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https://www.readbyqxmd.com/read/30409242/trends-in-incidence-and-mortality-of-tuberculosis-in-japan-a-population-based-study-1997-2016
#1
H Hagiya, T Koyama, Y Zamami, Y Minato, Y Tatebe, N Mikami, Y Teratani, A Ohshima, K Shinomiya, Y Kitamura, T Sendo, S Hinotsu, K Tomono, M R Kano
Japan is still a medium-burden tuberculosis (TB) country. We aimed to examine trends in newly notified active TB incidence and TB-related mortality in the last two decades in Japan. This is a population-based study using Japanese Vital Statistics and Japan Tuberculosis Surveillance from 1997 to 2016. We determined active TB incidence and mortality rates (per 100 000 population) by sex, age and disease categories. Joinpoint regression was applied to calculate the annual percentage change (APC) in age-adjusted mortality rates and to identify the years showing significant trend changes...
November 9, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/30383432/age-period-cohort-analyses-of-tuberculosis-incidence-rates-by-nativity-united-states-1996-2016
#2
Shareen A Iqbal, Carla A Winston, Barbara H Bardenheier, Lori R Armstrong, Thomas R Navin
OBJECTIVES: To assess changes in US tuberculosis (TB) incidence rates by age, period, and cohort effects, stratified according to race/ethnicity and nativity. METHODS: We used US National Tuberculosis Surveillance System data for 1996 to 2016 to estimate trends through age-period-cohort models. RESULTS: Controlling for cohort and period effects indicated that the highest rates of TB incidence occurred among those 0 to 5 and 20 to 30 years of age...
November 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/30373275/trends-of-medication-usage-and-associated-outcomes-for-taiwanese-patients-with-inflammatory-bowel-disease-from-2001-to-2015
#3
Meng-Tzu Weng, Chien-Chih Tung, Yuan-Ting Chang, Yew-Loong Leong, Yu-Ting Wang, Jau-Min Wong, Shu-Chen Wei
BACKGROUND: No nationwide, long-term follow-up study has assessed medication-associated outcomes for Asian patients with inflammatory bowel disease (IBD). This study examined medication-associated outcomes for Taiwanese patients with IBD. METHODS: In this nationwide cohort study, 3806 patients who had received catastrophic illness registration for IBD from 2001 to 2015 were enrolled. RESULTS: A higher accumulated dosage of 5-aminosalicylic acid (5-ASA) was associated with decreased risks of hospitalization (hazard ratio (HR) = 0...
October 27, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30372436/cost-effectiveness-of-genexpert-and-led-fm-for-diagnosis-of-pulmonary-tuberculosis-a-systematic-review
#4
Karuna D Sagili, Malaisamy Muniyandi, Kayzad Soli Nilgiriwala, Kalpita S Shringarpure, Srinath Satyanarayana, Richard Kirubakaran, Sarabjit S Chadha, Prathap Tharyan
BACKGROUND: Early and accurate diagnosis of tuberculosis is a priority for TB programs globally to initiate treatment early and improve treatment outcomes. Currently, Ziehl-Neelsen (ZN) stain-based microscopy, GeneXpert and Light Emitting Diode-Fluorescence Microscopy (LED-FM) are used for diagnosing pulmonary drug sensitive tuberculosis. Published evidence synthesising the cost-effectiveness of these diagnostic tools is scarce. METHODOLOGY: PubMed, EMBASE and Cost-effectiveness analysis registry were searched for studies that reported on the cost-effectiveness of GeneXpert and LED-FM, compared to ZN microscopy for diagnosing pulmonary TB...
2018: PloS One
https://www.readbyqxmd.com/read/30355403/modern-theory-of-tuberculosis-culturomic-analysis-of-its-historical-origin-in-europe-and-north-america
#5
S J Jay, U Kırbıyık, J R Woods, G A Steele, G R Hoyt, R B Schwengber, P Gupta
INTRODUCTION: An historical account of the modern theory of tuberculosis (TB) using a culturomic analysis has not been studied. OBJECTIVE: To analyze, using culturomic methods, the history of our modern understanding of TB as a unitary disease. METHODS: A culturomic analysis of millions of digitized texts was undertaken to quantify 200-year trends in usage of the modern term tuberculosis and pre-modern terms consumptive , phthisis , and scrofula , and to correlate these trends with significant historical events...
November 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30339803/risk-factors-of-multidrug-resistant-tuberculosis-a-global-systematic-review-and-meta-analysis
#6
REVIEW
Ivan Surya Pradipta, Lina Davies Forsman, Judith Bruchfeld, Eelko Hak, Jan-Willem Alffenaar
OBJECTIVES: Since the risk of multidrug-resistant tuberculosis (MDR-TB) may depend on the setting, we aimed to determine the associations of risk factors of MDR-TB across different regions. METHODS: A systematic review and meta-analysis was performed with Pubmed and Embase databases. Information was retrieved on 37 pre-defined risk factors of MDR-TB. We estimated overall Mantel-Haenszel odds ratio as a measure of the association. RESULTS: Factors of previous TB disease and treatment are the most important risk factors associated with MDR-TB...
October 16, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30335777/factors-associated-with-unsuccessful-treatment-outcome-in-tuberculosis-patients-among-refugees-and-their-surrounding-communities-in-gambella-regional-state-ethiopia
#7
Eyasu Ejeta, Getenet Beyene, Getu Balay, Zegeye Bonsa, Gemeda Abebe
BACKGROUND: Tuberculosis (TB) is a leading cause of public health challenges among immigrant refugees and their surrounding communities in developing countries. Evaluating the treatment outcome of TB patients is one of the key indicators to understand the performance of TB control program. Hence, this study aims to assess profile, treatment outcome and factors associated with unsuccessful outcome of TB patients treated under the TB control program among refugees and their surrounding communities (SCs) in Gambella Regional State, Ethiopia...
2018: PloS One
https://www.readbyqxmd.com/read/30332404/effect-of-schistosomiasis-on-the-outcome-of-patients-infected-with-hiv-1-starting-antiretroviral-therapy-in-rural-tanzania
#8
Katarina Stete, Tracy R Glass, Govert J van Dam, Alex Ntamatungiro, Emilio Letang, Claudia J de Dood, Paul L A M Corstjens, Robert Ndege, Herry Mapesi, Winfried V Kern, Christoph Hatz, Maja Weisser, Jürg Utzinger, Matthias C Müller
BACKGROUND: It has been hypothesized that schistosomiasis negatively influences immune reconstitution in people living with HIV starting antiretroviral therapy (ART). In this study, we investigated the effect of schistosomiasis on the course of HIV infection in patients starting ART in a rural part of Tanzania. METHODOLOGY: Retrospective study including patients prospectively enrolled in a HIV cohort in Ifakara, south-central Tanzania between January 1, 2013 and April 1, 2015...
October 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30322249/most-reliable-time-in-predicting-residual-kyphosis-and-stability-pediatric-spinal-tuberculosis
#9
Myung-Sang Moon, Sang-Jae Kim, Min-Su Kim, Dong-Suk Kim
Study Design: A case study. Purpose: To assess the chronological changes of the disease-related kyphosis after chemotherapy alone, secondly to clarify the role of growth cartilage in the healed lesion on kyphosis change, and to define the accurate prediction time in assessing residual kyphosis. Overview of Literature: None of the previous papers up to now dealt with the residual kyphosis, stability and remodeling processes of the affected segments...
October 16, 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/30321189/tuberculosis-patients-are-physically-challenged-and-socially-isolated-a-mixed-methods-case-control-study-of-health-related-quality-of-life-in-eastern-ethiopia
#10
Aklilu Abrham Roba, Tamirat Tesfaye Dasa, Fitsum Weldegebreal, Abyot Asfaw, Habtamu Mitiku, Zelalem Teklemariam, Mahantash Naganuri, Bahubali Jinnappa Geddugol, Frehiwot Mesfin, Hilina Befikadu, Eden Tesfaye
INTRODUCTION: Pulmonary tuberculosis (TB) impairs respiratory physiology and functional ability, resulting in economic and social dependence upon others. Patients with tuberculosis especially multi drug resistant (MDR-TB) suffer from social isolation, stigma, lack of support and economic constraints. In Ethiopia, the trend of MDR TB is increasing and becoming a serious public health problem. However, little is known about patients except treatment outcomes, financial burden and psychological distress with serious deficiency of data on Health Related Quality of Life (HRQOL)...
2018: PloS One
https://www.readbyqxmd.com/read/30316384/spectrum-of-infections-in-living-donor-kidney-transplant-recipients-an-experience-from-a-tertiary-center-in-nepal
#11
M P Kafle, M R Sigdel, M Shrestha, D S Shah
BACKGROUND: Kidney transplant recipients are always at risk of infections because they are on lifelong immunosuppressive medications. The spectrum of infections in this special population is not the same as in the general population. Post-transplant infections are extensively studied in the developed world. Publications about post-transplant infections from Nepal are scarce. This study was carried out to study the spectrum of infections, the trends in treatment, and the incidence of tuberculosis in kidney transplant recipients...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30314387/trends-in-tuberculosis-incidence-in-the-australian-born-in-victoria-opportunities-and-challenges-to-elimination
#12
Ouli Xie, Ee Laine Tay, Justin Denholm
Australia is a low tuberculosis incidence country. In the setting of increasing migration, we aimed to investigate the epidemiology and trends of tuberculosis in the Australian-born population in the state of Victoria between 1992 and 2017. We performed a retrospective descriptive analysis of demographic, clinical and outcome data extracted from a centralized notifiable disease database. The mean incidence of tuberculosis was 1.19 cases per 100,000 population per year with a small but significant reduction of 0...
October 11, 2018: Tropical Medicine and Infectious Disease
https://www.readbyqxmd.com/read/30308948/exploitation-of-mangrove-endophytic-fungi-for-infectious-disease-drug-discovery
#13
Danielle H Demers, Matthew A Knestrick, Renee Fleeman, Rahmy Tawfik, Ala Azhari, Ashley Souza, Brian Vesely, Mandy Netherton, Rashmi Gupta, Beatrice L Colon, Christopher A Rice, Mario A Rodríguez-Pérez, Kyle H Rohde, Dennis E Kyle, Lindsey N Shaw, Bill J Baker
There is an acute need for new and effective agents to treat infectious diseases. We conducted a screening program to assess the potential of mangrove-derived endophytic fungi as a source of new antibiotics. Fungi cultured in the presence and absence of small molecule epigenetic modulators were screened against Mycobacterium tuberculosis and the ESKAPE panel of bacterial pathogens, as well as two eukaryotic infective agents, Leishmania donovani and Naegleria fowleri . By comparison of bioactivity data among treatments and targets, trends became evident, such as the result that more than 60% of active extracts were revealed to be selective to a single target...
October 10, 2018: Marine Drugs
https://www.readbyqxmd.com/read/30303586/trends-patterns-and-causes-of-respiratory-disease-mortality-among-inpatients-in-tanzania-2006-2015
#14
Coleman Kishamawe, Susan F Rumisha, Irene R Mremi, Veneranda M Bwana, Mercy G Chiduo, Isolide S Massawe, Leonard E G Mboera
OBJECTIVE: To determine the causes, patterns and trends of respiratory diseases-related deaths in hospitals of Tanzania 2006-2015. METHODS: Retrospective study involving 39 hospitals. Medical records of patients who died in hospital were retrieved, reviewed and analysed. Sources of data were hospital admission registers, death registers, and International Classification of Diseases report forms. Information on demographic characteristics, date of death, the immediate underlying cause of death and co-morbid conditions was collected...
October 10, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/30285697/nationwide-surveillance-algorithms-for-tuberculosis-among-immigrant-workers-from-highly-endemic-countries-following-pre-entry-screening-in-taiwan
#15
Mei-Mei Kuan
BACKGROUND: This cross-sectional study was retrospectively performed to assess the trend of tuberculosis (TB) among Taiwan's immigrant workers from highly TB-endemic countries under an intervention of conducting a 4-round follow-up (at 0-3 days and 6, 18, and 30 months post-migration) screening program with initial chest X-ray (CXR) following an overseas, pre-entry normal CXR. METHODS: The immigrant workers with TB disease enrolled in the Taiwan TB registry database in 2011-2014 were analyzed and linked to an immigrant worker physical exam database to stratify TB case categories of actively screened or not for comparison...
October 3, 2018: BMC Public Health
https://www.readbyqxmd.com/read/30285633/modeling-tuberculosis-dynamics-with-the-presence-of-hyper-susceptible-individuals-for-ho-chi-minh-city-from-1996-to-2015
#16
Dao Nguyen Vinh, Dang Thi Minh Ha, Nguyen Thi Hanh, Guy Thwaites, Maciej F Boni, Hannah E Clapham, Nguyen Thuy Thuong Thuong
BACKGROUND: The depletion of CD4 cell is the underlying reason for TB hyper-susceptibility among people with HIV. Consequently, the trend of TB dynamics is usually hidden by the HIV outbreak. METHODS: Here, we aim to evaluate the trend of TB dynamics quantitatively by a simple mathematical model using the known prevalence of hyper-susceptible individuals in the population. In order to estimate the parameters governing transmission we fit this model in a maximum likelihood framework to both reported TB cases and data from samples tested with Interferon Gamma Assay from Ho Chi Minh City - a city with high TB transmission and strong synchronization between HIV/AIDS and TB dynamics...
October 1, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30277198/do-incarcerated-populations-serve-as-a-reservoir-for-tuberculosis-in-south-africa
#17
Alana Sharp, Travis Donahoe, Amanda Milliken, Jacqueline Barocio, Salome Charalambous, Zoë McLaren
Tuberculosis (TB) prevalence among incarcerated populations is as much as 1,000 times higher than in the general population. This study evaluates whether correctional facilities serve as a reservoir through which TB is transmitted to surrounding communities. Tuberculosis test data were extracted from the South African National Health Laboratory Service database for patients tested for TB between 2005 and 2011. We conducted graphical analysis to assess the relationship of TB rates between incarcerated and non-incarcerated populations over time...
October 1, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/30271731/insights-into-drug-resistant-tuberculosis-treatment-results-of-the-union-dr-tb-working-group-survey-2017
#18
K Mezwa, S McAnaw, C-Y Chiang, A Trébucq, C R Horsburgh
The past 4 years have seen the introduction of new regimens and new drugs to treat multidrug-resistant tuberculosis (MDR-TB). To identify implementation trends over time, the DR-TB Working Group of the International Union Against Tuberculosis and Lung Disease (The Union), in collaboration with RESIST-TB, launched an online survey to Union members around the world. Survey results showed substantial diversity in treatment roll-out: 36% of respondents stated that their country is using the 9-month regimen for MDR-TB treatment; 41% are using bedaquiline and delamanid, but not the 9-month regimen; 28% are using both; and 22% of respondents indicated that their country does not currently offer either of these treatment options...
September 21, 2018: Public Health Action
https://www.readbyqxmd.com/read/30268120/detection-of-a-streptomycin-resistant-mycobacterium-bovis-strain-through-antitubercular-drug-susceptibility-testing-of-tunisian-mycobacterium-tuberculosis-complex-isolates-from-cattle
#19
Saif Eddine Djemal, Cristina Camperio, Federica Armas, Mariam Siala, Salma Smaoui, Feriele Messadi-Akrout, Radhouane Gdoura, Cinzia Marianelli
BACKGROUND: A rising isolation trend of drug-resistant M. bovis from human clinical cases is documented in the literature. Here we assessed Mycobacterium tuberculosis complex isolates from cattle for drug susceptibility by the gold standard agar proportion method and a simplified resazurin microtitre assay (d-REMA). A total of 38 M. tuberculosis complex strains, including M. bovis (n = 36) and M. caprae (n = 2) isolates, from cattle in Tunisia were tested against isoniazid, rifampin, streptomycin, ethambutol, kanamycin and pyrazinamide...
September 29, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/30264687/child-and-adult-spinal-tuberculosis-at-tertiary-hospitals-in-the-western-cape-south-africa-4-year-burden-and-trend
#20
T N Mann, H S Schaaf, R N Dunn, S Dix-Peek, K du Preez, R P Lamberts, J du Toit, J H Davis
The aim of this retrospective review was to assess the overall burden and trend in spinal tuberculosis (TB) at tertiary hospitals in the Western Cape Province of South Africa. All spinal TB cases seen at the province's three tertiary hospitals between 2012 and 2015 were identified and clinical records of each case assessed. Cases were subsequently classified as bacteriologically confirmed or clinically diagnosed and reported with accompanying clinical and demographic information. Odds ratios (OR) for severe spinal disease and corrective surgery in child vs...
September 28, 2018: Epidemiology and Infection
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