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https://www.readbyqxmd.com/read/30112745/european-paediatric-surgeons-association-survey-on-the-management-of-pediatric-appendicitis
#1
Augusto Zani, Nigel J Hall, Abidur Rahman, Francesco Morini, Alessio Pini Prato, Florian Friedmacher, Antti Koivusalo, Ernest van Heurn, Agostino Pierro
AIM:  To define patterns in the management of pediatric appendicitis. METHODS:  A total of 169 delegates from 42 (24 European) countries completed a validated survey administered at the EUPSA 2017 annual congress. RESULTS:  In the work-up of children with suspected acute appendicitis, most surgeons rely on full blood count (92%), C-reactive protein (82%), and abdominal ultrasonography (76%), but rarely on computed tomography scans or magnetic resonance imaging...
August 15, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30112656/should-ace-inhibitors-and-arbs-be-used-in-combination-in-children
#2
Brian R Stotter, Michael A Ferguson
The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in a host of renal and cardiovascular functions. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), drugs that disrupt RAAS function, are effective in treating hypertension and offer other renoprotective effects independent of blood pressure (BP) reduction. As our understanding of RAAS physiology and the feedback mechanisms of ACE inhibition and angiotensin receptor blockade have improved, questions have been raised as to whether combination ACEI/ARB therapy is warranted in certain patients with incomplete angiotensin blockade on one agent...
August 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30111524/neonatal-screening-for-congenital-adrenal-hyperplasia-in-turkey-a-pilot-study-with-38-935-infants
#3
Tülay Güran, Başak Tezel, Fatih Gürbüz, Beray Selver Eklioğlu, Nihal Hatipoğlu, Cengiz Kara, Enver Şimşek, Filiz Mine Çizmecioğlu, Alev Ozon, Firdevs Baş, Murat Aydın, Feyza Darendeliler
BACKGROUND: Congenital adrenal hyperplasia (CAH) is the most common form of primary adrenal insufficiency in children. Neonatal screening for CAH is effective in detecting the salt-wasting form and reducing mortality. AIM: To estimate incidence of CAH in Turkey and to assess the characteristics and efficacy of the adopted newborn CAH screening strategy. METHOD: A pilot newborn CAH screening study was carried out under the authority of Turkish Directorate of Public Health...
August 14, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/30111479/-17%C3%AE-hydroxylase-deficiency-with-severe-hypertension-as-the-initial-symptom-in-a-child
#4
Hong-Ling Wei, Shan Lu, Xin-Li Wang, Jia-Wei Li, Yun-Pu Cui, Yan-Sheng Yao
A 14-year-old female (social gender) patient was admitted to the hospital due to severe hypertension for 11 days. The patient had primary amenorrhea. The blood pressure was 146/90 mm Hg. The skin color was slightly black. The development of secondary sexual characteristics was poor. The labia majora could be observed in the vulva. However, the labia minora, clitoris, vagina, and hymen were absent. The levels of renin, cortisol, and sex hormone were low, while the levels of adrenocorticotropic hormone and gonadotropin were high...
August 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30111320/surgical-treatment-of-children-with-total-colonic-aganglionosis-functional-and-metabolic-long-term-outcome
#5
Cristian Urla, Justus Lieber, Florian Obermayr, Andreas Busch, Roland Schweizer, Steven W Warmann, Hans-Joachim Kirschner, Jörg Fuchs
BACKGROUND: Total colonic aganglionosis (TCA) is a rare variant of Hirschsprung's disease occurring in 3-10% of the cases. Only few studies reported the long-term clinical and metabolic outcomes of patients with TCA. The aim of this study was to evaluate the functional and metabolic long-term outcomes of children undergoing surgical treatment for TCA. METHODS: A 15-year retrospective study was performed. Blood chemistry tests and stool analysis performed at the last follow-up visit were recorded...
August 15, 2018: BMC Surgery
https://www.readbyqxmd.com/read/30107492/measurement-of-central-aortic-blood-pressure-in-youth-role-of-obesity-and-sex
#6
Michelle M Harbin, Neil E Hultgren, Aaron S Kelly, Donald R Dengel, Nicholas G Evanoff, Justin R Ryder
Background: The relationship of pediatric severe obesity (SO) and central aortic blood pressure (BP) has yet to be established. Methods: We conducted a cross-sectional study of 348 youth (48.5% male, 12.7±0.1 years) with a wide range of body mass index (BMI) values: normal weight (NW; 5th and <85th BMI percentile); overweight/obesity (OW/OB; 85th to <120% of the 95th BMI percentile); and SO (≥120% of the 95th BMI percentile). Measures of central aortic blood pressure were obtained via applanation tonometry with SphygmoCor MM3 software...
August 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/30107231/unusual-cause-of-pediatric-vaginal-bleeding-infantile-capillary-hemangioma-of-the-cervix
#7
A K Ganti, J Ray, K L Mooney, E Zambrano, P J A Hillard, W Fok
BACKGROUND: The differential diagnosis for pediatric prepubertal vaginal bleeding is wide. Rare etiologies include vascular malformations and tumors, such as infantile hemangiomas (IH), which validate the usefulness of exam under anesthesia, vaginoscopy, and tissue diagnosis. CASE: We report a case of an infantile hemangioma in a 6 year-old girl causing vaginal bleeding requiring transfusion. Vaginoscopy revealed a less than 1 cm cervical IH. Expectant management and oral propranolol were successful management options...
August 11, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/30106871/hypothermia-as-an-outcome-predictor-tool-in-pediatric-trauma-a-propensity-matched-analysis
#8
Thomas R McCarty, Thomas J Abramo, Robert T Maxson, Gregory Albert, Mallikarjuna R Rettiganti, Marie E Saylors, Jonathan W Orsborn, Amanda I Hollingsworth
OBJECTIVE: Hypothermia is an independent risk factor for mortality in adult trauma patients. Two small studies have shown similar results in pediatric trauma patients. Temperature is not included in any pediatric trauma assessment scores. This study sought to compare mortality and various descriptive outcomes between pediatric hypothermic and normothermic trauma patients. METHODS: Data were obtained from the National Trauma Database from 2009 to 2012. Patients meeting inclusion criteria were stratified by presence of isolated head injury, head injury with multiple trauma, and absence of head injury...
August 13, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/30105363/performance-of-the-simplified-american-academy-of-pediatrics-table-to-screen-elevated-blood-pressure-in-children
#9
Yuanyuan Zhang, Liu Yang, Yaping Hou, Min Zhao, Pascal Bovet, Bo Xi
No abstract text is available yet for this article.
August 13, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/30104292/durable-response-to-nivolumab-in-a-pediatric-patient-with-refractory-glioblastoma-and-constitutional-biallelic-mismatch-repair-deficiency
#10
Musa AlHarbi, Nahla Ali Mobark, Latifa AlMubarak, Rasha Aljelaify, Mariam AlSaeed, Amal Almutairi, Fatmah Alqubaishi, M Emarat Hussain, Ali Abdullah O Balbaid, Amal Said Marie, Lamia AlSubaie, Saeed AlShieban, Nada alTassan, Shakti H Ramkissoon, Malak Abedalthagafi
Primary brain tumors are a leading cause of cancer-related morbidity and mortality in children. Glioblastoma (GBM) is a high-grade astrocytoma that occurs in both children and adults and is associated with a poor prognosis. Despite extensive study in recent years, the clinical management of these tumors has remained largely unchanged, consisting of surgical resection, conventional chemotherapy, and radiotherapy. Although the etiology and genomic drivers in GBM are diverse, constitutional mismatch repair-deficiency (CMMRD) syndrome is a rare, recessively inherited disease with a predisposition to gliomagenesis...
August 13, 2018: Oncologist
https://www.readbyqxmd.com/read/30104128/implementation-of-the-asthma-control-test-in-primary-care-to-improve-patient-outcomes
#11
Nancy Cantey Banasiak
BACKGROUND: Asthma is one of the major chronic diseases in the pediatric population, affecting 9.5% of children. The National Heart, Lung, and Blood Institute recommends the use of the Asthma Control Test (ACT) for periodic assessment of asthma control. The purpose of this evidence-based project was to implement the Asthma Control Test screening tool into the primary care practice to improve management of patients with asthma by more accurately addressing asthma control. METHODS: The project was a pre- and post-implementation study comparing two different groups of patients with asthma seen at the clinic over 5-week periods...
August 10, 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/30102482/restless-leg-syndrome-in-children-with-celiac-disease
#12
Sedat Işıkay, Nurgül Işıkay, Hüseyin Per, Kürşat Bora Çarman, Halil Kocamaz
Işıkay S, Işıkay N, Per H, Çarman KB, Kocamaz H. Restless leg syndrome in children with celiac disease. Turk J Pediatr 2018; 60: 70-75. Celiac disease (CD) is an immune-mediated enteropathy triggered by ingestion of dietary gluten in genetically predisposed individuals. The aim of the study was to determine the prevalence of restless leg syndrome (RLS) in children with CD and to investigate the associated factors for RLS. Totally 494 children with the ages ranging between 11-18 years were included. Among those, 226 were under follow-up with CD and constituted the study group while other 268 children did not have any symptoms or signs associated with CD and established the control group...
2018: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/30102481/assessment-of-central-venous-catheterization-and-complications-in-a-tertiary-pediatric-intensive-care-unit
#13
İlknur Tolunay, R Dinçer Yıldızdaş, Hüseyin Elçi, Derya Alabaz
Tolunay İ, Yıldızdaş RD, Elçi H, Alabaz D. Assessment of central venous catheterization and complications in a tertiary pediatric intensive care unit. Turk J Pediatr 2018; 60: 63-69. In catheter-using units as pediatric intensive care, it is important to know the complications that may occur during the insertion and use of central venous catheterization (CVC), and to take appropriate measures in order to reduce the mortality and morbidity of critical patients. The aim of this study was to evaluate CVC and catheter related complications in our tertiary pediatric intensive care unit...
2018: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/30102476/investigation-of-the-frequency-of-iron-insufficiency-among-infants-in-a-population-in-which-routine-iron-supplementation-is-implemented
#14
Nisa Eda Çullas-İlarslan, Fatih Günay, Dilber Talia İleri, Atilla Halil Elhan, Mehmet Ertem, Saadet Arsan
Çullas-İlarslan NE, Günay F, İleri DT, Elhan AH, Ertem M, Arsan S. Investigation of the frequency of iron insufficiency among infants in a population in which routine iron supplementation is implemented. Turk J Pediatr 2018; 60: 22-31. Iron deficiency anemia (IDA) represents the most common cause of anemia worldwide. Because of potential irreversible neurodevelopmental impairment, its prevention during infancy is essential. We aimed to investigate the frequency of iron insufficiency among infants in a population which routine iron supplementation is implemented; and to examine related risks...
2018: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/30101559/in-vitro-hemocompatibility-evaluation-of-ventricular-assist-devices-in-pediatric-flow-conditions-a-benchmark-study
#15
Chris Hoi Houng Chan, Sara Diab, Kayla Moody, O Howard Frazier, Luiz C Sampaio, Charles D Fraser, Jun Teruya, Iki Adachi
Development of pediatric ventricular assist devices (VADs) has significantly lagged behind that of adult devices. This frustrating reality is reflected by the fact that the Berlin Heart EXCOR VAD is currently the only approved pediatric-specific device in the USA. An alternative option is an off-label use of adult continuous-flow VADs, such as HeartMate II (HMII), which inevitably causes patient-device size mismatch in small children. We sought to conduct in vitro hemocompatibility testing in a pediatric flow condition, with a specific aim to provide benchmark values for future pediatric device development...
August 12, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30101470/chronic-nausea-and-orthostatic-intolerance-diagnostic-utility-of-orthostatic-challenge-duration-nausea-profile-questionnaire-and-neurohumoral-measures
#16
Ashley L Wagoner, Sally E Tarbell, Hossam A Shaltout, Debra I Diz, Debra E Weese-Mayer, John E Fortunato
BACKGROUND: Chronic nausea in pediatrics is a debilitating condition with unclear etiology. We aimed to define hemodynamic and neurohumoral characteristics of chronic nausea associated with orthostatic intolerance in order to improve identification and elucidate mechanism. METHODS: Children (10-18 years) meeting Rome III criteria for functional dyspepsia with nausea and symptoms of orthostatic intolerance (OI) completed a Nausea Profile Questionnaire followed by prolonged (45 minutes rather than the traditional 10 minutes) head-upright tilt (HUT) (70° tilt up) test...
August 13, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/30099920/genetic-polymorphism-of-vkorc1-1639-in-children-with-intracranial-hemorrhage-due-to-vitamin-k-deficiency
#17
Uğur Berber, Mehmet Akif Özdemir, Ekrem Unal, Serpil Taheri, Serkan Yildiz, Keziban Korkmaz Bayramov, Yunus Güler, Hüseyin Per
Intracranial hemorrhage due to vitamin K deficiency is a serious disease that can lead to morbidity, mortality, and mental retardation. Our goal in this study is to determine the frequency of VKORC1-1639 G>A polymorphism in patients who have undergone intracranial hemorrhage due to vitamin K deficiency bleeding (VKDB). To study VKORC1-1639 G>A polymorphism, blood was drawn from patients (n = 51, age 8:0 ± 6:5 years) followed at the Pediatric Neurology and Hematology section, Faculty of Medicine, Erciyes University, between 1990 and 2016, diagnosed with VKDB as idiopathic or from patients diagnosed with intracranial hemorrhage due to secondary vitamin K deficiency and also from volunteers (n = 51, age 11 ± 4...
August 13, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/30099638/a-5-year-study-of-the-performance-of-the-verigene-gram-positive-blood-culture-panel-in-a-pediatric-hospital
#18
Chairut Vareechon, Javier Mestas, Claudia M Polanco, Jennifer Dien Bard
High accuracy of direct from positive blood culture molecular panels is imperative, particularly for the detection of resistance determinants as it allows for antimicrobial optimization prior to conventional susceptibility testing. In this study, we provide extensive data since implementation of the Verigene Gram-positive blood culture panel (BC-GP) in 2013. Within 5 years, 1636 blood culture bottles positive for a Gram-positive organism were tested on the BC-GP panel. The BC-GP panel identified 1520 Gram-positive organisms in 1636 (92...
August 11, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30099581/pitfalls-in-the-management-of-congenital-tracheal-stenosis-is-conservative-management-feasible
#19
Yoshiko Usui, Shigeru Ono, Katsuhisa Baba, Yuki Tsuji
PURPOSE: Congenital tracheal stenosis (CTS) is rare and challenging. Complete tracheal rings cause a wide spectrum of airway-obstructing lesions and varying degrees of respiratory distress. Although surgical reconstruction is the primary option for symptomatic CTS, sometimes an appropriate management strategy may be difficult due to other anomalies. We aimed to identify pitfalls in the management of CTS. METHODS: We retrospectively reviewed the records of patients with CTS during the last 10 years in our institution...
August 11, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/30099539/general-principles-for-preoperative-planning-and-microsurgical-treatment-of-pediatric-brain-arteriovenous-malformations-2-dimensional-operative-video
#20
David L Penn, Kyle C Wu, Kayla R Presswood, Coleman P Riordan, R Michael Scott, Edward R Smith
Children with arteriovenous malformations (AVMs) are at cumulative, life-long risk of debilitating and fatal intracranial hemorrhage, especially with syndromes such as hereditary hemorrhagic telangiectasia. Cerebral angiography is the gold standard for diagnosis and allows simultaneous adjunctive embolization limiting radiation and contrast exposure and intraoperative blood loss, important in pediatric patients with low blood volume. Microsurgical resection of low-grade AVMs offers cure with minimal morbidity...
August 7, 2018: Operative Neurosurgery (Hagerstown, Md.)
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