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https://www.readbyqxmd.com/read/30300734/albuminuria-and-other-renal-damage-biomarkers-detect-acute-kidney-injury-soon-after-acute-ingestion-of-oxalic-acid-and-potassium-permanganate
#1
Thilini Madushanka Wijerathna, Fahim Mohamed, Dhammika Dissanayaka, Indika Gawarammana, Chathura Palangasinghe, Fathima Shihana, Zoltan Endre, Seyed Shahmy, Nicholas A Buckley
BACKGROUND: Deliberate self-poisoning with a combination washing powder containing oxalic acid (H2 C2 O4 ) and potassium permanganate (KMnO4 ) is a significant medical problem in the Southern Province of Sri Lanka. Acute kidney injury (AKI) is a frequent consequence. Biomarkers for early diagnosis of nephrotoxicity could guide appropriate supportive therapies. METHODS: We investigated the performance of three serum biomarkers and nine urinary biomarkers in 85 patients in an ongoing multicenter prospective cohort study in Sri Lanka exploring AKI following poisoning...
October 6, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/30247865/acute-kidney-injury-following-resection-of-hepatocellular-carcinoma-prognostic-value-of-the-acute-kidney-injury-network-criteria
#2
Alexsander K. Bressan, Matthew T. James, Elijah Dixon, Oliver F. Bathe, Francis R. Sutherland, Chad G. Ball
Background: Acute kidney injury (AKI) is associated with increased morbidity and mortality after liver resection. Patients with hepatocellular carcinoma (HCC) have a higher risk of AKI owing to the underlying association between hepatic and renal dysfunction. Use of the Acute Kidney Injury Network (AKIN) diagnostic criteria is recommended for patients with cirrhosis, but remains poorly studied following liver resection. We compared the prognostic value of the AKIN creatinine and urine output criteria in terms of postoperative outcomes following liver resection for HCC...
October 1, 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/30238012/quantifying-the-impact-of-inhalational-burns-a-prospective-study
#3
Si Jack Chong, Yee Onn Kok, Rosanna Xiang Ying Tay, Desai Suneel Ramesh, Kok Chai Tan, Bien Keem Tan
Background: Inhalational injury is a major cause of morbidity and mortality in burns patients. This study aims to analyse the clinical outcomes, complications and bacteriology of inhalational burn patients. Methods: A prospective study was done on consecutive admissions to Burn Department, Singapore General Hospital over 15 months from January 2015 to March 2016. Presence of inhalational injury, demographics, complications and outcomes was recorded. Diagnosis of inhalational injury was based on history, symptoms and nasoendoscopy...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/30236353/mortality-in-patients-with-out-of-hospital-cardiac-arrest-undergoing-a-standardized-protocol-including-therapeutic-hypothermia-and-routine-coronary-angiography-experience-from-the-hacore-registry
#4
Muharrem Akin, Jan-Thorben Sieweke, Florian Zauner, Vera Garcheva, Jörn Tongers, L Christian Napp, Lars Friedrich, Jens Treptau, Max-Udo Bahntje, Ulrike Flierl, Daniel G Sedding, Johann Bauersachs, Andreas Schäfer
OBJECTIVES: This study sought to analyze the impact of mandatory therapeutic hypothermia and cardiac catheterization in the absence of overt noncardiac cause of arrest as part of the Hannover Cardiac Resuscitation Algorithm before intensive care admission. BACKGROUND: Despite advanced therapies, out-of-hospital cardiac arrest (OHCA) is still associated with high mortality rates. Recently, the TTM (Target Temperature Management 33°C Versus 36°C After Out-of-Hospital Cardiac Arrest)-trial caused severe uncertainty about the efficacy of and need for therapeutic hypothermia...
September 24, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30231255/using-the-kinetic-estimating-glomerular-filtration-rate-equation-for-estimating-glomerular-filtration-rate-and-detecting-acute-kidney-injury-a-pilot-study
#5
Manohar Bairy, Faith H W See, Ru Sin Lim
BACKGROUND: Estimating the glomerular filtration rate (eGFR) when the creatinine (Cr) is rapidly changing, as in acute kidney injury (AKI), has been a challenge. The Kinetic Estimated Glomerular Filtration Rate (KeGFR) formula by S. Chen estimates the GFR in the acute state by factoring the time interval between rising Cr values and the volume of distribution (VD). It provides the clinician with an eGFR value for each non-steady state Cr value. We applied the KeGFR formula to detect AKI in an adult non-ICU inpatient setting...
September 19, 2018: Nephron
https://www.readbyqxmd.com/read/30218181/minimally-invasive-surgery-for-hallux-valgus-a-systematic-review-of-current-surgical-techniques
#6
REVIEW
Francesc Malagelada, Cyrus Sahirad, Miki Dalmau-Pastor, Jordi Vega, Rej Bhumbra, Maria Cristina Manzanares-Céspedes, Olivier Laffenêtre
PURPOSE: The aim of this study was to systematically evaluate the available literature on minimally invasive surgical (MIS) treatment for hallux valgus and to provide an overview of the different surgical techniques. METHODS: A systematic review of the literature available in MEDLINE, EMBASE, and the Cochrane database was performed including studies from January 2001 to 1 January 2018. The radiological outcomes (hallux valgus angle (HVA), intermetatarsal angle (IMA)), complication rates, and clinical outcome scores were evaluated...
September 14, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/30213520/restless-legs-syndrome-in-type-2-diabetes-mellitus
#7
Seydahmet Akın, Cem Bölük, Ülkü Türk Börü, Mustafa Taşdemir, Tuğçe Gezer, Fatma Gülhan Şahbaz, Özcan Keskin
AIMS: This study aimed to investigate the prevalence of restless leg syndrome (RLS) in type-2 diabetes mellitus (DM) patients and to determine the risk factors. METHODS: Patients were recruited from the Dr. Lütfi Kırdar Kartal Training and Research Hospital Diabetes Center. Patients between 18-80 years of age and meeting a minimum 5 years diagnosis of type-2 DM were included. All patients were examined by the same neurologist in terms of having RLS. The diagnosis was made according to the updated International Restless Legs Syndrome Study Group consensus criteria...
September 10, 2018: Primary Care Diabetes
https://www.readbyqxmd.com/read/30125380/sexually-transmitted-agents-and-their-association-with-leucocytospermia-in-infertility-clinic-patients
#8
Akin Akgul, Ates Kadioglu, Muammer O Koksal, Abdulkadir Ozmez, Ali Agacfidan
In this study, the presence of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum and Ureaplasma parvumDNA were investigated using real-time multiplex PCR detection kit in the urine samples of 50 patients who presented to the infertility polyclinic. Patients were classified into two groups in accordance with the WHO leucocytospermia criteria as over 1 × 106 /ml (n = 25) and below 1 × 106 /ml (controls; n = 25). In addition, the semen sample results of the patients were evaluated...
August 20, 2018: Andrologia
https://www.readbyqxmd.com/read/30111187/discoveries-on-the-genetics-of-adhd-in-the-21st-century-new-findings-and-their-implications
#9
Anita Thapar
The 21st century has witnessed the discovery of multiple rare and common gene variants associated with attention deficit hyperactivity disorder (ADHD), and these discoveries have already provided a starting point for the investigation of the biology of the disorder and novel treatments. The purpose of this selective review is to examine genetic findings from the past 5 years and consider their implications for the conceptualization of ADHD and future clinical practice. Recent discoveries reveal the strong genetic overlaps between ADHD and autism spectrum disorder (ASD) as well as intellectual disability...
August 16, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/30078412/clinical-implications-of-clonal-hematopoiesis
#10
REVIEW
David P Steensma
Clonal hematopoiesis (CH)-an expansion of blood cells derived from a single hematopoietic stem cell-is a defining feature of hematologic cancers, but recently CH was also found to be a frequent consequence of aging. When aging-associated CH results from acquisition of a somatic mutation in a driver gene associated with leukemia, and this mutation is present at a variant allele frequency of at least 0.02 (2%) yet the patient does not meet World Health Organization diagnostic criteria for a hematologic neoplasm, this state is termed clonal hematopoiesis of indeterminate potential (CHIP)...
August 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/30075798/a-worldwide-multicentre-evaluation-of-the-influence-of-deterioration-or-improvement-of-acute-kidney-injury-on-clinical-outcome-in-critically-ill-patients-with-and-without-sepsis-at-icu-admission-results-from-the-intensive-care-over-nations-audit
#11
Esther Peters, Massimo Antonelli, Xavier Wittebole, Rahul Nanchal, Bruno François, Yasser Sakr, Jean-Louis Vincent, Peter Pickkers
BACKGROUND: Acute kidney injury (AKI) is a common complication of critical illness and is associated with worse outcomes. However, the influence of deterioration or improvement in renal function on clinical outcomes is unclear. Using a large international database, we evaluated the prevalence and evolution of AKI over a 7-day period and its effects on clinical outcomes in septic and non-septic critically ill patients worldwide. METHODS: From the 10,069 adult intensive care unit (ICU) patients in the Intensive Care Over Nations database, all those with creatinine and urine output data were included in this substudy...
August 3, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30051166/drd3-gene-and-adhd-a-pharmaco-behavioural-genetic-study
#12
Weam Fageera, Sarojini M Sengupta, Aurelie Labbe, Natalie Grizenko, Ridha Joober
Results of candidate gene investigations in ADHD have been difficult to replicate. The complexity of the phenotypes and their underlying determinants, and the relatively small effect sizes of genetic variants may, in part, be contributing to these inconsistencies. The objective of this study is to conduct an exploratory analysis using a comprehensive approach to investigate the role of candidate genes. This approach combines a dimensional behavioural approach akin to Research Domain Criteria (RDoC), a pharmaco-dynamic evaluation of behaviours relevant to ADHD, together with association and linkage testing in a large sample of children with ADHD...
July 26, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/30025391/method-used-for-tumor-bed-closure-suture-vs-sealant-ischemia-time-and-duration-of-surgery-are-independent-predictors-of-post-nephron-sparing-surgery-acute-kidney-injury
#13
Omri Nativ, Zaher Bahouth, Edmond Sabo, Sarel Halachmi, Boaz Moskovitz, Elias G Hellou, Zaid Abassi, Ofer Nativ
INTRODUCTION: The aim of our study was to examine the influence of tumor complexity and operative variables on the degree and rate of post-nephron sparing surgery (NSS) acute kidney injury (AKI). METHODS: We retrospectively reviewed the records of 477 patients who underwent NSS for enhancing renal masses in our institution. AKI was determined using the latest definition by AKIN and RIFLE criteria. Serum creatinine was assessed daily starting from day 1 post-surgery and until discharge (usually on postoperative day 3)...
2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29984336/can-tumor-recurrence-be-reduced-with-plasma-kinetic-vaporization-of-the-area-around-the-tumor-in-nonmuscle-invasive-bladder-cancer
#14
Yüksel Yılmaz, Mehmet Cemal Kahya, Fatma Hüsniye Dilek, Osman Köse, Serkan Özcan, Ertan Can, Yiğit Akın, Batuhan Ergani, Ahmet Selçuk Dindar
Purpose: To investigate the effect on recurrence of vaporization of the tumor surroundings and suspicious areas with a plasma-kinetic (PK) system after transurethral resection (TUR) of nonmuscle invasive bladder cancer. Materials and Methods: The study included 121 patients with a primary superficial bladder tumor who were randomized as those who underwent TUR with the PK system (Group 1, n=62) and those who underwent TUR with the monopolar system (Group 2, n=59)...
July 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29980878/prediction-of-chronic-kidney-disease-after-acute-kidney-injury-in-icu-patients-study-protocol-for-the-predict-multicenter-prospective-observational-study
#15
Guillaume Geri, Bénédicte Stengel, Christian Jacquelinet, Philippe Aegerter, Ziad A Massy, Antoine Vieillard-Baron
BACKGROUND: Acute kidney injury (AKI) is frequent and associated with poor outcome in intensive care unit (ICU) patients. Besides the association with short- and long-term mortality, the increased risk of chronic kidney disease (CKD) has been recently highlighted in non-ICU patients. This study aims to describe the incidence and determinants of CKD after AKI and to develop a prediction score for CKD in ICU patients. METHODS: Prospective multicenter (n = 17) observational study included 1200 ICU patients who suffered from AKI (defined by an AKIN stage ≥ 1) during their ICU stay and were discharged alive from ICU...
July 6, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29970747/pediatric-acute-kidney-injury-in-north-india-a-prospective-hospital-based-study
#16
Shariq Nawaz, Kamran Afzal
The conducted study aimed to determine the incidence and clinical profile of acute kidney injury (AKI) in hospitalized patients using the AKI Network (AKIN) criteria. This prospective observational study was conducted at the Pediatric ward and pediatric Intensive Care Unit of a tertiary level teaching hospital in North India. The participants were 763 consecutive patients aged three months to 12 years from January 2014 to October 2015 and were assessed for eligibility. Of these, 163 patients were excluded from the study...
May 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29945330/pentraxin-3-predicts-short-and-mid-term-mortality-in-patients-with-sepsis-and-septic-shock-during-intensive-care-treatment
#17
Sonja Hamed, Michael Behnes, Dominic Pauly, Dominic Lepiorz, Max Barre, Tobias Becher, Siegfried Lang, Ibrahim Akin, Martin Borggrefe, Thomas Bertsch, Ursula Hoffmann
BACKGROUND: The prognostic value of the acute phase protein Pentraxin 3 (PTX-3) is not well evaluated in patients with septic shock, which reveal an unacceptably high short- and long-term mortality. New Sepsis-3 definitions are not yet implemented in most biomarker studies. Therefore, this study assesses the prognostic value of PTX-3 for short- and mid-term mortality in patients with sepsis or septic shock, as defined by the latest definitions, treated at a medical intensive care unit (ICU)...
June 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29928922/mast-cell-activation-syndrome-importance-of-consensus-criteria-and-call-for-research
#18
Peter Valent, Cem Akin, Patrizia Bonadonna, Karin Hartmann, Sigurd Broesby-Olsen, Knut Brockow, Joseph H Butterfield, Andreas Reiter, Jason Gotlib, Mariana Castells, Joshua D Milner, Melody C Carter, Hirsh Komarow, Deepti Radia, Animesh Pardanani, Karl Sotlar, Massimo Triggiani, Hans-Peter Horny, Michel Arock, Lawrence B Schwartz, Dean D Metcalfe
No abstract text is available yet for this article.
September 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29910040/sodium-bicarbonate-therapy-for-patients-with-severe-metabolic-acidaemia-in-the-intensive-care-unit-bicar-icu-a-multicentre-open-label-randomised-controlled-phase-3-trial
#19
MULTICENTER STUDY
Samir Jaber, Catherine Paugam, Emmanuel Futier, Jean-Yves Lefrant, Sigismond Lasocki, Thomas Lescot, Julien Pottecher, Alexandre Demoule, Martine Ferrandière, Karim Asehnoune, Jean Dellamonica, Lionel Velly, Paër-Sélim Abback, Audrey de Jong, Vincent Brunot, Fouad Belafia, Antoine Roquilly, Gérald Chanques, Laurent Muller, Jean-Michel Constantin, Helena Bertet, Kada Klouche, Nicolas Molinari, Boris Jung
BACKGROUND: Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic acidaemia is a possible treatment option but remains controversial, as no studies to date have examined its effect on clinical outcomes. Therefore, we aimed to evaluate whether sodium bicarbonate infusion would improve these outcomes in critically ill patients. METHODS: We did a multicentre, open-label, randomised controlled, phase 3 trial...
July 7, 2018: Lancet
https://www.readbyqxmd.com/read/29908974/severe-infrarenal-atheroma-load-in-open-aortic-aneurysm-repair-is-not-a-risk-factor-for-postoperative-acute-kidney-injury
#20
Sophie Ooms, Banne Nemeth, Jan Jacob Wever, Bob Knippenberg, Hans van Overhagen, Randolph George Statius van Eps
BACKGROUND: Acute kidney injury (AKI) after open aortic repair is subject to multiple patient- and operation-related variables. Hostile neck morphology in open aneurysm repair is thought to contribute to this AKI risk postoperatively. The aim of this study was to evaluate if large neck atheroma is a possible risk factor in the postoperative development of AKI. METHODS: Retrospectively 137 patients were evaluated for neck atheroma and AKI incidence. Atheroma load measurements were performed by 2 different techniques...
June 15, 2018: Annals of Vascular Surgery
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