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KDIGO criteria

Daniele Roberto Giacobbe, Alessandra di Masi, Loris Leboffe, Valerio Del Bono, Marianna Rossi, Dario Cappiello, Erika Coppo, Anna Marchese, Annarita Casulli, Alessio Signori, Andrea Novelli, Katja Perrone, Luigi Principe, Alessandra Bandera, Luca Enrico Vender, Andrea Misin, Pierpaolo Occhilupo, Marcello Melone, Paolo Ascenzi, Andrea Gori, Roberto Luzzati, Claudio Viscoli, Stefano Di Bella
This study aimed to assess the predictors of acute kidney injury (AKI) during colistin therapy in a cohort of patients with bloodstream infections (BSI) due to colistin-susceptible Gram-negative bacteria, focusing on the role of serum albumin levels. The study consisted of two parts: (1) a multicentre retrospective clinical study to assess the predictors of AKI during colistin therapy, defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria; and (2) bioinformatic and biochemical characterization of the possible interaction between human serum albumin and colistin...
August 10, 2018: Scientific Reports
Hamid Mohamadlou, Anna Lynn-Palevsky, Christopher Barton, Uli Chettipally, Lisa Shieh, Jacob Calvert, Nicholas R Saber, Ritankar Das
Background: A major problem in treating acute kidney injury (AKI) is that clinical criteria for recognition are markers of established kidney damage or impaired function; treatment before such damage manifests is desirable. Clinicians could intervene during what may be a crucial stage for preventing permanent kidney injury if patients with incipient AKI and those at high risk of developing AKI could be identified. Objective: In this study, we evaluate a machine learning algorithm for early detection and prediction of AKI...
2018: Canadian Journal of Kidney Health and Disease
Marco Ranucci, Tommaso Aloisio, Anna Cazzaniga, Umberto Di Dedda, Chiara Gallazzi, Valeria Pistuddi
BACKGROUND: Cardiac surgery-associated acute kidney injury (AKI) is a serious complication of cardiac surgery, even when renal replacement therapy (RRT) is not required. The existing risk models for cardiac surgery associated AKI are designed to predict AKI requiring RRT (RRT-AKI). The aim of this study is to validate three risk models for the prediction of RRT-dependent and non-RRT AKI after cardiac surgery. METHODS: Retrospective analysis on 7675 consecutive adult patients undergoing cardiac surgery with cardiopulmonary bypass...
July 24, 2018: International Journal of Cardiology
Lucy Ryan, Andrew Heed, Jonathan Foster, Manoj Valappil, Matthias L Schmid, Christopher J A Duncan
OBJECTIVES: This study sought to identify the incidence of, and risk factors for, acute kidney injury (AKI) in adults treated with parenteral aciclovir. METHODS: A single-centre retrospective cohort study of prospectively acquired electronic clinical, pharmacy and laboratory data was performed with approval of the Caldicott guardian. AKI was defined by Kidney Disease Improving Global OUTCOMES: (KDIGO) criteria, prior to analysis of baseline patient and treatment-related risk factors...
July 6, 2018: International Journal of Infectious Diseases: IJID
Jennifer S McDonald, Robert J McDonald, Cheryl L Tran, Amy B Kolbe, Eric E Williamson, David F Kallmes
RATIONAL & OBJECTIVE: The risks of iodinated contrast material administered to pediatric patients are not well defined. The purpose of this study was to examine the rates of postcontrast acute kidney injury (AKI), dialysis therapy, and death following administration of intravenous contrast material to pediatric patients. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Pediatric (aged <18 years) patients who underwent either contrast-enhanced (contrast group) or unenhanced (noncontrast group) computed tomography (CT) at our institution from December 2001 to January 2016...
July 21, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Bruno M Tavares, Paula Fcbc Fernandes, Cláudia Maria C Oliveira, Sônia L Silva, Márcia U Mota, Tacilla Hs Andrade, Samuel F Cunha, Evelyne S Girão
BACKGROUND: Chikungunya virus (CHIKV) infection is an acute febrile illness with polyarthralgia and arthritis. There are few data about CHIKV infection in kidney transplant recipients (KTR). We report the largest case series of CHIKV infection in this population. METHODS: We retrospectively analyzed 32 cases of CHIKV infection in KTR between January 2016 and December 2017 at Hospital Universitário Walter Cantídio of Federal University of Ceará. RESULTS: All patients had been in endemic area before the beginning of the symptoms...
July 13, 2018: Transplantation
Edgar Dehesa Lopez, Carlos Córdova-Cázarez, Rafael Valdez-Ortiz, Carlie Michelle Cardona-Landeros, María Fernanda Gutiérrez-Rico
AIM: To determine the prevalence of chronic kidney disease (CKD) and the epidemiological, clinical, and laboratory factors associated with CKD in Mexican HIV-infected patients. METHODS: Cross-sectional study. We included 274 patients with HIV/AIDS. CKD was defined by the estimated glomerular filtration rate (eGFR < 60 mL/min/1.73 m2 assessed by CKD-EPI) and albuminuria criteria from KDIGO guidelines. Clinical, epidemiological, and laboratory characteristics were compared between patients with and without CKD...
July 10, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Sérgio Luiz Arruda Parente Filho, Livia Maria Barbosa Lima, Gilberto Loiola de Alencar Dantas, Débora de Almeida Silva, Victor de Matos Rolim, Antônio Mendes Ponte de Oliveira Filho, Iamê Tavares Vale E Melo, Geraldo Bezerra da Silva Junior, Elizabeth De Francesco Daher
OBJECTIVE: To investigate prognostic factors among critically ill patients with community-acquired bacterial meningitis and acute kidney injury. METHODS: A retrospective study including patients admitted to a tertiary infectious disease hospital in Fortaleza, Brazil diagnosed with community-acquired bacterial meningitis complicated with acute kidney injury. Factors associated with death, mechanical ventilation and use of vasopressors were investigated. RESULTS: Forty-one patients were included, with a mean age of 41...
April 2018: Revista Brasileira de Terapia Intensiva
Ji-Hyun Lee, Ji-Yoon Jung, Sun-Woo Park, In-Kyung Song, Eun-Hee Kim, Hee-Soo Kim, Jin-Tae Kim
BACKGROUND: The objective of this retrospective study was to determine the risk factors for acute kidney injury (AKI), including albumin, in children who underwent cardiac surgery. In addition, we evaluated the association between preoperative serum albumin level and postoperative AKI in these patients. METHODS: This retrospective study included 505 pediatric patients who underwent congenital cardiac surgery. Preoperative and perioperative risk factors for AKI, including serum albumin level, were assessed...
July 11, 2018: Acta Anaesthesiologica Scandinavica
Amanda M Uber, Maria E Montez-Rath, David M Kwiatkowski, Catherine D Krawczeski, Scott M Sutherland
BACKGROUND: Though acute kidney injury (AKI) is often multifactorial, investigators are now emphasizing the specific contribution of nephrotoxins. This study examines the epidemiology of nephrotoxin exposure and nephrotoxin-associated AKI among children undergoing congenital heart surgery (CHS). METHODS: This is a retrospective cohort study of children admitted following CHS between June 1, 2014, and September 30, 2014. Nephrotoxins were defined according to the Nephrotoxic Injury Negated by Just-in-time-Action (NINJA) collaborative; high nephrotoxin exposure was defined as receipt of ≥ 3 nephrotoxins concurrently...
July 9, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Renata Garcia-Gigorro, Emilio Renes-Carreño, María Angélica Corres-Peiretti, Primitivo Arribas-López, Jose Luis Pérez-Vela, Julián Gutierrez-Rodríguez, Juan Francisco Delgado, Jose María Cortina-Romero, Juan Carlos Montejo-González
BACKGROUND: Little is known about the incidence of acute kidney injury (AKI), as defined using the Kidney Disease Improving Global Outcome (KDIGO) classification, after heart transplantation (HT). OBJECTIVE: Our objective was to evaluate the impact of AKI in a cohort of HT recipients. (Setting: University Hospital.) METHODS: We studied 310 consecutive HT recipients from 1999 to 2017, with AKI being defined according to the KDIGO criteria. Risk factors were analyzed by multivariable analyses, and survival by Kaplan-Meier curves and a risk-adjusted Cox proportional hazards regression model...
July 4, 2018: Transplantation
Moritz Schanz, Christoph Wasser, Sebastian Allgaeuer, Severin Schricker, Juergen Dippon, Mark Dominik Alscher, Martin Kimmel
Background: Early detection and prevention of acute kidney injury (AKI) is important to reduce morbidity and mortality. Discovery of early-detection biomarkers has enabled early preventive approaches. There are no data on early biomarker-guided intervention with nephrological consultation in emergency departments (EDs). Methods: In this prospective randomized controlled intervention trial, patients at high risk for AKI were screened with urinary [TIMP-2]·[IGFBP7] in the ED of Robert-Bosch-Hospital (Stuttgart, Germany)...
June 28, 2018: Nephrology, Dialysis, Transplantation
Qinglin Li, Meng Zhao, Xiaodan Wang
Objectives: To compare the differences between the Kidney Disease Improving Global Outcomes (KDIGO) criteria of the 48-hour window and the 7-day window in the diagnosis of acute kidney injury (AKI) in very elderly patients, as well as the relationship between the 48-hour and 7-day windows for diagnosis and 90-day mortality. Patients and methods: We retrospectively enrolled very elderly patients (≥75 years old) from the geriatrics department of the Chinese PLA General Hospital between January 2007 and December 2015...
2018: Clinical Interventions in Aging
Samuel H Howitt, Stuart W Grant, Camila Caiado, Eric Carlson, Dowan Kwon, Ioannis Dimarakis, Ignacio Malagon, Charles McCollum
BACKGROUND: The Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury (AKI) guidelines assign the same stage of AKI to patients whether they fulfil urine output criteria, serum creatinine criteria or both criteria for that stage. This study explores the validity of the KDIGO guidelines as a tool to stratify the risk of adverse outcomes in cardiac surgery patients. METHODS: Prospective data from consecutive adult patients admitted to the cardiac intensive care unit (CICU) following cardiac surgery between January 2013 and May 2015 were analysed...
June 25, 2018: BMC Nephrology
José Luís Martins, Luís Santos, Ana Faustino, Jesus Viana, José Santos
INTRODUCTION: Renal insufficiency, as evidenced by an increase in creatinine, is associated with higher mortality in patients with acute heart failure (AHF). Conversely, hemoconcentration (HC) in AHF is associated with lower mortality, but can also cause an increase in creatinine. Our aim was to assess the prognosis of HC in patients hospitalized for AHF presenting with or without worsening renal function (WRF). METHODS: A total of 618 consecutive patients admitted for AHF were included...
July 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Shi-Min Yuan
Acute kidney injury (AKI) is a common complication of pediatric cardiac surgery and is associated with increased morbidity and mortality. Literature of AKI after pediatric cardiac surgery is comprehensively reviewed in terms of incidence, risk factors, biomarkers, treatment and prognosis. The novel RIFLE (pediatric RIFLE for pediatrics), Acute Kidney Injury Network (AKIN) and Kidney Disease Improving Global Outcomes (KDIGO) criteria have brought about unified diagnostic standards and comparable results for AKI after cardiac surgery...
March 30, 2018: Pediatrics and Neonatology
Mohamed A Shalaby, Zinab A Sawan, Esraa Nawawi, Saad Alsaedi, Heidi Al-Wassia, Jameela A Kari
BACKGROUND: Acute kidney injury (AKI) is common in neonates admitted to the neonatal intensive care unit (NICU). AKI is associated with increased morbidity and mortality and a greater long-term risk of chronic kidney disease. OBJECTIVES: To study the incidence and outcome of neonatal AKI in a single Saudi Arabian center, level 2\3 NICU. METHODS: This single-center prospective cohort study included all infants who received level II or III NICU care during 2015 (January to December)...
June 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Joseph H Marcotte, Kinjal Patel, Ronak Desai, John P Gaughan, Deviney Rattigan, Kevin W Cahill, Robin F Irons, Justin Dy, Monika Dobrowolski, Helena McElhenney, Michael Kwiatt, Steven McClane
PURPOSE: Fluid management within Enhanced Recovery After Surgery (ERAS) protocols is designed to maintain a euvolemic state avoiding the negative sequelae of hypervolemia or hypovolemia. We sought to determine the effect of a recent ERAS protocol implementation on kidney function and on the incidence of postoperative acute kidney injury (AKI). METHODS: A total of 132 elective colorectal resections performed using our ERAS protocol were compared to a propensity-matched group prior to ERAS implementation...
May 28, 2018: International Journal of Colorectal Disease
Min Suk Chae, Youngchan Kim, Hyun Sik Chung, Chul Soo Park, Jaemin Lee, Jong Ho Choi, Sang Hyun Hong
Introduction: Previous studies have shown that a higher serum interleukin- (IL-) 6 level is associated with a higher risk of acute kidney injury (AKI) development after major nontransplant surgery. Our study investigated the potential association of preoperative serum cytokine profiles with new AKI development in patients who underwent living donor liver transplantation (LDLT). Methods: Serum levels of cytokines IL-2, IL-6, IL-10, IL-12, and IL-17, interferon- γ , and tumor necrosis factor- (TNF-) α were measured in 226 LDLT recipients preoperatively and analyzed retrospectively...
2018: Mediators of Inflammation
Cédrick Zaouter, Julien Potvin, Marie-Lise Bats, Marie-Christine Beauvieux, Alain Remy, Alexandre Ouattara
BACKGROUND: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent complication. The current criteria to detect CSA-AKI rise only when organic dysfunction has occurred. The Doppler Renal Resistive Index (RRI) and the urinary G1 cell cycle arrest proteins (TIMP-2 and IGFBP7) have been advocated to predict CSA-AKI at an early stage after cardiac surgery. The primary objective was to determine the predictive value of these new markers to detect CSA-AKI after elective heart surgery in patients at risk to develop AKI...
May 17, 2018: Anaesthesia, Critical Care & Pain Medicine
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