Neil H Segal, Nathalie E Blachere, Jose A Guevara-PatiƱo, Humilidad F Gallardo, Ho Yin A Shiu, Agnes Viale, Cristina R Antonescu, Jedd D Wolchok, Alan N Houghton
Cancer-testis or germ cell antigens (GCAs) are a category of tumor antigens expressed by male germ cells and by cancers of diverse histological origin, but not usually by normal adult somatic tissue. These antigens include products encoded by the MAGE, BAGE, GAGE, SSX, and LAGE/NY-ESO-1 families that encode antigenic peptides recognized by T lymphocytes. In this study, we exploit oligonucleotide technology to identify genes in melanoma and soft tissue sarcoma (STS) that display a cancer-testis/GCA expression profile...
February 1, 2005: Cancer Immunity