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https://www.readbyqxmd.com/read/30118386/safety-and-immunogenicity-of-an-upper-range-release-titer-measles-mumps-rubella-vaccine-in-children-vaccinated-at-12-to-15-months-of-age-a-phase-iii-randomized-study
#1
Michael Povey, Remon Abu-Elyazeed, Gregory Adams, Anitta Ahonen, Carmen Baccarini, Andrea Berry, Stephane Carryn, Archana Chatterjee, Nan-Chang Chiu, Christophe Dessart, Clemente Diaz-Perez, Byron Haney, Ouzama Henry, Li-Min Huang, Robert Jeanfreau, Nicola Klein, Michael Leonardi, Ming-Chih Lin, Marita Paassilta, Kwabena Sarpong, Peter Silas, Jerry Twiggs, Timo Vesikari, Leonard Weiner, Tsung Zu Wu
The titer of live attenuated viral vaccines, such as MMR vaccines, varies between batches and over the shelf-life of a batch, with the highest titer expected at batch release. As higher titers may theoretically lead to increased reactogenicity, we compared the safety profile of an upper-range release titer MMR-RIT lot with commercial MMR II lots in a phase III, randomized, controlled study (NCT02184572). We vaccinated 1736 children with MMR-RIT (N = 1164) or MMR II (N = 572), both administered as first doses with varicella, hepatitis A, and pneumococcal conjugate vaccines at 12-15 months of age...
August 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/30118358/emergency-medical-services-response-to-mass-shooting-and-active-shooter-incidents-united-states-2014-2015
#2
Aaron B Klassen, Morgan Marshall, Mengtao Dai, N Clay Mann, Matthew D Sztajnkrycer
BACKGROUND: The purpose of the current study was to describe the injury patterns, EMS response and interventions to mass shooting (MS) and active shooter (AS) incidents. METHODS: Retrospective analysis of 2014-15 National Emergency Medical Services Information System (NEMSIS) data sets. Date, time, and location for MS incidents were obtained from the Gun Violence Archive and then correlated with NEMSIS data set records. AS incidents were identified through FBI data...
August 17, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/30117532/plasma-adiponectin-array-in-women-with-alzheimer-s-disease
#3
Agnieszka Baranowska-Bik, Małgorzata Kalisz, Lidia Martyńska, Ewa Wolińska-Witort, Maria Styczyńska, Małgorzata Chodakowska-Żebrowska, Maria Barcikowska, Bogusława Baranowska, Wojciech Bik
Introduction Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. Typical features of AD include memory loss, social dysfunction and physical impairment. Although the pathological findings in the central nervous system are well established, the etiological factors are poorly known. Recent studies suggested the role of metabolic disturbances in the development of AD neurodegeneration. Adiponectin, an anti-inflammatory and metabolism regulating factor, was linked to AD. Aim The aim was to examine whether adiponectin fractions combined with insulin/insulin resistance-associated metabolic parameters correlate with AD progression...
August 17, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/30117519/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-the-diagnosis-of-hilar-and-mediastinal-lymph-node-metastases-of-melanoma
#4
José-Fernando Val-Bernal, María Martino, Elena Yllera, Félix Romay, María Sánchez-Ares, Ihab Abdulkader Nallib
OBJECTIVE: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique for investigating hilar and mediastinal lymphadenopathy. This study reports eleven cases in which EBUS-TBNA was used to assess mediastinal and hilar lymph nodes for the presence of metastatic melanoma. MATERIAL AND METHOD: A retrospective study was performed of all patients who had a history of melanoma and underwent EBUS-TBNA to assess hilar or mediastinal lymphadenopathy for the presence of metastatic melanoma...
August 17, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/30117387/postoperative-complications-and-90-day-mortality-in-radical-cystectomy-in-high-risk-patients-a-monocentric-retrospective-observational-study
#5
Carlo Pavone, Luigi Candela, Dario Fontana, Alchiede Simonato
AIM: Assessing the incidence of immediate postoperative complications and 90-day mortality in high-risk patients who have undergone radical cystectomy; evaluating the correlation between preoperative conditions and surgery outcomes. MATERIALS AND METHODS: This is a monocentric retrospective observational study in which data of 65 patients have been analyzed. High-risk criteria: (a) Age ≥75 years, (b) obesity, (c) age-adjusted Charlson Comorbidity Index ≥8, (d) anemic status, and (e) pT ≥3...
August 2018: Urologia
https://www.readbyqxmd.com/read/30117318/core-binding-factor-acute-myeloid-leukemia-with-t-8-21-risk-factors-and-a-novel-scoring-system-i-cbfit
#6
Celalettin Ustun, Elizabeth Morgan, Erica E M Moodie, Sheeja Pullarkat, Cecilia Yeung, Sigurd Broesby-Olsen, Robert Ohgami, Young Kim, Wolfgang Sperr, Hanne Vestergaard, Dong Chen, Philip M Kluin, Michelle Dolan, Krzysztof Mrózek, David Czuchlewski, Hans-Peter Horny, Tracy I George, Thomas Kielsgaard Kristensen, Nam K Ku, Cecilia Arana Yi, Michael Boe Møller, Guido Marcucci, Linda Baughn, Ana-Iris Schiefer, J R Hilberink, Vinod Pullarkat, Ryan Shanley, Jessica Kohlschmidt, Janie Coulombe, Amandeep Salhotra, Lori Soma, Christina Cho, Michael A Linden, Cem Akin, Jason Gotlib, Gregor Hoermann, Jason Hornick, Ryo Nakamura, Joachim Deeg, Clara D Bloomfield, Daniel Weisdorf, Mark R Litzow, Peter Valent, Gerwin Huls, Miguel-Angel Perales, Gautam Borthakur
BACKGROUND: Although the prognosis of core-binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. METHODS: Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). RESULTS: Complete remission (CR) rate was high (92...
August 16, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30117313/cancer-patients-as-frequent-attenders-in-emergency-departments-a-national-cohort-study
#7
Ting Hway Wong, Zheng Yi Lau, Whee Sze Ong, Kelvin Bryan Tan, Yu Jie Wong, Mohamad Farid, Melissa Ching Ching Teo, Alethea Chung Pheng Yee, Hai V Nguyen, Marcus Eng Hock Ong, N Gopalakrishna Iyer
BACKGROUND: Cancer patients contribute significantly to emergency department (ED) utilization. The objective of this study was to identify factors associated with patients becoming ED frequent attenders (FA) after a cancer-related hospitalization. METHODS: A retrospective cohort study was conducted using national administrative, billing, and death records of Singapore residents discharged alive from Singapore public hospitals from January 2012 to December 2015, with a primary discharge diagnosis of cancer...
August 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30117308/relationship-of-bmi-z-score-to-fat-percent-and-fat-mass-in-multiethnic-prepubertal-children
#8
M Wilkes, J Thornton, M Horlick, A Sopher, J Wang, E M Widen, R Pierson, D Gallagher
OBJECTIVE: The objective of the study is to examine the validity of body mass index z score (zBMI) as a measure of percent body fat in prepubertal children. METHODS: One hundred eleven multiethnic, healthy, Tanner 1 children aged 6-12 years had fat percent and fat mass measured by the four-compartment method as part of the Paediatric Rosetta Body Composition Cohort. Multiple regression models were developed with fat percent as the dependent variable and zBMI, age, sex and ethnicity as independent variables...
August 16, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/30117218/determinants-of-attitudes-and-beliefs-toward-human-papillomavirus-infection-cervical-cancer-and-human-papillomavirus-vaccine-among-parents-of-adolescent-girls-in-mysore-india
#9
Abraham Degarege, Karl Krupp, Vijaya Srinivas, Boubakari Ibrahimou, Laura A V Marlow, Anjali Arun, Purnima Madhivanan
AIM: This study examined the determinants of attitudes and beliefs about human papillomavirus (HPV) infection, cervical cancer and HPV vaccine among parents of adolescent girls in Mysore, India. METHODS: A random sample of 800 parents who had at least one adolescent-aged daughter attending school were recruited for a survey. RESULTS: Most parents (n = 778; 97.3%) completed the survey. Compared to Hindus, Muslims were more likely to perceive that their daughters are susceptible to HPV infection (adjusted odds ratio [aOR]: 4...
August 16, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/30117173/monoclonal-gammopathy-of-undetermined-significance-in-chinese-population-a-prospective-epidemiological-study
#10
Ling Ma, Shuang Xu, Jianhua Qu, Jian Hou, Zhaoxia Zhang, Yang Wang, Lei Wen, Yang Liu, Ying Kang, Ming Jiang, Weijun Fu, Juan Du, Lin Zhou, Xiaojun Huang, Jin Lu
The aim of this study was to identify the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in different groups of age and the clinical features in China. This multi-center prospective study enrolled 1797 health subjects. The overall prevalence of MGUS was 2.73%. The prevalence of different age groups was 1.19% (41-50 years), 1.16% (51-60 years), 2.19% (61-70 years), 3.66% (71-80 years), and 7.76% (≥ 81 years). The prevalence of MGUS in male (n=843) was 2.97%, while the prevalence of MGUS in female (n=952) was 2...
August 16, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/30116912/sorafenib-in-patients-with-progressed-and-refractory-bone-tumors
#11
Anna Raciborska, Katarzyna Bilska
Patients with metastatic, progressive, or recurrent bone tumors have a dismal outcome. Sorafenib has been proposed as an effective salvage regimen for some malignancies. Thus, we sought to evaluate this approach for young patients with relapsed or refractory bone tumors. Twelve patients with refractory bone tumors (two with Ewing sarcoma, two with chondrosarcoma, and eight with osteosarcoma) received salvage treatment with sorafenib. All patients had standard tumor imaging and laboratory evaluation. All toxicities were documented...
August 16, 2018: Medical Oncology
https://www.readbyqxmd.com/read/30116837/propensity-score-analysis-of-18-fdg-pet-ct-enhanced-staging-in-patients-undergoing-surgery-for-esophageal-cancer
#12
N Patel, Kieran G Foley, A G Powell, J R Wheat, D Chan, P Fielding, S A Roberts, W G Lewis
PURPOSE: PET/CT is now integral to the staging pathway for potentially curable esophageal cancer (EC), primarily to identify distant metastases undetected by computed tomography. The aim of this study was to analyze the effect of PET/CT introduction on survival and assess patterns of recurrence after esophagectomy. METHODS: A longitudinal cohort of EC patients staged between 1998 and 2016 were considered for inclusion. After co-variate adjustment using propensity scoring, a cohort of 496 patients (273 pre-PET/CT and 223 post-PET/CT) who underwent esophagectomy [median age 63 years (31-80), 395 males, 425 adenocarcinomas, 71 squamous cell carcinomas, 325 neoadjuvant therapy] were included...
August 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30116698/changes-in-sedentary-time-are-associated-with-changes-in-mental-wellbeing-over-1-year-in-young-adults
#13
Laura D Ellingson, Jacob D Meyer, Robin P Shook, Philip M Dixon, Gregory A Hand, Michael D Wirth, Amanda E Paluch, Stephanie Burgess, James R Hebert, Steven N Blair
Excessive sedentary time is related to poor mental health. However, much of the current literature uses cross-sectional data and/or self-reported sedentary time, and does not assess factors such as sedentary bout length. To address these limitations, the influence of objectively measured sedentary time including sedentary bout length (i.e. <30 min, ≥30 min) on mood, stress, and sleep, was assessed in 271 healthy adults (49% women; age 27.8 ± 3.7) across a 1-year period between 2011 and 2013 in Columbia, SC...
September 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/30116657/cryotherapy-versus-co-2-laser-in-the-treatment-of-plantar-warts-a-randomized-controlled-trial
#14
Nahid Hemmatian Boroujeni, Farhad Handjani
Background: Warts are one of the most common infections in humans. Plantar warts are a subtype of non-genital warts, and several procedures and topical treatments have been used in its treatment. Cryotherapy is one of the most popular modalities, but it is time-consuming and remission rates vary in different studies. CO2 laser was the first laser used for treating warts. To date, no clinical trial has been done to compare CO2 laser with cryotherapy in the treatment of plantar warts. Patients and Methods: This randomized controlled trial was performed in order to compare the efficacy and number of sessions needed to treat plantar warts in 60 patients who had received no previous treatment in the previous 3 months...
July 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/30116625/outcomes-of-wound-dehiscence-after-penetrating-keratoplasty-and-lamellar-keratoplasty
#15
Xin Wang, Ting Liu, Sai Zhang, Xiaolin Qi, Suxia Li, Weiyun Shi, Hua Gao
Objective: To investigate the incidence, causes, occurrence time, and range of wound and outcomes of wound dehiscence in patients treated by penetrating keratoplasty (PK) or lamellar keratoplasty (LK). Methods: We retrospectively reviewed medical records of keratoplasty in Shandong Eye Hospital from January 2006 to June 2017. Thirty-one eyes of 30 patients had sustained wound dehiscence (WD) after surgical treatment. The surgical type, causes, occurrence time, extent of the wound, treatment, and outcomes were recorded...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/30116505/prevalence-of-cardiometabolic-risk-factors-in-a-nationally-representative-sample-of-iranian-children-and-adolescents-the-caspian-v-study
#16
Mohammad Esmaeil Motlagh, Mostafa Qorbani, Amir-Masood Rafiemanzelat, Majzoubeh Taheri, Tahereh Aminaee, Gita Shafiee, Zeinab Ahadi, Mahshid Hajiali, Kimia Ghaderi, Ali Safaei, Azam Goodarzi, Hasan Ziaodini, Ramin Heshmat, Roya Kelishadi
Introduction: This study presents the prevalence of cardiometabolic risk factors in a nationally representative sample of Iranian children and adolescents. Methods: This multi-centric study was conducted in 2015 among 4200 students aged 7-18 years. They were selected by multistage cluster sampling from 30 provinces of Iran. Anthropometric indices, biochemical and clinical parameters were measured. Results: The mean of weight, height, waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood glucose (FBG) was higher in boys than in girls ( P < 0...
2018: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/30116495/the-effect-of-mitoq-on-aging-related-biomarkers-a-systematic-review-and-meta-analysis
#17
REVIEW
Andrea J Braakhuis, Rohith Nagulan, Vaughan Somerville
Mitochondria are metabolically active organelles that produce significant reactive oxygen species, linked with aging and degenerative diseases. In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging. MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30116368/combination-of-bevacizumab-and-photodynamic-therapy-vs-bevacizumab-monotherapy-for-the-treatment-of-wet-age-related-macular-degeneration-a-meta-analysis-of-randomized-controlled-trials
#18
Qingquan Wei, Junling Liu, Qingyu Liu, Chengda Ren, Wenting Cai, Xiuwei Liang, Jing Wen, Jing Yu
The purpose of this meta-analysis was to compare the efficacy and safety of the combination of bevacizumab and photodynamic therapy (PDT) with bevacizumab monotherapy for the treatment of age-related macular degeneration (AMD). Patients with active choroidal neovascularization (CNV) secondary to AMD were included in the present study. The treatment group included patients treated with a combination of bevacizumab and PDT and patients treated with bevacizumab monotherapy. Only randomized controlled trials (RCTs) were included in the analysis...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30116120/validation-of-a-new-judo-specific-ergometer-system-in-male-elite-and-sub-elite-athletes
#19
Norman Helm, Olaf Prieske, Thomas Muehlbauer, Tom Krüger, Helmi Chaabene, Urs Granacher
Our experimental approach included two studies to determine discriminative validity and test-retest reliability (study 1) as well as ecological validity (study 2) of a judo ergometer system while performing judo-specific movements. Sixteen elite (age: 23 ± 3 years) and 11 sub-elite (age: 16 ± 1 years) athletes participated in study 1 and 14 male sub-elite judo athletes participated in study 2. Discriminative validity and test-retest reliability of sport-specific parameters (mechanical work, maximal force) were assessed during pulling movements with and without tsukuri ( kuzushi )...
September 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/30115690/twelve-year-follow-up-after-peptide-receptor-radionuclide-therapy-prrt
#20
Michael Gabriel, Bernhard Nilica, Bernhard Kaiser, Irene J Virgolini
Peptide receptor radionuclide therapy (PRRT) has been used for more than twenty years as a systemic treatment approach in inoperable or metastatic somatostatin receptor (SSTR)-positive tumors. The purpose of this study was to analyze the long-term outcome of PRRT with regard to the most commonly used radiopharmaceuticals, 90 Y-DOTA-Tyr3-octreotide (90 Y-DOTA-TOC) and 177 Lu-DOTA-Tyr3-octreotate (177 Lu-DOTA-TATE). Methods: This retrospective clinical study included a total of 44 consecutive patients (27 men) with advanced tumors and enhanced SSTR expression...
August 16, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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