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KDIGO criteria

Jianjun Xu, Yun Xia, Suzhen Li, Xiang Cheng, Shaobo Hu, Xing Zhou, Yang Gao, Guoliang Wang, Qichang Zheng
BACKGROUND: The aspartate aminotransferase (AST) / alanine aminotransferase (ALT) ratio(AST/ALT) is an independent predictor of hepatic disease. OBJECTIVES: To evaluate the association between pre-operative AST/ALT and post-operative acute kidney injury(AKI) in hepatocellular carcinoma (HCC) patients. METHODS: A total of 422 hepatitis B- or C- virus associated HCC patients, who underwent hepatectomy between September 2012 and April 2018, were enrolled this retrospective study...
November 19, 2018: Annals of Clinical Biochemistry
Javier A Neyra, Federica Mescia, Xilong Li, Beverley Adams-Huet, Lenar Yessayan, Jerry Yee, Robert D Toto, Orson W Moe
Introduction: Chronic kidney disease (CKD) and acute kidney injury (AKI) are strongly associated with excess morbidity and mortality and frequently co-occur in critically ill septic patients, but how their interplay affects clinical outcomes is not well elucidated. Methods: We conducted a single-center, retrospective cohort study of 2632 adult patients admitted to the intensive care unit (ICU) with severe sepsis or septic shock. Subjects were classified into 6 groups according to baseline CKD (no-CKD: estimated glomerular filtration rate [eGFR] ≥60; CKD: eGFR 15-59 ml/min per 1...
November 2018: KI Reports
Tania C Spada, José M R D Silva, Lucila S Francisco, Lia J Marçal, Leila Antonangelo, Dirce M T Zanetta, Luis Yu, Emmanuel A Burdmann
PURPOSE: High-intensity interval resistance training (HIIRT) is an increasingly popular exercise program that provides positive results with short sessions. This study aimed to evaluate whether an HIIRT session causes muscle and kidney damage. METHODS: Fifty-eight healthy volunteers (median age 24 years, 50% women) participated in this study and performed a HIIRT session. The Borg CR10 scale for pain (CR10P) and blood and urine samples were collected before (baseline) and 2 and 24 hours after the HIIRT session...
2018: PloS One
Ryan W Haines, Alex J Fowler, Christopher J Kirwan, John R Prowle
BACKGROUND: As more patients are surviving the initial effects of traumatic injury clinicians are faced with managing the systemic complications of severe tissue injury. Of these acute kidney injury (AKI) may be a sentinel complication contributing to adverse outcomes. OBJECTIVE: To establish the incidence of AKI in patients admitted to critical care after major trauma, to explore any risk factors and to evaluate the association of AKI with outcomes. DATA SOURCES: Systematic search of MEDLINE, EMBASE and Cochrane library from January 2004 to April 2018...
October 23, 2018: Journal of Trauma and Acute Care Surgery
Jenny Hc Chen, Peter Hughes, Claudia Woodroffe, Paolo Ferrari
Baseline pre-donation eGFR appears to predict the risk of post-donation chronic kidney disease in live donors. New KIDGO guidelines recommend an eGFR ≥90ml/min/1.73m2 as an acceptable level of GFR for kidney donation. In the Australian Paired Kidney Exchange (AKX) program, all donors with a raw measured GFR (mGFR) ≥80ml/min are deemed suitable for donation, but the significance of this selection indicator is unclear. We analysed the first 129 live donors in the AKX program with at least 1-year follow-up linking records in the AKX database and ANZDATA...
October 24, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Nattachai Srisawat, Manasnun Kongwibulwut, Passisd Laoveeravat, Nuttha Lumplertgul, Pornlert Chatkaew, Pipat Saeyub, Krittayot Latthaprecha, Sadudee Peerapornratana, Khajohn Tiranathanagul, Somchai Eiam-Ong, Kriang Tungsanga
BACKGROUND: Laparoscopic abdominal surgery has been widely used to reduce the length of hospital stay and complications from open abdominal surgery. During the operation, the creation of pneumoperitoneum is used for better visualization of the operating field. However, the effect of pneumoperitoneum on kidney function is unknown. We aimed to identify risk factors and predictors associated with AKI development following laparoscopic abdominal surgery. METHODS: A single-center prospective cohort study of laparoscopic abdominal surgery patients between June 2012 and December 2013...
October 22, 2018: BMC Nephrology
Beate Appenrodt, Frank Lammert
Renal failure is a severe complication in patients with liver cirrhosis. It is associated with increased mortality and morbidity. Diagnosis is a challenge because it is mainly based on serum creatinine, which does not seem to be an ideal measure of renal function in cirrhosis. The definition of renal failure in these patients has been changed for optimizing treatment and for improving outcome and prognosis. The new criteria are based on the adapted KDIGO (Kidney Disease: Improving Global Outcomes) staging system...
August 2018: Visceral Medicine
Paulo Ricardo Gessolo Lins, Wallace Stwart Carvalho Padilha, Carolina Frade Magalhaes Giradin Pimentel, Marcelo Costa Batista, Aécio Flávio Teixeira de Gois
BACKGROUND: Acute kidney injury (AKI) is common in cirrhotic patients and is associated with negative outcomes. The aim of this study was to evaluate the presence of AKI and its progression according to KDIGO (Kidney Disease: Improving Global Outcomes) criteria in cirrhotic patients admitted to the emergency department and to determine the association of AKI with hospital mortality. METHODS: This retrospective study included 258 cirrhotic patients admitted to the emergency department of a university hospital from March 2015 to February 2017...
October 20, 2018: BMC Nephrology
D R McIlroy, R Bellomo, F T Billings, K Karkouti, J R Prowle, A D Shaw, P S Myles
BACKGROUND: Renal injury is a common perioperative complication. The adoption of renal endpoints, standardised and valid for use in perioperative clinical trials, would enhance the quality of perioperative clinical research. The Standardised Endpoints in Perioperative Medicine (StEP) initiative was established to derive standardised endpoints for use in perioperative clinical trials. METHODS: A systematic review was conducted to identify renal endpoints currently reported in perioperative clinical trials...
November 2018: British Journal of Anaesthesia
Samer A Naffouje, Kiara A Tulla, Regina Chorley, Nancy Armstrong, George I Salti
Introduction: Acute kidney injury (AKI) following cardiovascular surgery has been shown to increase costs and overall morbidity and mortality. The incidence, risk factors, and outcomes of AKI following other types of major surgeries have not been as well characterized. We sought to study the incidence of AKI following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) per the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Materials and methods: Patients undergoing CRS and HIPEC between 2013 and 2015 were included...
November 2018: Annals of Medicine and Surgery
Fang Fang, Xiaohan Hu, Xiaomei Dai, Sanfeng Wang, Zhenjiang Bai, Jiao Chen, Jian Pan, Xiaozhong Li, Jian Wang, Yanhong Li
BACKGROUND: Research on acute kidney injury (AKI) has focused on identifying early biomarkers. However, whether AKI could be diagnosed in the absence of the classic signs of clinical AKI and whether the condition of subclinical AKI, identified by damage or functional biomarkers in the absence of oliguria or increased serum creatinine (sCr) levels, is clinically significant remains to be elucidated in critically ill children. The aims of the study were to investigate the associations between urinary cystatin C (uCysC) levels and AKI and mortality and to determine whether uCysC-positive subclinical AKI is associated with adverse outcomes in critically ill neonates and children...
October 10, 2018: Critical Care: the Official Journal of the Critical Care Forum
Mariette J Chartier, Navdeep Tangri, Paul Komenda, Randy Walld, Ina Koseva, Charles Burchill, Kari-Lynne McGowan, Allison Dart
BACKGROUND: Chronic Kidney Disease (CKD) is common and its prevalence has increased steadily over several decades. Monitoring of rates and severity of CKD across populations is critical for policy development and resource planning. Administrative health data alone has insufficient sensitivity for this purpose, therefore utilizing population level laboratory data and novel methodology is required for population-based surveillance. The aims of this study include a) develop the Manitoba CKD Cohort, b) estimate CKD prevalence, c) identify individuals at high risk of progression to kidney failure and d) determine rates of comorbid health conditions...
October 10, 2018: BMC Nephrology
Polianna Lemos Moura Moreira Albuquerque, Louise Donadello Tessarolo, Fernanda Holanda Menezes, Thayanne Barreto de Lima, José Hícaro Hellano Gonçalves Lima Paiva, Geraldo Bezerra da Silva Júnior, Alice Maria Costa Martins, Elizabeth de Francesco Daher
INTRODUCTION: Loxoscelism is a clinical condition involving spiders of the genus Loxosceles. One of the most severe complications is acute kidney injury (AKI). This study aimed to investigate AKI and other complications associated with loxoscelism. METHODS: We analyzed cases diagnosed with loxoscelism in an area where most accidents were caused by Loxosceles amazonica from January 2010 to December 2015. AKI was defined according to the KDIGO criteria. RESULTS: Forty-five patients were recorded: 95...
September 2018: Revista da Sociedade Brasileira de Medicina Tropical
Wuhua Jiang, Jiawei Yu, Jiarui Xu, Bo Shen, Yimei Wang, Zhe Luo, Chunsheng Wang, Xiaoqiang Ding, Jie Teng
BACKGROUND: The association between pre-operative cardiac catheterization and cardiac surgery associated acute kidney injury (CSA-AKI) has been reported inconsistently. The purpose of this study is to evaluate the effect of the catheterization timing and contrast media dose on the incidence of postoperative acute kidney injury. METHODS: Patients who underwent cardiac catheterization and cardiac surgery successively from January 2015 to December 2015 were prospectively enrolled in this study...
October 5, 2018: BMC Cardiovascular Disorders
Brady S Moffett, Jennifer Morris, Charissa Kam, Marianne Galati, Ankhi Dutta, Ayse Akcan-Arikan
INTRODUCTION: Vancomycin associated acute kidney injury (vAKI) is a well known complication in pediatric patients. Identification and characterization of the incidence and risk factors for vAKI in the pediatric population would assist clinicians in potentially preventing or mitigating vAKI. METHODS AND MATERIALS: A 6 year retrospective cohort study was designed. Patients were included if they were < 19 years of age, received vancomycin as inpatients, and had a baseline SCr and one other SCr drawn during and up to 72 hours after the discontinuation of vancomycin...
2018: PloS One
Kumar Digvijay, Mauro Neri, Weixuan Fan, Zaccaria Ricci, Claudio Ronco
INTRODUCTION: Definition, prevention, and management of acute kidney injury (AKI) and the optimal prescription and delivery of renal replacement therapy (RRT) are currently matters of ongoing discussion. Due to the lack of definitive published literature, a wide gap might exist between routine clinical practice and available recommendations. The aim of this survey was to explore the clinical approach to AKI and RRT in a broad population of nephrologists and intensivists participating in the 36th International course on AKI and Continuous RRT (CRRT), held in Vicenza in June 2018...
September 28, 2018: Blood Purification
Rhys D R Evans, Marie Docherty, Anna Seeley, Alison Craik, Martha Mpugna, Shawna Mann, Queen Dube, Gavin Dreyer, Ulla Hemmila
INTRODUCTION: The epidemiology of acute kidney injury (AKI) in children in sub-Sahara Africa (SSA) is poorly described. The aim of this study was to establish the incidence, etiology, and outcomes of community-acquired AKI in pediatric admissions in Southern Malawi. METHODS: We conducted a prospective observational study of pediatric admissions to a tertiary hospital in Blantyre between 5 February and 30 April 2016. Children were screened for kidney disease on admission with measurement of serum creatinine and assessment of urine output...
November 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Ryan C Hoogmoed, Himanshu J Patel, Karen M Kim, David M Williams, G Michael Deeb, Bo Yang
BACKGROUND: Mechanisms contributing to acute kidney injury (AKI) after acute type B aortic dissection (ABAD) include renal malperfusion or underlying renal dysfunction. We characterized AKI after ABAD and evaluated its potential for adverse clinical and aortic outcomes. METHODS: 478 patients without prior dialysis requirement (mean age 62.1 years, 60.5% male) presented with ABAD (1995-2016). Renal malperfusion was identified in 87 (18.2%). AKI was assessed by the KDIGO criteria...
September 21, 2018: Annals of Thoracic Surgery
Won Uk Koh, Ha-Jung Kim, Hee-Sun Park, Min-Jeong Jang, Young-Jin Ro, Jun-Gol Song
BACKGROUND: The strategy for bilateral total knee arthroplasty (TKA) depends on the timing of surgery for each knee. The purpose of this study was to determine whether the type of surgical strategy for bilateral TKA (staggered, staged, or simultaneous) influences the incidence of acute kidney injury (AKI) and related complications. METHODS: Enrolled patients from a single tertiary teaching hospital were divided into 3 groups according to the surgical strategy for bilateral TKA: staggered (≤7 days between the first and second procedure; n = 368), staged (8 days to 1 year between the first and second procedure; n = 265), or simultaneous (n = 820)...
September 19, 2018: Journal of Bone and Joint Surgery. American Volume
Amalia Schiavetti, Valeria Pedetti, Giulia Varrasso, Oriana Marrucci, Camilla Celani, Gianmarco Andreoli, Enea Bonci
AIM: Little data is available on long-term renal impairment in survivors from childhood sarcoma. We investigated the prevalence of renal impairment and hypertension after very long-term follow-up in survivors who reached adulthood after treatment for childhood sarcoma. METHODS: A cross-sectional single center study was performed. Outcomes included estimating glomerular filtration rate (eGFR), albuminuria, glycosuria, serum phosphate and magnesium, tubular reabsorption phosphate (TRP), chronic kidney disease (CKD) according to the "Kidney Disease: Improving Global Outcomes" (KDIGO) guidelines and blood pressure (BP)...
September 19, 2018: Pediatric Hematology and Oncology
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