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Advanced adenoma

Christoph Schramm, Fabian Kütting, Sonja Lang, Philipp Kasper, Seung-Hun Chon, Hans-Michael Steffen
HINTERGRUND:  Die bisher veröffentlichte Studienlage zur Assoziation von Kolondivertikeln und kolorektalen Polypen einschließlich des kolorektalen Karzinoms (KRK) ist konträr. Ziel der Studie war es, die Assoziation für sämtliche relevanten histologischen Polypensubtypen, d. h. hyperplastische Polypen (HP), sessil und traditionell serratierte Adenome (SSA und TSA), klinisch relevante serratierte Polypen (krSP), tubuläre Adenome und fortgeschrittene Adenome in einer ausschließlichen Vorsorgekoloskopie-Kohorte zu untersuchen...
December 2018: Zeitschrift Für Gastroenterologie
Carole Vitellius, Margot Laly, Anne-Sophie Banaszuk, Isabelle Deherce, Nathanaëlle Cornet, Sandrine Bertrais, Patrick Saulnier, François-Xavier Caroli-Bosc
Colorectal cancer (CRC) is a major cause of cancer-related death of worldwide with high incidence and mortality rate, accessible to a screening program in France, first with guaiac- based fecal occult blood test (g-FOBT) then with fecal immunochemical tests (FIT), since 2015, because of better accuracy. The aim of our study was to compare the characteristics of screen-detected lesions in two successive CRC screening campaigns, using two different tests (Hemoccult II® and OC Sensor® ) in the department of Maine-et-Loire, and to precise the performance of these tests [participation rate, detection rates (DR), positive predictive value (PPV)]...
December 8, 2018: European Journal of Epidemiology
Carlo Senore, Partha Basu, Ahti Anttila, Antonio Ponti, Mariano Tomatis, Diama Bhadra Vale, Gugliemo Ronco, Isabelle Soerjomataram, Maja Primic-Žakelj, Emilia Riggi, Joakim Dillner, Miriam Klara Elfström, Stefan Lönnberg, Rengaswamy Sankaranarayanan, Nereo Segnan
OBJECTIVE: To present comparative data about the performance of colorectal cancer (CRC) screening programmes in the European Union Member States (EU MSs). DESIGN: Cross-sectional study. We analysed key performance indicators-participation rate, positivity rate (PR), detection rate (DR) and positive predictive value for adenomas and CRC-based on the aggregated quantitative data collected for the second EU screening report. We derived crude and pooled (through a random effects model) estimates to describe and compare trends across different MSs/regions and screening protocols...
December 10, 2018: Gut
Antonio Facciorusso, Konstantinos Triantafyllou, Mohammad Hassan Murad, Larry J Prokop, Georgios Tziatzios, Nicola Muscatiello, Siddharth Singh
BACKGROUND AND AIMS: Adenoma detection rate (ADR) is a quality metric for colorectal cancer screening. We performed a systematic review and network meta-analysis to assess the overall and comparative efficacies of different endoscopic techniques in adenoma detection. METHODS: We performed a systematic review of published articles and abstracts, through March 15, 2018, to identify randomized controlled trials of adults undergoing colonoscopy that compared the efficacy of different devices in detection of adenomas...
December 6, 2018: Clinical Gastroenterology and Hepatology
H Ishii, R Mihai, J C Watkinson, D S Kim
Background: The majority of patients with primary hyperparathyroidism (PHPT) have a single overactive adenoma. Advances in preoperative imaging and surgical adjuncts have given rise to minimally invasive parathyroidectomy (MIP), with lower complication rates in comparison with bilateral neck exploration. Misdiagnosis and undertreatment of multiglandular disease, leading to potentially higher recurrence rates, remains a concern. This study evaluated risks of long-term (1 year or more) recurrence following 'targeted' MIP in PHPT...
December 2018: BJS open
Sunny Dhadlie, Daniel Mehanna
Introduction: Acute appendicitis in older adults is relatively uncommon and could be the first presentation of an underlying colorectal carcinoma. Colonoscopy in these individuals affords the opportunity for earlier diagnosis and treatment. The finding of increased rates of colorectal cancer (CRC) with older patients who have had appendicitis was supported by a number of small studies and case reports in the early 1980s.With the advent of CT scanning and laparoscopic appendicectomy, increased ability to visualize the caecum has been achieved...
December 2018: Annals of Medicine and Surgery
C A Bertram, K Müller, R Klopfleisch
Disorders of the female genital tract are among the most common disorders in pet guinea pigs (Cavia porcellus); however, knowledge of many aspects of these disorders is sparse, especially regarding their incidence and age distribution. Ovarian cysts, as the most common genital tract disorder in guinea pigs, have been investigated in detail; however, information on the nature of these cysts is inconsistent. The present study reviewed genital tract disorders occurring within 655 full post-mortem examinations of intact female pet guinea pigs and 64 female genital tract biopsies examined over a 22...
November 2018: Journal of Comparative Pathology
Clasine M de Klerk, Els Wieten, Iris Lansdorp-Vogelaar, Patrick M Bossuyt, Manon Cw Spaander, Evelien Dekker
BACKGROUND: Faecal immunochemical tests (FITs) are recommended for colorectal cancer screening. Two frequently used FIT methods (FOB-Gold, Sentinel Diagnostics, Milan, Italy and OC-Sensor, Eiken Chemical, Tokyo, Japan) perform similarly in detecting advanced neoplasia (ie, colorectal cancer and advanced adenoma) at a fixed positivity cutoff for faecal haemoglobin concentration. It is unclear whether the performance of the two methods is also comparable at other thresholds. We compared the accuracy of the two assays in detecting advanced neoplasia across various thresholds...
November 26, 2018: Lancet. Gastroenterology & Hepatology
Vanessa Erben, Prudence R Carr, Bernd Holleczek, Christa Stegmaier, Michael Hoffmeister, Hermann Brenner
The risk of developing colorectal cancer (CRC) is associated with a wide range of dietary and lifestyle factors. The individual contribution of single modifiable factors, such as alcohol consumption, physical activity, smoking, body mass index (BMI) or dietary components, to the development of CRC has been investigated extensively, but evidence on their combined effect at various stages of colorectal carcinogenesis is sparse. The aim of this study was to analyze the association of a healthy lifestyle pattern with prevalence of early and advanced colorectal neoplasms...
November 23, 2018: International Journal of Cancer. Journal International du Cancer
Chan Hyuk Park, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Yoon Suk Jung
BACKGROUND: There are no established guidelines on screening strategies for persons with a family history of colorectal cancer (CRC) in Korea. We aimed to evaluate the age-specific risk of colorectal neoplasia according to family history of CRC. METHODS: Participants who underwent screening colonoscopy were included. Age-specific prevalence of non-advanced adenoma (NAA) and advanced colorectal neoplasia (ACRN) was calculated according to family history of CRC. RESULTS: Among 35,997 participants, 1,339 (3...
November 21, 2018: Journal of Gastroenterology and Hepatology
Jessica Chubak, Dale McLerran, Yingye Zheng, Amit G Singal, Douglas A Corley, V Paul Doria-Rose, Chyke A Doubeni, Aruna Kamineni, Jennifer S Haas, Ethan A Halm, Celette Sugg Skinner, Ann G Zauber, Karen J Wernli, Elisabeth F Beaber
Background: To reduce colorectal cancer incidence and mortality, experts recommend surveillance colonoscopy 3 years after advanced adenoma removal. Little is known about adherence to that interval. Methods: We describe patterns of and factors associated with subsequent colonoscopy among persons with ≥3 adenomas and/or ≥1 adenoma with villous/tubulovillous histology in four U.S. integrated healthcare delivery systems. We report Kaplan-Meier estimators of the cumulative percentage of patients undergoing colonoscopy 6 months to 3...
November 20, 2018: Cancer Epidemiology, Biomarkers & Prevention
Takashi Murakami, Yoichi Akazawa, Noboru Yatagai, Takafumi Hiromoto, Noriko Sasahara, Tsuyoshi Saito, Naoto Sakamoto, Akihito Nagahara, Takashi Yao
BACKGROUND: Colorectal sessile serrated adenoma/polyps (SSA/Ps) are considered early precursor lesions in the serrated neoplasia pathway. Recent studies have shown associations of SSA/Ps with lost MLH1 expression, a CpG island methylator phenotype, and BRAF mutations. However, the molecular biological features of SSA/Ps with early neoplastic progression have not yet been fully elucidated, owing to the rarity of cases of SSA/P with advanced histology such as cytologic dysplasia or invasive carcinoma...
November 20, 2018: Diagnostic Pathology
Neil O'Morain, Deirdre McNamara
Advances in colorectal polyp detection and resection methods aim to reduce interval cancer rates. Complete polypectomy is essential to reduce the risk of early recurrence and the development of interval cancers. To achieve this, polyps must first be correctly identified and then completely excised. This article reviews current adenoma detection methods in use and the management of residual disease.
November 20, 2018: Acta Oncologica
John C T Wong, Han-Mo Chiu, Hyun-Soo Kim, Jeong-Sik Byeon, Takahisa Matsuda, Nozomu Kobayashi, Deng-Chyang Wu, David E Ong, Joseph J Y Sung
BACKGROUND AND AIM: Recent guidelines propose higher adenoma detection rate (ADR) benchmarks for colonoscopies performed for positive fecal immunochemical tests (FIT), but this is based on low quality evidence. We aimed to compare ADR, advanced ADR (AADR), and number of adenoma per colonoscopy (APC) in direct screening colonoscopy (DSC) versus FIT positive colonoscopy (FITC) in a multicenter Asia Pacific cohort to justify differential targets. METHODS: Asymptomatic average-risk subjects at or above 50 years of age who underwent screening colonoscopy directly or as follow-up for positive OC-Sensor FIT were identified from eight sites across the Asia Pacific region...
November 16, 2018: Gastrointestinal Endoscopy
Murat Akarsu, Osman Kones
Background and Objectives: Colorectal cancer is the third leading cause of cancer-related death. Excision of premalignant polyps has a s ignificant impact on reducing colorectal cancer mortality and morbidity. Colonoscopy is considered to be the gold standard for the diagnosis and affords an opportunity for treatment of colonic polyps. In recent years, serious debates have taken place because of the biological characteristics of diminutive polyps (DPs), polypectomy complications, and serious costs...
October 2018: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Jing Qian, Kaja Tikk, Korbinian Weigl, Yesilda Balavarca, Hermann Brenner
BACKGROUND: Despite evidence that inflammation and metabolism play a crucial role in colorectal carcinogenesis, there have been few studies on the association of inflammatory and metabolic protein biomarkers in various stages of colorectal carcinogenesis. METHODS: Ninety-two inflammatory and metabolic biomarkers were measured in plasma samples of participants of screening colonoscopy. Markers identified to be significantly associated with the presence of advanced colorectal neoplasia (ACN) in a discovery set (n = 204) were validated in an independent replication set (n = 422)...
November 2018: British Journal of Cancer
In Sub Jung, Cheol Min Shin, Sung Jae Park, Young Soo Park, Hyuk Yoon, Hyun Jin Jo, Nayoung Kim, Dong Ho Lee
Background/Aims: To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas. Methods: Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients with CRC (46 with early-stage and 105 with advanced-stage cancers) were enrolled at a tertiary referral hospital. All subjects underwent colonoscopy, and had laboratory data, and computed tomography (CT) scan available for abdominal fat measurement...
November 12, 2018: Intestinal Research
Shu-Ling Wang, Qian Wang, Jun Yao, Sheng-Bing Zhao, Li-Sheng Wang, Zhao-Shen Li, Yu Bai
OBJECTIVE: Adequate bowel preparation is essential for a successful colonoscopy; clinical studies suggest reinforced education can improve the preparation process. However, there have been no trials to compare WeChat directions (the most widely used social media app in China) with those of the short message service (SMS). This study was aimed to assess the effect of WeChat and SMS on the bowel preparation quality. PARTICIPANTS AND METHODS: This was a single-center, prospective, endoscopically blinded, randomized, controlled study...
November 8, 2018: European Journal of Gastroenterology & Hepatology
Jarek Kobiela, Małgorzata Dobrzycka, Roman Danielewicz, Justyna Jończyk, Andrzej J Łachiński, Zbigniew Śledziński, Alicja Dębska-Ślizień
BACKGROUND Screening colonoscopy is not obligatory in kidney pre-transplant work-up guidelines. According to recommendations, only transplant recipients over age 50 years should be screened. The aim of this study was to characterize endoscopic findings revealed as part of pre-transplant work-up. MATERIAL AND METHODS We retrospectively reviewed pre-transplant work-up charts of 434 adult patients who received a cadaveric donor kidney transplantation (KT) from 2012 to 2015. Endoscopic findings analysis with age subgroup (<50 and ³50) analysis were performed...
November 9, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Tim J Miller, Melanie J Mccoy, Christine Hemmings, Barry Iacopetta, Cameron F Platell
Immunoediting is defined as a process whereby tumour cells develop the capacity to escape immune cell recognition. Accumulating evidence suggests that cancer stem-like cells (CSCs) have an enhanced capacity to interact with the immune system. The expression of CSCs and immune cell-associated markers has been demonstrated to change with disease progression from premalignant lesions to invasive cancer. The present study investigated the expression of putative CSC and immune cell-associated markers in different stages of progression from dysplasia to invasive malignancy in rectal lesions...
November 2018: Oncology Letters
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