Roberto Olivares Hernández, Lidia Riaño Umbarila, Baltazar Becerril, Alejandro Alagón Cano, Hilda Vazquez Lopez
A key aspect during the development of antivenoms is the evaluation of the efficiency and security of the therapeutic molecules. In this work, we report the pharmacokinetic analysis of a neutralizing single chain antibody fragment named LR (scFv LR) where three sheep were used as a large animal model. The animals were injected through i.v. route with 2 mg of scFv LR. Blood samples were drawn every minute within the first 15 min, the sampling continues at 20, 25, 30, 45, 60, 90, 120 min, subsequently at one-hour intervals, 3, 4, 5, 6 h, two more samples at 9 and 12 h and, two more samples at 24 and 48 hours and finally at one-day intervals during 4 days...
March 22, 2024: Toxicon: Official Journal of the International Society on Toxinology