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pediatric blood

Jie Dong, Yinkun Yan, Hui Fan, Xiaoyuan Zhao, Jie Mi
Background: Several formulas using spot urine have been developed to estimate 24-hour sodium excretion, but none of them have been validated in pediatrics. We aimed to evaluate the performance of eight formulas, including Kawasaki, Tanaka, International Cooperative Study on Salt, Other Factors, and Blood Pressure (INTERSALT1), INTERSALT without potassium (INTERSALT2), Mage, Whitton, Uechi simple-mean, and Uechi regression, in estimating 24-hour sodium excretion at both population and individual levels in Chinese young adolescents...
December 4, 2018: American Journal of Hypertension
Kerstin Rauwolf, Heidi Herbrüggen, Stefan Zöllner, Heike Thorer, Olga Makarova, Thomas Kaiser, Aleksandra Pettke, Claudia Rossig, Birgit Burkhardt, Andreas H Groll
Chronic hepatitis C virus (HCV) infection carries increased risks for morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) but has become curable through the advent of directly acting antiviral compounds. Current guidelines of the American Society for Blood and Marrow Transplantation (ASBMT) recommend that HCV-infected HSCT candidates preferably start and complete therapy prior to transplant. However, this is often not feasible due to time constraints or treatment limiting comorbidities, conditions and treatments...
December 5, 2018: Journal of Viral Hepatitis
Michael A Benvenuti, Thomas J An, Megan E Mignemi, Jeffrey E Martus, Gregory A Mencio, Stephen A Lovejoy, Jonathan G Schoenecker, Derek J Williams
OBJECTIVE: There are currently no algorithms for early stratification of pediatric musculoskeletal infection (MSKI) severity that are applicable to all types of tissue involvement. In this study, the authors sought to develop a clinical prediction algorithm that accurately stratifies infection severity based on clinical and laboratory data at presentation to the emergency department. METHODS: An IRB-approved retrospective review was conducted to identify patients aged 0 to 18 who presented to the pediatric emergency department at a tertiary care children's hospital with concern for acute MSKI over a 5-year period (2008 to 2013)...
March 7, 2018: Journal of Pediatric Orthopedics
Sniya Valsa Sudhakar, Karthik Muthusamy, Manohar Shroff
Brain has been considered as an immune-privileged site for centuries owing to the presence of blood-brain barrier, absent lymphatic drainage, and antigen-presenting cells. However, the present prevailing concept is of immune surveillance where brain is continuously surveyed by immune cells. However, the presence of immune cells in central nervous system (CNS) brings the risk of inflammation and autoimmunity involving both T and B cell mediated pathways. These mechanisms form the underlying pathology in a wide spectrum of pediatric CNS diseases manifesting as acquired neurological deficits...
December 2018: Topics in Magnetic Resonance Imaging: TMRI
A P Poornima, Shiffi Fazal, P S Shaiji, K C Usha, Lalitha Kailas
OBJECTIVES: To estimate the prevalence and specificity pattern of red blood cell (RBC) alloimmunization among pediatric multitransfused patients, and to identify the factors associated with alloimmunization. METHODS: This was a descriptive cross-sectional study conducted among mutitransfused pediatric patients over a period of two years. The relevant clinical details of patients were collected, and RBC antibody screening was done. Samples with positive antibody screen were subjected to antibody identification...
December 4, 2018: Indian Journal of Pediatrics
Gulsah Aynaoglu Yildiz, Omer Erkan Yapca, Ragip Atakan Al, Metin Ingec
We have interestedly read the article written by Thalia Wong BS in July 2015, which is about Pediatric Blood Cancer, including clinical findings and results of infants <1 year of age with Ewing sarcoma. We report a case with congenital Ewing's sarcoma that easily interfered with rabdomyosarcoma in a pregnant woman. A 32-year-old multigravida with a big neck mass at 35 weeks was referred to our clinic. The final diagnosis of extraskeletal Ewing's sarcoma was made. Hepatic metastasis was detected and treatment by chemotherapy was initiated...
October 2018: Eurasian Journal of Medicine
Mariella Valenzise, Federica Porcaro, Giuseppina Zirilli, Filippo De Luca, Maurizio Cinquegrani, Tommaso Aversa
Clinical picture of Hashimoto's thyroiditis (HT) may significantly vary in pediatric age, ranging from euthyroidism to subclinical hypothyroidism or hyperthyroidism; only rarely HT presentation may be characterized by a severe hypothyroidism also in pediatric age. Here we describe a 3-year-old Caucasian girl who was admitted to our Clinic due to pericardial effusion, muscle weakness and weight gain. At clinical examination, she presented with bradycardia, pale and round face, pseudohypertrophy of calf muscles and no pitting edema of the limbs...
December 5, 2018: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
Carmine Noviello, Mercedes Romano, Alfonso Papparella, Andrea Ciavattini, Ascanio Martino, Giovanni Cobellis
Isolated tubal torsion (ITT) is a rare cause of acute abdominal pain. Preoperative diagnosis is difficult because of a lack of specific signs. Surgery is recommended to preserve the integrity of the tube. Seven patients of median age of 13 years (range 9 to 15) came to our observation for worsening abdominal pain, nausea and vomiting. On admission, all girls had blood tests and ultrasound. Laparoscopy was performed for diagnosis in all cases. The girls had one-month and one-year ultrasound and clinic follow up...
December 4, 2018: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
Vladimir Milovanovic, Dejan Bisenic, Branko Mimic, Bilal Ali, Massimiliano Cantinotti, Ivan Soldatovic, Irena Vulicevic, Bruno Murzi, Slobodan Ilic
OBJECTIVE(S): Modified ultrafiltration has gained wide acceptance as a powerful tool against cardiopulmonary bypass morbidity in pediatric cardiac surgery. The aim of our study was to assess the importance of modified ultrafiltration within conditions of contemporary cardiopulmonary bypass characteristics. METHODS: Ninety⁻eight patients (overall cohort) weighing less than 12 kg undergoing surgical repair with cardiopulmonary bypass were prospectively enrolled in a randomized protocol to receive modified and conventional ultrafiltration (MUF group) or just conventional ultrafiltration (non-MUF group)...
December 1, 2018: Journal of Clinical Medicine
Fabienne Delay, Vincent Dochez, Florence Biquard, Marie-Thérèse Cheve, Philippe Gillard, Chloe Arthuis, Norbert Winer
INTRODUCTION: The incidence of fetal goiters is reported to be around 1 per 40 000 births. The risk of complications is first of all obstetric, directly related to goiter size, but it may also affect longer term fetal and child development, depending on whether the goiter is due to hypo- or hyperthyroidism. Management is multidisciplinary, but not yet consensual and not always optimal by either endocrinologists or obstetricians. OBJECTIVES: The principal objective of this retrospective study was to analyze the data that enabled the physicians to assess whether the goiter was hypo- or hyperthyroid and then to analyze the obstetric practices used in the Pays de Loire network to describe in detail the tools used to diagnose and characterize the goiters and the management chosen in these cases...
December 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
Fareed Khdair-Ahmad, Tariq Aladily, Olfat Khdair-Ahmad, Eman F Badran
Khdair-Ahmad F, Aladily T, Khdair-Ahmad O, Badran EF. Chelation therapy for secondary neonatal iron overload: Lessons learned from rhesus hemolytic disease. Turk J Pediatr 2018; 60: 335-339. Secondary neonatal iron overload occurs with intrauterine and post-natal blood transfusions. Treatment with intravenous Deferoxamine was reported only in four cases in the literature. Herein we report a case of a patient born at 36 weeks of gestation, who had rhesus hemolytic disease. He developed secondary iron overload, causing liver injury, after a total of six blood transfusions: four intrauterine and 2 post-natal transfusion therapies...
2018: Turkish Journal of Pediatrics
Jianming Guo, Lianrui Guo, Gao Zeng, Zhu Tong, Xixiang Gao, Yongquan Gu
Guo J, Guo L, Zeng G, Tong Z, Gao X, Gu Y. An infant case of renovascular hypertension in moyamoya disease treated by angioplasty. Turk J Pediatr 2018; 60: 331-334. Here we report the treatment experience of an 18-month-old female infant case of renovascular hypertension due to moyamoya disease by angioplasty. Although renal blood flow was recovered immediately after operation, 12 months follow-up found severe restenosis which required us to perform a right renal autotransplantation.
2018: Turkish Journal of Pediatrics
Feyza Hüsrevoğlu-Esen, Yasemin Altuner-Torun, Çiğdem Karakükçü, Seçil Köse, Ahmet Şehriyaroğlu, Dilek Kafadar, Aydın Esen, Mehmet Köse
Hüsrevoğlu-Esen F. Altuner-Torun Y, Karakükçü Ç, Köse S, Şehriyaroğlu A, Kafadar D, Esen A, Köse M. Gelsolin levels in patients with bronchiolitis. Turk J Pediatr 2018; 60: 286-289. Bronchiolitis is the leading cause of hospitalization in infants. Biomarkers can show severity of the disease and help in clinical management. In this study, the aim was to determine the clinical predictiveness of plasma gelsolin levels (pGSN) in acute bronchiolitis. From December 2013 to May 2014, 52 patients with bronchiolitis (aged < 24 months) were included in this study...
2018: Turkish Journal of Pediatrics
Miro Jukić, Zenon Pogorelić, Daniela Šupe-Domić, Ana Jerončić
BACKGROUND: The aim of this study was to compare inflammatory stress response between laparoscopic percutaneous inguinal ring suturing (PIRS) and open modified Marcy technique for pediatric inguinal hernia repair. METHODS: From May 2017 to April 2018, 32 male children with median age of 4.5 years undergoing inguinal hernia repair were included in randomized controlled trial. The patients were divided in two groups, by using random number generator, depending on surgical approach...
December 3, 2018: Surgical Endoscopy
Yahui Zhao, Junlin Lu, Qian Zhang, Yan Zhang, Dong Zhang, Rong Wang, Yuanli Zhao
OBJECTIVE: Indirect bypass surgery, which induces spontaneous neoangiogenesis in ischemic brain tissue and improves cerebral blood flow, is an effective treatment for moyamoya disease (MMD). The time course of neoangiogenesis development has not yet been investigated. This study aimed to determine the critical period of neovascularization after indirect bypass in MMD patients. METHODS: Patients with MMD who underwent indirect bypass surgery at Peking University International Hospital between January 2015 and October 2017 were retrospectively reviewed...
December 3, 2018: Clinical Neuroradiology
Patrick M Brunner, Ariel Israel, Alexandra Leonard, Ana B Pavel, Hyun Je Kim, Ning Zhang, Tali Czarnowicki, Krishna Patel, Morgan Murphrey, Kara Ramsey, Stephanie Rangel, Rema Zebda, Vinaya Soundararajan, Xiuzhong Zheng, Yeriel D Estrada, Hui Xu, James G Krueger, Amy S Paller, Emma Guttman-Yassky
No abstract text is available yet for this article.
November 30, 2018: Annals of Allergy, Asthma & Immunology
Alexandra G May, Ryan A Orizondo, Brian J Frankowski, Peter D Wearden, William J Federspiel
Respiratory failure is a significant problem within the pediatric population. A means of respiratory support that readily allows ambulation could improve treatment. The Pittsburgh Pediatric Ambulatory Lung (P-PAL) is being developed as a wearable pediatric pump-lung for long-term respiratory support and has previously demonstrated positive benchtop results. This study aimed to evaluate acute (4-6 hours) in vivo P-PAL performance, as well as develop an optimal implant strategy for future long-term studies. The P-PAL was connected to healthy sheep (n = 6, 23-32 kg) via cannulation of the right atrium and pulmonary artery...
November 21, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Gail Coppins Gettens, Beverly Baer Drouin
Childhood lead poisoning continues to be a persistent environmental pediatric health problem in New Hampshire (NH). In 2015, 660 (4.9%) children younger than 6 years had blood lead levels of 5 µg/dL or more, the Centers for Disease Control and Prevention's recommended level for public health action. Yet, only 16.8% of NH children younger than 6 years were tested. NH's Healthy Homes and Lead Poisoning Prevention Program (HHLPPP) identified 2 barriers to blood lead testing and the opportunities to resolve them: (1) venous testing had lower compliance and resulted in costly follow-up time for providers and (2) lack of understanding in the medical community about the importance of blood lead testing...
January 2019: Journal of Public Health Management and Practice: JPHMP
Soo Young Moon, Ji-Hyun Lim, Eun-Hee Kim, Youngwon Nam, Kyung-Sang Yu, Kyung Taek Hong, Jung Yoon Choi, Che Ry Hong, Hyery Kim, Hyoung Jin Kang, Hee Young Shin, Kyunghoon Lee, Junghan Song, Soo-Youn Lee, Sang Hoon Song
INTRODUCTION: Concentrations of 6-thioguanine (6TG) nucleotides and 6-methylmercaptopurine (6MMP) nucleotides in RBCs were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). This assay was validated for clinical use and was applied to blood samples from patients taking mercaptopurine (6MP). METHODS: RBCs were hemolyzed and deproteinized using perchloric acid, followed by heating for the hydrolysis of nucleotides, and the resultant base was measured using LC-MS/MS...
November 28, 2018: Therapeutic Drug Monitoring
Joshua D Robinson, Michael J Rose, Maria Joh, Kelly Jarvis, Susanne Schnell, Alex J Barker, Cynthia K Rigsby, Michael Markl
BACKGROUND: Cardiac MRI plays a central role in monitoring children with repaired tetralogy of Fallot (TOF) for long-term complications. Current risk assessment is based on volumetric and functional parameters that measure late expression of underlying physiological changes. Emerging 4-D flow MRI techniques promise new insights. OBJECTIVE: To assess whether 4-D flow MRI-derived measures of blood kinetic energy (1) differentiate children and young adults with TOF from controls and (2) are associated with disease severity...
December 1, 2018: Pediatric Radiology
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