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https://www.readbyqxmd.com/read/30342415/predictors-of-selenium-biomarker-kinetics-in-4-9-year-old-bangladeshi-children
#1
Helena Skröder, Maria Kippler, Jessica De Loma, Rubhana Raqib, Marie Vahter
BACKGROUND: Biomarker selenium concentrations vary greatly between studies. Concentrations in erythrocytes, urine, and hair vary even at similar plasma concentrations, suggesting that unknown factors influence the distribution of selenium between body compartments. OBJECTIVE: To assess predictors of the different selenium biomarkers in children. DESIGN: We used a mother-child cohort, nested in a population-based supplementation trial in rural Bangladesh (MINIMat), established for evaluation of arsenic toxicity...
October 17, 2018: Environment International
https://www.readbyqxmd.com/read/30342031/increased-mortality-of-patients-with-childhood-onset-inflammatory-bowel-diseases-compared-with-the-general-population
#2
O Olén, J Askling, M C Sachs, P Frumento, M Neovius, K E Smedby, A Ekbom, P Malmborg, J F Ludvigsson
BACKGROUND & AIMS: Childhood onset inflammatory bowel disease (IBD) is believed to be a more severe disease than adult-onset IBD, but there is little information on all-cause and cause-specific mortality in patients with childhood-onset IBD. We performed a population-based cohort study, with 50 years of follow up, to estimate absolute and relative risks for overall and cause-specific mortality in patients with childhood-onset IBD, during childhood and adulthood. METHODS: We identified children with a diagnosis of IBD (less than 18 years old) in the Swedish nationwide health registers (1964-2014; n=9442) and individuals from the general population matched for sex, age, calendar year, and place of residence (reference group; n=93,180)...
October 17, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30341537/prognostic-impact-of-skeletal-muscle-assessed-by-computed-tomography-in-patients-with-acute-myeloid-leukemia
#3
Nobuhiko Nakamura, Soranobu Ninomiya, Takuro Matsumoto, Hiroshi Nakamura, Junichi Kitagawa, Makoto Shiraki, Takeshi Hara, Masahito Shimizu, Hisashi Tsurumi
Skeletal muscle atrophy and loss of adipose tissue, referred to as sarcopenia and adipopenia, respectively, are often observed in cancer patients. We investigated the impact of sarcopenia and adipopenia on clinical outcomes in 90 adult patients with newly diagnosed acute myeloid leukemia (AML) who received induction chemotherapy. Computed tomography (CT) before treatment revealed sarcopenia in 39 patients (43%) and adipopenia in 35 patients (39%). We analyzed the treatment efficacy of induction chemotherapy and survival outcomes...
October 19, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30341265/morphological-analysis-of-the-skeletal-development-in-lateral-cephalometric-radiographs-of-hiv-infected-children-ongoing-highly-active-antiretroviral-therapy
#4
L-P Possagno, A Franco, L-R Paranhos, L-J Grando, A-A-S de Lima, I-S-Q Bezerra, Â Fernandes
BACKGROUND: To investigate the skeletal development of HIV infected children through a morphological analysis of the cervical vertebrae (CV) in lateral cephalometric radiographs. MATERIAL AND METHODS: The sample consisted of 86 lateral cephalometric radiographs of male and female children aged between 6 and 14 years old. The radiographs were equally distributed in groups 1 (HIV infected children) and 2 (non-infected children, paired by sex and age). Two examiners analyzed the CV according to the method of Hassel and Farman (1995)...
October 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/30340863/optimization-of-an-empiric-vancomycin-dosing-algorithm-for-improved-target-concentration-attainment-in-patients-with-thermal-injury
#5
David M Hill, Sai R Velamuri, Julio Lanfranco, Ivan Romero Legro, Scott E Sinclair, William L Hickerson
OBJECTIVE: Vancomycin empirical dosing studies in thermally injured patients have netted low successful target attainment and most excluded renal dysfunction, limiting applicability. In a previous study, the authors performed a retrospective analysis of 124 patients' measured pharmacokinetic parameters to calculate optimal dose and interval for intermittent infusion regimens and find predictors of clearance and total daily dose. The objective of this study was to improve the accuracy of attaining goal therapeutic targets with initial vancomycin regimens in patients with thermal injury through retrospective modeling...
October 16, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30339986/congenital-cmv-infection-via-a-re-infected-mother-with-original-antigenic-sin-a-case-report
#6
Tetsuo Koshizuka, Kuniaki Toriyabe, Yuko Sato, Kazufumi Ikuta, Tomoaki Ikeda, Tatsuo Suzutani
A 27-year-old pregnant woman positive for anti-cytomegalovirus (CMV) antibodies gave birth to a congenitally CMV-infected neonate at 40 weeks gestation. According to strain-specific serological analysis, which is able to determine the two types of CMV glycoprotein H (gH), the mother possessed anti-gH(To) antibodies only but the neonate possessed anti-gH(AD) and anti-gH(To) antibodies at 4 weeks after birth. As the anti-gH(To) IgG was decreased at 8 months post-delivery in the neonate, these antibodies are thought to have been transferred from mother as maternal antibodies...
October 16, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/30339902/right-axillary-artery-conduit-is-a-safe-and-reliable-access-for-implantation-of-impella-5-0-microaxial-pump
#7
Griffin Boll, Ariel Fischer, Navin Kapur, Payam Salehi
BACKGROUND: Impella 5.0 is a powerful mechanical circulatory support device placed into the left ventricle of patients in cardiogenic shock not responding to pharmacologic support alone. This therapy can support patient hemodynamics from weeks to several months, and patients can potentially ambulate with the device implanted while awaiting destination therapy. METHODS: From July 2012 to September 2017, twenty-two Impella 5.0 devices (Abiomed Inc., Danvers, MA) were implanted via right axillary artery at our center...
October 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30338245/synergistic-activity-of-niclosamide-in-combination-with-colistin-against-colistin-susceptible-and-colistin-resistant-acinetobacter-baumannii-and-klebsiella-pneumoniae
#8
Rafael Ayerbe-Algaba, María Luisa Gil-Marqués, Manuel Enrique Jiménez-Mejías, Viviana Sánchez-Encinales, Raquel Parra-Millán, María Eugenia Pachón-Ibáñez, Jerónimo Pachón, Younes Smani
Colistin is among the few antibiotics effective against multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae clinical isolates. However, in the last few years, colistin-resistant A. baumannii and K. pneumoniae strains have emerged. Therefore, combination therapies, between colistin and other old drugs, restoring the activity of colistin are required. The main objective of this study was to analyse the activity of niclosamide, an anthelmintic drug, in combination with colistin against colistin-susceptible (Col-S) and colistin-resistant (Col-R) A...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/30334957/individualized-reconstruction-for-severe-periprosthetic-fractures-around-the-tumor-prosthesis-of-knee-under-assistance-of-3d-printing-technology-a-case-report
#9
Qing Han, Xue Zhao, Chenyu Wang, Bingpeng Chen, Xiaonan Wang, Ziyan Zhang, Kesong Zhang, Yuhao Zheng, Jincheng Wang
INTRODUCTION: Periprosthetic femoral fractures (PFF) around tumor prosthesis of knee are stubborn problems for surgeons, huge bone defect and inappropriate biomechanics of the revision implant design can be disaster for reconstruction. With the development of three-dimensional (3D) printing technology, surgeons participate more in precise preoperative design and simulation for treatment of such fractures. In this study we explored an accurate and feasible way to restore normal anatomy and function of the knee joint with 3D printing technology...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30334903/young-adult-with-osteosarcoma-of-the-mandible-and-the-challenge-in-management-review-of-the-pediatric-and-adult-literatures
#10
Christopher Kuo, Paul M Kent
Neoadjuvant chemotherapy for osteosarcoma of the jaw (OSJ) remains controversial despite being a standardized treatment in osteosarcoma of the long bones. We present a case of a 22-year-old male with OSJ and performed a retrospective systemic review of previously published literatures of OSJ. We identified 27 articles: 7% recommended neoadjuvant chemotherapy, 22% recommended adjuvant chemotherapy, 19% recommended both neoadjuvant and adjuvant chemotherapy, 33% recommended against chemotherapy and 19% stated the role of chemotherapy is unknown...
October 16, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30334232/inpatient-complications-predict-tracheostomy-better-than-admission-variables-after-traumatic-brain-injury
#11
Ryne Jenkins, Nicholas A Morris, Bryce Haac, Richard Van Besien, Deborah M Stein, Wan-Tsu Chang, Gary Schwartzbauer, Gunjan Parikh, Neeraj Badjatia
BACKGROUND: Data regarding who will require tracheostomy are lacking which may limit investigations into therapeutic effects of early tracheostomy. METHODS: We performed an observational study of adult traumatic brain injury (TBI) patients requiring intensive care unit (ICU) admission for ≥ 72 h and mechanical ventilation for ≥ 24 h between January 2014 and December 2014 at a level 1 trauma center. Patients who had life-sustaining measures withdrawn were excluded...
October 17, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/30333267/diagnostic-accuracy-of-platelet-lymphocyte-ratio-for-screening-complex-coronary-lesion-in-different-age-group-of-patients-with-acute-coronary-syndrome
#12
Irma Wahyuni Anwar, Ika Prasetya Wijaya, Lugyanti Sukrisman, Sally A Nasution, Cleopas M Rumende
BACKGROUND: with the increasing number of patients with acute coronary syndrome (ACS) with complex coronary lesion and the increasing needs of coronary artery bypass grafting (CABG) procedures, there is an increasing need for a tool to perform early stratification in high-risk patients, which can be used in daily clinical practice, even at first-line health care facilities setting in Indonesia. It is expected that early stratification of high-risk patients can reduce morbidity and mortality rate in patients with ACS...
July 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/30332880/-surgical-methods-and-curative-effect-of-tibial-plateau-fracture-with-medial-large-block-split
#13
Yong Zhang, Qing Wang, Xian-Feng He, Bai-Ping Xiao, Yun-Qiang Zhuang, Yong Hu, Wei-Hu Ma
OBJECTIVE: To explore the clinical effects of protecting the internal structure of the knee and internal fixation through two different directions for the treatment of tibial plateau fractures with medial large block split. METHODS: From January 2010 to January 2016, data of 21 patients of tibial plateau with medial large block split fractures who were treated with protecting the internal structure of the knee and internal fixation through two different directions were retrospectively analyzed, including 17 males and 4 females, with an average age of (39...
September 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/30332875/-accordion-operation-for-the-bone-transport-in-treating-tibial-bone-defect
#14
Rui-Jian Peng, Yong-Hong Zhang, Xiao-Hui Li, Hua-Nan Shi, Yan-Jun Lu, Qi Yang
OBJECTIVE: To discuss clinical outcomes of accordion operation for the Ilizarov technique in treating tibial bone defects. METHODS: From January 2014 to June 2016, 22 patients with tibial bone defects were treated by Ilizarov bone-transport technique, including 19 males and 3 females with an average age of 44.04 years old ranging from 23 to 60 years old;the length of the bone defects before the bone transport was 5 to 11 cm with an average 7.68 cm; Cause of injury invlved traffic accidents in 14 cases, fall injury in 3, smashing injury in 4, high drop injury in 1; 6 cases were on the left and 16 cases were on the right...
September 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/30332708/-predictors-of-ambulatory-medical-care-utilization-by-the-elderly-with-osteoarthritis-rheumatoid-arthritis-or-osteoporosis
#15
Matthias Hans Belau, Oliver Razum, Judith Fuchs
BACKGROUND: Since chronic musculoskeletal disorders (MD) cause considerable costs for the German health care system, service providers and policy makers need information on the use of the different health care services. On the basis of Andersen's behavioral model, the article provides predictors of ambulatory medical care utilization in the fields of general medicine, orthopaedics and physiotherapy relevant to chronic MD in the 65- to 79-year-old population affected by arthritis, rheumatoid arthritis or osteoporosis in Germany...
October 17, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/30328310/self-reported-oral-status-and-habits-related-to-oral-care-in-adult-poles-a-questionnaire-study
#16
Renata Górska, Bartłomiej Górski
BACKGROUND: Bacterial plaque control plays a key role in the prevention of caries and periodontal diseases. Hygiene negligence in this respect may influence the state of gingiva, and - in the long term - the number of lost teeth. The recommended method of mechanical control of dental plaque is tooth brushing twice a day. OBJECTIVES: The aim of the study was to assess the frequency of tooth brushing, the use of various oral hygiene accessories, the number of preserved teeth, and the occurrence of gingival bleeding in adult Poles, based on a questionnaire study...
July 2018: Dental and medical problems
https://www.readbyqxmd.com/read/30326926/can-malaria-rapid-diagnostic-tests-by-drug-sellers-under-field-conditions-classify-children-5-years-old-or-less-with-or-without-plasmodium-falciparum-malaria-comparison-with-nested-pcr-analysis
#17
Freddy Eric Kitutu, Henry Wamani, Katarina Ekholm Selling, Fred Ashaba Katabazi, Ronald Bisaso Kuteesa, Stefan Peterson, Joan Nakayaga Kalyango, Andreas Mårtensson
BACKGROUND: Malaria rapid diagnostic tests (RDTs) available as dipsticks or strips, are simple to perform, easily interpretable and do not require electricity nor infrastructural investment. Correct interpretation of and compliance with the RDT results is a challenge to drug sellers. Thus, drug seller interpretation of RDT strips was compared with laboratory scientist re-reading, and PCR analysis of Plasmodium DNA extracted from RDT nitrocellulose strips and fast transient analysis (FTA) cards...
October 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30326170/interaction-between-warfarin-and-cannabis
#18
Per Damkier, Dorte Lassen, Mette Marie Hougaard Christensen, Kenneth Grønkjaer Madsen, Maja Hellfritzsch, Anton Pottegård
Delta-9-tetrahydrocannabinol (THC), the main psychoactive cannabinoid in cannabis, may inhibit the cytochrome P450 enzyme CYP2C9. Consequently, cannabis use might infer a risk of drug-drug interaction with substrates for this enzyme, which includes drugs known to have a narrow therapeutic window. In this study, we describe a case report of a 27-year-old man treated with warfarin due to mechanical heart valve replacement who presented with elevated international normalized ratio (INR) value (INR = 4.6) following recreational cannabis use...
October 16, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/30324998/abducens-nerve-palsy-in-pre-eclampsia-case-report
#19
Imen Ammous, Omar Hadj Said, Mejdi Boukari, Imen Zhioua, Khalil Errais, Raja Zhioua
Cranial nerves palsy associated with preeclampsia is reported in literature. Facial and abducens palsies were the most nerve disorders described. Only eleven cases have been reported in the literature. We report the case of a 27-years-old patient who presented abducens nerve palsy in immediately after the delivery of severe pre-eclampsia. No specific pathology was found. Symptoms of abducens nerve palsy have resolved spontaneously by controlling blood pressure after delivery.
January 2018: La Tunisie Médicale
https://www.readbyqxmd.com/read/30323896/clofarabine-based-reduced-intensity-conditioning-regimen-with-peripheral-blood-stem-cell-graft-and-post-transplant-cyclophosphamide-in-adults-with-myeloid-malignancies
#20
Patrice Chevallier, Pierre Peterlin, Alice Garnier, Amandine Le Bourgeois, Beatrice Mahé, Viviane Dubruille, Nicolas Blin, Cyrille Touzeau, Thomas Gastinne, Anne Lok, Yannick Le Bris, Marie C Béné, Steven Le Gouill, Philippe Moreau, Thierry Guillaume
Background: The Baltimore reduced-intensity conditioning (RIC) regimen using high-dose post-transplant cyclophosphamide (PTCY) is considered as a standard of care for haploidentical allogeneic stem cell transplantation (allo-SCT). However, it is associated with relatively low survivals and high incidence of relapse, especially when considering myeloid malignancies. Results: This retrospective study included 36 adults (males n = 18; median age: 60.5 years old; haplodonors n = 27; matched donors n = 8) with myeloid malignancies transplanted between March 2014 and March 2017 at the University Hospital of Nantes...
September 11, 2018: Oncotarget
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