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JOURNAL ARTICLE
Shu Aoyama, Akira Inoue, Yoshinori Kagawa, Takamichi Komori, Yuki Ozato, Yujiro Nishizawa, Tomoki Sugimoto, Hisateru Komatsu, Masashi Hirota, Yasuhiro Miyazaki, Akira Tomokuni, Masaaki Motoori, Hiroaki Fushimi, Gou Yamamoto, Kiwamu Akagi, Kazuhiro Iwase, Kazumasa Fujitani
BACKGROUND: APC and MUTYH are both well-known colorectal polyposis causative genes. However, 30-50% of colorectal adenomatous polyposis cases are classified as colonic adenomatous polyposis of unknown etiology and lack identifiable pathogenic variants. Although guidelines recommend total proctocolectomy for colonic adenomatous polyposis of unknown etiology with over 100 adenomas, evidence is lacking. This study presents a unique case of localized colonic adenomatous polyposis of unknown etiology with multiple adenocarcinomas, treated with hemicolectomy and regional lymph node dissection...
April 22, 2024: Surgical Case Reports
#2
JOURNAL ARTICLE
Salih Duman, Arda Sarıgül, Eren Erdoğdu, Berker Özkan, Adalet Demir, Murat Kara, S Alper Toker
Introduction: Hyperfunctional ectopic parathyroid glands in the mediastinum pose a challenge to diagnosis and require optimal surgical management. Video-assisted thoracoscopic surgery (VATS) has emerged as a promising minimally invasive approach, offering potential benefits in terms of both patient comfort and oncological principles. This study aimed to evaluate the effectiveness and safety of VATS for the treatment of hyperfunctional ectopic parathyroid glands in the mediastinum. Methods: Among the 538 patients with mediastinal tumors who underwent thoracoscopic surgery at Istanbul University (2008-2021), 11 exhibited hyperfunctional ectopic parathyroid glands...
April 19, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
#3
JOURNAL ARTICLE
Chang Tan, Geng Qin, Qian-Qian Wang, Yuan-Chen Zhou, Shu-Kun Yao
OBJECTIVES: Sessile serrated lesions (SSLs) are precursors of sporadic colorectal cancer (CRC) and have distinct characteristics compared with conventional adenomas (CAs). Several lifestyle and environmental factors may play critical roles in the development of advanced lesions. Our aim is to describe the features of SSLs and CAs and further explore risk factors for advanced lesions. METHODS: This is an observational study that collected demographic, endoscopic, and histological data from the China-Japan Friendship Hospital among the inpatient population with pathologically reported as SSL or CA between 2015 and 2022...
2024: Frontiers in Oncology
#4
JOURNAL ARTICLE
Mingqing Zhang, Yongdan Zhang, Lu Guo, Lizhong Zhao, Haoren Jing, Xiao Yang, Wen Zhang, Yong Zhang, Zhenguo Nie, Siwei Zhu, Shiwu Zhang, Xipeng Zhang
BACKGROUND: Compliance with colonoscopy among elderly individuals participating in colorectal cancer (CRC) screening programs is unsatisfactory, despite a high detection rate of bowel-related diseases. In this study, our aim was to analyze the impact of risk factors on the trends of compliance and detection rates in colonoscopy among high-risk individuals aged 60-74. METHODS: A retrospective study was conducted on the high-risk individuals aged 60-74 participating in the 2021 CRC screening program in Tianjin, China...
April 2024: Cancer Medicine
#5
JOURNAL ARTICLE
Xiaojuan Li, Mengting Hu, Zhangjun Wang, Mei Liu, Ying Chen
BACKGROUND: Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorectal carcinoma in situ (CCS) and neoplastic polyps. METHODS: Inpatients admitted from January 2018 to May 2023 were screened through the hospital information system. Polyps were classified according to pathological morphology. The prevalence of polyps was described by frequency and 95% confidence interval...
April 17, 2024: Journal of Translational Medicine
#6
JOURNAL ARTICLE
Alberto Savino, Emanuele Rondonotti, Simone Rocchetto, Alessandra Piagnani, Niccolò Bina, Pasquale Di Domenico, Francesco Segatta, Franco Radaelli
INTRODUCTION: The identification of early-stage colorectal cancers (CRC) and the resection of pre-cancerous neoplastic lesions through colonoscopy allows to decrease both CRC incidence and mortality. However, colonoscopy miss rates up to 26% for adenomas and 9% for advanced adenomas have been reported. In recent years, artificial intelligence (AI) systems have been emerging as easy-to-use tools, potentially lowering the risk of missing lesions. AREAS COVERED: This review paper focuses on GI Genius device (Medtronic Co...
April 15, 2024: Expert Review of Medical Devices
#7
JOURNAL ARTICLE
Masahiro Hashimoto, Yasuhiro Kojima, Takeharu Sakamoto, Yuki Ozato, Yusuke Nakano, Tadashi Abe, Kiyotaka Hosoda, Hideyuki Saito, Satoshi Higuchi, Yuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Tsuyoshi Hata, Satoshi Nagayama, Koichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Kazuki Takahashi, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Satoshi Fukuchi, Kazunari Murakami, Tomoharu Yoshizumi, Kenji Kadomatsu, Taro Tobo, Yoshinao Oda, Mamoru Uemura, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Masanobu Oshima, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, Koshi Mimori
BACKGROUND: Cell-cell interaction factors that facilitate the progression of adenoma to sporadic colorectal cancer (CRC) remain unclear, thereby hindering patient survival. METHODS: We performed spatial transcriptomics on five early CRC cases, which included adenoma and carcinoma, and one advanced CRC. To elucidate cell-cell interactions within the tumour microenvironment (TME), we investigated the colocalisation network at single-cell resolution using a deep generative model for colocalisation analysis, combined with a single-cell transcriptome, and assessed the clinical significance in CRC patients...
April 9, 2024: EBioMedicine
#8
Mena Louis, Elaine Lelli, Fernando Aycinena, Ezra Ellis
Small cell carcinoma of the rectum (SCCR) is a rare and aggressive neuroendocrine tumor. Its association with a tubulovillous adenoma is an exceptional occurrence, presenting significant implications for diagnosis and treatment. This case report details a 62-year-old male, undergoing treatment for hepatocellular carcinoma, presented with symptoms of diarrhea. A colonoscopy initially suggested a benign tubulovillous adenoma, but the presence of discordant clinical findings led to further evaluation. The final diagnosis, established post-surgery, was SCCR originating from a tubulovillous adenoma...
March 2024: Curēus
#9
Farid Gossili, Simona Gauduseviciene, Daiva Erentaite, Peter Iversen, Charlotte E Almasi
Primary hyperparathyroidism commonly results from a solitary parathyroid adenoma. A water clear cell parathyroid adenoma represents a rare histological variant. This report presents the challenges of preoperative detection of a giant parathyroid adenoma, which was of the water clear cell variant. A case of severe hypercalcemia in a patient without clinical symptoms and equivocal findings on standard imaging modalities, in which the use of [11 C]C-Methionine PET/CT facilitated the preoperative detection of a giant parathyroid adenoma...
June 2024: Radiology Case Reports
#10
REVIEW
Rajat Garg, Carol A Burke, Manik Aggarwal, Carole Macaron, Amandeep Singh, Michelle K Kim, Miguel Regueiro, Bhatt Amit, Prabhleen Chahal, Shashank Garg
Background and study aims Published studies report a higher adenoma detection rate (ADR) for FIT-DNA as compared with FIT. Data are less replete about the performance of stool-based tests for sessile serrated polyp (SSP) detection. We performed a meta-analysis to evaluate the performance of FIT and FIT-DNA testing for SSP detection rate (SSPDR) in patients undergoing colonoscopy for follow up of positive noninvasive tests. Methods A comprehensive literature search of multiple databases (until September 2022) was performed to identify studies reporting SSPDR in patients with positive FIT or FIT-DNA tests...
April 2024: Endoscopy International Open
#11
JOURNAL ARTICLE
Christopher Bouvette, Justin Kosirog, Bryce Yohannan, Alyssa Grossen, Ijlal Akbar Ali, Mohammad Madhoun
BACKGROUND: Smoking is linked with numerous adverse health effects. Nicotine staining on fingers or teeth is thought to suggest active or heavy smoking. The significance of nicotine staining within gastroenterology remains unclear. AIM: We set out to establish the predictive value of nicotine staining for adenomas and advanced adenomas. METHODS: This was a cross-section study of patients who underwent colonoscopy at the Oklahoma City Veterans Affairs Medical Center from November 2019 to November 2020...
April 5, 2024: Preventive Medicine
#12
EDITORIAL
Luis Ramon Rabago, Maria Delgado Galan
Colonoscopy is the gold standard for the screening and diagnosis of colorectal cancer, resulting in a decrease in the incidence and mortality of colon cancer. However, it has a 21% rate of missed polyps. Several strategies have been devised to increase polyp detection rates and improve their characterization and delimitation. These include chromoendoscopy (CE), the use of other devices such as Endo cuffs, and major advances in endoscopic equipment [high definition, magnification, narrow band imaging, i-scan, flexible spectral imaging color enhancement, texture and color enhancement imaging (TXI), etc...
March 16, 2024: World Journal of Gastrointestinal Endoscopy
#13
JOURNAL ARTICLE
Xianhua Mao, Ka Shing Cheung, Jing-Tong Tan, Lung-Yi Mak, Chi-Ho Lee, Chi-Leung Chiang, Ho Ming Cheng, Rex Wan-Hin Hui, Man Fung Yuen, Wai Keung Leung, Wai-Kay Seto
OBJECTIVE: Whether varying degrees of glycaemic control impact colonic neoplasm risk in patients with diabetes mellitus (DM) remains uncertain. DESIGN: Patients with newly diagnosed DM were retrieved from 2005 to 2013. Optimal glycaemic control at baseline was defined as mean haemoglobin A1c (HbA1c)<7%. Outcomes of interest included colorectal cancer (CRC) and colonic adenoma development. We used propensity score (PS) matching with competing risk models to estimate subdistribution HRs (SHRs)...
April 3, 2024: Gut
#14
JOURNAL ARTICLE
Anuj Verma, Raja R Seethala, He Wang
CONTEXT.—: High-grade transformation, previously known as dedifferentiation, in salivary gland carcinoma and carcinosarcoma ex pleomorphic adenoma is a rare phenomenon. It is, however, clinically relevant and affects treatment and prognosis. OBJECTIVE.—: To review the existing literature, describe the histologic and immunophenotypic features, and highlight the diagnostic criteria of high-grade transformation in various salivary gland carcinomas and carcinosarcoma; to review its effect on clinical presentation and prognosis; and to review relevant molecular characteristics and recent concepts and advances...
April 4, 2024: Archives of Pathology & Laboratory Medicine
#15
JOURNAL ARTICLE
Andrew Chang, Sravya Prabhala, Ali Daneshkhah, Jianan Lin, Hariharan Subramanian, Hemant Kumar Roy, Vadim Backman
Colonoscopy is accurate but inefficient for colorectal cancer (CRC) prevention due to the low (~ 7 to 8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa to identify patients who harbor CRC field carcinogenesis by evaluating chromatin 3D architecture. Supranucleosomal disordered chromatin chains (~ 5 to 20 nm, ~1 kbp) fold into chromatin packing domains (~ 100 to 200 nm, ~ 100 to 1000 kbp). In turn, the fractal-like conformation of DNA within chromatin domains and the folding of the genome into packing domains has been shown to influence multiple facets of gene transcription, including the transcriptional plasticity of cancer cells...
April 2, 2024: Scientific Reports
#16
JOURNAL ARTICLE
Jeffrey K Lee, Abhik Roy, Christopher D Jensen, Jennifer T Chan, Wei K Zhao, Theodore R Levin, Jessica Chubak, Ethan A Halm, Celette S Skinner, Joanne E Schottinger, Nirupa R Ghai, Andrea N Burnett-Hartman, Aruna Kamineni, Natalia Udaltsova, Douglas A Corley
IMPORTANCE: Postpolypectomy surveillance is a common colonoscopy indication in older adults; however, guidelines provide little direction on when to stop surveillance in this population. OBJECTIVE: To estimate surveillance colonoscopy yields in older adults. DESIGN, SETTING, AND PARTICIPANTS: This population-based cross-sectional study included individuals 70 to 85 years of age who received surveillance colonoscopy at a large, community-based US health care system between January 1, 2017, and December 31, 2019; had an adenoma detected 12 or more months previously; and had at least 1 year of health plan enrollment before surveillance...
April 1, 2024: JAMA Network Open
#17
JOURNAL ARTICLE
Raed A Azhar, Omar Buksh, Abdullah M Almalki, Rabea Akram, Hani Alzahrani, Abdullah Al-Gadheeb, Qusay Mandoorah, Adel A Alammari
Introduction Advancements in radiological imaging technology have increased the discovery of adrenal incidentalomas. Large adrenal tumors (LATs) are not common, and the likelihood of malignancy increases with tumor size. LATs were defined as tumors larger than four centimeters (cm) with various pathologic diagnoses. Traditionally, open adrenalectomy was considered the gold standard for LATs, but with recent advancements in minimally invasive surgery (MIS), optimum perioperative and long-term outcomes are achievable by the MIS approach...
February 2024: Curēus
#18
JOURNAL ARTICLE
Willemijn de Klaver, Meike de Wit, Anne Bolijn, Marianne Tijssen, Pien Delis-van Diemen, Margriet Lemmens, Manon Cw Spaander, Evelien Dekker, Monique E van Leerdam, Veerle Mh Coupé, Ruben van Boxtel, Hans Clevers, Beatriz Carvalho, Gerrit A Meijer
Environmental factors like the pathogenicity island polyketide synthase positive (pks+) Escherichia coli (E. coli) could have potential for risk stratification in colorectal cancer (CRC) screening. The association between pks+ E. coli measured in fecal immunochemical test (FIT) samples and the detection of advanced neoplasia (AN) at colonoscopy was investigated. Biobanked FIT samples were analyzed for both presence of E. coli and pks+ E. coli and correlated with colonoscopy findings; 5020 CRC screening participants were included...
March 29, 2024: Journal of Pathology
#19
JOURNAL ARTICLE
Jeton Luzha, Markus Kopp, Marco Wiesmüller, Lava Taha, Robin Rupp, Konstantinos Mantsopoulos, Michael Koch, Heinrich Iro, Matti Sievert
BACKGROUND A mass in the parotid gland usually indicates parotid gland neoplasia. Warthin tumors or pleomorphic adenomas are common differential diagnoses. Less frequently, other differential diagnoses and sites of origin are considered. Schwannomas are rare, benign tumors in the head and neck region. Even more rarely, these tumors occur in the intraparotid course of the facial nerve. In the following, we report about 2 patients in whom a mass in the right parotid gland was found incidentally during magnetic resonance imaging (MRI)...
March 29, 2024: American Journal of Case Reports
#20
JOURNAL ARTICLE
Rajmohan Rammohan, Sai Greeshma Magam, Melvin Joy, Wing Hang Lau, Abhishek Tadikonda, Dilman Natt, Sai Reshma Magam, Leeza Pannikodu, Jiten Desai, Rucha Jiyani, Saher Sheikh, Susan Bunting, Prachi Anand, Krishnaiyer Subramani, Nausheer Khan, Paul Mustacchia
Introduction Colorectal cancer (CRC) remains a significant public health challenge globally, with its pathogenesis involving the transformation of benign adenomas into malignant carcinomas. Despite advancements in screening and early detection significantly improving outcomes, the rise of digital platforms like YouTube for disseminating health information presents new challenges. Concerns over the accuracy and reliability of content underline the necessity for rigorous evaluation of these digital health education tools...
February 2024: Curēus
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