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https://www.readbyqxmd.com/read/30336540/early-detection-of-colorectal-cancer-a-multi-center-pre-clinical-case-cohort-study-for-validation-of-a-combined-dna-stool-test
#1
Matthias M Dollinger, Susanna Behl, Wolfgang E Fleig
BACKGROUND: Although colonoscopy-based screening has proven to be highly effective in detecting colorectal cancer (CRC), participation rates remain disappointing. Development of CRC is associated with a number of genetic or somatic mutations. New, non-invasive stool tests are currently being developed based on the detection of these alterations. We investigated if a non-invasive stool assay can offer sufficient sensitivity and specificity to supplement colonoscopy-based screening. METHODS: We compared a combined stool assay, which incorporates fecal occult blood testing (FOBT), quantification of human DNA (hDNA) as well as detection of genetic mutations of KRAS and BRAF (Combined DNA stool assay), with commercially available FOBT and M2-PK tests in a multi-centric six-armed pre-clinical case cohort study...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336539/the-dynamic-trends-of-urinary-lh-and-fsh-assayed-by-icma-during-triptorelin-stimulation-tests-in-girls-a-pilot-study
#2
Yaping Ma, Shuang Nie, Ze Ben, Zhuangjian Xu, Huan Zhou, Jinling Zhao, Feng Ren, Qing Wang, Shuyan Xie, Tingting Zhang
BACKGROUND: Gonadotropin-releasing hormone stimulation test is a gold standard for evaluating the function of the hypothalamic-pituitary-gonadal axis (HPGA) in children. These tests are usually uncomfortable because of multi-venipunctures. A urine specimen is a good alternative because it is noninvasive and convenient. More studies have shown the correlation between sera and urine LH and FSH levels under different physiological and pathological conditions. METHODS: The study investigated the dynamic trends of urine LH (uLH) and FSH (uFSH) assayed by immunochemiluminometric assays (ICMA) during triptorelin stimulation tests in girls...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336538/identification-of-potential-biomarkers-involved-in-gastric-cancer-through-integrated-analysis-of-non-coding-rna-associated-competing-endogenous-rnas-network
#3
Chao Xing, Zhengzhai Cai, Jian Gong, Jun Zhou, Jingjing Xu, Feng Guo
BACKGROUND: Gastric cancer is one of the most common malignant tumors worldwide. Increasing studies have indicated that non-coding RNAs (ncRNAs) play critical roles in cancer progression. They have shown great potential to be useful markers and therapeutic targets. METHODS: Bioinformatics analysis was conducted to detect mRNA and ncRNAs' expression changes between tumor samples and adjacent non-tumor samples. The gene expression profiles were obtained from the national center of biotechnology information gene expression omnibus (GEO)...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336535/multianalyte-determination-of-noacs-using-lc-ms-ms-and-comparison-with-functional-coagulation-assays
#4
Ludek Slavik, Jiri Lukes, David Friedecky, Monika Zhanelova, Marketa Nemcova, Jana Ulehlova, Jana Prochazkova, Antonin Hlusi, Miroslava Palova, Jan Vaclavik
BACKGROUND: Detection of new oral anticoagulant (NOAC) levels by screening, special and global tests, and liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) is important in clinical situations when the cause of bleeding needs to be determined. METHODS: We compared a routine coagulation test, special function test for NOACs, global coagulation test, and an LC-MS/MS method that enables simultaneous determination of apixaban, dabigatran and rivaroxaban in human plasma within one analysis to determine the optimal indication of the comparison methods, including their limitations and interferences...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336532/prognostic-value-of-alt-ast-and-aar-in-hepatocellular-carcinoma-with-b-type-hepatitis-associated-cirrhosis-after-radical-hepatectomy
#5
Li Zhou, Shao-Bin Wang, Shu-Guang Chen, Qiang Qu, Jing-An Rui
BACKGROUND: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and AST to ALT ratio (AAR) were shown to be associated with prognosis in some groups of hepatocellular carcinoma (HCC). However, their clinicopathologic and prognostic roles in HCC patients with B-type hepatitis-associated cirrhosis (HBAC) have not been comprehensively investigated. The present study aimed to address the issues. METHODS: A total of 125 patients with HCC and HBAC after radical hepatectomy were included...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336529/five-fibrosis-biomarkers-together-with-serum-ferritin-level-to-diagnose-liver-fibrosis-and-cirrhosis
#6
Said M Afify, Ashraf Tabll, Hend M Nawara, Mohamed El Kassas, Ashraf Elfert, Masaharu Seno, Salah El-Kousy
BACKGROUND: Liver fibrosis is a dynamic procedure that results from an irregularity between fibrogenesis and fibrolysis. After time this procedure can lead to cirrhosis of the liver. Liver fibrosis and cirrhosis assessment is very important for both therapeutic decisions and prognostic evaluations. In this study, we tried to use serum ferritin (SF) together with five fibrosis tests (Age-Platelet index (API), aspartate aminotransferase to alanine aminotransferase ratio (AAR), AST to platelet ratio index (APRI), Fibrosis 4 score (FIB-4), and fibro-quotient (Fibro-Q)) to assess liver fibrosis and cirrhosis and estimate possible correlation between inflammation and SF...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336524/serum-high-sensitivity-c-reactive-protein-improves-sensitivity-of-curb-65-in-predicting-icu-admission-and-mortality-in-community-acquired-pneumonia-patients
#7
Yan L Ge, Cong H Liu, Jing Xu, Zi Y Cui, Wei C Guo, Hui L Li, Ai S Fu, Hong Y Wang, Hai F Zhang, Xiao Y Zhu
BACKGROUND: The CURB-65 scoring system is a simple tool in assessment and prognosis prediction for communityacquired pneumonia (CAP) patients. However, the variations in performance of CURB-65 in young and elderly patients, underestimation or overestimation of the severity, and mortality have often been reported. The aim of this study was to investigate the usefulness of serum high-sensitivity C reactive protein (hs-CRP) combined with CURB-65 in predicting ICU admission and 30-day mortality in CAP patients...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336519/assessment-of-plasma-amino-acid-dynamics-in-response-to-acth-stimulation-by-liquid-chromatography-tandem-mass-spectrometry
#8
Michael Paal, Johanna M Lindner, Philipp Schmoeckel, Anna C Suhr, Simon Schafferer, Therese Koal, Josef Briegel, Michael Vogeser
BACKGROUND: The adrenocorticotropic hormone (ACTH) stimulation test is a widely used diagnostic tool to assess the adrenal gland function. Beyond that the ACTH test can be used in stress research to induce a biochemical stress response under standardized conditions. To study the impact of the stress response on protein metabolism, time-course plasma amino acid profiling in healthy individuals was performed with high performance liquid chromatography tandem-mass spectrometry (HPLC-MS/MS)...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336513/patients-awaiting-renal-transplantation-in-south-africa-the-need-for-highly-sensitive-laboratory-testing-and-immunological-risk-stratification
#9
Catherine M Worsley, Elizabeth S Mayne
BACKGROUND: Suitable laboratory testing prior to transplantation ensures that a patient's immunological risk is understood and allows the transplantation team to make the correct decisions on donor-recipient pairing. Preformed donor-specific anti-HLA antibodies mediate rejection in transplanted patients. Improved laboratory testing is needed to increase the chances of successful organ allocation. In this study, we show how Luminex™ single antigen assays are vital in determining immunological risk to transplantation and in predicting waiting time to transplantation...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336509/-practical-evaluation-of-patients-with-syncopal-events
#10
Blanka Nemeth, Elisabeth Weber, Lars Christian Huber
Syncope is defined as a transient, self-limited loss of consciousness due to insufficient cerebral blood perfusion. In a clinical setting, syncopal events usually present a diagnostic dilemma due to its broad differential diagnosis ranging from banal to potentially harmful causes. In the absence of a working hypothesis, multiple tests are ordered that result in high costs but are of questionable diagnostic and therapeutic value. This article provides a practical overview and, based on international guidelines and selected studies, proposes a standardized approach to patients with syncope...
October 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/30336508/-low-back-pain-focused-history-taking-and-physical-examination
#11
Jean-François Chenot
Low back pain is common, but serious underlying disorders are infrequent in ambulatory care. Extensive diagnostic testing is neither feasable nor reasonable due to epidemiological and economical considerations. A structured step wise approach allows to differentiate between specific and unspecific low back pain.
October 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/30336478/beam-walking-to-assess-dynamic-balance-in-health-and-disease-a-protocol-for-the-beam-multicenter-observational-study
#12
Tibor Hortobágyi, Azusa Uematsu, Lianne Sanders, Reinhold Kliegl, József Tollár, Renato Moraes, Urs Granacher
BACKGROUND: Dynamic balance keeps the vertical projection of the center of mass within the base of support while walking. Dynamic balance tests are used to predict the risks of falls and eventual falls. The psychometric properties of most dynamic balance tests are unsatisfactory and do not comprise an actual loss of balance while walking. OBJECTIVES: Using beam walking distance as a measure of dynamic balance, the BEAM consortium will determine the psychometric properties, lifespan and patient reference values, the relationship with selected "dynamic balance tests," and the accuracy of beam walking distance to predict falls...
October 18, 2018: Gerontology
https://www.readbyqxmd.com/read/30336474/c9orf72-repeat-expansion-frequency-among-patients-with-huntington-disease-genetic-testing
#13
Cristiane M Ida, Malinda L Butz, Patrick A Lundquist, D Brian Dawson
BACKGROUND: European studies identified the C9orf72 repeat expansion as the most frequent genetic alteration in patients with Huntington disease (HD)-like phenotypes but negative HD genetic testing. OBJECTIVE: To investigate C9orf72 repeat expansion frequency in individuals tested for HD in a North American tertiary referral laboratory. METHODS: Three hundred and seventy-three cases (115 positive and 258 negative for HD) were evaluated by genotyping PCR, with follow-up Southern blot and 5' repeat methylation status assessment by combined repeat-primed and methylation-specific PCR in a subset...
October 18, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/30336464/the-number-of-items-on-each-stroop-test-card-is-unrelated-to-its-sensitivity
#14
Keliang Chen, Lin Huang, Biying Lin, Yan Zhou, Qianhua Zhao, Qihao Guo
OBJECTS: Different variations of the Stroop Color-Word Test (SCWT) exist and the tests differ in the number of items on each test card. The optimal number of items per card of the SCWT is unclear. METHODS: A comprehensive neuropsychological battery including the SCWT was administered to 237 cognitively normal controls (NC), 221 patients with mild cognitive impairment (MCI), and 160 patients with Alzheimer's disease (AD). We compared the accuracy for different items of card C (SCWT-C10accuracy, SCWT-C24accuracy, and SCWT-C50accuracy) in distinguishing patients with MCI and AD from NC...
October 18, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/30336452/a-fast-approximate-algorithm-for-determining-bond-orders-in-large-polycyclic-structures
#15
Sergey Trepalin, Sasha Gurke, Mikhail Akhukov, Andrey Knizhnik, Boris Potapkin
Novel logarithmic time algorithm is proposed for determining the order of chemical bonds from known valences of the atoms. The algorithm has the order of complexity N · log(N) and is applicable to polycyclic compounds containing a combination of the cycles of any size and the atoms with the valences ≤4 in cycle nodes. The algorithm is applicable to structures containing triple and cumulene bonds in the cycles. It was tested for graphene, C[12,12] nanotubes, graphyne-GY1, graphyne-GY7, graphyne-like nanotube, fullerenes C20, C60, C70, C80, C82 and their aza-analogs, polypentadienes, as well as for porphine...
October 11, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/30336437/evaluating-dynamic-hydrological-connectivity-of-a-floodplain-wetland-in-north-bihar-india-using-geostatistical-methods
#16
Manudeo Singh, Rajiv Sinha
Spatio-temporal connectivity patterns of a wetland as a function of the land use/land cover (LULC) of its catchment have been analysed in a GIS environment. An innovative method has been implemented for mapping 'dynamic hydrological connectivity' for a water-stressed wetland of Kosi-Ganga interfluve area in the middle Ganga Plains, India for pre- and post-monsoon seasons over a time-span of 29 years (1989 to 2017). It was accomplished by using the time-series NDVI (Normalized Difference Vegetation Index) data and the connectivity response unit (CRU) approach by applying geostatistical methods namely the Getis-Ord Gi* and Mann-Kendall trend test statistics...
October 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30336435/elucidating-temporal-trends-in-trace-element-exposure-of-green-turtles-chelonia-mydas-using-the-toxicokinetic-differences-of-blood-and-scute-samples
#17
C A Villa, I Bell, C Madden Hof, C J Limpus, C Gaus
Blood is considered a suitable biomonitoring matrix for evaluating relatively recent exposure to environmental contaminants since abrupt changes in exposure regimes are rapidly reflected in blood. On the other hand, keratinized tissues, such as turtle scutes, are known to integrate trace element exposure over relatively long time periods. This study aimed to test the use of the differences in blood and scute to inform on the historical trace element exposure of green turtles. We propose a blood-scute kinetic model to predict how an increase in exposure would affect the concentrations in these two matrices over time...
October 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30336428/comparative-toxicities-of-four-benzophenone-ultraviolet-filters-to-two-life-stages-of-two-coral-species
#18
Tangtian He, Mirabelle Mei Po Tsui, Chih Jui Tan, Ka Yan Ng, Fu Wen Guo, Li Hsueh Wang, Te Hao Chen, Tung Yung Fan, Paul Kwan Sing Lam, Margaret Burkhardt Murphy
The benzophenone (BP) organic ultraviolet (UV) filters have been measured in seawater at ng/L to μg/L levels, but more data on their effects in non-target marine organisms are needed. Corals can be exposed to BPs due to wastewater discharges and coastal recreational activities. In this study, toxicities and bioaccumulation of BP-1 (2,4-dihydroxybenzophenone), BP-3 (oxybenzone), BP-4 (sulisobenzone) and BP-8 (dioxybenzone) to larvae and adults of two coral species, Pocillopora damicornis and Seriatopora caliendrum, were assessed at concentrations ranging from 0...
October 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30336425/biochar-soil-and-land-use-interactions-that-reduce-nitrate-leaching-and-n-2-o-emissions-a-meta-analysis
#19
REVIEW
Nils Borchard, Michael Schirrmann, Maria Luz Cayuela, Claudia Kammann, Nicole Wrage-Mönnig, Jose M Estavillo, Teresa Fuertes-Mendizábal, Gilbert Sigua, Kurt Spokas, James A Ippolito, Jeff Novak
Biochar can reduce both nitrous oxide (N2 O) emissions and nitrate (NO3 - ) leaching, but refining biochar's use for estimating these types of losses remains elusive. For example, biochar properties such as ash content and labile organic compounds may induce transient effects that alter N-based losses. Thus, the aim of this meta-analysis was to assess interactions between biochar-induced effects on N2 O emissions and NO3 - retention, regarding the duration of experiments as well as soil and land use properties...
October 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30336419/positive-end-expiratory-pressure-titrated-according-to-respiratory-system-mechanics-or-to-ardsnetwork-table-did-not-guarantee-positive-end-expiratory-transpulmonary-pressure-in-acute-respiratory-distress-syndrome
#20
Joerg Krebs, Paolo Pelosi, Patricia R M Rocco, Michael Hagmann, Thomas Luecke
PURPOSE: Pulmonary recruitment and positive end-expiratory pressure (PEEP) titrated according to minimal static elastance of the respiratory system (PEEPEstat,RS ) compared to PEEP set according to the ARDSNetwork table (PEEPARDSNetwork ) as a strategy to prevent ventilator-associated lung injury (VALI) in patients with acute respiratory distress syndrome (ARDS) increases mortality. Alternatively, avoiding negative end-expiratory transpulmonary pressure has been discussed as superior PEEP titration strategy...
October 10, 2018: Journal of Critical Care
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