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https://www.readbyqxmd.com/read/30310679/acute-kidney-injury-increases-the-rate-of-major-morbidities-in-cytoreductive-surgery-and-hipec
#1
Samer A Naffouje, Kiara A Tulla, Regina Chorley, Nancy Armstrong, George I Salti
Introduction: Acute kidney injury (AKI) following cardiovascular surgery has been shown to increase costs and overall morbidity and mortality. The incidence, risk factors, and outcomes of AKI following other types of major surgeries have not been as well characterized. We sought to study the incidence of AKI following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) per the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Materials and methods: Patients undergoing CRS and HIPEC between 2013 and 2015 were included...
November 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30305134/subclinical-acute-kidney-injury-is-associated-with-adverse-outcomes-in-critically-ill-neonates-and-children
#2
Fang Fang, Xiaohan Hu, Xiaomei Dai, Sanfeng Wang, Zhenjiang Bai, Jiao Chen, Jian Pan, Xiaozhong Li, Jian Wang, Yanhong Li
BACKGROUND: Research on acute kidney injury (AKI) has focused on identifying early biomarkers. However, whether AKI could be diagnosed in the absence of the classic signs of clinical AKI and whether the condition of subclinical AKI, identified by damage or functional biomarkers in the absence of oliguria or increased serum creatinine (sCr) levels, is clinically significant remains to be elucidated in critically ill children. The aims of the study were to investigate the associations between urinary cystatin C (uCysC) levels and AKI and mortality and to determine whether uCysC-positive subclinical AKI is associated with adverse outcomes in critically ill neonates and children...
October 10, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30305038/prevalence-socio-demographic-characteristics-and-comorbid-health-conditions-in-pre-dialysis-chronic-kidney-disease-results-from-the-manitoba-chronic-kidney-disease-cohort
#3
Mariette J Chartier, Navdeep Tangri, Paul Komenda, Randy Walld, Ina Koseva, Charles Burchill, Kari-Lynne McGowan, Allison Dart
BACKGROUND: Chronic Kidney Disease (CKD) is common and its prevalence has increased steadily over several decades. Monitoring of rates and severity of CKD across populations is critical for policy development and resource planning. Administrative health data alone has insufficient sensitivity for this purpose, therefore utilizing population level laboratory data and novel methodology is required for population-based surveillance. The aims of this study include a) develop the Manitoba CKD Cohort, b) estimate CKD prevalence, c) identify individuals at high risk of progression to kidney failure and d) determine rates of comorbid health conditions...
October 10, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30304281/acute-kidney-injury-due-to-systemic-loxoscelism-a-cross-sectional-study-in-northeast-brazil
#4
Polianna Lemos Moura Moreira Albuquerque, Louise Donadello Tessarolo, Fernanda Holanda Menezes, Thayanne Barreto de Lima, José Hícaro Hellano Gonçalves Lima Paiva, Geraldo Bezerra da Silva Júnior, Alice Maria Costa Martins, Elizabeth de Francesco Daher
INTRODUCTION: Loxoscelism is a clinical condition involving spiders of the genus Loxosceles. One of the most severe complications is acute kidney injury (AKI). This study aimed to investigate AKI and other complications associated with loxoscelism. METHODS: We analyzed cases diagnosed with loxoscelism in an area where most accidents were caused by Loxosceles amazonica from January 2010 to December 2015. AKI was defined according to the KDIGO criteria. RESULTS: Forty-five patients were recorded: 95...
September 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/30290766/impact-of-cardiac-catheterization-timing-and-contrast-media-dose-on-acute-kidney-injury-after-cardiac-surgery
#5
Wuhua Jiang, Jiawei Yu, Jiarui Xu, Bo Shen, Yimei Wang, Zhe Luo, Chunsheng Wang, Xiaoqiang Ding, Jie Teng
BACKGROUND: The association between pre-operative cardiac catheterization and cardiac surgery associated acute kidney injury (CSA-AKI) has been reported inconsistently. The purpose of this study is to evaluate the effect of the catheterization timing and contrast media dose on the incidence of postoperative acute kidney injury. METHODS: Patients who underwent cardiac catheterization and cardiac surgery successively from January 2015 to December 2015 were prospectively enrolled in this study...
October 5, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/30281600/vancomycin-associated-acute-kidney-injury-in-pediatric-patients
#6
Brady S Moffett, Jennifer Morris, Charissa Kam, Marianne Galati, Ankhi Dutta, Ayse Akcan-Arikan
INTRODUCTION: Vancomycin associated acute kidney injury (vAKI) is a well known complication in pediatric patients. Identification and characterization of the incidence and risk factors for vAKI in the pediatric population would assist clinicians in potentially preventing or mitigating vAKI. METHODS AND MATERIALS: A 6 year retrospective cohort study was designed. Patients were included if they were < 19 years of age, received vancomycin as inpatients, and had a baseline SCr and one other SCr drawn during and up to 72 hours after the discontinuation of vancomycin...
2018: PloS One
https://www.readbyqxmd.com/read/30269144/international-survey-on-the-management-of-acute-kidney-injury-and-continuous-renal-replacement-therapies-year-2018
#7
Kumar Digvijay, Mauro Neri, Weixuan Fan, Zaccaria Ricci, Claudio Ronco
INTRODUCTION: Definition, prevention, and management of acute kidney injury (AKI) and the optimal prescription and delivery of renal replacement therapy (RRT) are currently matters of ongoing discussion. Due to the lack of definitive published literature, a wide gap might exist between routine clinical practice and available recommendations. The aim of this survey was to explore the clinical approach to AKI and RRT in a broad population of nephrologists and intensivists participating in the 36th International course on AKI and Continuous RRT (CRRT), held in Vicenza in June 2018...
September 28, 2018: Blood Purification
https://www.readbyqxmd.com/read/30257995/incidence-etiology-and-outcomes-of-community-acquired-acute-kidney-injury-in-pediatric-admissions-in-malawi
#8
Rhys D Evans, Marie Docherty, Anna Seeley, Alison Craik, Martha Mpunga, Shawna Mann, Queen Dube, Gavin Dreyer, Ulla Hemmila
INTRODUCTION: The epidemiology of acute kidney injury (AKI) in children in sub-Sahara Africa (SSA) is poorly described. The aim of this study was to establish the incidence, etiology, and outcomes of community-acquired AKI in pediatric admissions in Southern Malawi. METHODS: We conducted a prospective observational study of pediatric admissions to a tertiary hospital in Blantyre between 5 February and 30 April 2016. Children were screened for kidney disease on admission with measurement of serum creatinine and assessment of urine output...
September 25, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/30248320/acute-kidney-injury-in-acute-type-b-aortic-dissection-outcomes-over-20-years
#9
Ryan C Hoogmoed, Himanshu J Patel, Karen M Kim, David M Williams, G Michael Deeb, Bo Yang
BACKGROUND: Mechanisms contributing to acute kidney injury (AKI) after acute type B aortic dissection (ABAD) include renal malperfusion or underlying renal dysfunction. We characterized AKI after ABAD and evaluated its potential for adverse clinical and aortic outcomes. METHODS: 478 patients without prior dialysis requirement (mean age 62.1 years, 60.5% male) presented with ABAD (1995-2016). Renal malperfusion was identified in 87 (18.2%). AKI was assessed by the KDIGO criteria...
September 21, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30234624/staggered-rather-than-staged-or-simultaneous-surgical-strategy-may-reduce-the-risk-of-acute-kidney-injury-in-patients-undergoing-bilateral-tka
#10
Won Uk Koh, Ha-Jung Kim, Hee-Sun Park, Min-Jeong Jang, Young-Jin Ro, Jun-Gol Song
BACKGROUND: The strategy for bilateral total knee arthroplasty (TKA) depends on the timing of surgery for each knee. The purpose of this study was to determine whether the type of surgical strategy for bilateral TKA (staggered, staged, or simultaneous) influences the incidence of acute kidney injury (AKI) and related complications. METHODS: Enrolled patients from a single tertiary teaching hospital were divided into 3 groups according to the surgical strategy for bilateral TKA: staggered (≤7 days between the first and second procedure; n = 368), staged (8 days to 1 year between the first and second procedure; n = 265), or simultaneous (n = 820)...
September 19, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/30230941/long-term-renal-function-and-hypertension-in-adult-survivors-of-childhood-sarcoma-single-center-experience
#11
Amalia Schiavetti, Valeria Pedetti, Giulia Varrasso, Oriana Marrucci, Camilla Celani, Gianmarco Andreoli, Enea Bonci
AIM: Little data is available on long-term renal impairment in survivors from childhood sarcoma. We investigated the prevalence of renal impairment and hypertension after very long-term follow-up in survivors who reached adulthood after treatment for childhood sarcoma. METHODS: A cross-sectional single center study was performed. Outcomes included estimating glomerular filtration rate (eGFR), albuminuria, glycosuria, serum phosphate and magnesium, tubular reabsorption phosphate (TRP), chronic kidney disease (CKD) according to the "Kidney Disease: Improving Global Outcomes" (KDIGO) guidelines and blood pressure (BP)...
September 19, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/30229506/high-preoperative-plasma-endothelin-1-levels-are-associated-with-increased-acute-kidney-injury-risk-after-pulmonary-endarterectomy
#12
Fabrizio Grosjean, Mara De Amici, Catherine Klersy, Gianluca Marchi, Antonio Sciortino, Federica Spaltini, Maurizio Pin, Valentina Grazioli, Anna Celentano, Benedetta Vanini, Giorgia Testa, Vincenzo Sepe, Teresa Rampino, Andrea Maria D'Armini
OBJECTIVES: The only curative treatment for chronic thromboembolic pulmonary hypertension (CTEPH) is pulmonary endarterectomy (PEA). PEA requires cardiopulmonary bypass (CPB) which is associated with a high acute kidney injury (AKI) risk. Circulating endothelin-1 (ET-1) levels are elevated in CTEPH, and ET-1 plays a pivotal role in AKI. Because AKI is burdened by high morbidity and mortality, we aimed to evaluate the association between preoperative ET-1 and the risk to develop AKI in CTEPH individuals who undergo PEA...
September 18, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/30225746/the-effect-of-short-course-gentamicin-therapy-on-kidney-function-in-patients-with-bacteraemia-a-retrospective-cohort-study
#13
Sarah Carlsen, Jonas Boel, Jens Otto Jarløv, Ida Gjørup, Christian Søborg, Magnus Arpi
The nephrotoxic potential of aminoglycosides is primarily correlated to the duration of therapy. However, there are discrepancies between previous studies regarding the effect of short course treatment. The aim of this study was to compare renal function, renal recovery and mortality in a large cohort of patients with bacteraemia, who were empirically treated with regimens with and without a short course (≤ 3 days) of once daily dosing of gentamicin. This was a retrospective propensity score-matched cohort study based on all patients with bacteraemia in a Danish hospital in the period 2010-2013...
September 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30223269/impact-of-kdigo-defined-acute-kidney-injury-on-mortality-after-percutaneous-coronary-intervention-for-acute-myocardial-infarction
#14
Vojko Kanic, Gregor Kompara, David Suran, Robert Ekart, Sebastjan Bevc, Radovan Hojs
BACKGROUND: There are limited data regarding the incidence and long-term impact of acute kidney injury (AKI) according to the KDIGO guidelines on the outcome in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI). The aim of the study was to evaluate the prevalence of AKI, as classified by the KDIGO criteria, and its association with long-term mortality. METHODS: Data from 5,859 MI patients undergoing PCI at our institution were analyzed...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/30197969/renal-outcomes-of-antidiabetic-treatment-options-for-type-2-diabetes-a-proposed-mare-definition
#15
REVIEW
Friedrich C Prischl, Christoph Wanner
One of the most critical long-term complications of type 2 diabetes is nephropathy, currently termed diabetic kidney disease. Although the prevalence is increasing, renal outcomes are heterogeneously defined. Intensive glucose control is effective for the prevention of microvascular complications, including kidney disease. However, the impact of specific drugs on renal outcome measures such as the incidence of kidney disease, albuminuria, progression to end-stage kidney disease, or death of renal cause remains unclear...
September 2018: KI Reports
https://www.readbyqxmd.com/read/30189043/acute-kidney-injury-after-burn-a-cohort-study-from-the-parkland-burn-intensive-care-unit
#16
Audra T Clark, Xilong Li, Rohan Kulangara, Beverley Adams-Huet, Sarah C Huen, Tarik D Madni, Jonathan B Imran, Herb A Phelan, Brett D Arnoldo, Orson W Moe, Steven E Wolf, Javier A Neyra
Rationale & Objective: Acute kidney injury (AKI) is a common and morbid complication in patients with severe burn. The reported incidence of AKI and mortality in this population vary widely due to inconsistent and changing definitions. We aimed to examine the incidence, severity, and hospital mortality of AKI patients after burn using consensus criteria. Study Design: Retrospective cohort study of adults with thermal injury admitted to the Parkland burn intensive care unit (ICU) from 2008 to 2015...
September 5, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30187381/acute-kidney-injury-following-coronary-angiography-a-nationwide-study-of-incidence-risk-factors-and-long-term-outcomes
#17
Dadi Helgason, Thorir E Long, Solveig Helgadottir, Runolfur Palsson, Gisli H Sigurdsson, Tomas Gudbjartsson, Olafur S Indridason, Ingibjorg J Gudmundsdottir, Martin I Sigurdsson
BACKGROUND: We studied the incidence and risk factors of acute kidney injury (AKI) following coronary angiography (CA) and examined short- and long-term outcomes of patients who developed AKI, including progression of chronic kidney disease (CKD). METHODS: This was a retrospective study of all patients undergoing CA in Iceland from 2008 to 2015, with or without percutaneous coronary intervention. All procedures were performed with iso-osmolar contrast. AKI was defined according to the SCr component of the KDIGO criteria...
October 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/30186012/role-of-intra-abdominal-pressure-in-early-acute-kidney-injury-a-prospective-cohort-study-in-critically-ill-obstetric-patients
#18
Asha Tyagi, Shubham Lahan, Gaurav Verma, Shukla Das, Mahendra Kumar
Aims: This prospective cohort study evaluated intra-abdominal pressure (IAP) and its role in causing acute kidney injury (AKI) in critically ill obstetric patients and utility of urinary neutrophil gelatinase-associated lipocalin (NGAL) to predict AKI. Methods: A total of 50 eligible obstetric patients admitted to our Intensive Care Unit were enrolled and daily IAP measured using indwelling Foley catheter. Early AKI was diagnosed as per the KDIGO criteria and urine assessed for NGAL using ELISA...
August 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/30170649/applicability-of-the-cleveland-clinic-scoring-system-for-the-risk-prediction-of-acute-kidney-injury-after-cardiac-surgery-in-a-south-asian-cohort
#19
Shobhana Nayak Rao, Pradeep Shenoy M, Mundayat Gopalakrishnan, Amith Kiran B
BACKGROUND: Acute kidney injury (AKI) after cardiac surgery is a frequent post-operative complication associated with an increased risk of mortality, morbidity and hospital costs. Preoperative risk scores such as the Cleveland Clinic Scoring Tool (CCST) have been validated in Western population group to identify patients at higher risk of AKI and may facilitate preventive strategies. However, the scoring tool has not been validated systematically in a South Asian cohort. We aimed to evaluate the applicability of the CCST in prediction of AKI after open cardiac surgery in a South-Indian tertiary care center...
July 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/30127836/cotreatment-with-furosemide-and-hypertonic-saline-decreases-serum-neutrophil-gelatinase-associated-lipocalin-ngal-and-serum-creatinine-concentrations-in-traumatic-brain-injury-a-randomized-single-blind-clinical-trial
#20
Marziye Jafari, Shahram Ala, Kaveh Haddadi, Abbas Alipour, Mojtaba Mojtahedzadeh, Saeid Ehteshami, Saeid Abediankenari, Misagh Shafizad, Ebrahim Salehifar, Foroogh Khalili
Acute kidney injury (AKI) occurs both after traumatic brain injury (TBI) and after hypertonic saline administration; furosemide may be useful in preventing AKI indirectly. Serum neutrophil gelatinase-associated lipocalin (sNGAL) is superior to serum creatinine (sCr) in diagnosing early AKI. We compared the administration of hypertonic saline plus furosemide (HTS+F) versus hypertonic saline (HTS), using sCr and sNGAL to investigate kidney injury in patients with TBI. This randomized, single-blind clinical trial was conducted from August 2016 to July 2017 in a neurosurgical intensive care unit, and included patients with a Glasgow Coma Score (GCS) 7-13 and brain edema...
2018: Iranian Journal of Pharmaceutical Research: IJPR
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