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https://www.readbyqxmd.com/read/30523562/subclinical-aki-ready-for-primetime-in-clinical-practice
#1
REVIEW
Jill Vanmassenhove, Wim Van Biesen, Raymond Vanholder, Norbert Lameire
There has been considerable progress over the last decade in the standardization of the acute kidney injury (AKI) definition with the publication of the RIFLE, AKIN, KDIGO and ERBP classification criteria. However, these classification criteria still rely on imperfect parameters such as serum creatinine and urinary output. The use of timed urine collections, kinetic eGFR (estimated glomerular filtration rate), real time measurement of GFR and direct measures of tubular damage can theoretically aid in a more timely diagnosis of AKI and improve patients' outcome...
December 6, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/30483313/risk-factors-for-acute-kidney-injury-in-coronary-artery-bypass-graft-surgery-patients-based-on-the-acute-kidney-injury-network-criteria
#2
Khosro Barkhordari, Ali Mohammad Fakhre Yasseri, Fardin Yousefshahi, Akbar Shafiee
Background: Acute kidney injury (AKI) after coronary artery bypass graft surgery (CABG) is a common complication. The present study sought to determine AKI risk factors based on the Acute Kidney Injury Network (AKIN) classification. Methods: In a cross-sectional study, performed from March 2010 to April 2012 at Tehran Heart Center, affiliated with Tehran University of Medical Sciences, 29 independent risk factors for AKI based on the AKIN criteria were examined in isolated post-CABG patients. The patients' demographic data and risk factors were extracted from the Electronic Database of Tehran Heart Center...
April 2018: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/30417613/-short-term-effectiveness-of-scarf-osteotomy-and-akin-osteotomy-combined-with-soft-tissue-procedures-in-treatment-of-hallux-valgus-associated-with-mild-to-moderate-metatarsus-adductus
#3
Fufeng Qu, Jie Cai, Xiaojun Liang, Jun Lu, Qiu Zeng, Weina Ji
Objective: To evaluate the short-term effectiveness of Scarf osteotomy and Akin osteotomy combined with soft tissue procedures for hallux valgus associated with mild to moderate metatarsus adductus. Methods: The clinical data of 30 patients (48 feet) who were diagnosised hallux valgus associated with mild to moderate metatarsus adductus and treated by Scarf osteotomy and Akin osteotomy combined with soft tissue procedures between February 2013 and May 2015 were analyzed retrospectively...
November 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/30358765/the-incidence-and-associations-of-acute-kidney-injury-in-trauma-patients-admitted-to-critical-care-a-systematic-review-and-meta-analysis
#4
Ryan W Haines, Alex J Fowler, Christopher J Kirwan, John R Prowle
BACKGROUND: As more patients are surviving the initial effects of traumatic injury clinicians are faced with managing the systemic complications of severe tissue injury. Of these acute kidney injury (AKI) may be a sentinel complication contributing to adverse outcomes. OBJECTIVE: To establish the incidence of AKI in patients admitted to critical care after major trauma, to explore any risk factors and to evaluate the association of AKI with outcomes. DATA SOURCES: Systematic search of MEDLINE, EMBASE and Cochrane library from January 2004 to April 2018...
October 23, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30358649/is-the-neutrophil-to-lymphocyte-ratio-associated-with-increased-morbidity-after-colorectal-surgery
#5
Cigdem Benlice, Akin Onder, Rovnat Babazade, Jennifer Hrabe, Luca Stocchi, Scott Steele, Emre Gorgun
PURPOSE: We aimed to evaluate the association between preoperative and postoperative neutrophil-to-lymphocyte ratio (NLR) and 30-day postoperative complications after colorectal surgery. METHODS: Patients undergoing elective colorectal surgery between January, 2010 and December, 2014 were identified. Patients who had preoperative and postoperative days 1 and 2 (Postoperative day [POD]-1, POD-2) NLR were included in the study. Primary study outcomes were optimal NLR cutoff values at preop, POD-1, and POD-2...
October 23, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/30333348/predictors-of-acute-kidney-injury-in-patients-undergoing-adult-cardiac-surgery
#6
Sreja Gangadharan, K R Sundaram, Senthilvelan Vasudevan, B Ananthakrishnan, Rakhi Balachandran, Abraham Cherian, Praveen Kerala Varma, Luis Bakero Gracia, K Murukan, Ashish Madaiker, Rajesh Jose, Rakesh Seetharaman, Kirun Gopal, Sujatha Menon, M Thushara, Reshmi Liza Jose, G Deepak, Sudheer Babu Vanga, Aveek Jayant
Background: Acute kidney injury (AKI) after cardiac surgery (CS) is not uncommon and has serious effects on mortality and morbidity. A majority of patients suffer mild forms of AKI. There is a paucity of Indian data regarding this important complication after CS. Aims and Objectives: The primary objective was to study the incidence of AKI associated with CS in an Indian study population. Secondary objectives were to describe the risk factors associated with AKI-CS in our population and to generate outcome data in patients who suffer this complication...
October 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/30333337/a-prospective-randomized-comparison-study-on-effect-of-perioperative-use-of-chloride-liberal-intravenous-fluids-versus-chloride-restricted-intravenous-fluids-on-postoperative-acute-kidney-injury-in-patients-undergoing-off-pump-coronary-artery-bypass-grafting
#7
K Bhaskaran, Ganapathy Arumugam, P V Vinay Kumar
Context and Aims: Off-pump coronary artery bypass graft (OPCABG) is a form of CABG surgery. It is performed without the use of cardiopulmonary bypass machine as a surgical treatment for coronary heart disease. Acute kidney injury (AKI) is one of the common postoperative complications of OPCABG. Previous studies suggest important differences related to intravenous fluid (IVF) chloride content and renal function. We hypothesize that perioperative use of chloride restricted IVFs may decrease incidence and severity of postoperative AKI in patients undergoing OPCABG...
October 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/30316371/clinical-outcomes-in-kidney-transplantation-from-deceased-donors-with-acute-kidney-injury-based-on-acute-kidney-injury-network-criteria
#8
J G Gwon, M-G Kim, K T Park, S-Y Ko, C W Jung
INTRODUCTION: Kidneys from acute kidney injury (AKI) donors are used for kidney transplantation. However, different Acute Kidney Injury Network (AKIN) criteria may show varying results after transplantation. We investigated the clinical outcomes in kidney transplantation from deceased donors with AKI as defined by the AKIN criteria at a single center. METHODS: We retrospectively reviewed the medical records of 101 consecutive deceased donors and kidney transplantation recipients from March 2009 to June 2015 in a single center...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30300734/albuminuria-and-other-renal-damage-biomarkers-detect-acute-kidney-injury-soon-after-acute-ingestion-of-oxalic-acid-and-potassium-permanganate
#9
Thilini M Wijerathna, Fahim Mohamed, Dhammika Dissanayaka, Indika Gawarammana, Chathura Palangasinghe, Fathima Shihana, Zoltan Endre, Seyed Shahmy, Nicholas A Buckley
BACKGROUND: Deliberate self-poisoning with a combination washing powder containing oxalic acid (H2 C2 O4 ) and potassium permanganate (KMnO4 ) is a significant medical problem in the Southern Province of Sri Lanka. Acute kidney injury (AKI) is a frequent consequence. Biomarkers for early diagnosis of nephrotoxicity could guide appropriate supportive therapies. METHODS: We investigated the performance of three serum biomarkers and nine urinary biomarkers in 85 patients in an ongoing multicenter prospective cohort study in Sri Lanka exploring AKI following poisoning...
December 15, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/30247865/acute-kidney-injury-following-resection-of-hepatocellular-carcinoma-prognostic-value-of-the-acute-kidney-injury-network-criteria
#10
Alexsander K. Bressan, Matthew T. James, Elijah Dixon, Oliver F. Bathe, Francis R. Sutherland, Chad G. Ball
Background: Acute kidney injury (AKI) is associated with increased morbidity and mortality after liver resection. Patients with hepatocellular carcinoma (HCC) have a higher risk of AKI owing to the underlying association between hepatic and renal dysfunction. Use of the Acute Kidney Injury Network (AKIN) diagnostic criteria is recommended for patients with cirrhosis, but remains poorly studied following liver resection. We compared the prognostic value of the AKIN creatinine and urine output criteria in terms of postoperative outcomes following liver resection for HCC...
October 1, 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/30238012/quantifying-the-impact-of-inhalational-burns-a-prospective-study
#11
Si Jack Chong, Yee Onn Kok, Rosanna Xiang Ying Tay, Desai Suneel Ramesh, Kok Chai Tan, Bien Keem Tan
Background: Inhalational injury is a major cause of morbidity and mortality in burns patients. This study aims to analyse the clinical outcomes, complications and bacteriology of inhalational burn patients. Methods: A prospective study was done on consecutive admissions to Burn Department, Singapore General Hospital over 15 months from January 2015 to March 2016. Presence of inhalational injury, demographics, complications and outcomes was recorded. Diagnosis of inhalational injury was based on history, symptoms and nasoendoscopy...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/30236353/mortality-in-patients-with-out-of-hospital-cardiac-arrest-undergoing-a-standardized-protocol-including-therapeutic-hypothermia-and-routine-coronary-angiography-experience-from-the-hacore-registry
#12
Muharrem Akin, Jan-Thorben Sieweke, Florian Zauner, Vera Garcheva, Jörn Tongers, L Christian Napp, Lars Friedrich, Jens Treptau, Max-Udo Bahntje, Ulrike Flierl, Daniel G Sedding, Johann Bauersachs, Andreas Schäfer
OBJECTIVES: This study sought to analyze the impact of mandatory therapeutic hypothermia and cardiac catheterization in the absence of overt noncardiac cause of arrest as part of the Hannover Cardiac Resuscitation Algorithm before intensive care admission. BACKGROUND: Despite advanced therapies, out-of-hospital cardiac arrest (OHCA) is still associated with high mortality rates. Recently, the TTM (Target Temperature Management 33°C Versus 36°C After Out-of-Hospital Cardiac Arrest)-trial caused severe uncertainty about the efficacy of and need for therapeutic hypothermia...
September 24, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30231255/using-the-kinetic-estimating-glomerular-filtration-rate-equation-for-estimating-glomerular-filtration-rate-and-detecting-acute-kidney-injury-a-pilot-study
#13
Manohar Bairy, Faith H W See, Ru Sin Lim
BACKGROUND: Estimating the glomerular filtration rate (eGFR) when the creatinine (Cr) is rapidly changing, as in acute kidney injury (AKI), has been a challenge. The Kinetic Estimated Glomerular Filtration Rate (KeGFR) formula by S. Chen estimates the GFR in the acute state by factoring the time interval between rising Cr values and the volume of distribution (VD). It provides the clinician with an eGFR value for each non-steady state Cr value. We applied the KeGFR formula to detect AKI in an adult non-ICU inpatient setting...
September 19, 2018: Nephron
https://www.readbyqxmd.com/read/30218181/minimally-invasive-surgery-for-hallux-valgus-a-systematic-review-of-current-surgical-techniques
#14
REVIEW
Francesc Malagelada, Cyrus Sahirad, Miki Dalmau-Pastor, Jordi Vega, Rej Bhumbra, Maria Cristina Manzanares-Céspedes, Olivier Laffenêtre
PURPOSE: The aim of this study was to systematically evaluate the available literature on minimally invasive surgical (MIS) treatment for hallux valgus and to provide an overview of the different surgical techniques. METHODS: A systematic review of the literature available in MEDLINE, EMBASE, and the Cochrane database was performed including studies from January 2001 to 1 January 2018. The radiological outcomes (hallux valgus angle (HVA), intermetatarsal angle (IMA)), complication rates, and clinical outcome scores were evaluated...
September 14, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/30213520/restless-legs-syndrome-in-type-2-diabetes-mellitus
#15
Seydahmet Akın, Cem Bölük, Ülkü Türk Börü, Mustafa Taşdemir, Tuğçe Gezer, Fatma Gülhan Şahbaz, Özcan Keskin
AIMS: This study aimed to investigate the prevalence of restless leg syndrome (RLS) in type-2 diabetes mellitus (DM) patients and to determine the risk factors. METHODS: Patients were recruited from the Dr. Lütfi Kırdar Kartal Training and Research Hospital Diabetes Center. Patients between 18-80 years of age and meeting a minimum 5 years diagnosis of type-2 DM were included. All patients were examined by the same neurologist in terms of having RLS. The diagnosis was made according to the updated International Restless Legs Syndrome Study Group consensus criteria...
September 10, 2018: Primary Care Diabetes
https://www.readbyqxmd.com/read/30125380/sexually-transmitted-agents-and-their-association-with-leucocytospermia-in-infertility-clinic-patients
#16
Akin Akgul, Ates Kadioglu, Muammer O Koksal, Abdulkadir Ozmez, Ali Agacfidan
In this study, the presence of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum and Ureaplasma parvumDNA were investigated using real-time multiplex PCR detection kit in the urine samples of 50 patients who presented to the infertility polyclinic. Patients were classified into two groups in accordance with the WHO leucocytospermia criteria as over 1 × 106 /ml (n = 25) and below 1 × 106 /ml (controls; n = 25). In addition, the semen sample results of the patients were evaluated...
August 20, 2018: Andrologia
https://www.readbyqxmd.com/read/30111187/discoveries-on-the-genetics-of-adhd-in-the-21st-century-new-findings-and-their-implications
#17
REVIEW
Anita Thapar
The 21st century has witnessed the discovery of multiple rare and common gene variants associated with attention deficit hyperactivity disorder (ADHD), and these discoveries have already provided a starting point for the investigation of the biology of the disorder and novel treatments. The purpose of this selective review is to examine genetic findings from the past 5 years and consider their implications for the conceptualization of ADHD and future clinical practice. Recent discoveries reveal the strong genetic overlaps between ADHD and autism spectrum disorder (ASD) as well as intellectual disability...
October 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/30078412/clinical-implications-of-clonal-hematopoiesis
#18
REVIEW
David P Steensma
Clonal hematopoiesis (CH)-an expansion of blood cells derived from a single hematopoietic stem cell-is a defining feature of hematologic cancers, but recently CH was also found to be a frequent consequence of aging. When aging-associated CH results from acquisition of a somatic mutation in a driver gene associated with leukemia, and this mutation is present at a variant allele frequency of at least 0.02 (2%) yet the patient does not meet World Health Organization diagnostic criteria for a hematologic neoplasm, this state is termed clonal hematopoiesis of indeterminate potential (CHIP)...
August 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/30075798/a-worldwide-multicentre-evaluation-of-the-influence-of-deterioration-or-improvement-of-acute-kidney-injury-on-clinical-outcome-in-critically-ill-patients-with-and-without-sepsis-at-icu-admission-results-from-the-intensive-care-over-nations-audit
#19
Esther Peters, Massimo Antonelli, Xavier Wittebole, Rahul Nanchal, Bruno François, Yasser Sakr, Jean-Louis Vincent, Peter Pickkers
BACKGROUND: Acute kidney injury (AKI) is a common complication of critical illness and is associated with worse outcomes. However, the influence of deterioration or improvement in renal function on clinical outcomes is unclear. Using a large international database, we evaluated the prevalence and evolution of AKI over a 7-day period and its effects on clinical outcomes in septic and non-septic critically ill patients worldwide. METHODS: From the 10,069 adult intensive care unit (ICU) patients in the Intensive Care Over Nations database, all those with creatinine and urine output data were included in this substudy...
August 3, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30051166/drd3-gene-and-adhd-a-pharmaco-behavioural-genetic-study
#20
Weam Fageera, Sarojini M Sengupta, Aurelie Labbe, Natalie Grizenko, Ridha Joober
Results of candidate gene investigations in ADHD have been difficult to replicate. The complexity of the phenotypes and their underlying determinants, and the relatively small effect sizes of genetic variants may, in part, be contributing to these inconsistencies. The objective of this study is to conduct an exploratory analysis using a comprehensive approach to investigate the role of candidate genes. This approach combines a dimensional behavioural approach akin to Research Domain Criteria (RDoC), a pharmaco-dynamic evaluation of behaviours relevant to ADHD, together with association and linkage testing in a large sample of children with ADHD...
December 2018: Neuromolecular Medicine
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