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Age 27

L Zhu, W H Li, X H Wang, K Tan, Q F Fang, Q X Zhu, K K Wu, Q Z Yang, A W Lin, H L Deng, J Bi, J Liu, S Y Zhao, Y Liu, S J Jing, Y M Wang, L M Li, Q Zhao, K H Yao, X Wang, L Jia, F Wang, J K Deng, J Sun, C H Zhu, K Zhou, J Liang, X Z Nie, S C Cao, D M Wang, S J Li, X X Chen, J Li, Y Wang, L Ye, Y H Zhang, F Dong, Z Li, Y H Yang, G Liu
Objective: To explore the clinical features, the serotype distribution and drug resistance of the isolates in patient with invasive pneumococcal disease (IPD). Methods: By retrieving the laboratory information system in 18 children's hospitals from 2012 to 2017, the children with IPD were enrolled. Streptococcus pneumoniae (Spn) must be isolated from the sterile sites (blood, cerebrospinal fluid, hydrothorax and joint effusion etc.). The clinical characteristics, serotype, drug resistance, treatment and prognosis were reviewed and analyzed...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
D Sylvain Zabsonre, Henri Lankoande, Chantal F C Zoungrana/Ouattara, Abdoulaye Thiombiano, Soumaila Ouedraogo, Abdoulaye Sanou, Pacome Yameogo, Sonia J E Kaboret-Douamba, Abel Kabre
BACKGROUND: Neural tube defects (spina bifidas or cephaloceles) are congenital malformations that can be associated with hydrocephalus. Even if the surgical management of each of these pathologies separately is well established, this is not the case for a combination of these conditions. AIM: To report our results of simultaneous or separate surgery for the association of hydrocephalus with neural tube defect in the same patient. METHODS: This was a retrospective study of the association of hydrocephalus with neural tube defect (spina bifida or cephalocele) managed over a period of 7 years at the Department of Neurosurgery, Yalgado Ouedraogo University Hospital, Ouagadougou, Burkina Faso...
December 5, 2018: Pediatric Neurosurgery
Samuel T Orange, Phil Marshall, Leigh A Madden, Rebecca V Vince
This study examined the relationship between sit-to-stand (STS) power and physical function in adults with severe obesity. Thirty-eight adults (age: 44 ± 12 years; body mass index [BMI]: 45.2 ± 7.8 kg/m2 ) completed evaluations of STS power, strength and functional performance. STS power was measured with a wearable inertial sensor, strength was assessed with the isometric mid-thigh pull, and function was measured with the timed up-and-go (TUG), six-minute walk test (6MWT) and 30-s chair STS. Power and strength (normalised to body mass) entered regression models in addition to age, gender, BMI and physical activity (daily step count)...
December 5, 2018: Journal of Sports Sciences
Mette Nygaard Einfeldt, Anne-Marie Schjerning Olsen, Søren Lund Kristensen, Usman Khalid, Jens Faber, Christian Torp-Pedersen, Gunnar H Gislason, Christian Selmer
Context: Hypothyroidism has detrimental effects on the cardiovascular system, but controversy remains concerning the benefits of levothyroxine (L-T4) substitution in patients with heart failure (HF). Objective: Examining the effects of L-T4 in patients with HF. Design: Retrospective cohort study. Setting and Participants: All Danish citizens aged ≥ 18 years diagnosed with HF between 1997 and 2012. L-T4 treatment was identified from nationwide registers...
December 4, 2018: Journal of Clinical Endocrinology and Metabolism
Magali Rios-Leyvraz, Pascal Bovet, René Tabin, Bernard Genin, Michel Russo, Michel F Rossier, Murielle Bochud, Arnaud Chiolero
Background: The gold standard to assess salt intake is 24-h urine collections. Use of a urine spot sample can be a simpler alternative, especially when the goal is to assess sodium intake at the population level. Several equations to estimate 24-h urinary sodium excretion from urine spot samples have been tested in adults, but not in children. Objective: The objective of this study was to assess the ability of several equations and urine spot samples to estimate 24-h urinary sodium excretion in children...
December 1, 2018: Journal of Nutrition
Claes Ohlsson, Maria Bygdell, Maria Nethander, Annika Rosengren, Jenny M Kindblom
Objective: The aim of this study was to determine the role of change in body mass index (BMI) during puberty, independent of childhood overweight, for the risk of adult type 2 diabetes in men. Study design, population and outcome: We included 36,176 men who had weight and height measured at age 8 (childhood) and 20 (young adult age) available from the BMI Epidemiology Study (BEST) and the Conscription register. Information on type 2 diabetes (n=1,777) was retrieved from the Swedish National Patient Register...
December 4, 2018: Journal of Clinical Endocrinology and Metabolism
Juliana L Torres, Silvia L A da Silva, Fabiane R Ferreira, Liliane P S Mendes, Luciana A Machado
Background: Chronic pain is known to increase health care use in high-income countries, but in Brazil, little is known. Objective: To investigate the association between chronic pain and health care use among Brazilian older adults and explore the relationship between pain severity and health care use. Methods: This cross-sectional study was derived from the population-based study Frailty in Brazilian Older People-FIBRA. Chronic pain, pain intensity and pain-related disability were assessed through additional telephone interviews...
December 5, 2018: Family Practice
María Laura Cordero, María Florencia Cesani
In contexts in which poverty compromises children's health and quality of life, the study of perceived health allows for the identification of aspects of quality of life affected by overweight and obesity. From this perspective, the objectives of this study were: 1) to determine the prevalence of overweight and obesity in schoolchildren aged 8-12 years living in contexts of poverty, 2) to describe and compare the perception of health of children according to the presence or absence of overweight and obesity, and 3) to identify possible factors associated with low quality of life related to health...
July 2018: Salud Colectiva
Ralph Antonio Xavier Ferreira, Claire Fernandes Kubelka, Luis Guillermo Coca Velarde, Jorge Paulo Strogoff de Matos, Laura Cunha Ferreira, Mariana Mancebo Reid, Sérgio Setúbal, Solange Artimos de Oliveira
INTRODUCTION: Dengue is one of the most important mosquito-borne infections. Severe cases are more frequently observed in adults. However, in 2008, the State of Rio de Janeiro, Brazil, experienced a severe dengue epidemic that primarily affected children and caused many cases of dengue hemorrhagic fever (DHF) and death. METHODS: A cross-sectional analytical study was conducted to examine laboratory diagnosis and clinical epidemiologic factors for confirmed dengue cases in patients aged less than 16 years, from January to June 2008, at a municipal hospital in the City of Rio de Janeiro, Brazil...
November 2018: Revista da Sociedade Brasileira de Medicina Tropical
Fernanda Cristina Winckler, Aline Marcia Marques Braz, Vanessa Nogueira da Silva, Marjorie de Assis Golim, Vanessa Gutierrez de Andrade, Paulo Eduardo de Abreu Machado, Liciana Vaz de Arruda Silveira, Giovanni Faria Silva
INTRODUCTION: Chronic hepatitis C is a leading cause of liver disease. Infection triggers an immediate immune response in the host that is mediated by humoral/cellular mechanisms. T cells respond to infection via secretion of cytokines, which inhibit or stimulate one another, leading to cytokine imbalance and ultimately affecting treatment. Studies using interferon (IFN) and ribavirin (RBV) showed that TCD8+ cells and cytokine levels are associated with sustainable virological response (SVR)...
November 2018: Revista da Sociedade Brasileira de Medicina Tropical
Luciano Antonacci Condessa, Carlos Alex Soares, Gregore Iven Mielke, Deborah Carvalho Malta, Waleska Teixeira Caiaffa
OBJECTIVE: To compare the prevalence of physically active adolescents living in Brazilian capitals, using 2012 and 2015 National Adolescent School-based Health Survey. METHOD: The sample consisted of 61,145 (2012) and 51,192 (2015) adolescents who were residents in 27 Brazilian capitals and were attending the 9th year of elementary school. The globally estimated physical activity indicator with the cutoff point of 300 minutes or more per week was used to determine the prevalence of physically active adolescents in both surveys...
November 29, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Ísis Eloah Machado, Mariana Santos Felisbino-Mendes, Deborah Carvalho Malta, Gustavo Velasquez-Melendez, Maria Imaculada de Fátima Freitas, Marco Antonio Ratzsch de Andreazzi
OBJECTIVE: To evaluate the relation between parental supervision and sociodemographic factors and alcohol use by Brazilian adolescents. METHODS: This is a cross-sectional study with data from National School-based Health Survey (PeNSE) 2015, which included 16,608 adolescents aged 13 to 17 years, students from Brazilian public and private schools. Variables related to alcohol use, sociodemographic factors and parental supervision were evaluated. In order to analyze the relation between sociodemographic variables, parental supervision and use of alcohol among adolescents, prevalence ratios stratified by sex were used...
November 29, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Samanta Bárbara Vieira de Oliveira, Soraya Coelho Costa Barroso, Maria Aparecida Camargos Bicalho, Adriano Max Moreira Reis
OBJECTIVE: To determine the profile of medications used for self-medication by the elderly. METHODS: A cross-sectional study based on interviews with elderly seen at a reference center for Elderly Health of a teaching hospital, from July 2014 to July 2015. Clinical, demographic and pharmacotherapeutic data were collected. RESULTS: A total of 170 elderly were interviewed, 85.9% female, and the median age was 76 years. The frequency of self-medication was 80...
November 29, 2018: Einstein
Manuela Brisot Felisbino, Frederico Leon Arrabal Fernandes, Maria Cecília Nieves Maiorano de Nucci, Regina Maria de Carvalho Pinto, Emilio Pizzichini, Alberto Cukier
OBJECTIVE: The clinical, functional, radiological and genotypic descriptions of patients with an alpha-1 antitrypsin (A1AT) gene mutation in a referral center for COPD in Brazil. METHODS: A cross-sectional study of patients with an A1AT gene mutation compatible with deficiency. We evaluated the A1AT dosage and genotypic, demographic, clinical, tomographic, and functional characteristics of these patients. RESULTS: Among the 43 patients suspected of A1AT deficiency (A1ATD), the disease was confirmed by genotyping in 27 of them...
September 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Mariane de Mello Fontanelli, Luana Romão Nogueira, Marcela Riccioppo Garcez, Cristiane Hermes Sales, José Eduardo Corrente, Chester Luiz Galvão César, Moisés Goldbaum, Regina Mara Fisberg
The study aimed to validate self-report of high cholesterol in São Paulo, Brazil, and verify factors associated with this information's sensitivity. Data were used from the Health Survey of the City of São Paulo 2015, a cross-sectional population-based study with a probabilistic sample of the city's residents. The sample included 886 individuals with information from the structured questionnaire, blood measurements of total cholesterol and fractions or who reported being on medication for high cholesterol...
November 29, 2018: Cadernos de Saúde Pública
Mustafa Aldag, Cemal Kocaaslan, Mehmet Senel Bademci, Zeynep Yildiz, Aydin Kahraman, Ahmet Oztekin, Mehmet Yilmaz, Tamer Kehlibar, Bulend Ketenci, Ebuzer Aydin
INTRODUCTION: The aim of this study was to determine the outcomes of patients developing ischemic stroke after coronary artery bypass grafting (CABG). METHODS: From March 2012 to January 2017, 5380 consecutive patients undergoing elective coronary surgery were analyzed. Ninety-five patients who developed ischemic strokes after on-pump coronary surgery were included in the study, retrospectively. The cohort was divided into four subgroups [total anterior circulation infarction (TACI), partial anterior circulation infarction (PACI), posterior circulation infarction (POCI), and lacunar infarction (LACI)] according to the Oxfordshire Community Stroke Project (OCSP) classification...
September 2018: Brazilian Journal of Cardiovascular Surgery
Domenico Penna, Terra L Lasho, Christy M Finke, Rangit R Vallapureddy, Curtis A Hanson, Rhett P Ketterling, Animesh Pardanani, Naseema Gangat, Ayalew Tefferi
In the last decade, several prognostic models for primary myelofibrosis (PMF) have been introduced and shown to be effective in predicting overall survival. The main objective for this study was to identify clinical and genetic markers of very long (20+ years) survival in PMF. A total of 1282 patients with PMF were considered (median age 65 years, range 19-92; 63% males); 26 (2%) patients (median age 51 years, range 28-71; 38% males) survived their disease for at least 20 years (long-lived patients) and 626 (49%) patients (median age 68 years, range 27-92; 66% males) died within 5 years of their diagnosis (short-lived patients)...
December 5, 2018: American Journal of Hematology
Martin Spångfors, Gitte Bunkenborg, Mats Molt, Karin Samuelson
AIMS AND OBJECTIVES: To evaluate if the scale used for assessment of hospital ward patients could predict in-hospital and 30-day mortality amongst those with deviating vital signs i.e. that patients classified as medium or high-risk would have increased risk of in-hospital and 30-day mortality compared to patients with low-risk. BACKGROUND: The National Early Warning Score (NEWS) is a widely-adopted scale for assessing deviating vital signs. A clinical risk-scale that comes with the NEWS divides the risk for critical illness into three risk-categories, low, medium and high...
December 5, 2018: Journal of Clinical Nursing
Ayalew Tefferi, Terra L Lasho, Mythri Mudireddy, Christy M Finke, Curtis A Hanson, Rhett P Ketterling, Naseema Gangat, Animesh Pardanani
JAK2 mutations in myeloproliferative neoplasms (MPNs) are associated with the germline GGCC (46/1) haplotype. In 2010, we reported an association between shortened survival in primary myelofibrosis (PMF) and nullizygosity for the JAK2 46/1 haplotype. In the current study, we have increased the number of informative cases from 130 to 414 (median age 63 years; 63% males), in order to revisit with the phenotypic and prognostic relevance of the JAK2 46/1 haplotype in PMF. JAK2 46/1 haplotype was documented in 69% of the study patients, including 25% in homozygous and 44% in heterozygous state...
December 5, 2018: American Journal of Hematology
Sheila A M Rauch, H Myra Kim, Corey Powell, Peter W Tuerk, Naomi M Simon, Ron Acierno, Carolyn B Allard, Sonya B Norman, Margaret R Venners, Barbara O Rothbaum, Murray B Stein, Katherine Porter, Brian Martis, Anthony P King, Israel Liberzon, K Luan Phan, Charles W Hoge
Importance: Meta-analyses of treatments for posttraumatic stress disorder (PTSD) suggest that trauma-focused psychotherapies produce greater benefits than antidepressant medications alone. Objective: To determine the relative efficacy of prolonged exposure therapy plus placebo, prolonged exposure therapy plus sertraline hydrochloride, and sertraline plus enhanced medication management in the treatment of PTSD. Design, Setting, and Participants: The Prolonged Exposure and Sertraline Trial was a randomized, multisite, 24-week clinical trial conducted at the Veterans Affairs Ann Arbor Healthcare System, Veterans Affairs San Diego Healthcare System, Ralph H...
December 5, 2018: JAMA Psychiatry
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