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pediatric blood

Soichi Narumoto, Seisuke Sakamoto, Kengo Sasaki, Yoshihiro Hirata, Akinari Fukuda, Toru Uchiyama, Rie Irie, Takako Yoshioka, Mureo Kasahara
Desensitization with RTX has been broadly introduced in adult LT across the ABO blood type barrier. For pediatric LT, the prophylactic use of RTX has not been standardized, especially for children under 2 years of age. A 20-month-old girl with BA underwent living donor LT from her ABO-I mother. On POD 6, she developed combined T cell-mediated and AMRs. Steroid bolus injection was immediately introduced, followed by antibody-depleting therapy with PE and IVIG. Based on a peripheral blood lymphocyte analysis by fluorescence-activated cell sorting, ATG and RTX were introduced for refractory rejection...
October 19, 2018: Pediatric Transplantation
Meghan E Byrne, Marian Tanofsky-Kraff, Nichole M Kelly, Anne Claire Grammer, Manuela Jaramillo, Sarah J Mi, Monika M Stojek, Lisa M Shank, Natasha L Burke, Omni Cassidy, Natasha A Schvey, Sheila M Brady, Andrew P Demidowich, Miranda M Broadney, Susan Z Yanovski, Jack A Yanovski
Objective:  Pediatric loss-of-control (LOC) eating is associated with, and predictive of, gains in adiposity and adverse metabolic outcomes. In addition, some preliminary data suggest that anxiety may exacerbate the relationship of LOC eating with weight and metabolic syndrome (MetS)-related measures. We therefore examined whether anxiety moderated the relationship between LOC eating and body mass index z (BMIz), adiposity, and MetS-related measures in youth. Methods:  A convenience sample of non-treatment-seeking boys and girls of varying weight strata were interviewed to determine the presence of LOC eating and completed a questionnaire assessing trait anxiety...
October 18, 2018: Journal of Pediatric Psychology
Kaynan Doctor, Kristen Breslin, James M Chamberlain, Deena Berkowitz
OBJECTIVES: Rising costs in healthcare have focused attention on interventions to optimize efficiency of patient care, including decreasing unnecessary diagnostic testing. The primary objective of this study was to determine the variability of laboratory and radiology testing among licensed independent providers (LIPs) with different training backgrounds treating low-acuity patients in a pediatric emergency department (PED). METHODS: We performed a retrospective review of the electronic health records of all encounters with patients 21 years or younger, triaged as low-acuity, visiting 2 urban, academic PEDs from January 2012 to December 2013...
October 17, 2018: Pediatric Emergency Care
Hong-Mei Zhao, Yong-Jia Yang, Jia-Qi Duan, Hong-Juan Ouyang, Li Liu, Li-Chun Yi, Thomas M Attard, Ding-You Li, Jie-Yu You
OBJECTIVES: The present study aims to identify the genotype-phenotype correlation in children with Peutz-Jeghers Syndrome (PJS) through the analysis of STK11 gene mutations in the context of clinical and pathological characteristics. METHOD: In this observational cohort study, the clinical characteristics of 18 families diagnosed with pediatric PJS were collected. Genomic DNA from the peripheral blood of affected children and their family members was collected. The coding region of STK11 was amplified by PCR and screened for mutation by Sanger sequencing...
October 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
Nikita Sood, John J Connolly, Frank D Mentch, Lyam Vazquez, Patrick M A Sleiman, Erik B Hysinger, Hakon Hakonarson
Asthma is the leading chronic disease in children. Several studies have identified genetic biomarkers associated with susceptibility and severity in both adult and pediatric cases. In this study, we evaluated outcomes in 400 African American and European American pediatric cases all of whom were regular users of inhaled corticosteroids. Patients were stratified by genotype using two single nucleotide polymorphisms in the β-2-adrenergic receptor (ADRB2) gene - rs1042713 and rs1042714, previously associated with asthma outcome...
November 2018: Pharmacogenetics and Genomics
Marketta Dalla Valle, Tiina Laatikainen, Hanna Potinkara, Päivi Nykänen, Jarmo Jääskeläinen
Background: Childhood obesity exposes individuals to cardiometabolic disturbances. We analyzed how family-based multidisciplinary obesity treatment influenced children's cardiometabolic health. Materials and methods: In this retrospective, two-year, follow-up study of 654 2- to 18-year-old children treated for obesity in three Finnish pediatric clinics in 2005-2012, blood pressure (BP), metabolic parameters, and the influence of sex, puberty and a change in body mass index standard deviation score (BMI SDS) were analyzed...
2018: Frontiers in Endocrinology
Sitao Li, Yao Cai, Congcong Shi, Mengxian Liu, Bingqing Liu, Lin Lin, Xin Xiao, Hu Hao
BACKGROUND The aim of this study was to perform gene detection in 2 clinical cases of highly suspected ornithine transcarbamylase deficiency (OTCD) pediatric patients by first-generation sequencing technology in order to confirm the pathogenic genetic factors of their families and allow the families to undergo genetic counselling and prenatal diagnosis. MATERIAL AND METHODS The peripheral DNA samples of 2 children with highly suspected OTCD (the probands) and their parents were collected. DNA fragments corresponding to exons 1-10 of the OTC gene from the samples were amplified using polymerase chain reaction (PCR), and then subjected to Sanger sequencing to confirm the pathogenic mutation sites...
October 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Antonino Granata, Caterina Gandolfo, Carlo Acierno, Marcello Piazza, Gaetano Burgio, Mario Traina
BACKGROUND: While coins are still the most common foreign bodies swallowed by children, ingestion of batteries has become more frequent among children due to the increasing access to electronic toys and devices. Coin battery ingestion is potentially life threatening for children. Aortoesophageal fistula is the most common cause of death in children who have swallowed coin batteries, and there have not been any reported survivors. CASE PRESENTATION: A 3-year-old Caucasian girl presented to the emergency room of a community hospital complaining of abdominal pain...
October 18, 2018: Journal of Medical Case Reports
Seham Awad El-Sherbini, Huda Marzouk, Riham El-Sayed, Sarah Hosam-ElDin
OBJECTIVE: This study aimed to study the incidence of stress hyperglycemia in critically ill children and to investigate the etiological basis of the hyperglycemia based on homeostasis model assessment. METHODS: This was a prospective cohort study in one of the pediatric intensive care units of Cairo University, including 60 critically ill children and 21 healthy controls. Serum blood glucose, insulin, and C-peptide levels were measured within 24 hours of admission...
July 2018: Revista Brasileira de Terapia Intensiva
Gabriela de la Vega Muns, Robert Quencer, Nisreen S Ezuddin, Gaurav Saigal
BACKGROUND: Cerebral venous sinus thrombosis (CVST) is a recognized cause of childhood and neonatal stroke with high morbidity and mortality and a challenging diagnosis in the pediatric population. OBJECTIVE: We hypothesize that measuring Hounsfield units (HU) of blood in venous sinuses is a more reliable method to diagnose CVST and that normalizing the measured HU in relation to the patient's hematocrit levels may further improve detection of CVST in the pediatric population...
October 16, 2018: Pediatric Radiology
Melikşah Keskin, Şenay Savaş-Erdeve, Semra Çetinkaya, Zehra Aycan
Keskin M, Savaş-Erdeve Ş, Çetinkaya S, Aycan Z. Low hemoglobin A1c levels in a patient with diabetic ketoacidosis: Fulminant type 1 diabetes mellitus. Turk J Pediatr 2018; 60: 201-205. Fulminant type 1 diabetes mellitus (FT1DM) is a clinical condition that is characterized by remarkably rapid and complete pancreatic β-cell destruction, rapid onset of hyperglycemic symptoms followed by ketoacidosis. In most cases this process takes a few days. Although rare, there have been clinical manifestations with a prolonged progress that lasts longer than one week...
2018: Turkish Journal of Pediatrics
Ahmet Sami Yazar, Seher Erdoğan, Ceyhan Şahin, Şirin Güven
Yazar AS, Erdoğan S, Şahin C, Güven Ş. Reliability of ultrasonography and the Alvarado scoring system in acute appendicitis. Turk J Pediatr 2018; 60: 173-179. In this study, we aimed to evaluate the diagnostic performance of ultrasonography, the Alvarado score, mean platelet volume and C-reactive protein in the diagnosis of acute appendicitis. Patients admitted to the pediatric emergency department with abdominal pain who were operated on with a preliminary diagnosis of acute appendicitis were evaluated...
2018: Turkish Journal of Pediatrics
Leila Khajavi, Gholamreza Khademi, Mehraneh Mehramiz, Abdolreza Norouzy, Mohammad Safarian
Khajavi L, Khademi G, Mehramiz M, Norouzy A, Safarian M. Association of dysglycemia with mortality in children receiving parenteral nutrition in pediatric intensive care unit. Turk J Pediatr 2018; 60: 134-141. One of the most important complications of parenteral nutrition (PN) is a high incidence of hyperglycemia. The aim of this study was to assess the effect of parenteral nutrition dysglycemia on clinical outcomes among critically ill children in pediatric intensive care unit (PICU). Charts of 201 critically ill children admitted in PICU during 2012-2015 were reviewed retrospectively...
2018: Turkish Journal of Pediatrics
Başak Akyıldız, Sedat Öztürk, Nazan Ülgen-Tekerek, Selim Doğanay, Süreyya Burcu Görkem
Akyıldız B, Öztürk S, Ülgen-Tekerek N, Doğanay S, Görkem SB. Comparison between high-flow nasal oxygen cannula and conventional oxygen therapy after extubation in pediatric intensive care unit. Turk J Pediatr 2018; 60: 126-133. The aim of this study was to compare the efficiency, safety, and outcomes of the high-flow nasal oxygen cannula (HFNC) and conventional oxygen therapy (COT) after extubation in children. A randomized controlled trial was conducted in a 13 bed pediatric intensive care unit. One-hundred children who underwent extubation were eligible for the study...
2018: Turkish Journal of Pediatrics
Stefan J Friedrichsdorf, Donna Eull, Christian Weidner, Andrea Postier
Introduction: Pain remains common, underrecognized, and undertreated in children's hospitals and pediatric clinics. Over 200,000 patients experience needle pain annually in our institution, caused by blood draws, intravenous access, vaccinations, and injections on all inpatient units, emergency departments, outpatient laboratories, and ambulatory clinics. Objectives: We implemented a hospital-based, system-wide initiative called the "Children's Comfort Promise," and created a new standard of care for needle procedures that required staff to consistently offer 4 strategies: (1) topical anesthetics, (2) sucrose or breastfeeding for infants 0 to 12 months, (3) comfort positioning (including swaddling, skin-to-skin, or facilitated tucking for infants; sitting upright for children), and (4) age-appropriate distraction...
September 2018: Pain Reports (Baltimore, Md.)
Xavier R J Moors, Stef J M Bouman, Joost H Peters, Pascal Smulders, Michelle B Oude Alink, Dennis Den Hartog, Robert Jan Stolker
OBJECTIVE: In the prehospital setting, the Nijmegen and Rotterdam helicopter emergency medical services administer packed red blood cells to critically ill or injured pediatric patients. Blood is given on scene or during transport and is derived from nearby hospitals. We summarize our experience with prehospital blood use in pediatric patients. METHODS: The databases from both the Nijmegen and Rotterdam helicopter emergency medical services were reviewed for all pediatric (< 18 years) patients who received packed red blood cells on scene or during transport to the hospital...
September 2018: Air Medical Journal
Sima T Bhatt, Jeffrey J Bednarski, Julia Berg, Kathryn Trinkaus, Lisa Murray, Robert Hayashi, Ginny Schulz, Monica Hente, Michael Grimley, Ka Wah Chan, Naynesh Kamani, David Jacobsohn, Michael Nieder, Gregory Hale, Lolie Yu, Roberta Adams, Jignesh Dalal, Michael A Pulsipher, Paul Haut, Sonali Chaudhury, Jeffrey Davis, Jennifer Jaroscak, Martin Andreansky, Jennifer Willert, Shalini Shenoy
Hematopoietic stem cell transplantation (HSCT) is a therapeutic option for many nonmalignant disorders (NMD) and is curative or prevents disease progression. Reduced intensity conditioning (RIC) in HSCT for NMD may reduce regimen-related acute toxicities and late complications. Myeloablation is often replaced by immune suppression in RIC regimens to support donor engraftment. The pace of immune reconstitution following immune suppression by RIC regimens is influenced by agents used, donor source, and graft-versus-host disease (GVHD) prophylaxis/treatment...
October 12, 2018: Biology of Blood and Marrow Transplantation
Juan J Díaz, Beatriz Espín, Oscar Segarra, Gloria Domínguez-Ortega, Javier Blasco-Alonso, Beatriz Cano, Ana Rayo, Ana Moreno
OBJECTIVE: To describe clinical, epidemiological and management characteristics of food protein-induced enterocolitis syndrome (FPIES) cases in Spain. PATIENTS AND METHODS: Multicenter observational retrospective study. FPIES cases diagnosed in specialized units in Spain over 12 months in 2017 (January to December) according to the recently published international diagnostic criteria were included. RESULTS: One hundred and twenty patients (53...
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
Jia-Huei Yan, Xin-Yuan Cai, Ying-Hsien Huang
BACKGROUND: Febrile children are often evaluated for the risk of bacterial infections in the pediatric emergency department (PER). Hepcidin is an acute phase inflammatory protein. In this study, we examined the plasma hepcidin levels in febrile children. METHODS: This study was conducted at a pediatric emergency department with 123 febrile children. We measured plasma hepcidin levels using an enzyme-linked immunosorbent assay. We further evaluated clinical characteristics and routine blood tests along with the hepcidin levels...
September 20, 2018: Pediatrics and Neonatology
Michael E Chua, Jin Kyu Kim, Michele Gnech, Jessica M Ming, Bisma Amir, Nicolas Fernandez, Armando J Lorenzo, Walid A Farhat, Diane Hebert, Joana Dos Santos, Martin A Koyle
Our study aims to assess the clinical implication of RAV/rBSA ratio in PRT as a predictor for attained renal function at 1 year post-transplantation and its association with surgical complications. A retrospective cohort was performed for PRT cases from January 2000 to December 2015 in our institution. Extracted clinical information includes the recipient's demographics, donor type, renal allograft characteristics, arterial, venous and ureteral anastomoses, vascular anastomosis time while kidney off ice, overall operative time, and estimated blood loss...
October 12, 2018: Pediatric Transplantation
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