identification of a subgroup with a clinical course distinct from that of NMOSD patients who are seropositive for aquaporin-4-IgG antibodies. MOG-IgG is associated with a wider clinical phenotype, not limited to NMOSD, with the majority of cases presenting with optic neuritis (ON), encephalitis with brain demyelinating lesions, and/or myelitis...
2018: Frontiers in Neurology
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