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Ovarian cancer target drugs

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https://www.readbyqxmd.com/read/30317611/overview-of-cd24-as-a-new-molecular-marker-in-ovarian-cancer
#1
REVIEW
Vahideh Tarhriz, Mojgan Bandehpour, Siavoush Dastmalchi, Elaheh Ouladsahebmadarek, Habib Zarredar, Shirin Eyvazi
Ovarian cancer (OC) is the fifth leading cause of cancer-related death among women. The high mortality rate is due to lack of early symptoms, late diagnosis, limited treatment options, and also emerging of drug resistance. Todays, molecular markers have become promising in tumor-targeted therapy. Several molecular markers have been known in OC immunotherapy. Identification of the specific molecular markers with prognostic significance is interested. CD24 is a small sialoglycoprotein which is localized in lipid rafts through its glycosylphosphatidylinositol (GPI) anchor...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30317035/human-endogenous-retroviruses-role-in-cancer-cell-stemness
#2
REVIEW
Claudia Matteucci, Emanuela Balestrieri, Ayele Argaw-Denboba, Paola Sinibaldi-Vallebona
Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the critical issues of oncological diseases. In this scenario, increasing scientific evidences demonstrate that the activation of human endogenous retroviruses (HERVs) is involved in the aggressiveness of tumors such as melanoma, breast, germ cell, renal, ovarian, liver and haematological cancers. In their dynamic regulation, HERVs have also proved to be important determinants of pluripotency in human embryonic stem cells (ESC) and of the reprogramming process of induced pluripotent stem cells (iPSCs)...
October 11, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/30314995/her2-decreases-drug-sensitivity-of-ovarian-cancer-cells-via-inducing-stem-cell-like-property-in-a-nf%C3%AE%C2%BAb-dependent-way
#3
Wenxiang Wang, Yuxia Gao, Jing Hai, Jing Yang, Shufeng Duan
Increasing evidence shows that cancer stem cells are responsible for drug resistance and relapse of tumors. In breast cancer, HER2 induces Herceptin resistance by inducing cancer stem cells. In this study, we explored the effect of HER2 on cancer stem cells induction and drug sensitivity of ovarian cancer cell lines. Firstly, we found that HER2 overexpression (HER2 OE) induced, while HER2 knockdown (HER2 KD) decreased CD44+/CD24- population. Consistently, HER2 expression was closely correlated with the sphere formation efficiency (SFE) of ovarian cancer cells...
October 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30306576/targeted-therapy-for-gynecologic-cancers-toward-the-era-of-precision-medicine
#4
Partha Basu, Asima Mukhopadhyay, Ikuo Konishi
Recent advances in molecular biology of cancer have led to the development of targeted agents, mainly of monoclonal antibodies and small-molecule compounds. Unlike traditional drugs that inhibit DNA synthesis and mitosis, these agents target the signaling pathways of cancer cells, stroma, and vasculature in tumor tissues. For gynecologic cancers, drugs targeting angiogenesis such as anti-VEGF antibody have been used in the treatment of advanced or recurrent ovarian and cervical cancers, and the drugs targeting homologous recombination deficiency such as PARP inhibitors have been approved for maintenance after chemotherapy in platinum-sensitive ovarian cancer...
October 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/30304728/nintedanib-for-advanced-epithelial-ovarian-cancer-a-change-of-perspective-summary-of-evidence-from-a-systematic-review
#5
REVIEW
Fabio Barra, Antonio Simone Laganà, Fabio Ghezzi, Jvan Casarin, Simone Ferrero
BACKGROUND/AIMS: Epithelial ovarian cancer (EOC) is the sixth most commonly diagnosed cancer among women. Results with available therapies are far from being satisfactory and, therefore, current research is focusing on new anticancer drugs to improve the clinical response of these patients. Nintedanib is an oral multiple tyrosine kinases inhibitor, which targets angiogenesis. Considering the current scenario, the aim of this systematic review is to highlight the prevailing knowledge about pharmacokinetics, pharmacodynamics, clinical efficacy, and safety of Nintedanib for the treatment of advanced EOC...
October 10, 2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/30301560/evaluating-class-iii-antiarrhythmic-agents-as-novel-myc-targeting-drugs-in-ovarian-cancer
#6
Anil Belur Nagaraj, Peronne Joseph, Olga Kovalenko, QuanQiu Wang, Rong Xu, Analisa DiFeo
OBJECTIVE: To evaluate the utility of amiodarone and its derivative dronedarone as novel drug repositioning candidates in EOC and to determine the potential pathways targeted by these drugs. METHODS: Drug-predict bioinformatics platform was used to assess the utility of amiodarone as a novel drug-repurposing candidate in EOC. EOC cells were treated with amiodarone and dronedarone. Cell death was assessed by Annexin V staining. Cell viability and cell survival were assessed by MTT and clonogenics assays respectively...
October 6, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30288129/targeting-egfr-and-upar-on-human-rhabdomyosarcoma-osteosarcoma-and-ovarian-adenocarcinoma-with-a-bispecific-ligand-directed-toxin
#7
Felix Oh, Deborah Todhunter, Elizabeth Taras, Daniel A Vallera, Antonella Borgatti
Purpose: Human sarcomas are rare and difficult to treat cancerous tumors typically arising from soft tissue or bone. Conversely, carcinomas are the most common cancer subtype in humans and the primary cause of mortality across all cancer patients. While conventional therapeutic modalities can prolong disease-free intervals and survival in some cases, treatment of refractory or recurrent solid tumors is challenging, and tumor-related mortality remains unacceptably high. The identification of overexpressed cell surface receptors on sarcoma and carcinoma cells has provided a valuable tool to develop targeted toxins as an alternative anticancer strategy...
2018: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/30287783/chemotherapeutic-efficacy-of-implantable-antineoplastic-treatment-protocols-in-an-optimal-mouse-model-for-human-ovarian-carcinoma-cell-targeting
#8
Jonathan M Pantshwa, Khadija Rhoda, Sarah J Clift, Priyamvada Pradeep, Yahya E Choonara, Pradeep Kumar, Lisa C du Toit, Clement Penny, Viness Pillay
The present study aimed to design and develop a nanocomposite drug delivery system employing an antineoplastic-loaded antibody functionalized nanomicelle encapsulated within a Chitosan⁻Poly(vinylpyrrolidone)⁻Poly(N-isopropylacrylamide) (C⁻P⁻N) hydrogel to form an in situ forming implant (ISFI), responsive to temperature and pH for cancer cell-targeting following intraperitoneal implantation. The optimum nanomicelle formulation was surface-functionalized with anti-MUC 16 (antibody) for the targeted delivery of methotrexate to human ovarian carcinoma (NIH:OVCAR-5) cells in Athymic nude mice that expressed MUC16, as a preferential form of intraperitoneal ovarian cancer (OC) chemotherapy...
October 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30277755/a-polymer-ligand-based-elisa-for-robust-high-throughput-quantitative-detection-of-p53-aggregates
#9
Elisabeth Maritschnegg, Nicole Heinzl, Stuart Wilson, Simon Deycmar, Markus Niebuhr, Lukas Klameth, Barbara M Holzer, Katarzyna Koziel, Nicole Concin, Robert Zeillinger
A growing number of diseases is being linked to protein misfolding and amyloid formation. Recently, also p53 was shown to associate into amyloid aggregates, raising the question whether cancer development is associated with protein aggregation as well. However, a lack in suitable tools was hampering the evaluation of their clinical relevance. Herein we report an enzyme-linked immunosorbent assay (ELISA) system, based on a poly-ionic high molecular weight ligand, which specifically captures aggregated oligomers and amyloid proteins...
October 2, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30274248/oncobox-bioinformatical-platform-for-selecting-potentially-effective-combinations-of-target-cancer-drugs-using-high-throughput-gene-expression-data
#10
Maxim Sorokin, Roman Kholodenko, Maria Suntsova, Galina Malakhova, Andrew Garazha, Irina Kholodenko, Elena Poddubskaya, Dmitriy Lantsov, Ivan Stilidi, Petr Arhiri, Andreyan Osipov, Anton Buzdin
Sequential courses of anticancer target therapy lead to selection of drug-resistant cells, which results in continuous decrease of clinical response. Here we present a new approach for predicting effective combinations of target drugs, which act in a synergistic manner. Synergistic combinations of drugs may prevent or postpone acquired resistance, thus increasing treatment efficiency. We cultured human ovarian carcinoma SKOV-3 and neuroblastoma NGP-127 cancer cell lines in the presence of Tyrosine Kinase Inhibitors (Pazopanib, Sorafenib, and Sunitinib) and Rapalogues (Temsirolimus and Everolimus) for four months and obtained cell lines demonstrating increased drug resistance...
September 29, 2018: Cancers
https://www.readbyqxmd.com/read/30267880/therapeutic-enhancement-of-a-cytotoxic-agent-using-photochemical-internalisation-in-3d-compressed-collagen-constructs-of-ovarian-cancer
#11
Layla Mohammad Hadi, Elnaz Yaghini, Katerina Stamati, Marilena Loizidou, Alexander J MacRobert
Photochemical internalisation (PCI) is a method for enhancing delivery of drugs to their intracellular target sites of action. In this study we investigated the efficacy of PCI using a porphyrin photosensitiser and a cytotoxic agent on spheroid and non-spheroid compressed collagen 3D constructs of ovarian cancer versus conventional 2D culture. The therapeutic responses of two human carcinoma cell lines (SKOV3 and HEY) were compared using a range of assays including optical imaging. The treatment was shown to be effective in non-spheroid constructs of both cell lines causing a significant and synergistic reduction in cell viability measured at 48 or 96 h post-illumination...
September 27, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30257595/a-mitochondrial-based-oncology-platform-for-targeting-cancer-stem-cells-cscs-mito-onc-rx
#12
Federica Sotgia, Bela Ozsvari, Marco Fiorillo, Ernestina Marianna De Francesco, Gloria Bonuccelli, Michael P Lisanti
Here, we wish to propose a new systematic approach to cancer therapy, based on the targeting of mitochondrial metabolism, especially in cancer stem cells (CSCs). In the future, we envision that anti-mitochondrial therapy would ultimately be practiced as an add-on to more conventional therapy, largely for the prevention of tumor recurrence and cancer metastasis. This mitochondrial based oncology platform would require a panel of FDA-approved therapeutics (e.g. Doxycycline) that can safely be used to inhibit mitochondrial OXPHOS and/or biogenesis in CSCs...
September 26, 2018: Cell Cycle
https://www.readbyqxmd.com/read/30249527/it-s-time-to-warm-up-to-hyperthermic-intraperitoneal-chemotherapy-for-patients-with-ovarian-cancer
#13
REVIEW
Oliver Zivanovic, Dennis S Chi, Olga Filippova, Leslie M Randall, Robert E Bristow, Roisin E O'Cearbhaill
The peritoneal spread of ovarian cancer makes it a potential target for hyperthermic intraperitoneal chemotherapy (HIPEC). Intraperitoneal delivery exposes the tumor to concentrations of cytotoxic drugs much greater than with intravenous delivery, and in vitro studies have also shown that combining hyperthermia and platinum leads to an additive cytotoxic effect. Pharmacokinetic analyses have confirmed very high concentrations of cytotoxic drugs in the peritoneal cavity, with minimal systemic exposure and toxicity...
September 22, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30240186/ptml-combinatorial-model-of-chembl-compounds-assays-for-multiple-types-of-cancer
#14
Harbil Bediaga, Sonia Arrasate, Humbert González-Díaz
Determining the target proteins of new anticancer compounds is a very important task in Medicinal Chemistry. In this sense, chemists carry out preclinical assays with a high number of combinations of experimental conditions (c j ). In fact, ChEMBL database contains outcomes of 65 534 different anticancer activity preclinical assays for 35 565 different chemical compounds (1.84 assays per compound). These assays cover different combinations of c j formed from >70 different biological activity parameters ( c0 ), >300 different drug targets ( c1 ), >230 cell lines ( c2 ), and 5 organisms of assay ( c3 ) or organisms of the target ( c4 )...
October 3, 2018: ACS Combinatorial Science
https://www.readbyqxmd.com/read/30240152/protein-nanotherapeutics-as-an-emerging-modality-for-cancer-therapy
#15
REVIEW
Liang Cheng, Liang Yang, Fenghua Meng, Zhiyuan Zhong
Protein drugs are a unique and versatile class of biotherapeutics that have not only high biological activity but also superb specificity. This rapidly evolving biotechnology has rendered it possible to produce various proteins in a large scale and reproducible way. Many proteins have demonstrated striking anticancer activities and have emerged as advanced alternatives to cytotoxic chemotherapeutic agents for cancer therapy. The clinical translation of anticancer proteins with intracellular targets is, nevertheless, severely hindered by their fast degradation in vivo, poor cell penetration, and inefficient intracellular transportation...
September 21, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30233672/sparcl1-suppresses-the-proliferation-and-migration-of-human-ovarian-cancer-cells-via-the-mek-erk-signaling
#16
Yan Ma, Yuan Xu, Li Li
Ovarian cancer is the most lethal gynecological malignancy worldwide and is one of the five leading causes of cancer-associated mortality in women. There is an urgent requirement to obtain a greater understanding of the molecular mechanism underlying ovarian cancer progression in order to identify novel drug targets and biomarkers. Secreted protein acidic and rich in cysteine-like protein 1 (SPARCL1) has been suggested as a candidate tumor suppressor in various types of human cancers. However, the potential role of SPARCL1 for ovarian cancer has not yet been clearly established...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30231353/moving-from-mutation-to-actionability
#17
Ilaria Colombo, Katherine C Kurnit, Shannon N Westin, Amit M Oza
The diffusion of high-throughput next-generation sequencing technologies has sustained massive parallel sequencing of tumor tissue providing a deep insight into tumor biology and advancement of personalized medicine. A substantial number of targeted agents have been investigated in gynecologic cancer and some have received U.S. Food and Drug Administration approval, like PARP inhibitors in ovarian cancer, bevacizumab in ovarian and cervical cancers, and pembrolizumab in microsatellite-unstable or mismatch repair-deficient endometrial cancer...
May 23, 2018: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/30231335/the-epigenetic-landscape-in-the-treatment-of-gynecologic-malignancies
#18
Ramez N Eskander
The care of patients with advanced-stage or recurrent endometrial, ovarian, and cervical cancer remains clinically challenging. Despite the identification of novel therapeutics and advancements in supportive care, survival outcomes have been relatively unchanged over the past decade. In addition to established genomic alterations and the contributions of the tumor microenvironment to cancer progression, epigenetic mechanisms have emerged as important contributors to gynecologic cancer progression. DNA methylation, histone modification, and noncoding RNA expression may be important contributors to disease initiation and progression and may represent novel therapeutic targets...
May 23, 2018: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/30229902/pyruvate-dehydrogenase-kinase-1-contributes-to-cisplatin-resistance-of-ovarian-cancer-through-egfr-activation
#19
Meng Zhang, Qing Cong, Xiao-Yan Zhang, Ming-Xing Zhang, Ying-Ying Lu, Cong-Jian Xu
Patients with ovarian cancer frequently develop acquired drug resistance after the long-term chemotherapy, leading to disease progression. Enhanced epithelial-mesenchymal transition (EMT) has been implicated in chemoresistance of ovarian cancer cells; however, the molecular mechanisms involved are largely undefined. Pyruvate dehydrogenase kinase 1 (PDK1), a key regulatory enzyme in glucose metabolism, has been recognized as a gatekeeper of the Warburg effect, a hallmark of cancer. In this study, the function of PDK1 in cisplatin resistance of ovarian cancer in terms of growth and EMT was investigated...
September 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30229771/low-intensity-focused-ultrasound-lifu-activated-nanodroplets-as-a-theranostic-agent-for-noninvasive-cancer-molecular-imaging-and-drug-delivery
#20
Jianxin Liu, Fenfen Xu, Ju Huang, Jinshun Xu, Yang Liu, Yuanzhi Yao, Meng Ao, Ao Li, Lan Hao, Yang Cao, Zhongqian Hu, Haitao Ran, Zhigang Wang, Pan Li
Theranostics is a new trend in the tumor research field, which involves the integration of diagnostic and therapeutic functions using imageable nanoparticles coupled with therapeutic drugs. Imaging-guided targeted delivery of therapeutics and diagnostics using nanocarriers hold great promise to minimize the side effects of conventional chemotherapy. Ultrasound microbubbles have been employed as theranostic agents over the last decade, which provide both real-time dynamic imaging for diagnosis and precise control for targeted tumor therapy...
September 19, 2018: Biomaterials Science
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