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https://www.readbyqxmd.com/read/30315282/risk-scores-for-predicting-advanced-colorectal-neoplasia-in-the-average-risk-population-a-systematic-review-and-meta-analysis
#1
REVIEW
Le Peng, Korbinian Weigl, Daniel Boakye, Hermann Brenner
OBJECTIVES: A systematic review and meta-analysis was performed to summarize the available evidence on risk scores for predicting advanced colorectal neoplasia (advanced adenomas and cancer) in average-risk and asymptomatic populations undergoing screening colonoscopy. METHODS: PubMed, EMBASE, and Web of Science databases were searched up to 28 March 2018. Studies that developed or validated a risk score to predict the risk of advanced colorectal neoplasia were included...
October 12, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/30315134/evaluation-of-a-novel-liquid-biopsy-based-coloscape-assay-for-mutational-analysis-of-colorectal-neoplasia-and-triage-of-fit-patients-a-pilot-study
#2
Mauro Scimia, Jinwei Du, Francesco Pepe, Maria Antonia Bianco, Silvana Russo Spena, Farah Patell-Socha, Qing Sun, Michael J Powell, Umberto Malapelle, Giancarlo Troncone
Circulating cell free tumour derived nucleic acids are becoming recognised as clinically significant and extremely useful biomarkers for detection of cancer and for monitoring the progression of targeted drug therapy and immunotherapy. Screening programmes for colorectal cancer in Europe use the Fetal Immunochemical Test (FIT) test as a primary screener. FIT+ patients are referred to immediate colonoscopy and the positive predictive value (PPV) is usually 25%. In this article, we report a study employing the ColoScape assay panel to detect mutations in the APC, KRAS, BRAF and CTNNB1 genes, in order to collect preliminary performance indicators and plan a future, larger population study...
October 12, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/30305797/impact-of-video-aid-on-quality-of-bowel-preparation-among-patients-undergoing-outpatient-screening-colonoscopy
#3
Sanna Fatima, Deepanshu Jain, Christopher Hibbard
Aim: To investigate the effect of video aid on quality of bowel preparation. Study: A retrospective study was done on patients undergoing outpatient screening colonoscopy. All subjects received educational video prior to colonoscopy in addition to the standard counseling. Patient charts were reviewed to collect data regarding quality of bowel preparation (adequate or inadequate). The study population was stratified into four groups according to viewing status: Group I 0% (control group), Group II <50%, Group III >50% to <75%, and Group IV watched ⩾75% of the video...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/30302380/endoscopic-full-thickness-resection-in-the-colorectum-a-single-center-case-series-evaluating-indication-efficacy-and-safety
#4
Bas van der Spek, Krijn Haasnoot, Christof Meischl, Dmitri Heine
Background and study aims  Endoscopic full-thickness resection (eFTR) allows en-bloc and transmural resection of colorectal lesions for which other advanced endoscopic techniques are unsuitable. We present our experience with a novel "clip first, cut later" eFTR-device and evaluate its indications, efficacy and safety. Patients and methods  From July 2015 through October 2017, 51 eFTR-procedures were performed in 48 patients. Technical success and R0-resection rates were prospectively recorded and retrospectively analyzed...
October 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/30291105/implications-of-epigenetic-drift-in-colorectal-neoplasia
#5
Georg E Luebeck, William D Hazelton, Kit Curtius, Sean K Maden, Ming Yu, Kelly T Carter, Wynn Burke, Paul D Lampe, Christopher I Li, Cornelia M Ulrich, Polly A Newcomb, Maria Westerhoff, Andrew M Kaz, Yanxin Luo, John M Inadomi, William M Grady
Many normal tissues undergo age-related drift in DNA methylation, providing a quantitative measure of tissue age. Here we identify and validate 781 CpG-islands (CGI) that undergo significant methylomic drift in 232 normal colorectal tissues and show that these CGI continue to drift in neoplasia while retaining significant correlations across samples. However, compared with normal colon, this drift advanced (~3-4 fold) faster in neoplasia, consistent with increased cell proliferation during neoplastic progression...
October 5, 2018: Cancer Research
https://www.readbyqxmd.com/read/30288285/fecal-immunochemical-test-for-hemoglobin-in-combination-with-fecal-transferrin-in-colorectal-cancer-screening
#6
Anton Gies, Katarina Cuk, Petra Schrotz-King, Hermann Brenner
Objective: Fecal transferrin has been suggested as a complementary or even superior marker for early detection of colorectal cancer (CRC) besides fecal hemoglobin. We aimed to evaluate both markers individually and in combination in a large cohort of participants of screening colonoscopy. Methods: Precolonoscopy stool samples were obtained from participants of screening colonoscopy and frozen at -80℃ until blinded analysis, using a dual-quantitative fecal immunochemical test (FIT) for hemoglobin and transferrin...
October 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/30288119/incidence-and-distribution-of-advanced-colorectal-adenomas-in-patients-undergoing-colonoscopy-for-screening-surveillance-and-symptoms
#7
Haifeng Kang, Yanmei Yang, Jianwei Qiu, Junbo Qian, Xiaobo Li
Purpose: The aim of the study was to determine the frequency and distribution of advanced colorectal adenomas (ACAs) in Chinese population. Methods: The patients who were referred to receive a colonoscopy were divided into three subgroups of screening, surveillance, and symptomatic, and then they were selected based on their indications. The symptomatic subgroup was further broken down into the alarm and non-alarm categories. The location and morphology of all colorectal lesions were both investigated and recorded...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30285055/divergent-long-term-detection-rates-of-proximal-and-distal-advanced-neoplasia-in-fecal-immunochemical-test-screening-programs-a-retrospective-cohort-study
#8
Manuel Zorzi, Cesare Hassan, Giulia Capodaglio, Elena Narne, Anna Turrin, Maddalena Baracco, Antonella Dal Cin, Annarita Fiore, Giancarla Martin, Alessandro Repici, Douglas Rex, Massimo Rugge
Background: Short-term studies have reported that the fecal immunochemical test (FIT) is less accurate in detecting proximal than distal colorectal neoplasia. Objective: To assess the long-term detection rates for advanced adenoma and colorectal cancer (CRC), according to anatomical location. Design: Retrospective study. Setting: Population-based, organized screening program in the Veneto region of Italy. Participants: Persons aged 50 to 69 years who completed 6 rounds of FIT screening...
October 2, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30282520/effect-of-once-only-flexible-sigmoidoscopy-screening-on-the-outcomes-of-subsequent-faecal-occult-blood-test-screening
#9
Jeremy P Brown, Kate Wooldrage, Ines Kralj-Hans, Suzanne Wright, Amanda J Cross, Wendy S Atkin
Objective To investigate the outcomes of biennial guaiac faecal occult blood test (gFOBT) screening after once-only flexible sigmoidoscopy (FS) screening. Methods Between 1994 and 1999, as part of the UK FS Screening Trial (UKFSST), adults aged 55-64 were randomly allocated to an intervention group (offered FS screening) or a control group (not contacted). From 2006, a subset of UKFSST participants (20,895/44,041 intervention group; 41,497/87,149 control group) were invited to biennial gFOBT screening by the English Bowel Cancer Screening Programme...
October 3, 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/30281534/blue-laser-imaging-a-new-image-enhanced-endoscopy-for-the-diagnosis-of-colorectal-lesions
#10
Carlos E O Dos Santos, Daniele Malaman, Naohisa Yoshida, Júlio C Pereira-Lima, Fernanda Q Onófrio, Rafaelle G Furlan, Fernando I Tabushi, Osvaldo Malafaia
BACKGROUND: Image-enhanced endoscopy enables real-time differential diagnosis of colorectal lesions through the observation of microvascular architecture. PURPOSE: To evaluate the efficacy of using blue laser imaging (BLI) for capillary pattern analysis in the differential diagnosis of neoplastic and non-neoplastic lesions. PATIENTS AND METHODS: This prospective study included 920 consecutive superficial lesions diagnosed in 457 patients. The capillary pattern was analysed using BLI-bright magnification on the basis of the Teixeira classification...
October 2, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30279628/sex-differences-in-associations-among-metabolic-syndrome-obesity-related-biomarkers-and-colorectal-adenomatous-polyp-risk-in-a-japanese-population
#11
Keisuke Nakai, Jiro Watari, Katsuyuki Tozawa, Akio Tamura, Ken Hara, Takahisa Yamasaki, Takashi Kondo, Tomoaki Kono, Toshihiko Tomita, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Jun Sakurai, Yongmin Kim, Yuji Hayakawa, Takashi Fujisawa, Takeshi Morimoto, Hiroto Miwa
To investigate sex differences in the associations among metabolic syndrome, obesity, adipose tissue-related biomarkers, and colorectal adenomatous polyps, a cross-sectional, multicenter study was conducted on 489 consecutive individuals who underwent their first colonoscopy at 3 hospitals. Plasma concentrations of adiponectin and leptin, as well as homeostatic model assessment of insulin resistance were also evaluated. The presence and number of adenomatous polyps, including advanced adenoma, were higher in men than in women...
September 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30273591/g-eye-colonoscopy-is-superior-to-standard-colonoscopy-for-increasing-adenoma-detection-rate-an-international-randomized-controlled-trial-with-videos
#12
Haim Shirin, Beni Shpak, Julia Epshtein, John Gásdal Karstensen, Arthur Hoffman, Rogier de Ridder, Pier Alberto Testoni, Sauid Ishaq, Acquisition Of Data, D Nageshwar Reddy, Seth A Gross, Helmut Neumann, Martin Goetz, Dov Abramowich, Menachem Moshkowitz, Meir Mizrahi, Peter Vilmann, Johannes Wilhelm Rey, Silvia Sanduleanu-Dascalescu, Edi Viale, Hrushikesh Chaudhari, Mark B Pochapin, Michael Yair, Mati Shnell, Shaul Yaari, Jakob Westergren Hendel, Daniel Teubner, Roel M M Bogie, Chiara Notaristefano, Roman Simantov, Nathan Gluck, Eran Israeli, Trine Stigaard, Shay Matalon, Alexander Vilkin, Ariel Benson, Stine Sloth, Amit Maliar, Amir Waizbard, Harold Jacob, Peter Thielsen, Eyal Shachar, Shmuel Rochberger, Tiberiu Hershcovici, Julie Isabelle Plougmann, Michal Braverman, Eduard Tsvang, Armita Armina Abedi, Yuri Brachman, Peter D Siersema, Ralf Kiesslich
BACKGROUND: Colorectal cancer (CRC) is largely preventable with routine screening and surveillance colonoscopy; however, interval cancers arising from precancerous lesions missed by standard colonoscopy (SC) still occur. Increased adenoma detection rate (ADR) has been found to be inversely associated with interval cancers. The G-EYE device comprises a reusable balloon integrated at the distal tip of a standard colonoscope, which flattens haustral folds, centralizes the colonoscope's optics and reduces bowel slippage...
September 28, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/30271216/accuracy-of-a-fecal-immunochemical-test-according-to-outside-temperature-and-travel-time
#13
Tobias Niedermaier, Korbinian Weigl, Anton Gies, Michael Hoffmeister, Hermann Brenner
Background: Fecal immunochemical tests (FITs) are widely used and recommended for colorectal cancer (CRC) screening. Fecal hemoglobin (Hb) may degrade with long transport durations and high ambient temperatures, potentially reducing sensitivity to detect CRC and its precursors. This study aimed at investigating the impact of temperatures and sample travel times on diagnostic performance of a quantitative FIT for detection of advanced neoplasms (AN, CRC, or advanced adenoma). Methods: Participants of screening colonoscopy in south-western Germany conducted a quantitative FIT prior to bowel preparation between February 2012 and June 2016...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/30267949/fibrous-pituitary-macroadenomas-predictive-role-of-preoperative-radiological-investigations-for-proper-surgical-planning-in-a-cohort-of-66-patients
#14
Martina Cappelletti, Andrea Gennaro Ruggeri, Lorenzo Spizzichino, Alberto D'Amico, Elena D'avella, Roberto Delfini
OBJECTIVE: Endoscopic technique is in many cases the technique of choice for the removal of pituitary adenomas. Extended endoscopic approaches make possible to remove lesions with suprasellar, parasellar extension and with fibrous consistency. We tried to identify some characteristics that might point to the adoption of an expanded approach in the preoperative phase. METHODS: We considered 66 consecutive cases treated for pituitary macroadenomas. All patients underwent to preoperative MRI and CT, as well as to postoperative MRI...
September 26, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30266580/risk-of-metachronous-advanced-lesions-after-resection-of-diminutive-and-small-non-advanced-adenomas
#15
Ido Laish, Ilia Sergeev, Assaf Stein, Timna Naftali, Fred M Konikoff
BACKGROUND AND AIMS: Current post-polypectomy surveillance interval guidelines do not discriminate between 1-2 diminutive (1-5mm) and small (6-9mm) non-advanced adenomas. This study compared the risk for metachronous advanced lesions in these groups. METHODS: Patients with 1-2 diminutive, non-advanced adenomas and no further advanced lesions, and patients with no polyps at baseline colonoscopy were retrospectively analyzed to determine the rate of metachronous advanced lesions...
September 25, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30254995/minimal-deviation-adenocarcinoma-adenoma-malignum-of-the-uterine-cervix-clinicopathological-analysis-of-17-cases
#16
Min Hee Lee, Eun Soo Kim, Min Chul Choi, Jin-Hyung Heo, Ja-Hyun Jang, Sang Geun Jung, Hyun Park, Won Duk Joo, Chan Lee, Je Ho Lee
Objective: The aim of this study was to evaluate the clinicopathological features of minimal deviation adenocarcinoma (MDA) and to analyze its prognostic factors. Methods: We retrospectively analyzed the medical records of 17 patients who were diagnosed with MDA at a single institution between January 2005 and December 2015. Results: The median age of the patients was 47.7 years (33-75 years). MDA was diagnosed in 7 patients (41.2%) before performing definitive surgery...
September 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/30245792/a-prospective-study-of-faecal-immunochemical-testing-following-polypectomy-in-a-colorectal-cancer-screening-population
#17
David J Gibson, Blathnaid Nolan, Joanna Rea, Maire Buckley, Gareth Horgan, Kieran Sheahan, Glen A Doherty, Diarmuid O'Donoghue, Hugh E Mulcahy, Alan Smith, Garret Cullen
Introduction: 52% of faecal immunohistochemistry test (FIT)-positive clients in the Irish National Colorectal Cancer Screening Programme (BowelScreen) have adenomatous polyps identified at colonoscopy in round 1. Although it is known that advanced adenomas and cancers cause an elevated FIT, it is not known if small (<5 mm) adenomas cause a positive FIT. Aims: Determine if removal of small polyps in an FIT-based colorectal cancer (CRC) screening programme is associated with a negative FIT on follow-up...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30242328/influence-of-varying-quantitative-fecal-immunochemical-test-positivity-thresholds-on-colorectal-cancer-detection-a-community-based-cohort-study
#18
Kevin Selby, Christopher D Jensen, Jeffrey K Lee, Chyke A Doubeni, Joanne E Schottinger, Wei K Zhao, Jessica Chubak, Ethan Halm, Nirupa R Ghai, Richard Contreras, Celette Skinner, Aruna Kamineni, Theodore R Levin, Douglas A Corley
Background: The fecal immunochemical test (FIT) is commonly used for colorectal cancer (CRC) screening. Despite demographic variations in stool hemoglobin concentrations, few data exist regarding optimal positivity thresholds by age and sex. Objective: To identify programmatic (multitest) FIT performance characteristics and optimal FIT quantitative hemoglobin positivity thresholds in a large, population-based, screening program. Design: Retrospective cohort study...
October 2, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30228897/individual-invitation-letters-lead-to-significant-increase-in-attendance-for-screening-colonoscopies-results-of-a-pilot-study-in-northern-hesse-germany
#19
K Stratmann, H Bock, N Filmann, P Fister, C Weber, W Tacke, B Simonis, M Höftmann, O Schröder, J Hausmann, S Zeuzem, I Blumenstein
Background: Colorectal cancer (CRC) is the second most common cancer in Germany. Screening colonoscopies are considered an effective tool for early detection and prevention of CRC and are recommended in Germany for citizens over the age of 55. To increase the participation rate for screening colonoscopies, an invitation procedure was initiated in parts of Germany for patients between the ages of 55 and 75 who had never undergone a screening colonoscopy before. Methods: We examined the number of participating patients before, during, and after the invitation procedure and compared the number of the participating patients who received a cover letter with the participating patients from the control group...
August 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/30228889/endoscopic-full-thickness-resection-of-duodenal-lesions-a-retrospective-analysis-of-20-ftrd-cases
#20
Markus Bauder, Arthur Schmidt, Karel Caca
Background: Endoscopic resections in the duodenum harbor a significant risk of complications. The full-thickness resection device (FTRD) has shown favorable results concerning efficacy and safety in the resection of colorectal lesions. Data of its use in the duodenum are limited to a single, small case series ( n  = 4). Methods: Data of all consecutive patients scheduled for endoscopic full-thickness resection (EFTR) of duodenal lesions by FTRD in our institution were collected and analyzed retrospectively...
August 2018: United European Gastroenterology Journal
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