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https://www.readbyqxmd.com/read/30555602/t-peak-t-end-t-peak-t-end-qt-ratio-and-t-peak-t-end-dispersion-for-risk-stratification-in-brugada-syndrome-a-systematic-review-and-meta-analysis
#1
Gary Tse, Mengqi Gong, Christien Ka Hou Li, Keith Sai Kit Leung, Stamatis Georgopoulos, George Bazoukis, Konstantinos P Letsas, Abhishek C Sawant, Giacomo Mugnai, Martin C S Wong, Gan Xin Yan, Pedro Brugada, Gian-Battista Chierchia, Carlo de Asmundis, Adrian Baranchuk, Tong Liu
Background: Brugada syndrome is an ion channelopathy that predisposes affected subjects to ventricular tachycardia/fibrillation (VT/VF), potentially leading to sudden cardiac death (SCD). Tpeak -Tend intervals, (Tpeak -Tend )/QT ratio and Tpeak -Tend dispersion have been proposed for risk stratification, but their predictive values in Brugada syndrome have been challenged recently. Methods: A systematic review and meta-analysis was conducted to examine their values in predicting arrhythmic and mortality outcomes in Brugada Syndrome...
December 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/30554324/association-between-rem-sleep-and-obstructive-sleep-apnea-in-obese-and-overweight-adolescents
#2
Orna Sever, Eric J Kezirian, Emily Gillett, Sally L Davidson Ward, Michael Khoo, Iris A Perez
PURPOSE: Overweight and obese children have demonstrated reduced rapid eye movement (REM) sleep, affecting energy balance regulation and predisposition to weight gain. Obstructive sleep apnea (OSA) is a known cause of decreased REM sleep. The purpose of this study is to examine the association between the percentage of REM sleep, BMI z-score, and OSA severity in overweight and obese adolescents. METHODS: We performed a cross-sectional study of 92 (43% female) overweight and obese adolescents (13-17 years old) who underwent overnight polysomnography (PSG) at Children's Hospital Los Angeles between 2010 and 2017...
December 15, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30554308/systemic-sclerosis-induced-by-the-use-of-cocaine-is-there-an-association
#3
REVIEW
Rafael Andreussi, Lila Morena Bueno Silva, Henrique Carriço da Silva, Ana Paula Luppino-Assad, Danieli Castro O Andrade, Percival D Sampaio-Barros
The association between cocaine abuse and systemic sclerosis (SSc) is rarely described. Two new cases of this association are presented: two young adults, after using inhaled cocaine for a few years, were diagnosed with SSc. While a 24 year-old white female patient presented with diffuse SSc with multiple digital ulcers and scleroderma renal crisis (SRC), a 27 year-old male patient presented limited SSc with skin ulcers and digital gangrene, rapidly evolving to death due to massive intestinal hemorrhage. The authors performed a literature search and found only eight previously published cases...
December 15, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30553633/an-unexpected-cause-of-chronic-cough-in-a-young-woman-tachycardia-induced-cardiomyopathy
#4
Eiryu Sakihara, Akira Kuriyama, Koya Okabe, Tetsunori Ikegami
Heart failure typically manifests with exertional dyspnea or limb edema. Old age, underlying heart disease, and coronary risk factors are known risk factors for heart failure. Thus, congestive heart failure is rarely considered as a differential diagnosis of chronic cough in a previously healthy young person. However, tachycardia-induced cardiomyopathy (TIC) can result in such a situation. A case of a previously healthy 27-year-old woman with TIC is described herein. On the first examination, the patient presented with left ventricular (LV) dysfunction caused by persistent tachyarrhythmia...
December 10, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30553600/molecular-and-immunologic-analysis-of-laryngeal-squamous-cell-carcinoma-in-smokers-and-non-smokers
#5
Ian-James Malm, Lisa M Rooper, Justin A Bishop, Selmin Karatayli Ozgursoy, Alexander T Hillel, Lee M Akst, Simon R Best
BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is strongly associated with tobacco use, but recent reports suggest an increasing incidence of LSCC in patients without traditional risk factors, suggesting an alternative etiology of tumorigenesis. The purpose of this study is to characterize this non-smoking population and to compare immunohistochemical markers in tumor specimens from non-smokers and smokers with LSCC. METHODS: A retrospective chart review of patients with LSCC at Johns Hopkins Hospital (JHH) was performed...
November 22, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/30552889/management-of-invasive-squamous-cell-carcinomas-of-the-conjunctiva-treatment-of-invasive-conjunctival-carcinoma
#6
Alexandra Santoni, Juliette Thariat, Célia Maschi, Joel Herault, Stéphanie Baillif, Sandra Lassalle, Marie Laure Peyrichon, Julia Salleron, Jean-Pierre Caujolle
PURPOSE: Ocular Surface Squamous Neoplasia includes a spectrum of diseases from dysplasia to invasive squamous cell carcinoma of the conjunctiva. Whether the degree of invasion influences outcomes is debated. We evaluated the outcomes and management of conjunctival carcinomas defined as ≤0.2mm invasion of the chorion (miSCC) or over (SCC). DESIGN: this is a retrospective case series. METHODS: Clinical, tumor and therapeutic characteristics and outcomes were collected for consecutive patients with histology-proven invasive conjunctival miSCC/SCC treated between 2002 and 2017...
December 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/30550802/repair-of-untreated-older-patients-with-tetralogy-of-fallot-with-major-aortopulmonary-collaterals
#7
Sumeet Vaikunth, Holly Bauser-Heaton, George K Lui, Lisa Wise-Faberowski, Frandics P Chan, Ritu Asija, Frank L Hanley, Doff B McElhinney
BACKGROUND: Our programmatic approach to tetralogy of Fallot with major aortopulmonary collaterals emphasizes single-stage unifocalization with complete intracardiac repair during infancy. Little is known about suitability for complete repair in patients beyond infancy. We sought to analyze outcomes of our approach in older patients with previously untreated tetralogy of Fallot with major aortopulmonary collaterals. METHODS: Any patient with this lesion not treated prior to 2 years of age referred to our center from 2002-17 met inclusion criteria...
December 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30550487/individual-and-sexual-network-predictors-of-hiv-incidence-among-men-who-have-sex-with-men-in-nigeria
#8
Rebecca G Nowak, Andrew Mitchell, Trevor A Crowell, Hongjie Liu, Sosthenes Ketende, Habib O Ramadhani, Nicaise Ndembi, Sylvia Adebajo, Julie Ake, Nelson L Michael, William A Blattner, Stefan D Baral, Manhattan E Charurat
BACKGROUND: To date, HIV incidence studies among men who have sex with men (MSM) across sub-Saharan Africa have focused on studying sexual risk practices with less focus on sexual networks. SETTING: TRUST/RV368 conducted in Abuja and Lagos, Nigeria recruited MSM using respondent driven sampling (RDS) and followed HIV negative men for incident infection over 4 years. METHODS: Four-hundred forty-one HIV-uninfected MSM underwent a parallel rapid HIV testing algorithm every 3 months for up to 18 months...
December 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/30550457/activation-of-supraspinatus-and-infraspinatus-partitions-and-periscapular-musculature-during-rehabilitative-elastic-resistance-exercises
#9
Ranjit Joseph, Talia Alenabi, Tea Lulic, Clark R Dickerson
OBJECTIVE: The purpose of this study was to quantify the activation of partitions within supraspinatus and infraspinatus and some periscapular muscles during four resistance exercises with elastic bands. DESIGN: 27 right handed healthy volunteers (22.5 ± 2.7 years old) were recruited. Intramuscular EMG from supraspinatus (anterior and posterior) and infraspinatus (superior and middle) and surface EMG data from the upper, middle and lower trapezius and serratus anterior were recorded during four elastic resistance exercises (Y, T, W, L)...
December 13, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/30550152/-application-of-technique-of-hrct-and-multipliate-plane-reconstruction-in-analysis-of-image-features-of-superior-semicircular-canal-dehiscence
#10
T Chen, Y Liang, W Zhang, M L Ban, W Chen
Objective: Application of technique of high resolution CT (HRCT) and multipliate plane reconstruction, analyzed the image features of suspicious superior semicircular canal dehiscence (SSCD) to improve the understanding of the SSCD. Method: From January 2016 to April 2017, a total of 230 adult patients who checked temporal bone HRCT were collected in this retrospective study, of which 160 cases (320 ears) of the non-SSCD, 73 cases were male (146 ears), 87 cases were female (174 ears), aged 18 to 70 years old; 70 cases (113 ears) were suspicious diagnosed with SSCD, 33 cases were male (55 ears), 37 cases were female (58 ears), and 18 to 71 years old...
July 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/30548864/vestibular-atelectasis-decoding-pressure-and-sound-induced-nystagmus-with-bilateral-vestibulopathy
#11
Sinisa Maslovara, Silva Butkovic-Soldo, Ivana Pajic-Matic, Anamarija Sestak
We present the case of a 27-year-old male who presented with vertigo when pressing the entrance of his right auditory meatus and exposing his right ear to loud noise. A diagnostic procedure revealed bilateral labyrinth weakness, which was confirmed by caloric and rotational testing. The ocular vestibular evoked myogenic potentials investigation demonstrated a significant weakness of the right utriculus, whereas the cervical vestibular evoked myogenic potentials were normal, indicating preservation of the saccular response...
December 13, 2018: Laryngoscope
https://www.readbyqxmd.com/read/30546977/a-rare-pathological-couplet-of-colocolic-intussusception-plus-cecal-bascule-in-a-young-adult-a-case-report
#12
Auerilius E Hamilton, Angad Singh, Kirk K Austin, JooShik Shin, Jonathan S Hong
This report is of a rare case involving a 27-year-old female who presented to the hospital with the pathological couplet of colocolic intussusception and cecal bascule causing bowel obstruction. Up to the time of presentation to the hospital, this patient had not undergone a full investigation for a known iron deficiency, anemia. Subsequently, during the emergency admission and after having an operative surgical procedure, the patient was found to have both a congenitally malpositioned cecum and a benign colonic polyp-forming condition...
October 9, 2018: Curēus
https://www.readbyqxmd.com/read/30546284/the-association-between-frequency-of-social-contact-and-frailty-in-older-people-korean-frailty-and-aging-cohort-study-kfacs
#13
Doukyoung Chon, Yunhwan Lee, Jinhee Kim, Kyung-Eun Lee
Background: The trend of aging society is occurring globally, and with it, one of the health problems that is emerging is frailty. Efforts are being made to account for the increasing prevalence of frailty, and various modifiable factors are being considered in regards to frailty. Because social contact has shown beneficial effects in terms of health in previous studies, it is increasingly being considered in relation to frailty. The purpose of this study was to assess the association of different types of social contact with frailty status...
December 17, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/30545548/repeated-pulmonary-embolism-with-cardiac-arrest-after-uterine-artery-embolization-for-uterine-arteriovenous-malformation-a-case-report-and-literature-review
#14
Balkenze Imankulova, Milan Terzic, Talshyn Ukybassova, Gauri Bapayeva, Timur Lesbekov, Gulnar Mustafinova, Nurlan Smagulov, Fariza Shauyen
OBJECTIVE: Uterine arteriovenous malformation (AVM) is an abnormal and nonfunctional communication between uterine arteries and veins, currently managed by uterine artery embolization (UAE). Pulmonary embolism (PE) is the most severe and life-threatening complication of this procedure. CASE REPORT: We report a case of 27 year-old woman with heavy vaginal bleeding and abdominal pain caused by AVM. UAE was performed uneventfully, but 2 h after the procedure the first attack of pulmonary embolism occurred, treated by anticoagulation therapy...
December 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/30542785/genetic-analysis-of-a-case-of-helicobacter-pylori-uninfected-intramucosal-gastric-cancer-in-a-family-with-hereditary-diffuse-gastric-cancer
#15
Taro Funakoshi, Shin'ichi Miyamoto, Nobuyuki Kakiuchi, Mitsuhiro Nikaido, Takeshi Setoyama, Akira Yokoyama, Takahiro Horimatsu, Atsushi Yamada, Masako Torishima, Shinji Kosugi, Hidetaka Yamada, Haruhiko Sugimura, Hironori Haga, Yoshiharu Sakai, Seishi Ogawa, Hiroshi Seno, Manabu Muto, Tsutomu Chiba
Germline mutations in CDH1, encoding E-cadherin, are known to be the causative mechanism of hereditary diffuse gastric cancer (HDGC). We encountered two cases of gastric cancer in a Japanese family with HDGC. A 28-year-old man (Case 1) died of advanced gastric cancer. His younger sister aged 27 (Case 2) was diagnosed with intramucosal signet ring cell carcinoma (SRCC). Both had identical germline CDH1 mutations, but Case 1 was positive for Helicobacter pylori infection, whereas Case 2 was negative. Case 2 underwent total gastrectomy...
December 12, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/30542768/clinical-outcomes-of-oral-metronomic-vinorelbine-in-advanced-non-small-cell-lung-cancer-correlations-with-pharmacokinetics-and-mdr1-polymorphisms
#16
Milena Gusella, Felice Pasini, Donatella Caruso, Carmen Barile, Yasmina Modena, Anna Paola Fraccon, Laura Bertolaso, Daniela Menon, Giorgio Crepaldi, Antonio Bononi, Roberto Spezzano, Giorgia Anna Telatin, Giuseppe Corona, Roberto Padrini
PURPOSE: This study investigated correlations of the clinical outcomes of oral metronomic vinorelbine (VNR) with VNR pharmacokinetics and MDR1 polymorphisms. METHODS: Eighty-two patients with metastatic non-small cell lung cancer (NSCLC) unfit for standard chemotherapy were treated with VNR at the oral doses of 20-30 mg every other day or 50 mg three times a week. They had a performance status (PS) ≤ 3, were > 70-year-old and drug-naïve or cisplatin-pretreated...
December 12, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/30541326/afatinib-in-the-treatment-of-advanced-non-small-cell-lung-cancer-with-rare-egfr-in-exon-18-t179x-mutation-a-case-report
#17
Čoupková Helena, Vyzula Rostislav
INTRODUCTION: Exon 18-T719X EGFR mutation in non-small cell lung cancer is rare, only 1-5% of all EGFR mutations. The efficacy of EGFR tyrosin kinase inhibitors in tumours with uncommon mutations is still unclear and the prediction of response of such tumours to therapy remains unexplored. CASE: A 71-year-old woman with no previous smoking history with disseminated lung adenocarcinoma with exon 18-T719X EGFR mutation was treated with afatinib. A partial response was achieved in 2 months, progression-free survival was 19 months...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/30541324/pituitary-metastasis-in-a-patient-with-pulmonary-adenocarcinoma-presenting-with-a-disturbance-of-consciousness
#18
Cahajlová Radka, Kollerová Jana
BACKGROUND: Brain metastases are one of the main causes of morbidity and mortality of patients with oncological disease. In non-small cell lung carcinoma (NSCLC), the risk of CNS secondary development is 30-50%. An unusual diagnostic and therapeutic problem is the finding of suspicious pituitary lesions. Obtaining a differential diagnosis relies on evaluating the clinical course of the disease (visual disturbances, diabetes insipidus (DI), weakness etc.), and performing endocrinological examinations and imaging analyses (CT, but mainly MRI)...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/30541301/ciliary-body-melanoma-treatment-by-stereotactic-radiosurgery
#19
A Furdová, J Juhas, M Šramka, G Králik
INTRODUCTION: Malignant melanoma of the ciliary body (corpus ciliare) represents 10 to 15 percent of tumors of the uveal tract. The aim of the work is to evaluate the effectiveness of stereotactic radiosurgery performed on LINAC linear accelerator and the occurrence of postoperative complications. MATERIAL AND METHODS: Retrospective analysis of patients with ciliary body melanoma treated with stereotactic radiosurgery on linear accelerator in the period 1/2011 to 12/2016 in Slovakia...
2018: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/30541222/-epidemiological-investigation-and-analysis-of-an-outbreak-of-mycoplasma-pneumoniae-pneumonia-in-adult
#20
L Gu, W Liu, G X Lai, X Zhou, D L Liu, D S Jia, Y B Liu, W Wen
Objective: To conduct an epidemiological investigation and analysis of an outbreak of mycoplasma pneumonia in adults. Methods: The first case was a 23-year-old male came from the Third Military Medical University, who served as an intern in the Fuzhou General Hospital of PLA and presented on July 16, 2015 with a history of low-grade fever, dizziness, fatigue and chest tightness. Chest CT revealed pulmonary nodules shadow. It was found that other 11 individuals who had been in close contact with the first patient also had similar pulmonary nodules shadow after chest CT examination...
December 11, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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