Takahiro Takahashi, Hisashi Shiga, Kunio Tarasawa, Yusuke Shimoyama, Takeo Naito, Rintaro Moroi, Masatake Kuroha, Yoichi Kakuta, Kiyohide Fushimi, Kenji Fujimori, Yoshitaka Kinouchi, Atsushi Masamune
INTRODUCTION: Cyclosporine or infliximab (IFX) have been used to avoid surgery in patients with severe refractory ulcerative colitis (UC). Tacrolimus (Tac) is occasionally used as an alternative to cyclosporine; however, the comparative efficacy of Tac and IFX has not been reported. We aimed to compare the effectiveness of Tac and IFX in hospitalized UC patients. METHODS: In a propensity score (PS)-matched cohort derived from a large nationwide database, 4-year effectiveness was compared between patients initiated on Tac or IFX...
September 27, 2023: Clinical and Translational Gastroenterology